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High mobility group box 1 in the central nervous system:regeneration hidden beneath inflammation

Neural Regeneration Research 2025年第1期20卷 107-115页

作者： Hanki Kim Bum Jun Kim Seungyon Koh Hyo jin Cho xuelian jin Byung Gon Kim Jun Young Choi Department of Brain Science Ajou University School of MedicineSuwonSouth Korea Department of Biomedical Sciences Ajou University Graduate School of MedicineSuwonSouth Korea Department of Neurology Ajou University School of MedicineSuwonSouth Korea Department of Geriatrics The Affiliated Suqian First People’s Hospital of Nanjing Medical UniversitySuqianJiangsu ProvinceChina

High-mobility group box 1 was first discovered in the calf thymus as a DNA-binding nuclear protein and has been widely studied in diverse fields,including neurology and ***-mobility group box 1 in the extracellular space functions as a pro-inflammatory damage-associated molecular pattern,which has been proven to play an important role in a wide variety of central nervous system disorders such as ischemic stroke,Alzheimer’s disease,frontotemporal dementia,Parkinson’s disease,multiple sclerosis,epilepsy,and traumatic brain *** drugs that inhibit high-mobility group box 1 as a damage-associated molecular pattern,such as glycyrrhizin,ethyl pyruvate,and neutralizing anti-high-mobility group box 1 antibodies,are commonly used to target high-mobility group box 1 activity in central nervous system *** it is commonly known for its detrimental inflammatory effect,high-mobility group box 1 has also been shown to have beneficial pro-regenerative roles in central nervous system *** this narrative review,we provide a brief summary of the history of high-mobility group box 1 research and its characterization as a damage-associated molecular pattern,its downstream receptors,and intracellular signaling pathways,how high-mobility group box 1 exerts the repair-favoring roles in general and in the central nervous system,and clues on how to differentiate the pro-regenerative from the pro-inflammatory *** targeting high-mobility group box 1 in the central nervous system may benefit from differentiating between the two functions rather than overall suppression of high-mobility group box 1.

关键词： central nervous system damage-associated molecular pattern ethyl pyruvate glycyrhizzin high mobility group box 1 inflammation neural stem cells neurodevelopment oligodendrocyte progenitor cells redox status regeneration

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Progress in reentry trajectory planning for hypersonic vehicle

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Journal of Systems Engineering and Electronics 2014年第4期25卷 627-639页

作者： Jiang Zhao Rui Zhou xuelian jin School of Automation Science and Electrical Engineering Beihang University Beijing Microelectronics Technology Institute

The reentry trajectory planning for hypersonic vehicles is critical and challenging in the presence of numerous nonlinear equations of motion and path constraints, as well as guaranteed satisfaction of accuracy in meeting all the specified boundary conditions. In the last ten years, many researchers have investigated various strategies to generate a feasible or optimal constrained reentry trajectory for hypersonic vehicles. This paper briefly reviews the new research efforts to promote the capability of reentry trajectory planning. The progress of the onboard reentry trajectory planning, reentry trajectory optimization, and landing footprint is summarized. The main challenges of reentry trajectory planning for hypersonic vehicles are analyzed, focusing on the rapid reentry trajectory optimization, complex geographic constraints, and coop- erative strategies.

关键词： hypersonic vehicle reentry trajectory planning on-board planning reentry trajectory optimization footprint.

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Identification of an Underactuated Unmanned Surface Vehicle

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西北工业大学学报 2012年第5期30卷 699-705页

作者： Zhao Jiang Yan Weisheng jin xuelian Gao Jian College of Marine Engineering Northwestern Polytechnical University Xi'an 710072 China

Hydrodynamic coefficients strongly affect the dynamic performance of underactuated unmanned surface vehicle (USV) . Towing tank test is the traditional approach to identify these coefficients,however, the obtained values are not completely reliable since experimental difficulties and errors are involved. In this paper,an extended Kalman filter (EKF) method and a least squares (LS) method are proposed,only using onboard sensor data for identification of a small underactuated USV. The vehicle prototype as well as the system integration is delineated. Performance of the identification is evaluated by comparing the estimated coefficients,and the feasibility and accuracy of the proposed approach is demonstrated by simulation.

关键词：工业大学教学管理教育事业教育发展

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Modeling subcortical ischemic white matter injury in rodents:unmet need for a breakthrough in translational research

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Neural Regeneration Research 2021年第4期16卷 638-642页

作者： Yuexian Cui xuelian jin Jun Young Choi Byung Gon Kim Department of Brain Science Ajou University School of MedicineSuwonKorea Neuroscience Graduate Program Department of Biomedical SciencesAjou University Graduate School of MedicineSuwonKorea Department of Neurology Ajou University School of MedicineSuwonKorea Department of Neurology Yanbian University HospitalYanjiJilin ProvinceChina Department of Nephrology Suqian First HospitalSuqianJiangsu ProvinceChina

Subcortical ischemic white matter injury(SIWMI),pathological correlate of white matter hyperintensities or leukoaraiosis on magnetic resonance imaging,is a common cause of cognitive decline in *** its high prevalence,it remains unknown how various components of the white matter degenerate in response to chronic *** incomplete knowledge is in part due to a lack of adequate animal *** current review introduces various SIWMI animal models and aims to scrutinize their advantages and disadvantages primarily in regard to the pathological manifestations of white matter *** SIWMI animal models are categorized into 1)chemically induced SIWMI models,2)vascular occlusive SIWMI models,and 3)SIWMI models with comorbid vascular risk *** induced models display consistent lesions in predetermined areas of the white matter,but the abrupt evolution of lesions does not appropriately reflect the progressive pathological processes in human white matter *** occlusive SIWMI models often do not exhibit white matter lesions that are sufficiently unequivocal to be *** combined with comorbid vascular risk factors(specifically hypertension),however,they can produce progressive and definitive white matter lesions including diffuse rarefaction,demyelination,loss of oligodendrocytes,and glial activation,which are by far the closest to those found in human white matter hyperintensities ***,considerable surgical mortality and unpredictable natural deaths during a follow-up period would necessitate further refinements in these *** the meantime,in vitro SIWMI models that recapitulate myelinated white matter track may be utilized to study molecular mechanisms of the ischemic white matter *** in vivo and in vitro SIWMI models will contribute in a complementary manner to making a breakthrough in developing effective treatment to prevent progression of white matter hyperintensities.

关键词： animal model axonal degeneration demyelination hypertension ischemia oligodendrocytes subcortical ischemic white matter injury vascular cognitive impairment white matter hyperintensities

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Spectral Properties and Positivity of Flows in Infinite Networks with Dynamic Boundary Control Nodes

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Journal of Systems Science and Information 2009年第4期7卷 319-325页

作者： xuelian jin Fu Zheng Ming Fang Chao Gao Dept. of Mathematics ＆ Physics Liaoning University of Technology Jinzhou 121013 China Dept. of Mathematics Bahai University Jinzhou 121013 China Beijing Institute of Information and Control Beijing 100037 China Dept. of Mathematics Science College Yanbian University Yanji 133002 China

In this paper we study transport processes on infinite networks with dynamic boundary control nodes. These flows can be modeled by operator semigroups on a suitable Banach space. Using functional analytical and graph theoretical methods, we investigate its spectral properties of the system and positivity of the semigroup under appropriate assumptions on the network.

关键词： Co-semigroup spectrum positivity

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ANOTHER FORM OF KKM TYPE THEOREM AND ITS APPLICATIONS ON GENERALIZED CONVEX SPACES

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Applied Mathematics(A Journal of Chinese Universities) 2006年第2期21卷 207-213页

作者：朴勇杰金雪莲 Dept. of Math. Yanbian Univ. Yanji 133002China

In this paper, another form of KKM type theorem on generalized convex spaces is obtained and the problems of von Neumann-Fan type sup inf sup inequalities and variational inequalities are discussed for their *** main ... 详细信息

关键词： generalized convex space Г-quasiconvex (quasiconcave) function KKM map Г-convex trappable upper(lower) semicontinuous.

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孤独症儿童自我-他人来源记忆监测损伤:学习时间分配的作用

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心理与行为研究 2022年第6期20卷 768-774页

作者：金雪莲姜英杰东北师范大学心理学院长春130024 吉林医药学院应用心理学院吉林132013

通过采用物品命名的来源记忆范式,结合眼动追踪技术,考察ASD儿童自我-他人来源记忆监测的特点及学习时间分配的作用。结果发现:(1)ASD儿童自我来源记忆监测准确性显著高于他人来源记忆监测,但自我和他人来源记忆监测准确性均显著低于TD... 详细信息

通过采用物品命名的来源记忆范式,结合眼动追踪技术,考察ASD儿童自我-他人来源记忆监测的特点及学习时间分配的作用。结果发现:(1)ASD儿童自我来源记忆监测准确性显著高于他人来源记忆监测,但自我和他人来源记忆监测准确性均显著低于TD儿童。(2)ASD儿童的自我-他人来源记忆学习时间显著少于TD儿童。(3)学习时间分配的动态过程中,ASD儿童和TD儿童的自我来源记忆的学习时间均长于他人来源记忆的时间。研究表明,ASD儿童自我-他人来源记忆监测准确性存在损伤,表现为高估,其认知机制可能是ASD儿童对自我和他人来源记忆材料的学习时间分配均少于TD儿童。

关键词：元记忆监测信心判断学习时间分配孤独症眼动追踪

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抑制二次电子发射方法的研究

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材料导报 2021年第7期35卷 7176-7182页

作者：金雪莲吴雪梅诸葛兰剑金成刚苏州大学物理科学与技术学院苏州215006 江苏省薄膜材料重点实验室苏州215006 苏州大学分析测试中心苏州215006 哈尔滨工业大学空间环境与物质科学研究院哈尔滨150001

电介质和金属表面被激发出来的二次电子(Secondary electron emission,SEE)可以显著地改变该表面附近的电势分布和通量。在一些情况下,如电子束焊机、扫描电子显微镜、透射式电子显微镜、电子衍射仪、俄歇电子能谱仪、电子倍增管等应用... 详细信息

电介质和金属表面被激发出来的二次电子(Secondary electron emission,SEE)可以显著地改变该表面附近的电势分布和通量。在一些情况下,如电子束焊机、扫描电子显微镜、透射式电子显微镜、电子衍射仪、俄歇电子能谱仪、电子倍增管等应用中,二次电子的次级倍增效应得到很好的应用。然而在另一些情况下,例如射频放大器、粒子加速器和霍尔推进器、电子真空管、空间宇宙飞行器表面等应用中,二次电子会对仪器产生不利的影响。因此,抑制二次电子发射及研究减少二次电子产额(Secondary electron yield,SEY)是非常有意义的。现有的抑制二次电子发射的研究方法有外加偏置场法和表面处理法,其中通过外加电场或磁场来抑制二次电子的激发会对入射束流、束斑产生不利影响,因此表面处理法更具优势。表面处理法主要分为三类:表面陷阱构造(矩形以及三角形的凹槽、微孔结构、纤维结构、泡沫结构等)、表面镀膜(石墨烯膜、TiN膜等)、表面束流处理(激光刻蚀、磁控溅射法)。这些抑制二次电子激发的方法主要为了达到两个目的,一是减少物体表面的真二次电子的发射,二是捕获发射的二次电子,使之不能逃逸。本文总结了一些抑制二次电子激发的方法,比较不同方法或不同影响因素对二次电子的影响。

关键词：二次电子发射表面构造表面镀膜离子束轰击

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国外共情训练理论与实践对我国留守儿童情感教育的启示

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外国教育研究 2018年第9期45卷 104-115页

作者：姜英杰金雪莲东北师范大学心理学院吉林长春130024

共情训练是通过亲身参与的情绪情感体验性活动,提高受训者辨别和理解他人情绪情感能力的训练。共情训练的理论研究发现其具有重要的情感教育功能,可以有效提高儿童情绪识别和情绪理解能力,促进同情心和道德感的发展。国外共情训练实践... 详细信息

共情训练是通过亲身参与的情绪情感体验性活动,提高受训者辨别和理解他人情绪情感能力的训练。共情训练的理论研究发现其具有重要的情感教育功能,可以有效提高儿童情绪识别和情绪理解能力,促进同情心和道德感的发展。国外共情训练实践方案主要有五类:动物情绪体验、卷入式故事、随堂讨论、角色扮演和社交共情训练。上述共情训练实践对我国留守儿童情感教育具有以下启示意义:开发早期共情训练计划,把握留守儿童情感教育关键期;制定个性化共情训练方案,增强留守儿童情感教育目的性;设计校本化共情训练活动,增强留守儿童情感教育针对性;坚持日常教学活动中的共情训练,保障留守儿童情感教育常态化。这可以推动共情训练在留守儿童情感教育中的应用,促进留守儿童情感健康发展。

关键词：共情训练共情留守儿童情感教育

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造血干细胞移植后中枢神经系统并发症的诊治分析(附五例报道)

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中华神经医学杂志 2020年第6期19卷 601-606页

作者：靳雪莲李祥飞陈心传四川大学华西医院血液内科成都610041

造血干细胞移植(hematopoietic stem cell transplantation,HSCT)术后中枢神经系统并发症(central nervous system complications,CNSC)的发生率为11%~59%,常影响患者的生活质量,甚至危及生命。基础疾病、HSCT类型、预处理毒性、血小板减少症和(或)凝血异常引起的出血并发症、免疫抑制相关感染、移植物抗宿主病(graft-versus-host disease,GVHD)和不适当的免疫应答都可能导致CNSC,可发生于移植术后的各个阶段,诊断和治疗均比较困难。本研究回顾性分析四川大学华西医院血液内科自2015年4月至2018年8月收治的5例HSCT后出现CNSC患者的临床资料,并结合近几年相关的文献报道,分析HSCT后不同阶段CNSC发生的危险因素、发病机制及诊治规范。

关键词：造血干细胞移植中枢神经系统并发症移植时期

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