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The landscape of aging

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Science China(Life Sciences) 2022年第12期65卷 2354-2454页

作者： Yusheng Cai Wei Song Jiaming Li Ying Jing Chuqian Liang Liyuan Zhang Xia Zhang Wenhui Zhang Beibei Liu Yongpan An Jingyi Li Baixue Tang Siyu Pei Xueying Wu Yuxuan Liu Cheng-Le Zhuang Yilin Ying xuefeng dou Yu Chen Fu-Hui Xiao Dingfeng Li Ruici Yang Ya Zhao Yang Wang Lihui Wang Yujing Li Shuai Ma Si Wang Xiaoyuan Song Jie Ren Liang Zhang Jun Wang Weiqi Zhang Zhengwei Xie Jing Qu Jianwei Wang Yichuan Xiao Ye Tian Gelin Wang Ping Hu Jing Ye Yu Sun Zhiyong Mao Qing-Peng Kong Qiang Liu Weiguo Zou Xiao-Li Tian Zhi-Xiong Xiao Yong Liu Jun-Ping Liu Moshi Song Jing-Dong J.Han Guang-Hui Liu State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Institute for Stem Cell and Regeneration Chinese Academy of SciencesBeijing 100101China Beijing Institute for Stem Cell and Regenerative Medicine Beijing 100101China Frontier Science Center for Immunology and Metabolism Medical Research InstituteCollege of Life SciencesWuhan UniversityWuhan 430071China CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China CAS Key Laboratory of Tissue Microenvironment and Tumor Shanghai Institute of Nutrition and HealthChinese Academy of SciencesShanghai 200031China CAS Key Laboratory of Pathogenic Microbiology and Immunology Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China Peking University International Cancer Institute Peking University Health Science CenterPeking UniversityBeijing 100191China School of Pharmaceutical Sciences Tsinghua UniversityBeijing 100084China State Key Laboratory of Molecular Developmental Biology Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China School of Pharmaceutical Sciences Beijing Advanced Innovation Center for Structural BiologyMinistry of Education Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical BiologyTsinghua UniversityBeijing 100084China Colorectal Cancer Center/Department of Gastrointestinal Surgery Shanghai Tenth People’s Hospital Affiliated to Tongji UniversityShanghai 200072China Department of Geriatrics Medical Center on Aging of Shanghai Ruijin HospitalShanghai Jiaotong University School of MedicineShanghai 200025China International Laboratory in Hematology and Cancer Shanghai Jiaotong University School of Med

Aging is characterized by a progressive deterioration of physiological integrity,leading to impaired functional ability and ultimately increased susceptibility to death.It is a major risk factor for chronic human diseases,including cardiovascular disease,diabetes,neurological degeneration,and cancer.Therefore,the growing emphasis on “healthy aging” raises a series of important questions in life and social sciences.In recent years,there has been unprecedented progress in aging research,particularly the discovery that the rate of aging is at least partly controlled by evolutionarily conserved genetic pathways and biological processes.In an attempt to bring full-fledged understanding to both the aging process and age-associated diseases,we review the descriptive,conceptual,and interventive aspects of the landscape of aging composed of a number of layers at the cellular,tissue,organ,organ system,and organismal levels.

关键词： aging mechanism intervention

Frequency spectrum analysis on micro-seismic signal of rock bursts induced by dynamic disturbance

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Mining Science and Technology 2010年第5期20卷 682-685页

作者： XU xuefeng dou Linming LU Caiping ZHANG Yinliang State Key Laboratory of Coal Resources and Mine Safety School of Mines China University of Mining & Technology Xuzhou 221008 China School of Energy Science and Engineering Henan Polytechnic University Jiaozuo 454000 China Yuejin Coal Mine of Yima Coal Mining Group Yima 472300 China

Blasting and breaking of hard roof are main inducing causes of rock bursts in coal mines with danger of rock burst,and it is important to find out the frequency spectrum distribution laws of these dynamic stress waves and rock burst waves for researching the mechanism of rock burst.In this paper,Fourier transform as a micro-seismic signal conversion method of amplitude-time character to amplitude-frequency character is used to analyze the frequency spectrum characters of micro-seismic signal of blasting,hard roof breaking and rock bursts induced by the dynamic disturbance in order to find out the difference and relativity of different signals.The results indicate that blasting and breaking of hard roof are high frequency signals,and the peak values of dominant frequency of the signals are single.However,the results indicate that the rock bursts induced by the dynamic disturbance are low frequency signals,and there are two obvious peak values in the amplitude-frequency curve witch shows that the signals of rock bursts are superposition of low frequency signals and high frequency signals.The research conclusions prove that dynamic disturbance is necessary condition for rock bursts,and the conclusions provide a new way to research the mechanism of rock bursts.

关键词：岩石破裂干扰信号频谱分析频率信号微地震顶板破碎高频信号动力扰动

Shunxin decoction(顺心组方) improves diastolic function in rats with heart failure with preserved ejection fraction induced by abdominal aorta constriction through cyclic guanosine monophosphate-dependent protein kinase Signaling Pathway

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Journal of Traditional Chinese Medicine 2022年第5期42卷 764-772页

作者： ZHANG Jiaying WEI Xiangxiang LI xuefeng YUAN Yang dou Yinghuan SHI Yanbin XIE Ping ZHOU Mengru ZHAO Junnan LI Miao ZHANG Shuwen ZHU Rui TIAN Ying TAN Hao TIAN Feifei School of basic medical sciences Institute of Integrated Chinese and Western MedicineLanzhou UniversityLanzhou 730000China Department of Cardiology Gansu Provincial hospitalLanzhou 730000China

OBJECTIVE: To determine whether Shunxin decoction(顺心组方) improves diastolic function in rats with heart failure with preserved ejection fraction(HFp EF) by regulating the cyclic guanosine monophosphatedependent protein kinase(c GMP-PKG) signaling pathway. METHODS: Except for control group 8 and sham surgery group 8, the remaining 32 male Sprague-Dawlay rats were developed into HFp EF rat models using the abdominal aorta constriction method. These rats in the HFp EF model were randomly divided into the model group, the Shunxin high-dose group, the Shunxin lowdose group, and the Qiliqiangxin capsule group. The three groups received high-dose Shunxin decoction, lowdose Shunxin decoction, and Qiliqiangxin capsule by gavage, respectively, for 14 d. After the intervention, the diastolic function of each rat was evaluated by testing E/A, heart index, hematoxylin-eosin staining, Masson, myocardial ultrastructure, and N-terminal pro-brain natriuretic peptide(NT-pro BNP). The Bioinformatics Analysis Tool for Molecular Mechanism of Traditional Chinese Medicine(BATMAN-TCM) software was used to predict targets for which Shunxin decoction acts on the c GMP-PKG pathway. Natriuretic peptide receptor A(NPRA) and guanylate cyclase(GC) were detected by immunohistochemistry, and e NOS, phosphodiesterase 5A(PDE5A), and c GMP-dependent protein kinase 1(PKG I) were determined by Western blotting. RESULTS: Compared to the model group, the thickness of the interventricular septum at the end of diastole(IVSd) and the thickness of the posterior wall at the end of diastole(PWd) of the Shunxin decoction high-dose group, Shunxin decoction low-dose group, and Qiliqiangxin capsule group were all significantly reduced(P < 0.01). Furthermore, Shunxin decoction high-dose group E/A value was decreased(P < 0.01). Compared to the model group, the expression of NPRA and GC increased in the Shunxin decoction low-dose group and the Qiliqiangxin capsule group(P < 0.01). Compared to the model group, the expressions of e NOS and PKG I increased(P < 0.05) in

关键词： heart failure preserved ejection fraction diastole cyclic GMP-dependent protein kinases signal transduction Shunxin decoction

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多功能环空带压地面诊断方法及装置研究

西南石油大学学报（自然科学版） 2023年第5期45卷 131-139页

作者：杨顺辉何汉平张智窦雪锋银熙炉中国石化石油工程技术研究院北京昌平102206 西南石油大学石油与天然气工程学院四川成都610500 中国石化江汉油田采气一厂重庆万州404120

为突破国外技术封锁,解决国内技术功能较少的缺点,克服现有装置体积大、质量重、搬运不方便的问题,提出了一种多功能环空带压地面诊断方法,设计了一套模块化设计方案和集成组合方案,并研制出了便携式实物装置系统。该系统包括气液分离... 详细信息

为突破国外技术封锁,解决国内技术功能较少的缺点,克服现有装置体积大、质量重、搬运不方便的问题,提出了一种多功能环空带压地面诊断方法,设计了一套模块化设计方案和集成组合方案,并研制出了便携式实物装置系统。该系统包括气液分离及固相过滤模块、温压及流量监测模块、气相参数监测模块、液相参数监测模块及液面高度监测模块,可形成不同功能的集成组合方案,结合数据无线传输技术和配套分析软件,具备环空带压原因分析、漏点位置计算、泄漏程度评估及风险程度判断等多种诊断分析功能。现场测试结果显示,案例井环空压力增加的原因是水泥环胶结存在一定缺陷,漏点深度为3120 m左右,泄漏速率0.012 m^(3)/min。系统测得结果与实际情况吻合,验证了诊断方法的合理性和装置的可靠性。

关键词：环空带压无线传输地面诊断泄漏速率风险程度

Beidou Integrated Disaster Reduction Application Platform

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China Communications 2015年第8期12卷 169-182页

作者： Lü xuefeng LIAO Yongfeng LI Bo DENG Lan National Disaster Reduction Center of China Key Laboratory of Integrated Disaster Assessment and Risk Government of the Ministry of Civil Affairs

To better improve the emergency communication and location-based services of disaster information reporting network for serious natural disaster emergency response and relief,the national natural disaster reduction application platform based on Beidou navigation satellite system is constructed.The administrative distributed platform is integrated with Beidou positioning and multiple communication ways so as to achieve main disaster reduction application services,including disaster information acquisition and monitoring,emergency relief for trapped people,on-site emergency relief command service,relief supplies' transportation monitoring,and disaster information publishing service.By the platform,serious disaster information reporting time may be reduced to one hour and the emergency decision-making information service for serious natural disasters can be effectively improved,and it will be helpful to provide technical references for the industrial application and promotion of Beidou integrated disaster reduction.

关键词：北斗导航卫星系统应用平台综合减灾基于位置的服务灾害信息多种通信方式自然灾害分布式平台

Evaluation of recombinant multi-epitope proteins for diagnosis of water buffalo schistosomiasis by enzyme-linked immunosorbent assay

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Evaluation of recombinant multi-epitope proteins for diagnos...

第五届全国人畜共患病学术研讨会

作者： Chao Lv Yang Hong Ke Lu Tao Wang Xiaodan Cao Chuangang Zhu Hao Li xuefeng dou Yuanxi Shen Zuhang Zhang Jinli Zai Zhiqiang Fu Jiaojiao Lin Key Laboratory of Animal Parasitology Ministry of Agriculture of ChinaShanghai Veterinary Research InstituteChinese Academy of Agricultural Sciences College of life and Environmental Science Shanghai Normal University Jiangsu Co-innovation Center for Prevention and Control of ImportantAnimal Infectious Diseases and Zoonoses

Schistosomiasis is a huge threat to human and animal health.According to an epidemiological survey,schistosome-infected cattle and buffalo are the main sources of Schistosoma japonicum infection in China,so development of an accessible,more sensitive and specific bovine schistosomiasis diagnostic technique is required.In this study,five recombinant antigens were

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miRNA在川崎病发病机制中的研究进展

齐齐哈尔医学院学报 2022年第24期43卷 2344-2349页

作者：宋雪峰窦常胜皖南医学院第一附属医院弋矶山医院 241000

川崎病(Kawasaki disease,KD)是一种急性、发热性、全身血管炎症疾病,可引起冠状动脉的损伤,其发病机制尚不明确,但已有研究表明,miRNA可能通过调控相关炎性因子与炎症通路,引起内皮细胞的损伤,参与川崎病的发病机制。本文就miRNA在川... 详细信息

川崎病(Kawasaki disease,KD)是一种急性、发热性、全身血管炎症疾病,可引起冠状动脉的损伤,其发病机制尚不明确,但已有研究表明,miRNA可能通过调控相关炎性因子与炎症通路,引起内皮细胞的损伤,参与川崎病的发病机制。本文就miRNA在川崎病发病机制中的作用作一综述。

关键词：川崎病 miRNA 冠状动脉损伤发病机制

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遗传改良对杉木针叶和种实性状的影响

广西植物 2023年第7期43卷 1296-1307页

作者：张学峰杨双云蔡红黄豆叶代全边黎明南京林业大学林木遗传与生物技术教育部重点实验室南京210037 南京林业大学南方现代林业协同创新中心南京210037 福建省洋口国有林场福建顺昌353211

为揭示遗传改良对主要造林用材树种叶和种实性状的影响,阐明性状的变异趋势,该研究以杉木第4轮育种的精选树(改良群体)、四省五地的表型优树与古树(未改良群体)为对象,调查了218个无性系的针叶和种实性状指标,采用方差分析和多重对比方... 详细信息

为揭示遗传改良对主要造林用材树种叶和种实性状的影响,阐明性状的变异趋势,该研究以杉木第4轮育种的精选树(改良群体)、四省五地的表型优树与古树(未改良群体)为对象,调查了218个无性系的针叶和种实性状指标,采用方差分析和多重对比方法研究遗传改良对杉木及不同类型杉木的表型差异,并通过相关性分析探究遗传改良对杉木针叶和球果部分表型性状的影响,以及利用主成分分析和聚类分析进行了分类。结果表明:(1)未改良群体的针叶长、针叶宽和出籽率分别比改良群体小13.28%、10.81%和33.90%,其他性状表现为未改良群体大于改良群体,差异在10.90%~27.03%之间。未改良群体球果长、球果宽和出籽率的变异系数,分别比改良群体大9.14%、12.73%和15.38%。(2)球果长、球果宽、苞鳞长和苞鳞宽4个性状,在未改良群体中仅有球果长和球果宽(0.931)、苞鳞长和苞鳞宽(0.622)之间呈极显著正相关,经遗传改良后,这4个性状两两之间均呈显著或极显著正相关。(3)四川雅安(SCYA)的球果长和球果宽的性状比改良群体大48.83%和53.26%,安徽黄山(AHHS)的百粒重比改良群体大16.92%。(4)遗传改良导致松张型球果的杉木比例降低,紧包型和反翘型球果的杉木比例增加。综上认为,杉木的遗传改良导致球果大小下降,改变了不同针叶和球果类型的比例,同时会改变针叶性状和种实性状的相关性,将为杉木种质资源评价和未来多目标育种提供依据。

关键词：杉木遗传改良育种群体针叶种实

N-乙酰半乳糖胺偶联小干扰RNA类药物的非临床毒性研究进展

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药物评价研究 2023年第12期46卷 2709-2716页

作者：窦德虎王陈鲁静张慧宫新江张雪峰江苏鼎泰药物研究(集团)股份有限公司江苏南京211800

小干扰核糖核酸(siRNA)作为核苷酸类药物,通过RNA干扰(RNAi)特异性诱导基因沉默而发挥作用,在代谢性疾病、抗感染及肿瘤等领域被广泛应用。目前已获批上市4款基于N-乙酰半乳糖胺(GalNAc)偶联技术siRNA药物,汇总分析已上市GalNAc偶联药... 详细信息

小干扰核糖核酸(siRNA)作为核苷酸类药物,通过RNA干扰(RNAi)特异性诱导基因沉默而发挥作用,在代谢性疾病、抗感染及肿瘤等领域被广泛应用。目前已获批上市4款基于N-乙酰半乳糖胺(GalNAc)偶联技术siRNA药物,汇总分析已上市GalNAc偶联药物的非临床毒性特征及临床不良反应,初步明确非临床研究中毒性常见类型,包括脱靶与非脱靶毒性等。结合GalNAc-siRNA类药物非临床研究实践,了解可预测的脱靶毒性及对于非临床安全性评价中的毒性关注点,以期为GalNAc-siRNA药物临床研究提供参考。

关键词：小干扰核糖核酸 N-乙酰半乳糖胺偶联技术基因沉默脱靶毒性安全性评价