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Resuscitating acupuncture therapy for glucose metabolism in acute cerebral infarction of basal ganglia

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Neural Regeneration Research 2010年第14期5卷 1050-1054页

作者： Pengfei Shen xuemin shi First Affiliated Hospital Tianjin University of Traditional Chinese Medicine Tianjin 300193 China

BACKGROUND： Acupuncture can improve motor function in patients with cerebral infarction, and activate brain glucose metabolism in relevant brain areas. However, the association between encephalic region activation and acupuncture, as well as the clinical significance of activation remain unclear. OBJECTIVE： Through the use of positron emission tomography-computed tomography （PET-CT）, acute cerebral infarction patients were analyzed for global cerebral metabolism, cerebral infarction focus, peripheral edema, and pyramidal tract pathway changes, which were directly related to clinical symptoms. The influence of resuscitating acupuncture on cerebral glucose metabolism was analyzed in patients with acute cerebral infarction in basal ganglia. DESIGN, TIME AND SETTNG： Randomized, controlled, clinical trials were performed from March 2007 to October 2008 at the PET-CT Center of the General Hospital of Tianjin Medical University, China. PARTICIPANTS： Twelve patients with acute basal ganglia infarction were recruited from the First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, the Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin Chinese Medicine Hospital, and Affiliated Hospital of Medical College of Chinese People＇s Armed Police Force. METHODS： The cerebral infarcted patients were randomly assigned to acupuncture and control groups. In addition to routine treatment, the acupuncture group was treated by acupuncture at the main acupoints for resuscitation [Neiguan （PC 6）, Renzhong （DU 26）, and Sanyinjiao （SP 6）], while the control group received routine treatment. MAIN OUTCOME MEASURES： Before and after treatment, patients with acute cerebral infarction were evaluated for global brain, cerebral infarction focus, and surrounding edema and glucose metabolism in encephalic region of pyramidal tract conduction by 18-labeled fluorodeoxyglucose for PET-CT imaging. RESULTS： The resuscitating acupuncture th

关键词： resuscitating acupuncture positron emission tomography cerebral glucose metabolism acupuncture acute basal ganglia infarction brain injury neural regeneration

站在巨人的肩上:从“醒脑开窍”到“疏肝调神”——谈符文彬教授对石学敏院士学术与学科专科建设经验的传承与创新

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中华针灸电子杂志 2024年第1期13卷 1-4页

作者：罗丁石学敏符文彬广州中医药大学第二临床医学院/广东省中医院 510120 广东省中医院石学敏院士工作室 510120 天津中医药大学第一附属医院 300381 国家中医针灸临床医学研究中心天津300381

国医大师石学敏院士从医60余年,创立的醒脑开窍针刺法救人无数,他在临床实践与科学研究中奉行的科学与创新原则也给针灸学科发展带来巨大动力,是推动针灸走向世界的战略医学家。符文彬教授深入领悟了石院士醒脑开窍的学术思想,将石院士... 详细信息

国医大师石学敏院士从医60余年,创立的醒脑开窍针刺法救人无数,他在临床实践与科学研究中奉行的科学与创新原则也给针灸学科发展带来巨大动力,是推动针灸走向世界的战略医学家。符文彬教授深入领悟了石院士醒脑开窍的学术思想,将石院士对“神”的认识、针刺手法量学观点、单元疗法蕴藏于“疏肝调神”整合针灸学术思想体系中。石院士在学科建设与管理、人才培养方面的经验也给符教授极大启发。符教授在多年的临床和科研工作中不断完善“疏肝调神”学术思想、创立“整合针灸”治疗抑郁障碍相关疾病以及学科、专科建设,是对石学敏院士学术与学科、专科建设经验的传承与创新,并致力于将针灸学科提升至新高度、为人类健康贡献中医针灸力量。

关键词：醒脑开窍针刺疗法继承创新

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针灸大数据发展的整体观

中华针灸电子杂志 2024年第2期13卷 45-49页

作者：李礼石学敏姚晨王舒石江伟天津中医药大学第一附属医院 300381 国家中医针灸临床医学研究中心天津300381 北京大学第一医院北京大学临床研究所100191 天津市中医药研究院附属医院 300120 国家中医药管理局脑病针刺疗法重点研究室天津300381 天津市针灸学重点实验室 300381

国家全面推进健康医疗大数据基础建设,针灸行业可顺势推动自我发展。天河灵枢大模型是针灸拥抱大数据的标志性成果。但针灸大数据的良性发展仍需要立足于针灸自身特点做好顶层设计,统筹规划并系统推进针灸大数据工程,以便加速针灸与大... 详细信息

国家全面推进健康医疗大数据基础建设,针灸行业可顺势推动自我发展。天河灵枢大模型是针灸拥抱大数据的标志性成果。但针灸大数据的良性发展仍需要立足于针灸自身特点做好顶层设计,统筹规划并系统推进针灸大数据工程,以便加速针灸与大数据的深度融合。基于此,从目标定位、支撑和应用体系、相关交叉学科建设等角度分析针灸大数据发展的需求,以便为后续制定行业规划提供参考。

关键词：针灸学大数据整体观针灸交叉学科

北京大学首钢医院发热门诊1223例患者临床资料分析

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中国卫生标准管理 2024年第15期15卷 82-85页

作者：史雪敏张丽梅宁武北京大学首钢医院感染性疾病科北京100043

目的分析发热门诊患者的流行病学特征,了解发热门诊患者发热原因和临床表现,为疾病的防治提供帮助。方法选取2022年1月—2023年1月北京大学首钢医院发热门诊收治的1223例患者的临床资料进行回顾性分析,包括患者的性别、年龄、体温、发... 详细信息

目的分析发热门诊患者的流行病学特征,了解发热门诊患者发热原因和临床表现,为疾病的防治提供帮助。方法选取2022年1月—2023年1月北京大学首钢医院发热门诊收治的1223例患者的临床资料进行回顾性分析,包括患者的性别、年龄、体温、发病时间以及血象等。结果1223例发热患者中男女比例为1.12∶1,各年龄段发热患者中有2个发热高峰,>15~25岁402例,占比32.87%;>25~35岁365例,占比29.84%。患者就诊数例最多的时间段为1月份,其次是2月份和12月份,发热患者的体温主要分布在38.0~38.9℃,共868例,占70.97%;发热类型主要为不规则发热,1091例,占比最高达到了89.21%;发热时间普遍为1~3 d。发热患者中的血象变化主要是中性粒细胞计数降低、淋巴细胞计数升高同时改变,共589例,占比48.16%;其次是单纯淋巴细胞降低,256例,占比20.93%。患者中有呼吸系统症状的有697例,占比56.99%;其次是泌尿系统症状,有306例患者,占比25.02%;病因诊断主要是呼吸系统疾病,有795例次,占比为65.00%。结论病毒感染是门诊发热患者就诊的主要原因,其中以呼吸系统疾病最为常见,中青年人群为主要发病群体,患者主要为中度、不规则发热,应加强呼吸道传染疾病知识的健康宣教,更好地防治疾病。

关键词：发热门诊发热患者流行病学呼吸道传染病发热原因临床表现

Safety and efficacy of Danqipiantan capsule for treatment of stroke: a systematic review

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Journal of Traditional Chinese Medicine 2013年第6期33卷 707-714页

作者： Jiashen Li Haizhen Zheng Xiaofeng Zhao Shu Wang xuemin shi Institute of Acupuncture and Moxibustion First Teaching Hospital of Tianjin University of Traditional Chinese Medicine Tianjin Key Laboratory of Acupuncture and Moxibustion Science

OBJECTIVE： To evaluate the efficacy and safety of Danqipiantan capsule （DPC） for the treatment of stroke. METHODS： PubMed, China Science And Technolo- gy Journal Database, Wanfang Database, Chinese periodicals in the China National Knowledge Infra- structure, and the General Hospital of Tianjin Medi- cal University＇s Library were searched until July 2012. Randomized controlled trials （RCTs） and ob- servational studies that reported the use of DPC for treatment of stroke were selected. RESULTS： Eleven articles that included 12 RCTs, and 2 articles that included 3 observational studies were identified. A total of 2590 patients participat- ed in the studies. We found that there was a signifi-cant statistical difference between DPC treatment groups and the control groups in terms of the effec- tive rate [risk ratio （RR）, 1.14; 95% confidence inter- vals （CI）, 1.04, 1.25; P=0.01], FugI-Meyer Assessment Scale [weighted mean difference （WMD）, 9.77; 95% CI （4.84, 14.70）; P=0.00], Barthel Index [WMD=6.40; 95% CI （3.15, 9.65）], and mean flow velocity [WMD= 5.79; 95% CI （1.64, 9.94）]. There were no significant differences for The National Institutes of Health Stroke Scale [WMD=0.60; 95% CI （ - 1.09, 2.29）], vi- sual field defects [left visual field： WMD= - 203.10; 95% CI （ - 424.41, 18.21）; right visual field： WMD= - 172.60; 95% CI （ - 409.29, 64.09）] or the functional independence measure [WMD= - 7.90; 95% CI （ - 16.64, 0.84）]. Seven articles that included eight RCTs reported the safety of DPC treatment. Two ar- ticles that included three observational studies also reported beneficial effects for DPC. Because the Chinese studies were of poor methodological quali- ty, and most of the sample sizes were small, our analysis was likely affected by bias. CONCLUSION： DPC has a beneficial effect and is relatively safe when used for the treatment of stroke.

关键词： KeStroke Treatment outcome Safety Re-view Danqipiantan capsule

Optimal stimulation parameters for Renzhong (DU 26) electro-acupuncture for improving motor function in a rat model of middle cerebral artery occlusion

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Neural Regeneration Research 2011年第12期6卷 929-934页

作者： Lin Han Shu Wang Jinquan Ma Wenping Yao Yan Shen xuemin shi Acupuncture Institute of First Affiliated Hospital Tianjin University of Traditional Chinese Medicine Tianjin 300193 China Key Laboratory of Cerebropathy Acupuncture Therapy of State Administration of Traditional Chinese Medicine Tianjin Key Laboratory of Acupuncture and Moxibustion Tianjin 300193 China

The selection of electro-acupuncture parameters remains poorly unified between clinical studies. The present study observed the effects of electro-acupuncturing Renzhong （DU 26） with different stimulation parameters on motor function recovery following middle artery occlusion injury in rats. Results showed an optimal stimulation parameter for Renzhong electro-acupuncture that was low frequency and mild current （2 Hz, 1 mA） significantly improved cortical excitability and conductive function, and promoted recovery in a rat model of motor function in middle artery occlusion. Frequency had a greater impact than current or interaction, and played a critical role in electro-acupuncture therapy.

关键词： electro-acupuncture acupoint middle artery occlusion injury motor-evoked potential stimulation parameters orthogonal design

Proteomics analysis of cerebral cortex in Wistar rats

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Frontiers in Biology 2008年第4期3卷 419-427页

作者： Xiaofeng ZHAO Jingrong WEN Shu WANG xuemin shi First Hospital Affiliated to Tianjin University of Traditional Chinese Medicine Tianjin 300193China Tianjin University of Traditional Chinese Medicine Tianjin 300193China

To analyze the protein expression pattern of the cerebral cortex in Wistar rats using the proteomics approach,proteins were separated by two-dimensional gel electrophoresis,stained with Coomassie brilliant blue and digested with ***,we analyzed the peptide section using a matrix-assisted laser desorption/ionization time of flight mass spectrometry(MALDI-TOF-MS)and identified the protein by indexing special database(SwissProt)according to the finger printing of the peptide ***-four protein spots were identified,including metabolic enzymes,skeleton proteins,heat shock proteins,antioxidant proteins,signaling proteins,proteasome related proteins,neuron and glial specific proteins and serum associated *** result of this study enriches the database of the proteome in the cerebral cortex of rats and lays a foundation for further research of neurological disorders in rat models.

关键词： brain proteomics two-dimensional gel electrophoresis(2-DE) matrix-assisted laser desorption/ionization time of flight mass spectrometry(MALDI-TOF-MS)

Transport properties of p-type CaMg_(2)Bi_(2) thermoelectrics

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Journal of Materiomics 2019年第4期5卷 567-573页

作者： Cheng Sun xuemin shi Liangtao Zheng Bo Chen Wen Li Interdisciplinary Materials Research Center School of Materials Science and EngineeringTongji Univ.4800 Caoan Rd.Shanghai201804China School of Materials Science and Engineering Tongji Univ.4800 Caoan Rd.Shanghai201804China Key Laboratory of Performance Evolution and Control for Engineering Structures of Ministry of Education Tongji Univ.1239 Siping Rd.Shanghai200092China

Due to the complex crystal structure for low lattice thermal conductivity and the tunable valence bands for superior electronic performance,CaAl_(2)Si_(2)-structured AB_(2)C_(2) Zintl compounds have been frequently proven as promising p-type thermoelectric *** this work,thermoelectric properties of CaMg_(2)Bi_(2) are systematically investigated in a broad carrier concentration(10^(18)-10^(20) cm^(-3))through Agdoping for comprehensively evaluating its potential for thermoelectric *** broad carrier concentration enables a well assessment of the carrier transport properties by single parabolic band with acoustic phonon scattering and a revelation of the carrier transport by multiple valence orbitals when the carrier concentration higher than ~2×10^(19) cm^(-3),leading to a significant enhancement in electronic *** the help of additional point defect phonon scattering introduced by BaMg_(2)Bi_(2)-alloying,a reduction in lattice thermal conductivity in the entire temperature range and the lowest one of ~0.7 W/m-K are achieved,leading to a 100% enhancement in average *** addition to the contribution of a multiband *** work not only demonstrates CaMg_(2)Bi_(2) as a promising thermoelectric material,but also provides a well understanding of its underlying material physics.

关键词： Thermoelectric CaMg_(2)Bi_(2) Carrier concentration Band manipulation

Activation of various brain areas during acupuncture at Taixi (KI 3) and Qiuxu (GB 40) acupoints

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Neural Regeneration Research 2011年第12期6卷 925-928页

作者： Shangjie Chen Huajun Cheng Shanshan Wu Jun Chen Pengcheng Ran xuemin shi Department of Rehabifitation Baoan Hospital Affiliated to Southern Medical University Shenzhen 518101 Guangdong Province China Tianjin University of Traditional Chinese Medicine Tianjin 300193 China Department of Image Guangdong Hospital of Traditional Chinese Medicine Guangzhou 510120 Guangdong Province China

A number of previous studies of acupuncture acupoint specificity have used sham acupoints, sham acupuncture or meridian acupoints at a great distance from each other as controls in functional MRI （fMRI） experiments. However, few studies have compared different meridian acupoints within the same segment, which are associated with similarly intense needle sensations. We performed fMRI on 12 healthy young volunteers and observed differences in brain activation elicited by acupuncture of the Taixi （KI 3） and Qiuxu （GB 40） acupoints. Acupuncture was applied at the Taixi and Qiuxu acupoints, using a multiple-block fMRI design with three blocks, involving three altemations of resting and task phases. After scanning, needle sensation was assessed. The behavioral results revealed that the subjective needle sensation was similar between the Taixiand Qiuxu acupoints. The fMRI results revealed that acupuncture at the right Taixi acupoint activated the right superior temporal gyrus （BA 22）, left middle frontal gyrus （BA 46） and inferior frontal gyrus （BA 45）, bilateral parietal lobe postcentral gyrus （BA 2）, right parietal lobe （BA 3）, and left parietal lobe （BA 40）. Acupuncture at the right Qiuxu acupoint activated the left superior temporal gyrus （BA 42）, right parietal lobe postcentral gyrus （BA 40, BA 43）, right inferior frontal gyrus （BA 47）, bilateral superior temporal gyrus （BA 22）, and right insula BA13. These results suggest that the right Taixiand Qiuxu acupoints activated different brain areas.

关键词： acupuncture therapy functional magnetic resonance imaging Taixi acupoint Qiuxu acupoint neural regeneration