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人类白细胞抗原相合同胞新鲜脐血移植治疗儿童β重型地中海贫血

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中国组织工程研究 2025年第23期29卷 4899-4906页

作者：温建芸陈丽白何岳林冯晓勤刘璇徐肖肖李秀刘秋君吴学东南方医科大学南方医院儿科广东省广州市510515

背景:异基因造血干细胞移植是目前根治重型地中海贫血最有效的方法,然而仅有不到一半的患者能找到相合的骨髓或外周血干细胞。同胞来源脐血干细胞与骨髓和外周血干细胞具有不同的特征,是重型地中海贫血患者移植治疗的一种潜在造血干细... 详细信息

背景:异基因造血干细胞移植是目前根治重型地中海贫血最有效的方法,然而仅有不到一半的患者能找到相合的骨髓或外周血干细胞。同胞来源脐血干细胞与骨髓和外周血干细胞具有不同的特征,是重型地中海贫血患者移植治疗的一种潜在造血干细胞替代来源。目的:探讨应用人类白细胞抗原相合同胞新鲜脐血移植治疗儿童β重型地中海贫血的疗效。方法:选择2010年6月至2020年6月南方医科大学南方医院收治的β重型地中海贫血患儿48例,男28例,女20例,中位年龄4岁,均接受人类白细胞抗原相合同胞新鲜脐血移植治疗,脐血移植前均采用清髓性不含抗胸腺细胞球蛋白的预处理方案,脐血移植后均采用环孢素A+吗替麦考酚酯+/-短程甲氨蝶呤预防移植物抗宿主病。结果与结论:(1)48例患儿输注的总有核细胞中位数为8.17×10^(7)/kg,输注的CD34^(+)细胞中位数为2.40×10^(5)/kg,脐血移植后中位随访时间98个月,44例植入成功,粒细胞和血小板植入中位时间分别为28 d和31 d,其中37例移植后植入证据检测为供者型完全嵌合,7例移植后早期检测为供受者稳定混合嵌合;(2)44例植入成功患儿中,4例发生急性移植物抗宿主病,分别为Ⅰ级(n=2)和Ⅱ级(n=2),受累器官均为皮肤,均未发生慢性移植物抗宿主病;(3)脐血移植后,48例患儿中5例发生巨细胞病毒感染及激活,12例发生败血症,3例发生侵袭性真菌病,21例发生口腔炎,8例发生出血性膀胱炎,1例发生肝静脉闭塞;(4)48例患儿中,47例存活,1例在移植后28 d因重症肺炎合并急性心力衰竭死亡,43例无病存活,3例发生原发性植入失败,1例发生移植后全血细胞减少,5年总生存率和无病生存率分别为98%和89%,1年时移植相关死亡的累计发病率为2.1%;(5)结果显示,人类白细胞抗原相合同胞新鲜脐血移植治疗儿童β重型地中海贫血的效果良好,移植物抗宿主病的发生风险低。

关键词：异基因造血干细胞移植新鲜脐血移植 β重型地中海贫血移植物抗宿主病儿童

Epidemiology and treatment of beta thalassemia major in China

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Pediatric Investigation 2020年第1期4卷 43-47页

作者： Xiaoxiao Xu xuedong wu Departments of pediatrics Nanfang HospitalSouthern Medical UniversityGuangzhouGuangdongChina

Thalassemia, classified as the main types α- and β-thalassemia, is a single gene disorder resulting from globin chain synthesis impairment through the mutation or deletion of globin genes. The incidence of thalassemia is high worldwide, with high associated mortality. Therefore, treatment is important to improve patient outcomes. This paper reviews the current status of β-thalassemia major in China, including its epidemiology and treatment.

关键词： Thalassemia Epidemiology Treatment China

Delayed exploration and repair to manage pediatric anterior urethral blast injury

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World Journal of Pediatric Surgery 2020年第3期3卷 23-24页

作者： Ning Wang Yin Chen xuedong wu Xiaodong Lin Department of Pediatric Surgery the First Affiliated HospitalDali UniversityDaliChina Department of Clinic the First Affiliated HospitalDali UniversityDaliChina Department of Medical Imaging the First Affiliated HospitalDali UniversityDaliChina

The major cause of pediatric anterior urethral injuries(AUIs)is blunt trauma.12 Penetrating injuries caused by explosive trauma are rare in pediatric *** early and delayed urethral repairs are optional strategies to manage *** from clinical manage-ment of blunt trauma have concluded rich ***,poor experiences can be used to manage explosive *** this case,a 7-year old boy threw a detonator into the *** external genitalia and bilateral medial region of the thigh were injured in a sudden *** spongiosum penis was covered by incomplete *** glans penis with high-degree edema concealed the urethral *** swollen testis was detected in the tattered *** layer was included in explosive inju-ries of the bilateral thigh(figure 1).Surgical debridement was performed urgently.

关键词： injuries urethral pediatric

One Stage Reconstruction of Esophageal Atresia and Distal Tracheoesophageal Fistula in a 3250-gm Neonate: A Case Report

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Open Journal of Pediatrics 2015年第2期5卷 147-150页

作者： Bijay Upadhyay xuedong wu Jun Li Ning Wang Shanshan Zhang Na Li Department of Pediatric Surgery Affiliated Hospital of Dali University Dali China

Esophageal atresia (EA) occurs when the upper part of the esophagus does not connect with the lower part of esophagus and stomach. Tracheoesophageal fistula (TEF) is an abnormal connection between the upper part of the esophagus and the trachea. Treatment for esophageal atresia has advanced over several decades due to improvements in surgical techniques and neonatal intensive care. The aim is to share our experience regarding the treatment of esophageal atresia with tracheoesophageal fistula. A 4-day-old neonate suffering from esophageal atresia with type IIIB tracheoesophageal fistula underwent one stage esophageal reconstruction and obtained good outcome without any complications. In this paper, a simple intra-operative technique for tracheal fistula repair and end to end esophageal anastomosis is discussed. We used a simple technique that we have found useful for ligation of tracheal fistula. Anastomosis of lower and upper esophagus without any complication like anastomotic leakage or stricture/stenosis of the neonate with EA/TEF (type IIIB), was proved to be safe and effective.

关键词： Esophageal Atresia Tracheoesophageal Fistula Esophageal Reconstruction End to End Anastamosis

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从马克思的劳动思想看剩余价值论的科学性

中南大学学报（社会科学版） 2014年第6期20卷 45-50页

作者：吴学东皖西学院思想政治理论课教学部安徽六安237012

随着知识经济对传统经济学的挑战以及我国市场经济的发展,剩余价值论的科学性再次成为学界关注的焦点。马克思的劳动思想是理解剩余价值论的科学性的重要维度:马克思对劳动主体和劳动过程的分析,奠定了剩余价值论的唯物史观基础;劳动辩... 详细信息

随着知识经济对传统经济学的挑战以及我国市场经济的发展,剩余价值论的科学性再次成为学界关注的焦点。马克思的劳动思想是理解剩余价值论的科学性的重要维度:马克思对劳动主体和劳动过程的分析,奠定了剩余价值论的唯物史观基础;劳动辩证法作为科学的认识方法,是剩余价值论的理论基石;剩余价值论借助劳动内在矛盾的分析,揭示了资本主义生产方式发展的历史必然性即资本主义生产方式必然产生和走向灭亡的规律。

关键词：马克思剩余价值论科学性劳动劳动思想

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毛泽东探索精神的养成与特点

学术论坛 2005年第6期28卷 1-4页

作者：吴学东广西大学社会科学与管理学院广西南宁530004

作为一个伟大的领袖,毛泽东富于探索精神。他的探索精神的养成和发展经历了少年时期、青年时期、争取中国革命胜利时期以及建国后等四个阶段,他的探索精神的养成具有强烈的"问题意识",敢于求异,大胆怀疑和批判;具有求实性;具有高度的自... 详细信息

作为一个伟大的领袖,毛泽东富于探索精神。他的探索精神的养成和发展经历了少年时期、青年时期、争取中国革命胜利时期以及建国后等四个阶段,他的探索精神的养成具有强烈的"问题意识",敢于求异,大胆怀疑和批判;具有求实性;具有高度的自觉性与主动性;具有求是和求佳等四大特点。毛泽东的探索精神是毛泽东科学精神的核心,也是毛泽东能够领导中国革命和建设取得巨大成功的重要原因。

关键词：毛泽东探索精神养成和发展特点

Venous thromboembolism in children with acute lymphoblastic leukemia in China:a report from the Chinese Children’s Cancer Group-ALL-2015

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Frontiers of Medicine 2023年第3期17卷 518-526页

作者： Mengmeng Yin Hongsheng Wang Xianmin Guan Ju Gao Minghua Yang Ningling Wang Tianfeng Liu Jingyan Tang Alex WK Leung Fen Zhou xuedong wu Jie Huang Hong Li Shaoyan Hu Xin Tian Hua Jiang Jiaoyang Cai Xiaowen Zhai Shuhong Shen Qun Hu Department of Pediatrics Tongji Hospital of Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Hematology/Oncology Children’s Hospital of Fudan UniversityShanghai 201100China Department of Hematology/Oncology Shanghai Children’s Medical CenterSchool of MedicineShanghai Jiao Tong UniversityKey Laboratory of Pediatric Hematology&Oncology of China Ministry of HealthShanghai 200120China Department of Hematology/Oncology Chongqing Medical University Affiliated Children’s HospitalChongqing 400015China Department of Pediatrics Key Laboratory of Birth Defects and Related Disease of Women and ChildrenMinistry of EducationWest China Second University HospitalSichuan UniversityChengdu 610041China Department of Pediatrics Xiangya Hospital Central South UniversityChangsha 410008China Department of Pediatrics Anhui Medical University Second Affiliated HospitalHefei 230601China State Key Laboratory of Experimental Hematology and Division of Pediatric Blood Diseases Center Institute of Hematology and Blood Diseases HospitalPeking Union Medical CollegeChinese Academy of Medical SciencesTianjin 300020China Department of Pediatrics Hong Kong Children’s HospitalThe Chinese University of Hong KongHong Kong SAR 999077China Department of Pediatrics Union Hospital of Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of Pediatrics Nanfang HospitalSouthern Medical UniversityGuangzhou 516006China Department of Hematology/Oncology Children’s Hospital of Nanjing Medical UniversityNanjing 210008China Department of Hematology/Oncology Shanghai Children’s HospitalShanghai Jiao Tong UniversityShanghai 200062China Department of Hematology/Oncology Children’s Hospital of Soochow UniversitySuzhou 215002China Department of Hematology/Oncology Kunming Children’s HospitalKunming 650103China Department of Hematology/Oncology Guangzhou Women and Children’s Medical CenterGuangzhou 510620China

Venous thromboembolism(VTE)is a complication in children with acute lymphoblastic leukemia(ALL).The Chinese Children’s Cancer Group-ALL-2015 protocol was carried out in China,and epidemiology,clinical characteristics,and risk factors associated with VTE were *** collected data on VTE in a multiinstitutional clinical study of 7640 patients with ALL diagnosed in 20 hospitals from January 2015 to December ***,VTE occurred in 159(2.08%)patients,including 90(56.6%)during induction therapy and 108(67.92%)in the upper extremities.T-ALL had a 1.74-fold increased risk of VTE(95%CI 1.08–2.8,P=0.022).Septicemia,as an adverse event of ALL treatment,can significantly promote the occurrence of VTE(P<0.001).Catheter-related thrombosis(CRT)accounted for 75.47%(n=120);and,symptomatic VTE,58.49%(n=93),which was more common in patients aged 12–18 years(P=0.023),non-CRT patients(P<0.001),or patients with cerebral thrombosis(P<0.001).Of the patients with VTE treated with anticoagulation therapy(n=147),4.08%(n=6)had *** VTE recurrence rate was 5.03%(n=8).Patients with VTE treated by non-ultrasoundguided venous cannulation(P=0.02),with residual thrombus(P=0.006),or with short anticoagulation period(P=0.026)had high recurrence ***,preventing repeated venous puncture and appropriately prolonged anticoagulation time can reduce the risk of VTE recurrence.

关键词： acute lymphoblastic leukemia child venous thromboembolism epidemiology clinical characteristic risk factor

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表面修饰纳米粒子的摩擦学性能

上海交通大学学报 1999年第2期33卷 224-227页

作者：乌学东王大璞张信刚杨生荣上海交通大学化学化工学院中国科学院兰州化学物理所固体润滑开放实验室

分别用沉淀法和溶胶－凝胶法合成了二烷基二硫代磷酸（ＤＤＰ）、硬脂酸修饰的ＭｏＳ２、ＴｉＯ２纳米粒子，并用作油品添加剂．通过表面修饰的方法不但解决了油溶性问题，而且由于修饰层控制了粒子的长大和团聚．在四球机上研究其摩擦... 详细信息

分别用沉淀法和溶胶－凝胶法合成了二烷基二硫代磷酸（ＤＤＰ）、硬脂酸修饰的ＭｏＳ２、ＴｉＯ２纳米粒子，并用作油品添加剂．通过表面修饰的方法不但解决了油溶性问题，而且由于修饰层控制了粒子的长大和团聚．在四球机上研究其摩擦学性质．试验结果表明，有机基团修饰的纳米粒子具有优良的抗磨、减摩能力，并根据摩擦表面光电子能谱分析提出润滑机理假设．

关键词：纳米粒子添加剂润滑油摩擦学性能表面修饰

基于改进多目标海樽群算法的电力系统优化调度

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电测与仪表 2023年第7期60卷 77-82页

作者：夏爱明伍雪冬江苏科技大学电子信息学院江苏镇江212000

文中提出了一种新的多目标海樽群优化算法,将其与等式约束修正技术和可行解占优约束处理技术相结合,用于求解高度约束的电力系统环境经济优化调度问题。该算法采用高斯采样策略和变异操作增强其寻优性能;通过一种改进的基于动态拥挤距... 详细信息

文中提出了一种新的多目标海樽群优化算法,将其与等式约束修正技术和可行解占优约束处理技术相结合,用于求解高度约束的电力系统环境经济优化调度问题。该算法采用高斯采样策略和变异操作增强其寻优性能;通过一种改进的基于动态拥挤距离的非支配排序方法获得分布均匀的帕累托最优前沿;应用模糊集理论为决策者提供最佳折中解。在IEEE 30节点6机组标准测试系统上进行算例仿真,并与其它优化算法进行了对比。结果表明,所提算法在求解电力系统环境经济调度问题时具有更好的优化效果。

关键词：环境经济调度多目标海樽群算法约束处理方法最佳折中解