Modeling subcortical ischemic white matter injury in rodents:unmet need for a breakthrough in translational research

作     者：Yuexian Cui Xuelian Jin Jun Young Choi Byung Gon Kim Yuexian Cui;Xuelian Jin;Jun Young Choi;Byung Gon Kim

作者机构：Department of Brain ScienceAjou University School of MedicineSuwonKorea Neuroscience Graduate ProgramDepartment of Biomedical SciencesAjou University Graduate School of MedicineSuwonKorea Department of NeurologyAjou University School of MedicineSuwonKorea Department of NeurologyYanbian University HospitalYanjiJilin ProvinceChina Department of NephrologySuqian First HospitalSuqianJiangsu ProvinceChina 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2021年第16卷第4期

页      面：638-642页

核心收录：

学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学] 

基　　金：This work was supported by the National Research Foundation of Korea(NRF)grants funded by the Korea government(MSIT,Ministry of Science and ICT)(NRF-2018M3A9E8023853(to JYC) NRF-2018R1C1B6006145(to JYC) NRF-2018R1A2A1A05020292(to BGK)and NRF-2019R1A5A2026045(to JYC and BGK) 

主　　题：animal model axonal degeneration demyelination hypertension ischemia oligodendrocytes subcortical ischemic white matter injury vascular cognitive impairment white matter hyperintensities 

摘      要：Subcortical ischemic white matter injury(SIWMI),pathological correlate of white matter hyperintensities or leukoaraiosis on magnetic resonance imaging,is a common cause of cognitive decline in *** its high prevalence,it remains unknown how various components of the white matter degenerate in response to chronic *** incomplete knowledge is in part due to a lack of adequate animal *** current review introduces various SIWMI animal models and aims to scrutinize their advantages and disadvantages primarily in regard to the pathological manifestations of white matter *** SIWMI animal models are categorized into 1)chemically induced SIWMI models,2)vascular occlusive SIWMI models,and 3)SIWMI models with comorbid vascular risk *** induced models display consistent lesions in predetermined areas of the white matter,but the abrupt evolution of lesions does not appropriately reflect the progressive pathological processes in human white matter *** occlusive SIWMI models often do not exhibit white matter lesions that are sufficiently unequivocal to be *** combined with comorbid vascular risk factors(specifically hypertension),however,they can produce progressive and definitive white matter lesions including diffuse rarefaction,demyelination,loss of oligodendrocytes,and glial activation,which are by far the closest to those found in human white matter hyperintensities ***,considerable surgical mortality and unpredictable natural deaths during a follow-up period would necessitate further refinements in these *** the meantime,in vitro SIWMI models that recapitulate myelinated white matter track may be utilized to study molecular mechanisms of the ischemic white matter *** in vivo and in vitro SIWMI models will contribute in a complementary manner to making a breakthrough in developing effective treatment to prevent progression of white matter hyperintensities.