Venous thromboembolism in children with acute lymphoblastic leukemia in China:a report from the Chinese Children’s Cancer Group-ALL-2015

作     者：Mengmeng Yin Hongsheng Wang Xianmin Guan Ju Gao Minghua Yang Ningling Wang Tianfeng Liu Jingyan Tang Alex WK Leung Fen Zhou Xuedong Wu Jie Huang Hong Li Shaoyan Hu Xin Tian Hua Jiang Jiaoyang Cai Xiaowen Zhai Shuhong Shen Qun Hu Mengmeng Yin;Hongsheng Wang;Xianmin Guan;Ju Gao;Minghua Yang;Ningling Wang;Tianfeng Liu;Jingyan Tang;Alex WK Leung;Fen Zhou;Xuedong Wu;Jie Huang;Hong Li;Shaoyan Hu;Xin Tian;Hua Jiang;Jiaoyang Cai;Xiaowen Zhai;Shuhong Shen;Qun Hu

作者机构：Department of PediatricsTongji Hospital of Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Hematology/OncologyChildren’s Hospital of Fudan UniversityShanghai 201100China Department of Hematology/OncologyShanghai Children’s Medical CenterSchool of MedicineShanghai Jiao Tong UniversityKey Laboratory of Pediatric Hematology&Oncology of China Ministry of HealthShanghai 200120China Department of Hematology/OncologyChongqing Medical University Affiliated Children’s HospitalChongqing 400015China Department of PediatricsKey Laboratory of Birth Defects and Related Disease of Women and ChildrenMinistry of EducationWest China Second University HospitalSichuan UniversityChengdu 610041China Department of PediatricsXiangya Hospital Central South UniversityChangsha 410008China Department of PediatricsAnhui Medical University Second Affiliated HospitalHefei 230601China State Key Laboratory of Experimental Hematology and Division of Pediatric Blood Diseases CenterInstitute of Hematology and Blood Diseases HospitalPeking Union Medical CollegeChinese Academy of Medical SciencesTianjin 300020China Department of PediatricsHong Kong Children’s HospitalThe Chinese University of Hong KongHong Kong SAR 999077China Department of PediatricsUnion Hospital of Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of PediatricsNanfang HospitalSouthern Medical UniversityGuangzhou 516006China Department of Hematology/OncologyChildren’s Hospital of Nanjing Medical UniversityNanjing 210008China Department of Hematology/OncologyShanghai Children’s HospitalShanghai Jiao Tong UniversityShanghai 200062China Department of Hematology/OncologyChildren’s Hospital of Soochow UniversitySuzhou 215002China Department of Hematology/OncologyKunming Children’s HospitalKunming 650103China Department of Hematology/OncologyGuangzhou Women and Children’s Medical CenterGuangzhou 510620China 

出 版 物：《Frontiers of Medicine》 (医学前沿（英文版）)

年 卷 期：2023年第17卷第3期

页      面：518-526页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：VIVA-China Children's Cancer Foundation and Prof.Pui team 

主　　题：acute lymphoblastic leukemia child venous thromboembolism epidemiology clinical characteristic risk factor 

摘      要：Venous thromboembolism(VTE)is a complication in children with acute lymphoblastic leukemia(ALL).The Chinese Children’s Cancer Group-ALL-2015 protocol was carried out in China,and epidemiology,clinical characteristics,and risk factors associated with VTE were *** collected data on VTE in a multiinstitutional clinical study of 7640 patients with ALL diagnosed in 20 hospitals from January 2015 to December ***,VTE occurred in 159(2.08%)patients,including 90(56.6%)during induction therapy and 108(67.92%)in the upper extremities.T-ALL had a 1.74-fold increased risk of VTE(95%CI 1.08–2.8,P=0.022).Septicemia,as an adverse event of ALL treatment,can significantly promote the occurrence of VTE(P0.001).Catheter-related thrombosis(CRT)accounted for 75.47%(n=120);and,symptomatic VTE,58.49%(n=93),which was more common in patients aged 12–18 years(P=0.023),non-CRT patients(P0.001),or patients with cerebral thrombosis(P0.001).Of the patients with VTE treated with anticoagulation therapy(n=147),4.08%(n=6)had *** VTE recurrence rate was 5.03%(n=8).Patients with VTE treated by non-ultrasoundguided venous cannulation(P=0.02),with residual thrombus(P=0.006),or with short anticoagulation period(P=0.026)had high recurrence ***,preventing repeated venous puncture and appropriately prolonged anticoagulation time can reduce the risk of VTE recurrence.