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Journal of Materials Science & Technology 2024年第3期170卷 200-211页

作者： Yanyan Zhao Xu fan Hongxing Zheng Enzhou Liu Jun fan xuejun Wang College of Biology Pharmacy and Food Engineering Shangluo UniversityShangluo 726000China QinLing-Bashan Mountains Bioresources Comprehensive Development C.I.C. Shaanxi University of TechnologyHanzhong 723001China School of Chemical Engineering Northwest UniversityXi’an 710069China

Constructing of heterojunction was identified as a feasible way to improve photocatalytic activity of *** this work,a n-p type Bi_(2)WO_(6)/AgInS_(2)S-scheme heterojunction was successfully prepared for organic pollutants *** Bi_(2)WO_(6)/AgInS_(2)S-scheme heterojunction exhibited much higher pho-tocatalytic activity towards Rhodamine B(92.24%,expose to visible light for 60 min),norfloxacin(81.73%,expose to visible light for 90 min)and levofloxacin(87.46%,expose to visible light for 90 min)than pure Bi_(2)WO_(6)and pure AgInS_(2).Toxicity analysis indicated the low environmental toxicity of Rhodamine B degradation intermediates for Rye seeds and Sudangrass seeds germination and *** study displayed that AgInS_(2)and Bi_(2)WO_(6)work as the primary photocatalyst to form·O_(2)−and ·OH,*** improved photocatalytic activity of the Bi_(2)WO_(6)/AgInS_(2)S-scheme heterojunction was due to the im-proved light response range and intensified carrier separation ***,a S-scheme charge transfer mechanism including multiple charge transfer channels was *** work could provide an effective strategy for organic pollutants degradation in wastewater.

关键词： Photocatalysis S-scheme heterojunction AgInS_(2) Bi_(2)WO_(6) Toxicity experiments

HER3 intracellular domains play a crucial role in HER3/HER2 dimerization and activation of downstream signaling pathways

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Protein & Cell 2012年第10期3卷 781-789页

作者： Byung-Kwon Choi Xiumei Cai Bin Yuan Zhao Huang xuejun fan Hui Deng Ningyan Zhang Zhiqiang An Texas Therapeutics Institute Brown Foundation Institute of Molecular MedicineUniversity of Texas Health Science Center at HoustonHoustonTX 77030USA Department of Biochemistry and Molecular Biology Shanghai Medical CollegeFudan UniversityShanghai 200032China The Methodist Hospital Research Institute HoustonTX 77030USA

Dimerization among the EGFR family of tyrosine kinase receptors leads to allosteric activation of the kinase domains of the *** other members in the family,the kinase domain of HER3 lacks key amino acid residues for catalytic *** a result,HER3 is suggested to serve as an allosteric activator of other EGFR family members which include EGFR,HER2 and *** study the role of intracellular domains in HER3 dimerization and activation of downstream signaling pathways,we constructed HER3/HER2 chimeric receptors by replacing the HER3 kinase domain(HER3-2-3)or both the kinase domain and the C-terminal tail(HER3-2-2)with the HER2 counterparts and expressed the chimeric receptors in Chinese hamster ovary(CHO)*** over expression of the intact human HER3 transformed CHO cells with oncogenic properties such as AKT/ERK activation and increased proliferation and migration,CHO cells expressing the HER3-2-3 chimeric receptor showed significantly reduced HER3/HER2 dimerization and decreased phosphorylation of both AKT and ERK1/2 in the presence of neuregulin-1(NRG-1).In contrast,CHO cells expressing the HER3-2-2 chimeric receptor resulted in a total loss of downstream AKT activation in response to NRG-1,but maintained partial activation of ERK1/*** results demonstrate that the intracellular domains play a crucial role in HER3’s function as an allosteric activator and its role in downstream signaling.

关键词： HER3 HER2 cell proliferation cell migration PI3K/AKT MAPK/ERK1/2

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架空输电线路巡检装置用伺服电机设计分析

微特电机 2024年第7期52卷 31-35,39页

作者：马朝李永亮范学军温乐鹏王浩丞国网河北省电力有限公司邯郸供电分公司邯郸056004 河北省智能电网配用电运维技术创新中心邯郸056004

架空输电线路智能巡检装置作为一种能够代替人工进行长距离巡检作业的设备,能显著提升巡检效率,降低劳动强度。为保证智能巡检装置在线路上高精度、平稳地运行,设计了一种高功率密度、低转矩脉动的永磁伺服电机。通过理论分析与有限元... 详细信息

架空输电线路智能巡检装置作为一种能够代替人工进行长距离巡检作业的设备,能显著提升巡检效率,降低劳动强度。为保证智能巡检装置在线路上高精度、平稳地运行,设计了一种高功率密度、低转矩脉动的永磁伺服电机。通过理论分析与有限元方法对电机进行了电磁分析,对永磁体厚度以及极弧系数进行了优化,降低了电机的转矩脉动;运用有限元仿真软件对电机进行了振动校核,进行了径向电磁力计算以及对电机定子和外加机壳系统分别进行了模态校核,分析了电机的振动情况。结果证明,设计的永磁伺服电机各项性能均满足运行需求,为输电线路智能巡检装置用伺服电机设计与分析工作提供了一定的指导意义。

关键词：架空输电线路智能巡检装置永磁伺服电机电磁分析振动校核

Effects of Vapor Pressure and Super-Hydrophobic Nanocomposite Coating on Microelectronics Reliability

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Engineering 2015年第3期1卷 384-390页

作者： xuejun fan Liangbiao Chen C.P.Wong Hsing-Wei Chu G.Q.Zhang Department of Mechanical Engineering Lamar University State Key Laboratory of Solid State Lighting School of Materials Science and Engineering Georgia Tech Delft University of Technology Institute of Semiconductors Chinese Academy of Sciences

Modeling vapor pressure is crucial for studying the moisture reliability of microelectronics, as high vapor pressure can cause device failures in environments with high temperature and humidity. To minimize the impact of vapor pressure, a super-hydrophobic(SH) coating can be applied on the exterior surface of devices in order to prevent moisture penetration. The underlying mechanism of SH coating for enhancing device reliability, however, is still not fully understood. In this paper, we present several existing theories for predicting vapor pressure within microelectronic materials. In addition, we discuss the mechanism and effectiveness of SH coating in preventing water vapor from entering a device, based on experimental results. Two theoretical models, a micro-mechanics-based whole-field vapor pressure model and a convection-diffusion model, are described for predicting vapor pressure. Both methods have been successfully used to explain experimental results on uncoated samples. However, when a device was coated with an SH nanocomposite, weight gain was still observed, likely due to vapor penetration through the SH surface. This phenomenon may cast doubt on the effectiveness of SH coatings in microelectronic devices. Based on current theories and the available experimental results, we conclude that it is necessary to develop a new theory to understand how water vapor penetrates through SH coatings and impacts the materials underneath. Such a theory could greatly improve microelectronics reliability.

关键词： vapor pressure moisture semiconductor reliability microelectromechanical systems (MEMS) superhydrophobic nanocomposite coating

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大庆徐深气田致密气藏间歇开井增产机理

油气井测试 2020年第5期29卷 14-20页

作者：范学君中国石油大庆油田有限责任公司试油试采分公司黑龙江大庆163412

大庆致密气藏储层物性差,自然测试产能较低,采用大规模多段压裂以实现储量动用和提高单井产能的方法,难以确定本类储层增产原因。对徐家围子致密气区块气藏岩心的微观渗吸置换室内实验进行研究,优化出3种类型储层Ⅰ类储层渗吸效果好,产... 详细信息

大庆致密气藏储层物性差,自然测试产能较低,采用大规模多段压裂以实现储量动用和提高单井产能的方法,难以确定本类储层增产原因。对徐家围子致密气区块气藏岩心的微观渗吸置换室内实验进行研究,优化出3种类型储层Ⅰ类储层渗吸效果好,产能增加明显;Ⅱ类储层渗吸效果一般,产能增加不多;Ⅲ类储层几乎无渗吸,产能无增加;根据储层类别,确定间歇开井时机、优化及完善求产技术。经对Ⅰ类储层Y9井进行间歇开井增产实验,关井16 d渗吸置换,重新开井测气,产量增加83%。该研究结果提高了对徐家围子区域总体认识,指导了区域间歇开井后试气求产,为求产工艺提供了技术指导。

关键词：徐深气田致密气藏储层分类间歇开井试气产能岩心实验

超声速燃烧数值模拟中复杂化学反应的建模方法

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空气动力学学报 2020年第3期38卷 552-576页

作者：吴坤范学军中国科学院力学研究所高温气体动力学国家重点实验室北京100190 中国科学院大学工程科学学院北京100049

高保真度的数值模拟有助于研究超声速条件下点火、熄火、火焰传播以及稳焰等关键物理-化学过程,推动对冲压发动机中复杂燃烧现象的准确理解与可靠预测。然而,实际发动机中碳氢燃料燃烧导致的广泛时空尺度对湍流燃烧的建模带来了极大的... 详细信息

高保真度的数值模拟有助于研究超声速条件下点火、熄火、火焰传播以及稳焰等关键物理-化学过程,推动对冲压发动机中复杂燃烧现象的准确理解与可靠预测。然而,实际发动机中碳氢燃料燃烧导致的广泛时空尺度对湍流燃烧的建模带来了极大的挑战。为此,必须首先解决超声速燃烧数值模拟中复杂化学反应的高保真建模问题。本文对超声速燃烧模拟中湍流-化学反应相互作用模型、机理简化以及求解加速方法的研究现状进行了总结。以典型燃料燃烧建模为主线,介绍了复杂化学反应的高保真建模方法以及不同化学反应机理在超燃模拟中的适用性及其影响。以反应机理三层次保真度评估体系为基础,进一步明确了简化机理在超燃数值模拟中的优势与不足,阐明了动态自适应化学方法在研究超声速条件下细致燃烧过程的必要性和可行性。

关键词：超声速燃烧碳氢燃料复杂化学反应简化反应机理动态自适应化学

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内盲孔射孔器与管式泵联作技术的研究与应用

钻采工艺 2006年第1期29卷 62-63页

作者：范学君大庆油田有限责任公司试油试采分公司

介绍了内盲孔射孔器与管式泵联作技术的选泵标准、起爆方式、原理和流程以及内盲孔射孔器的研制。该技术是将油管输送射孔与采油管柱结合起来,使射孔完井与新井下泵一趟管柱完成,在下完抽油杆之后,密封井口,采用油套环空加压引爆射孔枪... 详细信息

介绍了内盲孔射孔器与管式泵联作技术的选泵标准、起爆方式、原理和流程以及内盲孔射孔器的研制。该技术是将油管输送射孔与采油管柱结合起来,使射孔完井与新井下泵一趟管柱完成,在下完抽油杆之后,密封井口,采用油套环空加压引爆射孔枪的方式,射孔后立即启动抽油机,进行采油。该工艺可提高射孔完井效率,又可预防井喷事故发生,减少作业次数和井喷压井所带来的水泥车和压井液费用,同时减轻了工人劳动强度。在大庆油田采油三厂N5-9-B52井的现场应用见到了明显的效果。

关键词：油管输送射孔内盲孔射孔器抽油泵采油

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金融体系与经济增长:来自中国的实证检验

金融研究 2006年第3期 57-66页

作者：范学俊华东师范大学商学院上海市200062

本文运用最大似然协整分析法及1992年第一季度至2004年第三季度数据检验中国金融发展与经济增长之间的动态关系。结果表明,虽然银行部门与股票市场在长期都对经济增长有正的影响,但股票市场对经济增长的影响大大强于银行部门对经济增长... 详细信息

本文运用最大似然协整分析法及1992年第一季度至2004年第三季度数据检验中国金融发展与经济增长之间的动态关系。结果表明,虽然银行部门与股票市场在长期都对经济增长有正的影响,但股票市场对经济增长的影响大大强于银行部门对经济增长的影响,这与认为银行主导的金融体系比市场主导的金融体系更能促进长期经济增长的观点截然不同。因此立足于长远,扩大股票市场在中国金融体系中的作用将对中国经济的可持续发展具有重大的意义。

关键词：金融发展经济增长协整分析

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孔子的诗教:《诗》教何以成为一种教化

湖北社会科学 2023年第7期 99-104页

作者：樊雪君新乡学院人文学院河南新乡453000

《诗》是孔子所编订的文本之一,在后来儒家的传统中形成了一种“诗教”传统。在此就需要讨论一个问题,孔子的《诗》教何以成为一种教化。这里核心在于《诗》的本质与教化是否一致。教化是这样一个过程,即是化单一为普遍的过程。而就《... 详细信息

《诗》是孔子所编订的文本之一,在后来儒家的传统中形成了一种“诗教”传统。在此就需要讨论一个问题,孔子的《诗》教何以成为一种教化。这里核心在于《诗》的本质与教化是否一致。教化是这样一个过程,即是化单一为普遍的过程。而就《诗》而言,可以分为三个部分:一是“情”,即诗咏情;二是“言”,所谓“不学《诗》,无以言”;三是“思”,即是《诗经》中所蕴含的“微言大义”。在诗之“情”中,有作为单一物的“情欲”“情绪”,以及作为普遍物的真情。《诗》通过对情欲和情绪的扬弃,使学者对“天涯共此情”的真情进行把握,从而化掉了单一的方面,获得了普遍性的规定。就“言”的方面,《诗》通过优美的语言促使单一的对象从个体之域走向公共之域,成为普遍物。而“思”则是以“喻”的方式,主要是主体的领悟和阐释,使得“道”向主体自身敞开,这就使得处于幽暗的直接性之中的“道”走向了现实的普遍性,在主体的“思”中澄明和彰显。由此可以看出《诗》本身就具有教化的本质。

关键词：《诗》教化情言思

Novel Approach for Quantitative Measurement of Matrix Metalloprotease-1 (MMP1) in Human Breast Cancer Cells Using Mass Spectrometry

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Journal of Analytical Sciences, Methods and Instrumentation 2013年第1期3卷 54-61页

作者： Ming Fa Kathleen Hoch xuejun fan William P. Dubinsky Zhiqiang An Ningyan Zhang Proteomics Center Brown Foundation Institute of Molecular Medicine The University of Texas Health Science Center at Houston Houston USA Proteomics Center Brown Foundation Institute of Molecular Medicine The University of Texas Health Science Center at Houston Houston USA. Texas Therapeutics Institute Houston USA

Identification and quantification of low abundance growth factors and regulators in complex biological samples still present a challenging task in analytical biochemistry. Immunoassays are often used for such purpose but immunoassays face limitation of both availability and qualities of antibody reagents that are necessary for development of immune assays. With genomics data base available, mass spectrometry (MS) can analyze protein tryptic peptides directly for quantitative determination of proteins. In this study, we report a method for detection of matrix metalloproteinase 1 (MMP1), an important extracellular matrix modulator, in human breast cancer cells by quadrupole time-of-flight (Q-TOF) MS. Absolute quantification of MMP1 was conducted using the selected reaction monitoring (SRM) on a triple quadrupole (Triple-Quad) MS via transitions selected from MMP1 tryptic peptides using non isotope labeled MMP1 protein as a titration standard. In comparison with immune based assay, this MS method showed picogram level sensitivity for quantitative determination of MMP1 intotal cell lysates. Our results demonstrated the feasibility of absolute quantification of low abundance proteins using label-free protein standard by mass spectrometry. Therefore, this method provides not only advantages of high sensitivity but also cost saving in comparison with the commonly used mass spectrometry that currently employs isotype labeled proteins for quantitative analysis.

关键词： Matrix Metalloprotease-1 (MMP1) SKBR3 Breast Cancer Cells Mass Spectrometry Selected Reaction Monitoring Absolute Quantification