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International Journal of Minerals,Metallurgy and Materials 2021年第5期28卷 816-825页

作者： Yi-shuang Yu Bin Hu Min-liang Gao Zhen-jia Xie xue-quan rong Gang Han Hui Guo Cheng-jia Shang Collaborative Innovation Center of Steel Technology University of Science and Technology BeijingBeijing 100083China Institute of Advanced Materials and Technology University of Science and Technology BeijingBeijing 100083China State Key Laboratory of Metal Material for Marine Equipment and Application Anshan 114021China

Here we present a novel approach of intercritical heat treatment for microstructure tailoring,in which intercritical annealing is introduced between conventional quenching and *** induced a heterogeneous microstructure consisting of soft intercritical ferrite and hard tempered martensite,resulting in a low yield ratio(YR)and high impact toughness in a high-strength low-alloy *** initial yielding and subsequent work hardening behavior of the steel during tensile deformation were modified by the presence of soft intercritical ferrite after intercritical annealing,in comparison to the steel with full martensitic *** increase in YR was related to the reduction in hardness difference between the soft and hard phases due to the precipitation of nano-carbides and the recovery of dislocations during *** excellent low-temperature toughness was ascribed not only to the decrease in probability of microcrack initiation for the reduction of hardness difference between two phases,but also to the increase in resistance of microcrack propagation caused by the high density of high angle grain boundaries.

关键词： heterogeneous microstructure yield ratio impact toughness intercritical heat treatment high-strength low-alloy steel

Effects of exogenous human leptin on heat shock protein 70 expression in MCF-7 breast cancer cells and breast carcinoma of nude mice xenograft model

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Chinese Medical Journal 2012年第4期125卷 680-686页

作者： xue rong-quan Gu Jun-chao Yu Wei Wang Yu Zhang Zhong-tao Ma xue-mei Capital Med Univ Beijing Friendship Hosp Dept Gen Surg Beijing 100050 Peoples R China Capital Med Univ Beijing Tiantan Hosp Dept Gen Surg Beijing 100050 Peoples R China

Background It is important to identify the multiple sites of leptin activity in obese women with breast *** this study,we examined the effect of exogenous human leptin on heat shock protein 70 （HSP70） expression in MCF-7 human breast cancer cells and in a breast carcinoma xenograft model of nude *** We cultured MCF-7 human breast cancer cells and established nude mice bearing xenograffs of these cells,and randomly divided them into experimental and control *** experimental group was treated with human leptin,while the control group was treated with the same volume of normal saline.A real-time reverse transcriptase-polymerase chain reaction （RT-PCR） assay was developed to quantify the mRNA expression of HSP70 in the MCF-7 human breast cancer cells and in tumor *** blotting analysis was applied to quantify the protein expression of HSP70 in the MCF-7 *** staining was done to assess the positive rate of HSP70 expression in the tumor *** Leptin activated HSP70 in a dose-dependent manner in vitro：leptin upregulated significantly the expression of HSP70 at mRNA and protein levels in MCF-7 human breast cancer cells （P 〈0.001）.There was no significant difference in expression of HSP70 mRNA in the implanted tumors between the leptin-treated group and the control group （P〉0.05）.Immunohistochemical staining revealed no significant difference in tumor HSP70 expression between the leptin-treated group and the control group （P〉0.05）.Conclusions A nude mouse xenograft model can be safely and efficiently treated with human leptin by subcutaneous injections around the ***70 may be target of leptin in breast *** can significantly upregulate the expression of HSP70 in a dose-dependent manner in vitro.

关键词： human leptin breast cancer xenografi model heat shock protein 70

Lentivirus-mediated RNA interference targeting the ObR gene in human breast cancer MCF-7 cells in a nude mouse xenograft model

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Chinese Medical Journal 2012年第9期125卷 1563-1570页

作者： xue rong-quan GU Jun-chao DU Song-tao YU Wei WANG Yu ZHANG Zhong-tao BAI Zhi-gang MA xue-mei Department of General Surgery Beijing Friendship Hospital Capital Medical University Beijing 100050 China Department of General Surgery Beijing Tiantan Hospital Capital Medical University Beijing 100050 China

Background There is a significant association between obesity and breast cancer, which is possibly due to the expression of leptin. Therefore, it is important to clarify the role of leptin/ObR （leptin receptor） signaling during the progression of human breast cancer. Methods Nude mice with xenografts of MCF-7 human breast cancer cells were administered recombinant human leptin subcutaneous via injection around the tumor site. Mice in the experimental group were intratumorally injected with ObR-RNAi-lentivirus, while negative control group mice were injected with the same dose of negative-lentivirus. Tumor size was blindly measured every other day, and mRNA and protein expression levels of ObR, estrogen receptor a （ERa）, and vascular endothelial growth factor （VEGF） for each group were determined.Results Knockdown of ObR-treated xenografted nude mice with a high leptin microenvironment was successfully established. Local injection of ObR-RNAi-lentivirus significantly suppressed the established tumor growth in nude mice. ObR level was significantly lower in the experimental group than in the negative control group, while the amounts of ERα and VEGF expression were significantly lower in the leptin group than in the control group （P 〈0.01 for all）.Conclusions Inhibition of leptin/ObR signaling is essential to breast cancer proliferation and possible crosstalk between ObR and ERa, and VEGF, and may lead to novel therapeutic treatments aiming at targeting ObR in breast cancers.

关键词： RNA interference breast neoplasms xenografi model leptin receptor estrogen receptor α vascular endothelial growth factor

匹罗卡品对正常眼压老年人眼前段结构变化的影响

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眼科新进展 2009年第2期29卷 121-123页

作者：孙怡艾育德薛荣泉内蒙古医学院附属医院眼科内蒙古呼和浩特市010050 内蒙古医院普外科内蒙古呼和浩特市010017

目的探讨匹罗卡品对正常眼压老年人眼前段结构变化影响的作用机制,进一步对比窄前房角和宽前房角老年人眼前段结构的形态特征。方法根据房角镜检查,选取具有窄前房角的患者21例(32眼)和宽前房角的正常志愿者20例(30眼),眼压均在正常范围... 详细信息

目的探讨匹罗卡品对正常眼压老年人眼前段结构变化影响的作用机制,进一步对比窄前房角和宽前房角老年人眼前段结构的形态特征。方法根据房角镜检查,选取具有窄前房角的患者21例(32眼)和宽前房角的正常志愿者20例(30眼),眼压均在正常范围内,使用超声生物显微镜对2组滴10g·L-1匹罗卡品滴眼液前后房角结构指标进行观察并运用专用软件给予测量。结果窄角眼滴匹罗卡品后表现前房深度减小,虹膜厚度变小,小梁虹膜角增加,房角开放距离增加,睫状体厚度增加,虹膜晶状体接触距离增加。宽角眼滴匹罗卡品后表现前房深度减小,虹膜厚度变小,小梁虹膜角减小,房角开放距离减小,睫状体厚度增加,虹膜晶状体接触距离增加。滴匹罗卡品滴眼液前后,2组前房深度、小梁虹膜角、房角开放距离变化差异有显著统计学意义(P0.05)。结论匹罗卡品可以引起窄角眼前房角增宽,其对房角的改变依靠于滴药前房角的状况,它对正常眼压老年人的窄角眼的治疗是有效的。

关键词：超声生物显微镜眼前段老年人眼压匹罗卡品

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正常眼压老年人眼前段超声生物显微镜的研究

中国实用眼科杂志 2006年第11期24卷 1127-1130页

作者：孙怡艾育德周炜薛荣全内蒙古医学院附属医院眼科呼和浩特010050 南宁市第一医院眼科内蒙古医院普外科

目的对比窄前房角和宽前房角老年人眼前段结构的形态特征。方法选取59-73岁正常眼压老年人41名(62眼)作为观察对象。根据房角镜检查分为窄房角组(32只眼)和宽房角组(30只眼),分别用A超及超声生物显微镜(UBM)检测前房深度、晶体厚度、眼... 详细信息

目的对比窄前房角和宽前房角老年人眼前段结构的形态特征。方法选取59-73岁正常眼压老年人41名(62眼)作为观察对象。根据房角镜检查分为窄房角组(32只眼)和宽房角组(30只眼),分别用A超及超声生物显微镜(UBM)检测前房深度、晶体厚度、眼轴长度、晶体相对位置测量,睫状体厚度、房角开放距离、小梁虹膜角、虹膜厚度、虹膜晶体接触距离,并且对比点1%匹罗卡品滴眼液前后眼前段结构的变化。结果与宽角眼相比,窄角眼前房浅、晶体厚度较大、相对晶体位置前移、睫状体薄、小梁虹膜角窄,房角开放距离小、虹膜厚度小、虹膜晶体接触距离较大;睫状体厚度与晶体厚度呈负相关(r1=-0.53,p0.05)。结论老年人窄前房角的眼前段结构预示,他们可能是发生闭角青光眼的高危人群。

关键词：超声生物显微镜眼前段老年人眼压

基于数据挖掘探析推拿治疗小儿遗尿症选穴规律

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中华中医药杂志 2015年第12期30卷 4434-4437页

作者：王杰全薛蓉王艳国天津中医药大学天津300193 天津中医药大学第一附属医院天津300193

目的:探讨推拿治疗小儿遗尿症的选穴规律。方法:收集中国生物医学文献数据库、知网、维普、万方4个数据库中治疗小儿遗尿症的推拿处方,录入到中医传承辅助平台(V2.0)软件,使用该软件集成的规则分析、改进互信息法等数据挖掘方法,统计所... 详细信息

目的:探讨推拿治疗小儿遗尿症的选穴规律。方法:收集中国生物医学文献数据库、知网、维普、万方4个数据库中治疗小儿遗尿症的推拿处方,录入到中医传承辅助平台(V2.0)软件,使用该软件集成的规则分析、改进互信息法等数据挖掘方法,统计所有穴位的频次、比例,以及核心穴位组合特点。结果:筛选出治疗小儿遗尿症的推拿处方215个,非辨证推拿处方69个,涉及穴位69个,其中小儿推拿特定穴26个,频次184次,占总频次的36.15%,手部及前臂、腹腰部穴位占特定穴总频次的94.02%;十四经穴及经外奇穴43个,频次325次,占总频次63.85%,腰背骶部及腹部的穴位和归属督脉、任脉、膀胱经、脾经的穴位占所有非小儿推拿特定穴频次的68.92%和86.15%。常用穴位组合39个,其中2个穴位组合26个,3个穴位组合11个,4个穴位组合2个。结论:小儿遗尿症的非辨证推拿治疗选穴规律是集中于督脉、任脉、膀胱经、脾经四经的针灸特定穴和小儿推拿特定穴相结合,穴位主要分布于腹部及腰骶部。

关键词：小儿遗尿症推拿选穴规律数据挖掘

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以“三个代表”重要思想指引图书馆管理行为

图书馆论坛 2004年第2期24卷 27-28,54页

作者：杨学泉葛海蓉河海大学常州校区图书馆江苏常州213022

以“三个代表”重要思想为指导 ,研究与开发图书馆中的管理行为 ,提高图书馆的管理水平 ,追求其价值与效果最大化。阐述了图书馆管理与管理行为的重要性 ,以“三个代表”

关键词： “三个代表” 图书馆管理管理行为先进文化领导行为馆员行为创新行为

RNA干扰技术在乳腺癌基因治疗中的研究进展

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肿瘤研究与临床 2011年第9期23卷 643-646页

作者：薛荣泉(综述) 谷俊朝(审校) 首都医科大学附属北京友谊医院普外科 100050

RNA干扰技术作为一种简单、有效的代替基因敲除的手段为肿瘤的基因治疗提供了新思路，文章综述RNA干扰的机制、特点及在乳腺癌基因治疗等方面的应用进展。

关键词： RNA干扰乳腺肿瘤基因疗法

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超声生物显微镜对窄角眼房角的观察

内蒙古医学杂志 2005年第8期37卷 697-700页

作者：孙怡艾育德薛荣全内蒙古医学院附属医院眼科内蒙古呼和浩特010050 内蒙古医学院2002级研究生内蒙古呼和浩特010059

目的:了解窄角眼房角结构的解剖形态特征,分析其形成原因。方法:选取门诊窄房角患者21例(32只眼);宽角30眼作为对照,分别采用A超测厚仪及超声生物显微镜(UBM)对研究对象及正常对照组分别进行观察并运用专用软件给与测量。结果:与宽角眼... 详细信息

目的:了解窄角眼房角结构的解剖形态特征,分析其形成原因。方法:选取门诊窄房角患者21例(32只眼);宽角30眼作为对照,分别采用A超测厚仪及超声生物显微镜(UBM)对研究对象及正常对照组分别进行观察并运用专用软件给与测量。结果:与宽角眼相比,窄角眼具有浅前房、晶体厚度增加、眼轴缩短、相对晶体位置前移、睫状体变薄、小梁虹膜角变窄,房角开放距离变小、虹膜厚度缩小、虹膜晶体接触距离增大等解剖特点;晶体厚度和前房深度与睫状体厚度测量位置1与位置2有明显相关性。结论:窄角眼具有前房浅、晶体厚,晶状体相对位置偏前、眼轴变短、睫状体位置前移、小梁虹膜角变窄、房角开放距离变小、虹膜厚度缩小、虹膜晶体接触距离增大等解剖特点;窄角眼中睫状体变薄是晶体前移,厚度增加,前房变浅的重要相关因素之一。

关键词：超声生物显微镜窄角睫状体

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南疆盆地1961—2005年气温变化特征

沙漠与绿洲气象 2008年第2期2卷 23-26页

作者：刘进新全学荣兰州大学大气科学学院甘肃兰州730000 阿克苏气象局新疆阿克苏843000

通过对新疆南疆盆地近45a气温变化特征分析,发现南疆盆地年平均气温在1989年开始发生暖突变。从1980年代末夜间温度开始异常升高,白天温度也随之升高,从而导致南疆盆地整体温度异常暖突变。最高、最低气温和气温日较差的变化具有明显的... 详细信息

通过对新疆南疆盆地近45a气温变化特征分析,发现南疆盆地年平均气温在1989年开始发生暖突变。从1980年代末夜间温度开始异常升高,白天温度也随之升高,从而导致南疆盆地整体温度异常暖突变。最高、最低气温和气温日较差的变化具有明显的季节差异。在各个季节中,秋季和冬季温度的异常偏暖对年平均温度异常暖突变的贡献最大。在各种温度升高过程中,升温幅度最大的是最低气温,而最高气温的升温幅度远小于最低气温,从而日较差表现为减小的趋势。

关键词：南疆盆地气温变化突变