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World Journal of Gastrointestinal Surgery 2022年第12期14卷 1363-1374页

作者： xue-mei lu Deng-Shuai Jia Rui Wang Qing Yang Shan-Shan Jin Lan Chen School of Nursing Shanghai Jiao Tong UniversityShanghai 200025China Department of Nursing Shanghai General HospitalShanghai Jiao Tong UniversityShanghai 200080China Department of Critical Care Medicine Shanghai General HospitalShanghai Jiao Tong UniversityShanghai 200080China

BACKGROUND Enteral nutrition(EN)is essential for critically ill ***,some patients will have enteral feeding intolerance(EFI)in the process of *** To develop a clinical prediction model to predict the risk of EFI in patients receiving EN in the intensive care *** A prospective cohort study was *** enrolled patients’basic information,medical status,nutritional support,and gastrointestinal(GI)symptoms were *** baseline data and influencing factors were *** regression analysis was used to establish the model,and the bootstrap resampling method was used to conduct internal *** The sample cohort included 203 patients,and 37.93%of the patients were diagnosed with *** the final regression analysis,age,GI disease,early feeding,mechanical ventilation before EN started,and abnormal serum sodium were *** the internal validation,500 bootstrap resample samples were performed,and the area under the curve was 0.70(95%CI:0.63-0.77).CONCluSION This clinical prediction model can be applied to predict the risk of EFI.

关键词： Enteral feeding intolerance Critical care medicine Clinical prediction model Nutrition assessment Nutritional support Critical care nursing

Melanocortin-1 receptor gene variants in four Chinese ethnic populations

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Cell Research 2001年第1期11卷 81-84页

作者： SHI PENG, xue mei lu, HUAI RONG luO, JIN-GONG XIANG-YU, YA PING ZHANG (Laboratory of Cellular and Molecular Evolution, Kunming Institute of Zoology, the Chinese Academy of Sciences, Kunming 650223, China) Laboratory of Cellular and Molecular Evolution Kunming Institute of Zoology the Chinese Academy of Sciences Kunming China

There is strong relationship between melanocortin-1 receptor (MCIR) gene variants and human hair color and skin type. Based on a sequencing study of MC1R gene in 50 individuals from the Uygur, Tibetan, Wa and Dai ethnic populations, we discuss the occurrence of 7 mc1r variants consisting of 5 nonsynonymous sites (Val60Leu, Arg67Gln, Val92Met, Arg163Gln and Ala299Val) and 2 synonymous sites (C414T and A942G), among which C414T and Ala299Val were reported for the first time. Confirmation and analysis were the made of 122 individuals at three common point mutations (Val92Met, Arg163Gln, A942G) using PCR-SSCP. The frequency of Arg163Gln variant varies in the four ethnic populations, with percentage of 40%, 85.0%, 66. 2% and 72.7%, respectively, while those of Val92Met and A942G are roughly similar in these four populations. The different environments, migration and admixture of various ethnic groups in China might have impact on the observed frequency of Arg163Gln.

关键词： MC1R gene ethnic populations nonsynonymous site synonymous site.

The high diversity of SARS-CoV-2-related coronaviruses in pangolins alerts potential ecological risks

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Zoological Research 2021年第6期42卷 834-844页

作者： Min-Sheng Peng Jian-Bo Li Zheng-Fei Cai Hang Liu Xiaolu Tang Ruochen Ying Jia-Nan Zhang Jia-Jun Tao Ting-Ting Yin Tao Zhang Jing-Yang Hu Ru-Nian Wu Zhong-Yin Zhou Zhi-Gang Zhang Li Yu Yong-Gang Yao Zheng-Li Shi xue-mei lu Jian lu Ya-Ping Zhang State Key Laboratory of Genetic Resources and Evolution Yunnan Laboratory of Molecular Biology of Domestic AnimalsKunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650201China Kunming College of Life Science University of Chinese Academy of SciencesKunmingYunnan 650204China KIZ/CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases Kunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650201China State Key Laboratory for Conservation and Utilization of Bio-resources in Yunnan Yunnan UniversityKunmingYunnan 650091China State Key Laboratory of Protein and Plant Gene Research Center for BioinformaticsSchool of Life SciencesPeking UniversityBeijing 100871China Molbreeding Biotechnology Co. Ltd.ShijiazhuangHebei 050035China Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences&Yunnan Province Kunming Institute of ZoologyKunmingYunnan 650201China CAS Key Laboratory of Special Pathogens and Biosafety Wuhan Institute of VirologyChinese Academy of SciencesWuhanHubei 430071China Center for Excellence in Animal Evolution and Genetics Chinese Academy of SciencesKunmingYunnan 650201China

Understanding the zoonotic origin and evolution history of SARS-CoV-2 will provide critical insights for alerting and preventing future outbreaks.A significant gap remains for the possible role of pangolins as a reservoir of SARS-CoV-2 related coronaviruses(SC2r-CoVs).Here,we screened SC2r-CoVs in 172 samples from 163 pangolin individuals of four species,and detected positive signals in muscles of four Manis javanica and,for the first time,one *** analysis of pangolin mitochondrial DNA traced their origins from Southeast *** in-solution hybridization capture sequencing,we assembled a partial pangolin SC2r-CoV(pangolin-CoV)genome sequence of 22895 bp(MP20)from the *** *** analyses revealed MP20 was very closely related to pangolin-CoVs that were identified in *** seized by Guangxi Customs.A genetic contribution of bat coronavirus to pangolin-CoVs via recombination was *** analysis revealed that the genetic diversity of pangolin-CoVs is substantially higher than previously *** the potential infectivity of pangolin-CoVs,the high genetic diversity of pangolin-CoVs alerts the ecological risk of zoonotic evolution and transmission of pathogenic SC2r-CoVs.

关键词： SARS-CoV-2 Pangolin Recombination Diversity Sequencing mtDNA

重症手足口病合并神经源性肺水肿11例临床研究

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中国现代神经疾病杂志 2018年第3期18卷 198-203页

作者：晋兴楠邹映雪于玫鲁卓林天津市儿童医院感染科 300134

目的总结重症手足口病合并神经源性肺水肿的临床特点和有效治疗方法。方法回顾分析11例重症手足口病合并神经源性肺水肿患儿的诊断与治疗经过,包括临床表现、实验室、影像学和神经电生理学检查。结果 11例患儿均有手足口病接触史,临床... 详细信息

目的总结重症手足口病合并神经源性肺水肿的临床特点和有效治疗方法。方法回顾分析11例重症手足口病合并神经源性肺水肿患儿的诊断与治疗经过,包括临床表现、实验室、影像学和神经电生理学检查。结果 11例患儿均有手足口病接触史,临床表现为发热伴皮疹、易惊、肺水肿;4例入院时Glasgow昏迷量表评分≤7分;5例头部MRI显示脑桥和延髓长T_1、长T_2信号影,2例脑桥长T_2信号影,1例延髓长T_1、长T_2信号影;9例超声心动图射血分数≥41.50%。均予气管插管呼吸机辅助通气、降低颅内压、合理应用血管活性药物、激素、静脉注射免疫球蛋白并辅以营养神经和心肌等对症支持治疗,合并呼吸机相关肺炎者联合应用抗生素。3例(3/11)完全康复,5例(5/11)转入康复科继续康复治疗,3例(3/11)死亡。结论重症手足口病合并神经源性肺水肿起病急骤,发展迅速,病死率较高。予气管插管呼吸机辅助通气、降低颅内压、合理应用血管活性药物、激素和静脉注射免疫球蛋白可以改善预后,治疗成功的关键在于积极气管插管呼吸机辅助通气,正确处理神经源性循环功能障碍。

关键词：手足口病肺水肿肠道病毒感染超声心动描记术

碘化铯/非晶硅数字摄影系统拍摄胸片的适宜管电压:高千伏摄影是否适用于间接DR

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实用放射学杂志 2006年第4期22卷 411-413页

作者：郭雪梅宋鲁新蒋学祥北京大学第一医院放射科北京大学第一医院放射科北京100034

目的探索碘化铯/非晶硅数字摄影系统(间接DR)拍摄胸片的适宜管电压。方法(1)分别对60名正常成人拍摄80、100、150 kV正位胸片,由5位放射科医师对比每人的3张图像质量,对多个解剖部位的显示情况和图像总体印象进行评分;(2)分别固定表面... 详细信息

目的探索碘化铯/非晶硅数字摄影系统(间接DR)拍摄胸片的适宜管电压。方法(1)分别对60名正常成人拍摄80、100、150 kV正位胸片,由5位放射科医师对比每人的3张图像质量,对多个解剖部位的显示情况和图像总体印象进行评分;(2)分别固定表面入射剂量和出射剂量,对人胸部体模拍摄80、100、120、150 kV正位胸片,对肺内模拟病变进行评分。结果成人胸片和肺内模拟病变的显示均随管电压增高,图像质量降低;80 kV对比度最好,但外观略接近低千伏摄影胸片。结论间接DR拍摄正位胸片的适宜管电压为80~100 kV,高千伏摄影不再适用于DR。

关键词：间接数字X线摄影高千伏摄影胸部

蜂毒肽对新生大鼠心肌细胞Na^+,K^+-ATP酶基因表达的影响

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复旦学报（医学版） 2001年第4期28卷 340-342,346页

作者：杨申张雪梅陆利民江明华复旦大学药学院药理学教研室上海200032 复旦大学基础医学院生理学教研室上海200032

目的　观察蜂毒肽对新生大鼠培养心肌细胞Na+,K+ ATP酶α1和 β1亚基mRNA的表达。方法　采用逆转录聚合酶链反应 (RT PCR)技术。药物与培养的心肌细胞温育 1h后 ,观察蜂毒肽对Na+,K+ ATP酶基因表达的影响。用GAPDHmRNA作为内参照。　结... 详细信息

目的　观察蜂毒肽对新生大鼠培养心肌细胞Na+,K+ ATP酶α1和 β1亚基mRNA的表达。方法　采用逆转录聚合酶链反应 (RT PCR)技术。药物与培养的心肌细胞温育 1h后 ,观察蜂毒肽对Na+,K+ ATP酶基因表达的影响。用GAPDHmRNA作为内参照。　结果　蜂毒肽对α1亚基mRNA表达有显著促进作用。经GAPDH校正 ,光密度值对照组为 0 .47± 0 .14(n =5 ) ,蜂毒肽 0 .0 1mmol/L组为 0 .6 6± 0 .10 (n =6 ,P <0 .0 5 ) ,哇巴因 1mmol/L组为 0 .6 7± 0 .0 9(n =6 ,P <0 .0 5 )。蜂毒肽 0 .0 1mmol/L组和哇巴因 1mmol/L组对Na+,K+ ATP酶β1亚基mRNA表达无显著影响。结论　蜂毒肽 0 .0 1mmol/L对Na+,K+ ATP酶α1亚基mRNA表达有促进作用 ,但对

关键词：蜂毒肽酶信使核糖核酸逆转录聚合酶链反应基因表达

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工艺优化节能先进技术减排

工业安全与环保 2008年第12期34卷 25-26页

作者：薛玫璐田秀林太钢焦化厂太原030003

介绍了太钢焦化厂在技术改造过程中采用的工艺节能、减少排放的先进技术,以及先进技术带来的效果,详细介绍了7.63 m焦炉工艺新技术、干熄焦和脱硫脱氰新工艺的显著效果,成熟的工艺节能技术和减排措施,推进企业可持续发展,经济效益、社... 详细信息

介绍了太钢焦化厂在技术改造过程中采用的工艺节能、减少排放的先进技术,以及先进技术带来的效果,详细介绍了7.63 m焦炉工艺新技术、干熄焦和脱硫脱氰新工艺的显著效果,成熟的工艺节能技术和减排措施,推进企业可持续发展,经济效益、社会效益显著。

关键词：焦炉节能技术减排措施可持续发展

Clinical value of combining epirubicin with mindfulness intervention in patients with urinary system tumors and depression

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World Journal of Psychiatry 2025年第1期15卷 54-62页

作者： Juan Liu Yan-Ping Guo Yan-mei lu Bei-Lin Wang Department of Urology Surgery Zhumadian Central HospitalZhumadian 463000Henan ProvinceChina Department of Psychiatry Zhumadian Mental HospitalZhumadian 463000Henan ProvinceChina

BACKGROUND Urinary system tumors often cause negative psychological symptoms,such as depression and dysphoria which significantly impact immune function and indirectly affect cancer *** epirubicin(EPI)is recommended by the European Association of Urology and can improve prognosis,its long-term use can cause toxic side effects,reduce treatment compliance,and increase psycho-logical ***,an appropriate intervention mode is *** This was a retrospective study including 110 patients with urinary system tumors and depression admitted to Zhumadian Central Hospital between March 2021 and July *** were divided into conventional(n=55)and joint inter-vention(n=55)*** conventional group received mitomycin and routine nursing,while the joint intervention group received EPI and mindfulness *** groups underwent three cycles of *** function(CD4+cells,CD8+cells,CD4+/CD8+ratio),tumor marker levels[urinary bladder cancer antigen(UBC),bladder tumor antigen(BTA)and nuclear matrix protein 22(NMP22)],quality of life questionnaire-core 30(QLQ-C30),17-item Hamilton depression scale(HAMD-17),and cancer-related fatigue[cancer fatigue scale(CFS)]were *** reactions and nursing satisfaction were recorded and *** Post-intervention,CD4+,CD8+,and CD4+/CD8+levels increased in both groups,with the joint intervention group showing more significant improvement(PluSION EPI combined with mindfulness intervention significantly improved clinical outcomes in patients with urinar

关键词： Urinary system tumor Bladder cancer Prostate cancer Depression Epirubicin

Recent progress in the applications of presynaptic dopaminergic positron emission tomography imaging in parkinsonism

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Neural Regeneration Research 2025年第1期20卷 93-106页

作者： Yujie Yang Xinyi Li Jiaying lu Jingjie Ge Mingjia Chen Ruixin Yao mei Tian Jian Wang Fengtao Liu Chuantao Zuo Key Laboratory of Arrhythmias Ministry of EducationDepartment of Medical GeneticsShanghai East HospitalSchool of MedicineTongji UniversityShanghaiChina Department of Neurology National Research Center for Aging and MedicineNational Center for Neurological Disordersand State Key Laboratory of Medical NeurobiologyHuashan HospitalFudan UniversityShanghaiChina Department of Nuclear Medicine&PET Center National Center for Neurological Disordersand National Clinical Research Center for Aging and MedicineHuashan HospitalFudan UniversityShanghaiChina International Human Phenome Institutes(Shanghai) ShanghaiChina Human Phenome Institute Fudan UniversityShanghaiChina

Nowadays,presynaptic dopaminergic positron emission tomography,which assesses deficiencies in dopamine synthesis,storage,and transport,is widely utilized for early diagnosis and differential diagnosis of *** review provides a comprehensive summary of the latest developments in the application of presynaptic dopaminergic positron emission tomography imaging in disorders that manifest *** conducted a thorough literature search using reputable databases such as PubMed and Web of *** criteria involved identifying peer-reviewed articles published within the last 5 years,with emphasis on their relevance to clinical *** findings from these studies highlight that presynaptic dopaminergic positron emission tomography has demonstrated potential not only in diagnosing and differentiating various Parkinsonian conditions but also in assessing disease severity and predicting ***,when employed in conjunction with other imaging modalities and advanced analytical methods,presynaptic dopaminergic positron emission tomography has been validated as a reliable in vivo *** validation extends to screening and exploring potential neuropathological mechanisms associated with dopaminergic *** summary,the insights gained from interpreting these studies are crucial for enhancing the effectiveness of preclinical investigations and clinical trials,ultimately advancing toward the goals of neuroregeneration in parkinsonian disorders.

关键词： aromatic amino acid decarboxylase brain imaging dopamine transporter Parkinson’s disease parkinsonism positron emission tomography presynaptic dopaminergic function vesicle monoamine transporter type 2

Understanding the local structure and thermophysical behavior of Mg-La liquid alloys via machine learning potential

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 439-449页

作者： Jia Zhao Taixi Feng Guimin lu National Engineering Research Center for Integrated Utilization of Salt Lake Resource East China University of Science and TechnologyShanghai 200237China Joint International Laboratory for Potassium and Lithium Strategic Resources East China University of Science and TechnologyShanghai 200237China

The local structure and thermophysical behavior of Mg-La liquid alloys were in-depth understood using deep potential molecular dynamic(DPMD) simulation driven via machine learning to promote the development of Mg-La alloys. The robustness of the trained deep potential(DP) model was thoroughly evaluated through several aspects, including root-mean-square errors(RMSEs), energy and force data, and structural information comparison results;the results indicate the carefully trained DP model is reliable. The component and temperature dependence of the local structure in the Mg-La liquid alloy was analyzed. The effect of Mg content in the system on the first coordination shell of the atomic pairs is the same as that of temperature. The pre-peak demonstrated in the structure factor indicates the presence of a medium-range ordered structure in the Mg-La liquid alloy, which is particularly pronounced in the 80at% Mg system and disappears at elevated temperatures. The density, self-diffusion coefficient, and shear viscosity for the Mg-La liquid alloy were predicted via DPMD simulation, the evolution patterns with Mg content and temperature were subsequently discussed, and a database was established accordingly. Finally, the mixing enthalpy and elemental activity of the Mg-La liquid alloy at 1200 K were reliably evaluated,which provides new guidance for related studies.

关键词： magnesium-lanthanum liquid alloys local structure macroscopic properties thermodynamic behavior deep potential mo-lecular dynamic simulation