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Neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio:Markers predicting immune-checkpoint inhibitor efficacy and immune-related adverse events

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 577-582页

作者： qiu-Yu Jiang Ru-Yi xue Department of Gastroenterology and hepatology Zhongshan HospitalShanghai Institute of Liver DiseaseFudan UniversityShanghai 200032China Department of Gastroenterology and hepatology Shanghai Baoshan District Wusong Central Hospital(Zhongshan Hospital Wusong BranchFudan University)Shanghai 200940China

We conducted a comprehensive review of existing prediction models pertaining to the efficacy of immune-checkpoint inhibitor(ICI)and the occurrence of immune-related adverse events(irAEs).The predictive potential of neutrophil-to-lymphocyte ratio(NLR)and platelet-to-lymphocyte ratio(PLR)in determining ICI effectiveness has been extensively investigated,while limited research has been conducted on predicting ***,the combined model incor-porating NLR and PLR,either with each other or in conjunction with additional markers such as carcinoembryonic antigen,exhibits superior predictive capabilities compared to individual markers *** and PLR are promising markers for clinical *** models ought to incorporate established efficacious models and newly identified ones,thereby constituting a multifactor composite ***,efforts should be made to explore effective clinical application approaches that enhance the predictive accuracy and efficiency.

关键词： Neutrophil-to-lymphocyte ratio Platelet-to-lymphocyte ratio Immunecheckpoint inhibitor Immune-related adverse event

Water quality, agriculture and food safety in China:Current situation, trends, interdependencies, and management

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Journal of Integrative Agriculture 2015年第11期14卷 2365-2379页

作者： ZHANG Xiao-nan GUO qiu-ping SheN Xiao-xue YU Sheng-wen qiu Guo-yu Shenzhen Engineering Laboratory for Water Desalinization with Renewable Energy School of Environment and EnergyPeking University Chinese Academy for Environmental Planning

Water quality in China is becoming a severe challenge for agriculture and food safety, and it might also impact health of population via agriculture and food. Thus, it is causing widespread concern. Based on extensive literatures review and data mining, current situation of water pollution in China and its effects on food safety were analyzed. The 2nd National Water Resource Survey in China show that the surface water all over the country was under slight pollution and about 60% of groundwater is polluted. Drinking water quality is basically guaranteed in urban area but it is worrisome in rural areas. In addition, China is the largest consumer of fertilizer and pesticide in the world and the amounts of application still show increasing trends. Fertilizers and pesticides are the most important sources of pollution, which affect human health as persistent organic pollutants and environmental endocrine disruptors. Eutrophication of surface water and nitrate pollution of groundwater are serious threats to drinking water safety. Sewage irrigation is becoming a pollution source to China＇s water and land because of lacking of effective regulations. Although, with the advance in technology and management level, control of nitrogen and phosphorus emissions and reducing water pollution is still a major challenge for China.

关键词： agriculture drinking water eutrophication fertilizer food safety groundwater heavy metals microcystin nitrate pesticide pollution water quality

Application of GA-SVM in classification of surrounding rock based on model reliability examination

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Mining Science and Technology 2010年第3期20卷 428-433页

作者： qiu Daohong LI Shucai ZHANG Lewen xue Yiguo Research Center of Geotechnical and Structural Engineering Shandong UniversityJinan 250061China

In order to improve the discrimination precision of support vector machine(SVM) in classification of surrounding rock, a Genetic Algorithm(GA) was used to optimize SVM parameters in the solution *** idea of examination of model reliability was introduced to check the reliability of the SVM parameters,obtained by genetic *** the process of model reliability,a trend examination method is presented,which checks the reliability of the model via the influence trend of impact factors on the object of evaluation and their evaluation *** examination methods are universal,showing new ideas in model reliability examination and can be used in any problems of examination of reliability of models,based on previous *** established a GA-SVM based reliability model of a classification the surrounding rock and applied it to a practical engineering *** result shows that the improved SVM has a high capability for generalization and prediction accuracy in classification of surrounding rock.

关键词： support vector machine classification of surrounding rock reliability genetic algorithm

Recent advances in nanoscale metal-organic frameworks biosensors for detection of biomarkers

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Chinese Chemical Letters 2022年第1期33卷 22-32页

作者： qiu-Yang Xu Zheng Tan xue-Wei Liao Chen Wang Department of Chemistry China Pharmaceutical UniversityNanjing 211198China Analytical and Testing Center Nanjing Normal UniversityNanjing 210046China Jiangsu Key Laboratory of New Power Batteries School of Chemistry and Materials ScienceNanjing Normal UniversityNanjing 210023China

Early and precise diagnosis are propitious to timely treatment and simultaneously increase the chance of successful *** is of critical importance to develop rapid,sensitive,and reliable sensing techniques of physiological biomarkers for disease *** to the advantages of structural designability and property tunability,nanoscale metal-organic frameworks(nMOFs)have been widely applied in the field of biomedicine in recent ***,enhanced stability,more modification sites and improved distribution make nMOFs more suitable as biosensors for detection of *** review article will summarize the recent advancements of n MOFs-based biosensors for detection of biomarkers,classified into four sections via different sensing modes:fluorescent sensing,colorimetric sensing,electrochemical sensing and surface-enhanced Raman scattering(SERS)sensing within the latest *** introducing and comparing the role of n MOFs in different sensing modes,designing strategies of n MOFs-based biosensors are involved as *** last,a brief conclusion and outlook for further applications are provided,which is helpful for exploring multi-functional biologic nano-platforms with *** expect that this review can inspire the interest on this promising research area of n MOFs-based biosensors for detection of biomarker and early diagnosis.

关键词： Nanoscale metal-organic frameworks Biosensors Biomarkers Nano-platforms Early diagnosis

Arabidopsis MSBP1 Is Activated by HY5 and HYH and Is Involved in Photomorphogenesis and Brassinosteroid Sensitivity Regulation

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Molecular Plant 2011年第6期4卷 1092-1104页

作者： qiu-Ming Shi Xi Yang Li Song Hong-Wei xue National Key Laboratory of Plant Molecular Genetics Institute of Plant Physiology and Ecology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences 300 Fenglin Road 200032 Shanghai PR China

Membrane Steroid Binding Protein 1 （MSBP1） can bind steroids in vitro and negatively regulates brassinosteroid （BR） signaling, as well as cell elongation and expansion. Detailed analysis of the MSBP1 expression pattern based on quantitative real-time RT-PCR and promoter-GUS fusion studies revealed that MSBP1 expression in hypocotyls is stimulated by various light conditions, Interestingly, MSBP1 expression is greatly suppressed in hyS, hyh, or hy5hyh mutants but enhanced in cop1 mutants, Further analysis employing a yeast one-hybrid assay, an electrophoretic mobility shift assay （EMSA）, and a Chromatin IP （CHIP） assay confirmed the direct binding of Long Hypocotyl 5 （HY5） and HY5 Homolog （HYH） to the promoter region of MSBP1, indicating that MSBP1 is involved in light-regulated hypocotyl growth by serving as a direct target for HY5 and HYH. In addition, hy5 and hy5 hyh mutants show altered BR responses to light, which is consistent with the suppressed expression of MSBP1 in these mutants. These results suggest that light triggers MSBP1 ex- pression through direct binding to and activation by HY5 and HYH, thereby inhibiting hypocotyl elongation. The findings also provide informative clues regarding the mechanisms for the negative regulation of BR sensitivity and photomorpho- genesis during the dark-light transition.

关键词： MSBP1 HY5 HYH photomorphogenesis BR signaling.

Synthesis,crystal structure and properties of inorganic-organic hybrid polymers based on 8-hydroxylquinoline-5-sulfonic acid

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Science China Chemistry 2009年第10期52卷 1602-1608页

作者： Ying Wang Ming xue JiaNing Xu GuangShan Zhu ShiLun qiu State Key Laboratory of Inorganic Synthesis and Preparative Chemistry Jilin University Changchun 130012 China

Two new inorganic-organic hybrid polymers, Mn(QS)(H2O) (1) and Co(QS)(H2O)2 (2) (H2QS=8-hydroxylquinoline-5-sulfonic acid), based on 8-hydroxylquinoline-5-sulfonate ligand, have been synthesized under solvothermal conditions and their structures were solved by single-crystal X-ray diffraction analysis. Compound 1 is a three-dimensional open framework with rutile topology structure, and compound 2 is a three-dimensional supramolecular structure. These compounds were characterized by powder XRD, infrared spectroscopy, thermogravimetric analysis, fluorescence properties and magnetism properties.

关键词： Inorganic-organic hybrid polymers 8-hydroxylquinoline-5-sulfonate fluorescence properties magnetism properties

Two New Cadmium Metal-organic Frameworks Based on a Mixed-donor Ligand

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Chemical Research in Chinese Universities 2016年第4期32卷 539-544页

作者： WANG Xiaofang SONG Qingshan PAN Ying qiu Shilun xue Ming State Key Laboratory of lnorganie Synthesis and Preparative Chemistry Jilin University Changehun 130012 P. R. China

The self-assembly of a prominent mixed-donor ligand, 5-[4-（1H-tetrazolyl）phen]isophthalic acid（H3TZPl）, with a Cd2＋ center generates two new metal-organic frameworks： [Cd（H2TZPI）2（H2O）2]n（JUC-163） and [Cd2（TZPI）（μ3-OH）（H2O）2]-***（JUC-164）. The two complexes demonstrate different structures for the ligand＇s different coordination modes and configurations. JUC-163 shows a 2D layer structure and further forms into a 3D supramolecular framework by noncovalent interactions（C--H…O, O--H…N and π…π interactions）, whereas JUC-164 exhibits a fascinating 3D framework for the outstanding coordination modes and configurations of the ligand, which are fit for the complex structure. And also, the factor of different cadmium salts（chloride and nitrate） which are used in synthesis progress is worth to notice for the construction of the two distinct structures. The luminescent properties of these metal-organic frameworks were also investigated.

关键词： Cadmium Mixed-donor ligand Metal-organic framework Luminescence

Theoretical Study About Effects of H20 and Na＋ on Adsorption of CO2 on Kaolinite Surfaces

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Chemical Research in Chinese Universities 2016年第1期32卷 118-126页

作者： WU Dinglu JIANG Wen LIU Xiaoqiang qiu Nianxiang xue Ying College of Chemistry Sichuan University Chengdu 610064 P. R. China

The density functional theory（DFT） was used to investigate the adsorptions of carbon dioxide（CO2） on kaolinite surfaces and the influences ofNa＋ and heO on the adsorption. Both cluster and periodic models of kaolinite were considered. The calculated results indicate that stable complexes can be formed between adsorbed CO2 and the surfaces of kaolinite in the presence or absence of sodium cation and water molecule. The Al-O octahedral surface has a larger adsorption affinity for CO2 than the Si-O tetrahedral surface of kaolinite because the hydroxyl groups of kaolinite Al-O surface present more activity than the basal O atoms of the Si-O tetrahedral surface in the intermolecular interactions. The existence of exchangeable sodium cations exerts the significant effect on the adsorption of CO2 with the dramatic increase of the adsorption energy, while the presence of water molecule decreases the adsorption strength insignificantly. The calculated Gibbs free energies of the adsorption reveal that the adsorptions of CO2 on all the investigated kaolinite surfaces are feasible thermodynamically in the gas phase. Surface free energy was calculated to provide the predictions of the surface stability as a function of temperature.

关键词： Carbon capture, storage, and utilization(CCSU) CO2 Kaolinite Adsorption Density functional theory

An analog of Friedel oscillations in nanoconfined water

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National Science Review 2022年第9期9卷 204-211页

作者： Minmin xue Zhili Hu Hu qiu Chun Shen Wanlin Guo Zhuhua Zhang Key Laboratory for Intelligent Nano Materials and Devices of Ministry of Education State Key Laboratory of Mechanics and Control of Mechanical Structures and Institute for Frontier Science Nanjing University of Aeronautics and Astronautics

Water confined in nanometer-scale crevices and cavities underpins a wide range of fundamental processes,such as capillary flow,ion transport and protein ***,how water responds within these confined spaces,with prevalent inhomogeneity built in or caused by impurities,is not well ***,we show theoretically that water confined in one-dimensional nano channels with localized perturbation exhibits pronounced density *** oscillations occur vividly like the Friedel oscillations in electron density resulting from defects in metals.A model analysis reveals that the density oscillations result from the perturbation-induced molecular scattering that is augmented by the confinement-enhanced correlation of water *** renders the oscillations a general behavior independent of the channel geometries and specific forms of the *** confinements comparable to biological ion channels,such oscillations can strikingly extend over 10 nm,resulting in non-trivial effects at large distances that,for example,repel all ions from the channels with their long-range *** results deepen the understanding of biological functions and inspire new applications in a variety of domains,such as ionic sensing and seawater desalination.

关键词： ion sieving Friedel oscillations confined water water transport