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NHE7 upregulation potentiates the uptake of small extracellular vesicles by enhancing maturation of macropinosomes in hepatocellular carcinoma

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Cancer Communications 2024年第2期44卷 251-272页

作者： Yue Yao Yi Xu Liang Yu Ting-Mao xue zhi-Jie Xiao Pui-Chi Tin Hiu-Ling Fung Hoi-Tang Ma Jing-Ping Yun Judy Wai Ping Yam Department of Pathology School of Clinical MedicineLi Ka Shing Faculty of MedicineThe University of Hong KongHong KongP.R.China Department of Endocrinology and Metabolism Second Affiliated Hospital of Harbin Medical UniversityHarbinHeilongjingP.R.China Department of Hepatopancreatobiliary Surgery Second Affiliated Hospital of Harbin Medical UniversityHarbinHeilongjingP.R.China State Key Laboratory of Oncology in South China Cancer Center of Sun Yat-sen UniversityGuangzhouGuangdongP.R.China Department of Hepatobiliary Surgery II Zhujiang HospitalSouthern Medical UniversityGuangzhouGuangdongP.R.China Scientific Research Center The Seventh Affiliated HospitalSun Yat-sen UniversityShenzhenGuangdongP.R.China State Key Laboratory of Liver Research The University of Hong KongHong KongP.R.China Department of Pathology Cancer Center of Sun Yat-sen UniversityGuangzhouGuangdongP.R.China

Background:Small extracellular vesicles(sEVs)mediate intercellular commu-nication that contributes to hepatocellular carcinoma(HCC)progression via multifaceted *** success of cell entry determines the effect of sEV on recipient ***,we aimed to delineate the mechanisms underlying the uptake of sEV in ***:AF,Alexa Fluor;ANOVA,analysis of variance;ATP9A,ATPase Phospholipid Transporting 9A;BCECF-AM,2.,7’-bis-(2.barboxyethyl)-5-(and-6)-carboxyfluorescein,acetoxymethyl ester;BSA,bovine serum albumin;CCMR,Centre for Comparative Medicine Research;CRISPR,clustered regularly interspaced short palindromic repeats;CTL,ctrl;CXCR4,C-X-C Chemokine Receptor Type 4;DAPI,4′,6-diamidino-2.phenylindole;DFS,disease-free survival;DMEM,Dulbecco’s Modified Eagle Medium;DMSO,dimethyl sulfoxide;Dox,doxycycline;EEA1,early endosome antigen 1;EIPA,5-(N-ethyl-N-isopropyl)-amiloride;FBS,fetal bovine serum;FITC,fluorescein isothiocyanate;GAPDH,glyceraldehyde-3-phosphate dehydrogenase;GM130,Golgi matrix protein 130;HCC,hepatocellular carcinoma;HEPES,4-(2.hydroxyethyl)-1-piperazineethanesulfonic acid;HPRT1,hypoxanthine phosphoribosyltransferase 1;H-score,histoscore;IAA,indole-3-acetic acid;KD,knockdown;KO,knockout;mAID,mini-auxin-inducible degron;MTT,3-(4,5-dimethylthiazol-2.yl)-2.5-diphenyltetrazolium bromide;NHE7,Na(+)/H(+)exchanger 7;ns,non-significant;OD,optical density;OS,overall survival;PBS,phosphate-buffered saline;PCR,polymerase chain reaction;pHe,endosomal pH;pHi,intracellular pH;PKH67,Paul Karl Horan 67;Rab2.,Ras-associated binding protein 2.;RIPA,radioimmunoprecipitation assay;SAM,synergistic activation mediator;SEMs,standard error of the means;sEVs,small extracellular vesicles;sgRNA,single-guide RNA;shRNA,short-hairpin RNA;SLC9,solute carrier gene 9;SLiCE,Seamless Ligation Cloning Extract;TCGA,The Cancer Genome Atlas;TCL,total cell lysates;TGN,trans-Golgi network;TMA,tissue microarray;TMR,tetramethyl rhodamine;TSG101,tumor susceptibility gene *** Yao an

关键词： hepatocellular carcinoma small extracellular vesicles macropinocytosis pH regulation sodium-hydrogen exchanger

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Inhibition of Bcl-6 Expression Ameliorates Asthmatic Characteristics in Mice

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Current Medical Science 2024年第1期44卷 110-120页

作者： Chang-zhi ZHOU Xiong XIONG Wei-jun TAN Ya-fei WANG Zhen YANG xue-ying LI Xiu-wen YANG Xiao-fan LIU Sun-feng YU Liang-chao WANG Shuang GENG Department of Respiratory and Critical Care Medicine The Central Hospital of WuhanTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430014China Department of General Surgery Wuhan Wuchang HospitalWuhan University of Science and TechnologyWuhan 430063China

Objective The function of Bcl-6 in T follicular helper(Tfh)cell maturation is indispensable,and Tfh cells play a pivotal role in *** study investigated the impact of Bcl-6 on asthmatic *** The microscopic pathological alterations,airway resistance(AR),and lung compliance(LC)were determined in asthmatic mice and Bcl-6 interference *** surface molecular markers of Tfh cells and the Bcl-6 mRNA and protein expression were determined by flow cytometry,RT-qPCR,and Western blotting,*** relationships between the Tfh cell ratio and the IgE and IgG1 concentrations in peripheral blood mononuclear cells(PBMCs)and bronchoalveolar lavage fluid(BALF)were *** Asthmatic inflammatory changes were observed in the lung tissue and were attenuated by Bcl-6 siRNA and dexamethasone(DXM).Asthmatic mice exhibited an increased AR and a decreased LC,while Bcl-6 siRNA or DXM mitigated these *** percentages of Tfh cells and eosinophils were significantly increased in the asthmatic mice,and they significantly decreased after Bcl-6 inhibition or DXM ***-qPCR and Western blotting analyses revealed that the Bcl-6 expression level in PBMCs was significantly higher in asthmatic mice,and it decreased following Bcl-6 inhibition or DXM *** IgE expression in the serum and BALF and the B cell expression in PBMCs exhibited a similar *** asthmatic mice,the ratio of Tfh cells in the peripheral blood showed a strong positive correlation with the IgE levels in the serum and BALF,but not with the IgG1 *** The amelioration of airway inflammation and airway hyper-responsiveness is achieved through Bcl-6 suppression,which effectively hinders Tfh cell differentiation,ultimately resulting in a concurrent reduction in IgE production.

关键词： Bcl-6 Tfh asthma airway hyper-responsiveness mouse model

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U-Pb dating of monazite in the Bainiuchang silver polymetallic deposit,Yunnan Province,and its limitation on Mesozoic mineralization

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China Geology 2024年第3期7卷 592-595页

作者： Bo-de Lu Wen-chang Li xue-long Liu Guang-zhi Meng Qi-he Long Hong Zhang Jun-shan Dao Fang-lan Li Jie-hu Zhou Mao-huang Fan xue Mi Nan Shi Zhen-liang Cao College of Land Resources and Engineering Kunming University of Science and TechnologyKunming 650093China Geological Team 306 of Yunnan Non-ferrous Metals Geological Bureau Kunming 650217China Mengzi Mining and Metallurgy Co. Ltd.Mengzi 661199China

*** The Gejiu-Bozhushan-Laojunshan tin-tungsten polymetallic metallogenic belt is located in southeastern *** is bounded by the Mile-Shizong Fault and the Yangzi Plate to the north and west,respectively,while the Honghe Fault represents its southwestern *** is adjacent to the Ailaoshan Fault,and extends to Guangxi and Vietnam to the southeast(Fig.1a;Liu JP et al.,2.2.).

关键词： silver dating southeast

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Modulating the Oxidation Degree of Linear Polyethyleneimine for Preparation of Highly Efficient and Low-cytotoxicity Degradable Gene Delivery Carriers

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Chinese Journal of Polymer Science 2024年第11期 1699-1709页

作者： Xiao-Ya Guo zhi-Yu Yang Hua-Pan Fang Dan-Hua Zhou Xuan Pang Hua-Yu Tian xue-Si Chen Changchun Institute of Applied Chemistry Chinese Academy of Sciences School of Applied Chemistry and Engineering University of Science and Technology of China State Key Laboratory of Physical Chemistry of Solid Surfaces College of Chemistry and Chemical Engineering Xiamen University Innovation Laboratory for Sciences and Technologies of Energy Materials of Fujian Province (IKKEM)

Polyethyleneimine （PEI）,as a widely used polymer material in the field of gene delivery,has been extensively studied for modification and shielding to reduce its ***,research aimed at preparing degradable PEI is *** this work,the hydrogen peroxide（H2.2. oxidation method was used to introduce degradable amide groups in the PEI and a series of oxidized PEI2.k （oxPEI2.k） with different degrees of oxidation were synthesized by regulating the dosage of *** relationship between the oxidation degree of oxPEI2.k and the gene transfection efficiency of oxPEI2.k was studied in detail,confirming that the oxPEI2.k with oxidation degrees of 16.7%and 2..6%achieved improved transfection efficiency compared to unmodified *** oxPEI2.k also proved reduced cytotoxicity and improved ***,this strategy was extended to the synthesis of low-molecular-weight *** oxPEI1.8k with suitable oxidation degree also achieved improved transfection efficiency and reduced *** brief,this work provided high-efficiency and low-cytotoxicity degradable gene delivery carriers by regulating the oxidation degree of PEI,which was of great significance for promoting clinical applications of PEI.

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Uridine diphosphate glucuronosyltransferase 1A1 prevents the progression of liver injury

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World Journal of Gastroenterology 2024年第9期30卷 1189-1212页

作者： Jin-Lian Jiang Yi-Yang Zhou Wei-Wei Zhong Lin-Yan Luo Si-Ying Liu Xiao-Yu Xie Mao-Yuan Mu zhi-Gang Jiang Yuan xue Jian Zhang Yi-Huai He Department of Infectious Diseases Affiliated Hospital of Zunyi Medical UniversityZunyi 563000Guizhou ProvinceChina Department of Infectious Diseases Jingmen Central HospitalJingmen 448000Hubei ProvinceChina Department of Respiratory Medicine Anshun People’s HospitalAnshun 561099Guizhou ProvinceChina Department of General Practice Affiliated Hospital of Zunyi Medical UniversityZunyi 563000Guizhou ProvinceChina Department of Intervention Radiology Affiliated Hospital of Zunyi Medical UniversityZunyi 563000Guizhou ProvinceChina School of Public Health Zunyi Medical UniversityZunyi 563099Guizhou ProvinceChina Department of Liver Diseases Third People’s Hospital of ChangzhouChangzhou 213000Jiangsu ProvinceChina Department of Digestion Dafang County People’s HospitalBijie 551600Guizhou ProvinceChina

BACKGROUND Uridine diphosphate glucuronosyltransferase 1A1(UGT1A1)plays a crucial role in metabolizing and detoxifying endogenous and exogenous ***,its contribution to the progression of liver damage remains *** To determine the role and mechanism of UGT1A1 in liver damage *** We investigated the relationship between UGT1A1 expression and liver injury through clinical ***,the impact and mechanism of UGT1A1 on the progression of liver injury was analyzed through a mouse model *** Patients with UGT1A1 gene mutations showed varying degrees of liver damage,while patients with acute-onchronic liver failure(ACLF)exhibited relatively reduced levels of UGT1A1 protein in the liver as compared to patients with chronic *** suggests that low UGT1A1 levels may be associated with the progression of liver *** mouse models of liver injury induced by carbon tetrachloride(CCl_(4))and concanavalin A(ConA),the hepatic levels of UGT1A1 protein were found to be *** mice with lipopolysaccharide or liver steatosis-mediated liver-injury progression,the hepatic protein levels of UGT1A1 were decreased,which is consistent with the observations in patients with ***1A1 knockout exacerbated CCl_(4)-and ConA-induced liver injury,hepatocyte apoptosis and necroptosis in mice,intensified hepatocyte endoplasmic reticulum(ER)stress and oxidative stress,and disrupted lipid *** UGT1A1 is upregulated as a compensatory response during liver injury,and interference with this upregulation process may worsen liver ***1A1 reduces ER stress,oxidative stress,and lipid metabolism disorder,thereby mitigating hepatocyte apoptosis and necroptosis.

关键词： Uridine diphosphate glucuronosyltransferase 1A1 Liver injury progression Endoplasmic reticulum stress Oxidative stress Lipid metabolism disorders

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Amplified circularly polarized luminescence of chiral metal-organic frameworks via post-synthetic installing pillars

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Chinese Chemical Letters 2024年第10期35卷 485-489页

作者： xue-zhi Wang Yi-Tong Liu Chuang-Wei Zhou Bei Wang Dong Luo Mo Xie Meng-Ying Sun Yong-Liang Huang jie Luo Yan Wu Shuixing Zhang Xiao-Ping Zhou Dan Li Department of Radiology The First Affiliated HospitalJinan UniversityGuangzhou 510632China College of Chemistry and Materials Science and Guangdong Provincial Key Laboratory of Functional Supramolecular Coordination Materials and ApplicationsJinanUniversityGuangzhou510632China Department of Medicinal Chemistry Shantou University Medical CollegeShantou 515041China Department of Anesthesiology The First Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 50080China

Post-synthetic installation strategy is an effective approach to improve the functions of metal-organic frameworks(MOFs).Herein,a pair of chiral MOFs is successfully constructed through solvothermal subcomponent self-assembly and exhibit circularly polarized luminescence(CPL).These MOFs contain coordinatively unsaturated Zn sites and channels,which allow the installation of pyridyl-terminated pillars into the original *** a post-synthetic installation process reinforces the MOFs'rigidity and increases the photoluminescence quantum yields(PLQYs).Furthermore,the luminescence dissymmetry factors(glum)of these post-modified MOFs are amplified after installing the *** work provides an appealing strategy for boosting the CPL performance of chiral MOFs.

关键词： Chiral metal-organic frameworks Circularlypolarized luminescence Post-synthetic installation Pyridyl-terminated pillars Chirality transfer

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中华民族现代文明的深刻内涵、鲜明特征与价值意蕴

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新疆师范大学学报（哲学社会科学版） 2024年第6期45卷 24-34,F0002页

作者：田芝健王雪苏州大学马克思主义学院教育部人文社科重点研究基地苏州大学中国特色城镇化研究中心江苏省习近平新时代中国特色社会主义思想研究中心(苏州大学基地) 江苏苏州215006

中华民族现代文明是中华优秀传统文化根脉和马克思主义魂脉有机结合、融会贯通的结果,以人类文明有益成果为外部借鉴,以中国式现代化为实践基础,是中国共产党领导中国人民创造的社会主义现代文明。这一文明新形态体现了中国共产党基于... 详细信息

中华民族现代文明是中华优秀传统文化根脉和马克思主义魂脉有机结合、融会贯通的结果,以人类文明有益成果为外部借鉴,以中国式现代化为实践基础,是中国共产党领导中国人民创造的社会主义现代文明。这一文明新形态体现了中国共产党基于“五位一体”总体布局实践的整体文明观,在实践中表现为不断增进物质富足与精神富有、全体人民共同富裕与人的全面发展、社会全面进步与生态持续优化、国内和睦与世界和平、古今传承与未来拓展的有机统一;其鲜明特征体现了民族性和世界性的交融、时代性和发展性的互动、主体性和包容性的统一。建设中华民族现代文明对于强化中华民族历史自觉与历史主动精神、推动中国式现代化实践创新、创造人类文明新形态、构建人类命运共同体具有重要价值意蕴。

关键词：中华民族现代文明人类文明新形态人类命运共同体

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Overlooked uneven progress across sustainable development goals at the global scale: Challenges and opportunities

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The Innovation 2024年第2期5卷 42-50页

作者： Yali Liu Jianqing Du Yanfen Wang Xiaoyong Cui Jichang Dong Pan Gu Yanbin Hao Kai xue Hongbo Duan Anquan Xia Yi Hu zhi Dong Bingfang Wu Jüurgen P.Kropp Bojie Fu School of Grassland Science Beijing Forestry UniversityBeijing 100083China Beijing Yanshan Earth Critical Zone National Research Station University of Chinese Academy of SciencesBeijing 101408China College of Resources and Environment University of Chinese Academy of SciencesBeijing 100049China State Key Laboratory of Tibetan Plateau Earth System Environment and ResourcesChinese Academy of SciencesBeijing 100101China College of Life Sciences University of Chinese Academy of SciencesBeijing 100049China School of Economics and Management University of Chinese Academy of SciencesBeijing 100190China School of Humanities University of Chinese Academy of SciencesBeijing 100049China Key Laboratory of Adaptation and Evolution of Plateau Biota Northwest Institute of Plateau BiologyChinese Academy of SciencesXining 810001China School of Innovation and Entrepreneurship University of Chinese Academy of SciencesBeijing 100190China State Key Laboratory of Remote Sensing Science Aerospace Information Research InstituteChinese Academy of SciencesBeijing 100101China Potsdam Institute for Climate Impact Research 14412 PotsdamGermany Institute for Environmental Science and Geography University of Potsdam14412 PotsdamGermany State Key Laboratory of Urban and Regional Ecology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China

Differences in progress across sustainable development goals(SDGs)are widespread globally;meanwhile,the rising call for prioritizing specific SDGs may exacerbate such ***,how these progress differences would influence global sustainable development has been long ***,we present the first quantitative assessment of SDGs’progress differences globally by adopting the SDGs progress evenness *** results highlight that the uneven progress across SDGs has been a hindrance to sustainable development because(1)it is strongly associated with many public health risks(e.g.,air pollution),social inequalities(e.g.,gender inequality,modern slavery,wealth gap),and a reduction in life expectancy;(2.it is also associated with deforestation and habitat loss in terrestrial and marine ecosystems,increasing the challenges related to biodiversity conservation;(3)most countries with low average SDGs performance show lower progress evenness,which further hinders their fulfillment of SDGs;and(4)many countries with high average SDGs performance also showcase stagnation or even retrogression in progress evenness,which is partly ascribed to the antagonism between climate actions and other *** findings highlight that while setting SDGs priorities may be more realistic under the constraints of multiple global stressors,caution must be exercised to avoid new problems from intensifying uneven progress across ***,our study reveals that the urgent needs regarding SDGs of different regions seem complementary,emphasizing that regional collaborations(e.g.,demand-oriented carbon trading between SDGs poorly performed and well-performed countries)may promote sustainable development achievements at the global scale.

关键词： globally priori inequality

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中小学教材质量评价标准构建的三重逻辑

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教学与管理 2024年第25期 60-65页

作者：田雪刘学智东北师范大学教育学部长春130024

构建新时代中小学教材质量评价标准是顺应国际课程教材改革之势,提升我国中小学教材质量,建立健全中小学教材质量保障体系的必然选择。遵循新时代中小学教材质量评价标准构建的理论逻辑,在厘清其内涵要义与建设向度的基础上,将马克思主... 详细信息

构建新时代中小学教材质量评价标准是顺应国际课程教材改革之势,提升我国中小学教材质量,建立健全中小学教材质量保障体系的必然选择。遵循新时代中小学教材质量评价标准构建的理论逻辑,在厘清其内涵要义与建设向度的基础上,将马克思主义理论及其中国化的重大理论成果创造性地转化为中小学教材质量评价标准构建的目标愿景与方法路径。结合全球化、信息化的时代背景以及党和国家人才培养目标对新时代中小学教材质量提出的新要求,在全面考量教材目标、内容、教学及文本四大要素的基础上,提出了新时代中小学教材质量评价标准构建的实践逻辑。

关键词：教材质量评价评价标准中小学教材

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Long-and short-term outcomes for resectable gallbladder carcinoma patients treated with curative-intent laparoscopic versus open resection:a multicenter propensity score-matched comparative study

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Hepatobiliary Surgery and Nutrition 2024年第5期13卷 788-800,I0002页

作者： zhi-Peng Liu Xing-Xing Su Long-Fei Chen xue-Lei Li Yi-Shi Yang zhi-Long You Xiao-Lin Zhao Fan Huang Chao Yu Zhao-Ping Wu Wei Chen Jin-xue Zhou Wei Guo Da-Long Yin Ping Yue Rui Ding Yi Zhu Wei Chen Yan Jiang Jie Bai Jing-Jing Wang Yan-Qi Zhang Dong Zhang Hai-Su Dai Wan Yee Lau zhi-Yu Chen The Biliary Surgery Branch of Elite Group of Chinese Digestive Surgery(EGCDS) Department of Hepatobiliary Surgery Southwest HospitalThird Military Medical University(Army Medical University)ChongqingChina Hepato-pancreato-biliary Center Tsinghua Changgung HospitalTsinghua UniversityBeijingChina Department of General Surgery Third Affiliated Hospital of Zunyi Medical UniversityZunyiChina Department of General Surgery First Affiliated Hospital of Anhui Medical UniversityHefeiChina Department of Hepatobiliary Surgery Affiliated Hospital of Guizhou Medical UniversityGuiyangChina Department of Hepatopancreatobiliary Surgery Jiujiang First People’s HospitalJiujiangChina Department of Hepatopancreatobiliary Surgery First Affiliated Hospital of Sun Yat-sen UniversityGuangzhouChina Department of Hepatopancreatobiliary Surgery Henan Provincial Tumor HospitalZhengzhouChina Department of General Surgery Capital Medical University Affiliated Beijing Friendship HospitalBeijingChina Department of Hepatobiliary Surgery First Affiliated Hospital of USTCHefeiChina Department of General Surgery Lanzhou University First Affiliated HospitalLanzhouChina Department of Hepatopancreatobiliary Surgery First Affiliated Hospital of Air Force Medical UniversityXi’anChina Department of Hepatopancreatobiliary Surgery The Second Affiliated Hospital Zhejiang University School of MedicineHangzhouChina Department of Health Statistics College of Military Preventive MedicineThird Military Medical University(Army Medical University)ChongqingChina Department of Hepatobiliary Surgery First Affiliated Hospital of Xi’an Jiaotong UniversityXi’anChina Faculty of Medicine the Chinese University of Hong KongHong KongChina 不详

Background:Gallbladder cancer(GBC)was once considered a contraindication for laparoscopic surgery,but it is becoming more common to use laparoscopic surgery for GBC *** aim of this study was to analyze the long-and short-term outcomes of patients with more advanced T-staged GBC treated with curative intent as defined by the National Comprehensive Cancer Network(NCCN)after laparoscopic resection(LR)versus open resection(OR).Methods:A multicenter database was used to select consecutive GBC patients treated with curative-intent resection as defined by the NCCN between 2.16 and *** patients were divided into the LR group and the OR *** score matching(PSM)was used to eliminate selection *** endpoints were overall survival(OS),progression-free survival(PFS),and short-term *** factors that were independently associated with OS and PFS were ***:Of 62. GBC patients treated with curative-intent resection,after PSM,51 patients were in the LR group and 153 patients were in the OR *** LR group had more patients who were suitable to receive adjuvant chemotherapy(AC),a longer operation time,more harvested lymph nodes,and a lower overall morbidity *** rates of OS and PFS were not significantly different between the two *** was independently associated with better OS and ***:The overall morbidity of GBC patients after LR was lower,but the long-term outcomes between LR and OR were not significantly *** GBC patients treated with LR were more likely to receive AC,and the use of AC after curative-intent resection of GBC helped achieve better long-term survival outcomes.

关键词： Gallbladder cancer(GBC) laparoscopic resection(LR) morbidity survival adjuvant chemotherapy(AC)

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