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不同基因型羊草数量性状的可塑性及遗传分化

植物生态学报 2017年第3期41卷 359-368页

作者：杨雪申俊芳赵念席高玉葆南开大学生命科学学院.天津300071

为了深入探讨植物对环境变化的适应机制,该文以内蒙古草原区羊草(Leymus chinensis)不同基因型为对象,在人工控制条件下,研究了羊草基因型、刈割、干旱及其交互作用对羊草11个数量性状的影响。结果显示:(1)所观测的11个性状(光系统Ⅱ光... 详细信息

为了深入探讨植物对环境变化的适应机制,该文以内蒙古草原区羊草(Leymus chinensis)不同基因型为对象,在人工控制条件下,研究了羊草基因型、刈割、干旱及其交互作用对羊草11个数量性状的影响。结果显示:(1)所观测的11个性状(光系统Ⅱ光化学效率、最大净光合速率、蒸腾速率、比叶面积、相对生长速率、分蘖增长数、地上及地下生物量、叶总酚浓度、根非结构性碳水化合物总量和根冠比)受环境因素(干旱、刈割或两者交互)影响显著,表明该物种具有较强的表型可塑性;且在4种环境条件(对照、刈割、干旱、刈割干旱)下,不同基因型羊草的反应规范并不一致,其中,最大净光合速率、蒸腾速率、比叶面积、相对生长速率、叶总酚浓度和根非结构性碳水化合物总量受环境和基因型交互作用影响显著,表明这些性状的表型可塑性具有一定的遗传基础。(2)对同一环境条件下,不同基因型间的性状进行分析显示,分蘖增长数、地下生物量和根非结构性碳水化合物含量在4种环境条件下均未检测到基因型间的差异;而其余8个性状在基因型间的差异显著,表明这些性状的差异具有一定的遗传基础,其中,与生长相关的6个性状的遗传力(H^2)较高,均大于0.5,而叶总酚浓度和根冠比仅在刈割干旱条件下检测出显著差异,H^2分别为0.145和0.202。这些实验结果为理解羊草这一重要物种在内蒙古草原区的广泛分布提供了适应机制方面的数据支持,为合理预测未来气候变化对该物种的影响提供了科学依据,为合理利用和保护该物种及其生态系统提供了理论依据。

关键词：羊草基因型适应遗传分化表型可塑性反应规范

The complex roles of m^(6)A modifications in neural stem cell proliferation, differentiation, and self-renewal and implications for memory and neurodegenerative diseases

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Neural Regeneration Research 2025年第6期20卷 1582-1598页

作者： Yanxi Li Jing xue Yuejia Ma Ke Ye xue zhao fangliang Ge Feifei Zheng Lulu Liu Xu Gao Dayong Wang Qing Xia Department of Biochemistry and Molecular Biology College of Basic Medical SciencesHarbin Medical UniversityHarbinHeilongjiang ProvinceChina College of Basic Medical Sciences Harbin Medical UniversityHarbinHeilongjiang ProvinceChina Basic Medical Institute Heilongjiang Academy of Medical SciencesHarbinHeilongjiang ProvinceChina Key Laboratory of Heilongjiang Province for Genetically Modified Animals Harbin Medical UniversityHarbinHeilongjiang ProvinceChina Translational Medicine Research and Cooperation Center of Northern China Heilongjiang Academy of Medical SciencesHarbinHeilongjiang ProvinceChina Dongzhimen Hospital Beijing University of Chinese MedicineBeijingChina

N6-methyladenosine(m^(6)A), the most prevalent and conserved RNA modification in eukaryotic cells, profoundly influences virtually all aspects of mRNA metabolism. mRNA plays crucial roles in neural stem cell genesis and neural regeneration, where it is highly concentrated and actively involved in these processes. Changes in m^(6)A modification levels and the expression levels of related enzymatic proteins can lead to neurological dysfunction and contribute to the development of neurological diseases. Furthermore, the proliferation and differentiation of neural stem cells, as well as nerve regeneration, are intimately linked to memory function and neurodegenerative diseases. This paper presents a comprehensive review of the roles of m^(6)A in neural stem cell proliferation, differentiation, and self-renewal, as well as its implications in memory and neurodegenerative diseases. m^(6)A has demonstrated divergent effects on the proliferation and differentiation of neural stem cells. These observed contradictions may arise from the time-specific nature of m^(6)A and its differential impact on neural stem cells across various stages of development. Similarly, the diverse effects of m^(6)A on distinct types of memory could be attributed to the involvement of specific brain regions in memory formation and recall. Inconsistencies in m^(6)A levels across different models of neurodegenerative disease, particularly Alzheimer's disease and Parkinson's disease, suggest that these disparities are linked to variations in the affected brain regions. Notably, the opposing changes in m^(6)A levels observed in Parkinson's disease models exposed to manganese compared to normal Parkinson's disease models further underscore the complexity of m^(6)A's role in neurodegenerative processes. The roles of m^(6)A in neural stem cell proliferation, differentiation, and self-renewal, and its implications in memory and neurodegenerative diseases, appear contradictory. These inconsistencies may be a

关键词： Alzheimer's disease cell self-renewal central nervous system memory microglia nerve regeneration neurodegenerative diseases neurogenesis RNA methylation

The interaction between KIF21A and KANK1 regulates dendritic morphology and synapse plasticity in neurons

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Neural Regeneration Research 2025年第1期20卷 209-223页

作者： Shi-Yan Sun Lingyun Nie Jing Zhang xue fang Hongmei Luo Chuanhai Fu Zhiyi Wei Ai-Hui Tang Hefei National Research Center for Physical Sciences at the Microscale CAS Key Laboratory of Brain Function and DiseaseMinistry of Education Key Laboratory for Membrane-less Organelles and Cellular DynamicsDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Institute of Artificial Intelligence Hefei Comprehensive National Science CenterHefeiAnhui ProvinceChina CAS Center for Excellence in Molecular Cell Sciences Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Department of Neurobiology School of Life SciencesSouthern University of Science and TechnologyShenzhenGuangdong ProvinceChina Brain Research Center Southern University of Science and TechnologyShenzhenGuangdong ProvinceChina

Morphological alterations in dendritic spines have been linked to changes in functional communication between neurons that affect learning and ***-4 KIF21A helps organize the microtubule-actin network at the cell cortex by interacting with KANK1;however,whether KIF21A modulates dendritic structure and function in neurons remains *** this study,we found that KIF21A was distributed in a subset of dendritic spines,and that these KIF21A-positive spines were larger and more structurally plastic than KIF21A-negative ***,the interaction between KIF21A and KANK1 was found to be critical for dendritic spine morphogenesis and synaptic *** of either KIF21A or KANK1 inhibited dendritic spine morphogenesis and dendritic branching,and these deficits were fully rescued by coexpressing full-length KIF21A or KANK1,but not by proteins with mutations disrupting direct binding between KIF21A and KANK1 or binding between KANK1 and *** down KIF21A in the hippocampus of rats inhibited the amplitudes of long-term potentiation induced by high-frequency stimulation and negatively impacted the animals’cognitive *** together,our findings demonstrate the function of KIF21A in modulating spine morphology and provide insight into its role in synaptic function.

关键词： actin cytoskeleton dendrite KANK1 KIF21A microtubule spine morphology spine synaptic plasticity talin1

本科与专科护生评判性思维能力现状及影响因素分析

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蚌埠医学院学报 2016年第11期41卷 1512-1513,1517页

作者：薛芳赵静宋松蚌埠医学院护理学系安徽蚌埠233030 蚌埠医学院学生处安徽蚌埠233030

目的：调查本科和专科护生评判性思维能力现状，并分析其影响因素。方法：整群抽取本科和专科护生共500名进行问卷调查。调查工具包括一般情况调查表和中文版评判性思维能力测量表。采用非条件 logistic 回归模型分析护生评判性思维能... 详细信息

目的：调查本科和专科护生评判性思维能力现状，并分析其影响因素。方法：整群抽取本科和专科护生共500名进行问卷调查。调查工具包括一般情况调查表和中文版评判性思维能力测量表。采用非条件 logistic 回归模型分析护生评判性思维能力的影响因素。结果：本科护生评判性思维能力总分为（254.33±9.11）分，专科护生评判性思维能力总分为（227.53±8.88）分，本科护生评判性思维能力的7个维度评分及总分均明显高于专科护生（P〈0.01）。护生评判性思维能力的主要影响因素为性格类型、是否参加学校社团活动和教师是否运用仿真模拟教学（P〈0.05～P〈0.01）。结论：本科和专科护生具备正性评判性思维能力，但总体处于中等偏下水平。

关键词：护生评判性思维能力教学方法

Highly mass activity electrocatalysts with ultralow Pt loading on carbon black for hydrogen evolution reaction

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 182-190页

作者： Shaorou Ke Yajing zhao Xin Min Yanghong Li Ruiyu Mi Yangai Liu Xiaowen Wu Minghao fang zhaohui Huang Engineering Research Center of Ministry of Education for Geological Carbon Storage and Low Carbon Utilization of Resources Beijing Key Laboratory of Materials Utilization of Nonmetallic Minerals and Solid WastersNational Laboratory of Mineral MaterialsSchool of Materials Science and TechnologyChina University of Geosciences(Beijing)Beijing 100083China

Pt-based nanocatalysts offer excellent prospects for various ***,the low loading of Pt with excellent performance for efficient and stable nanocatalysts still presents a considerable *** this study,nanocatalysts with ultralow Pt content,excellent performance,and carbon black as support were prepared through in-situ ***~2-nm particles uniformly and stably dispersed on carbon black because of the strong s-p-d orbital hybridizations between carbon black and Pt,which suppressed the agglomeration of Pt *** unique structure is beneficial for the hydrogen evolution *** catalysts exhibited remarkable catalytic activity for hydrogen evolution reaction,exhibiting a potential of 100 mV at 100 mA·cm^(-2),which is comparable to those of commercial Pt/C *** activity(1.61 A/mg)was four times that of a commercial Pt/C catalyst(0.37 A/mg).The ultralow Pt loading(6.84wt%)paves the way for the development of next-generation electrocatalysts.

关键词： hydrogen evolution reaction ultralow platinum in-situ synthesis ultrasound

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常春藤皂苷元的研究进展

中国实验方剂学杂志 2017年第22期23卷 226-234页

作者：邢颖南敏伦王雪赫玉芳赵昱玮何忠梅吉林农业大学长春130118 吉林省中医药科学院长春130012

常春藤皂苷元(hederagenin)是一种从植物中分离得到的五环三萜类化合物,广泛分布于多种药用植物中,是许多天然产物的主要活性成分。通过整合及分析国内外相关文献,综述了常春藤皂苷元的资源分布、结构修饰及药理作用的最新研究进展,为... 详细信息

常春藤皂苷元(hederagenin)是一种从植物中分离得到的五环三萜类化合物,广泛分布于多种药用植物中,是许多天然产物的主要活性成分。通过整合及分析国内外相关文献,综述了常春藤皂苷元的资源分布、结构修饰及药理作用的最新研究进展,为深入研究常春藤皂苷元的结构修饰及药理作用提供参考依据。研究表明,常春藤皂苷元广泛分布于川续断科、忍冬科、毛茛科、五加科及败酱科等多种药用植物中,自然界中资源较为丰富。常春藤皂苷元具有溶解性差、生物利用度低、口服给药效果差等特点,从而使常春藤皂苷元的临床应用受到限制,为此国内外学者对其进行结构修饰,目前对常春藤皂苷元的结构修饰主要发生在其C-28位,C-3位,C-23位,C-12位,C-13位上,其中C-28位的结构修饰相对较多。药理活性研究表明,常春藤皂苷元具有抗肿瘤、抗抑郁、抗菌抗炎、抗糖尿病等多种药理作用,但是其相关作用机制尚缺乏深入研究。通过对常春藤皂苷元的资源分布、结构修饰及药理作用的系统综述,可以为常春藤皂苷元的深入研究提供参考,为常春藤皂苷元及其衍生物安全有效的应用于临床提供科学依据。

关键词：常春藤皂苷元资源分布结构修饰药理作用

建设健康社会的催化剂:健康社会工作者与全科医生在基层的合作

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中国全科医学 2025年第4期28卷 516-520页

作者：李奕桦赵艾杨曾飞方雪张旺王欣武汉大学中南医院创伤与显微骨科湖北省武汉市430071 巴东县人民医院骨科湖北省恩施土家族苗族自治州444300

以“健康中国”战略为导向,从优势互补专业知识、共同连接医院社区、拓展研究社会健康三个方面去探讨健康社会工作者与全科医生在基层卫生环境中的合作价值,尤其在完善公共卫生应急体系和构建医联体上,健康社会工作者与全科医生的合作... 详细信息

以“健康中国”战略为导向,从优势互补专业知识、共同连接医院社区、拓展研究社会健康三个方面去探讨健康社会工作者与全科医生在基层卫生环境中的合作价值,尤其在完善公共卫生应急体系和构建医联体上,健康社会工作者与全科医生的合作可以发挥必不可少的作用,能有效推动健康社会的建设进程。同时文章也指明了目前健康社会工作面临的主要挑战,并提出相应的对策。

关键词：健康社会健康社会工作者全科医生基层卫生公共卫生应急医联体

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粘贴式光纤光栅应变传感器动态特性实验研究

武汉工业学院学报 2003年第2期22卷 21-23页

作者：梁磊罗裴周雪芳赵申武汉理工大学光纤传感国家重点工业性实验基地湖北武汉430070

从应变传感模型的角度分析了光纤光栅应变传感器的轴向应变检测特性的理论基础,研究了粘贴式光纤布拉格光栅应变传感器和压电陶瓷加速度传感器对柔性梁的动态响应特性。结果表明,粘贴式光纤布拉格光栅传感器具有和压电陶瓷加速度传感器... 详细信息

从应变传感模型的角度分析了光纤光栅应变传感器的轴向应变检测特性的理论基础,研究了粘贴式光纤布拉格光栅应变传感器和压电陶瓷加速度传感器对柔性梁的动态响应特性。结果表明,粘贴式光纤布拉格光栅传感器具有和压电陶瓷加速度传感器一致的动态响应特性,是一种新的高灵敏度在线监测技术。

关键词：光纤布拉格光栅应变传感器压电陶瓷加速度传感器柔性梁健康监测工程结构模型动态响应轴向应变检测

Bromate removal by gamma irradiation in aqueous solutions

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Nuclear Science and Techniques 2016年第1期27卷 44-49页

作者： zhao-Lian Ye xue-Hui fang Hui-Qi Hou College of Chemistry and Environmental Engineering Jiangsu University of Technology Department of Environmental Science and Engineering Fudan University

Bromate(BrO_3) is a disinfection by-product in drinking water, and its removal is very difficult especially at low levels.60 Co gamma rays were used to remove BrO_3in aqueous solution in this study. The effects of absorbed doses, BrO_3initial concentration, gas saturation, p H value and coexisting anions(Cl, NO 3, SO2 4and HCO 3=CO_3^(2 -))on BrO_3reduction were evaluated. After 4.0-k Gy irradiation of air-equilibrated solution of 30.7 lg/L BrO_3, the residual BrO_3was 8.3 lg/L, which is below the maximum contaminant level of drinking water. The BrO_3reduction rate increased with the dose, in the order of N2[ air [ O_2[ N_2O atmosphere under similar conditions. The results also show that high p H favored the BrO_3removal. According to the experimental results, it can be concluded that the efficiency of decomposing BrO_3by reactive species followed the order of e aq[ H [ HO_2 [ O_2. Coexisting Cl, HCO 3=CO_3^(2 -)and SO2 4ions have little effect on BrO_3removal, whereas NO_3can inhibit its removal as a result of competition with BrO_3for e aq.

关键词： γ射线照射水溶液溴酸盐吸收剂量二氧化碳高pH值消毒副产物含气饱和度