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Blow-up *** Finiteness for an Evolution p-Laplace System with Nonlinear Boundary Conditions

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Communications in Mathematical Research 2009年第4期25卷 309-317页

作者： WU xue-song gao WEN-JIE School of Mathematics Jilin University Changchun 130012

In this paper, the authors consider the positive solutions of the system of the evolution p-Laplacian equationswith nonlinear boundary conditionsand the initial data （u0, v0）, where Ω is a bounded domain in Rn with smooth boundary δΩ, p 〉 2, h（·,·） and s（·,· ） are positive C1 functions, nondecreasing in each variable. The authors find conditions on the functions f, g, h, s that prove the global existence or finite time blow-up of positive solutions for every （u0, v0）.

关键词： nonlinear boundary value problem evolution p-Laplace system blowup

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Screening of hepatocyte proteins binding to F protein of hepatitis C virus by yeast two-hybrid system

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World Journal of Gastroenterology 2005年第36期11卷 5659-5665页

作者： Yan-Ping Huang Jun Cheng Shu-Lin Zhang Lin Wang Jiang Guo Yan Liu Yuan Yang Li-Ying Zhang Gui-Qin Bai xue-song gao Dong ji Shu-Mei Lin Qing Shao The First Hospital of Xi'an Jiaotong University Xi'an 710004 Shaanxi Province China Institute of Infectious Diseases Ditan Hospital Anwai Street Beijing 100011 China

AIM： To investigate the biological function of F protein by yeast two-hybrid system. METHODS： We constructed F protein bait plasmid by cloning the gene of F protein into pGBKT7, then recombinant plasmid DNA was transformed into yeast AH109 （a type）. The transformed yeast AH109 was mated with yeast Y187 （α type） containing liver cDNA library plasmid in 2×YPDA medium. Diploid yeast was plated on synthetic dropout nutrient medium （SD/-Trp-Leu-HisAde） containing X-α-gal for selection and screening. After extracting and sequencing plasmids from positive （blue） colonies, we underwent sequence analysis by bioinformatics. RESULTS： Thirty-six colonies were selected and sequenced. Among them, 11 colonies were zymogen granule protein, 5 colonies were zinc finger protein, 4 colonies were zinc-α-2-glycoprotein, 1 colony was sialyltransferase, 1 colony was complement control protein factor I, 1 colony was vitronectin, and 2 colonies were new genes with unknown function. CONCLUSION： The yeast two-hybrid system is an effective method for identifying hepatocyte proteins interacting with F protein of hepatitis C virus. F protein may bind to different proteins. 2005 The WJG Press and Elsevier Inc. All rights reserved

关键词： Hepatitis C virus F protein Yeast two-hybridsystem

Screening of genes of proteins interacting with p7 protein of hepatitis C virus from human liver cDNA library by yeast two-hybrid system

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World Journal of Gastroenterology 2005年第30期11卷 4709-4714页

作者： Yan-Ping Huang Shu-Lin Zhang Jun Cheng Lin Wang Jiang Guo Yan Liu Yuan Yang Li-Ying Zhang Gui-Qin Bai xue song gao Dong Ji Shu-Mei Lin Yan-Wei Zhong Qing Shao The First Hospital of Xi'an Jiaotong University Xi'an 710061 Shaanxi Province China Institute of Infectious Diseases Ditan Hospital Anwai Street Beijing 100011 China

AIM： To investigate the biological function of p7 protein and to look for proteins interacting with p7 protein in hepatocytes. METHODS： We constructed p7 protein bait plasmid by cloning the gene of p7 protein into pGBKTT, then transformed it into yeast AH109 （a type）. The transformed yeast was mated with yeast Y187 （α type） containing liver cDNA library plasmid, pACT2 in 2×YPDA medium. Diploid yeast was plated on synthetic dropout nutrient medium （SD/- Trp-Leu-His-Ade） containing x-α-gal for selection and screening. After extracting and sequencing of plasmids from blue colonies, we performed sequence analysis by bioinformatics. RESULTS： Fifty colonies were selected and sequenced. Among them, one colony was Homo sapiens signal sequence receptor, seven colonies were Homo sapiens H19, seven colonies were immunoglobulin superfamily containing leucine-rich repeat, three colonies were spermatid peri-nuclear RNA binding proteins, two colonies were membrane-spanning 4-domains, 24 colonies were cancer-associated antigens, four colonies were nudeoporin 214 ku and two colonies were CLL-associated antigens. CONCLUSION： The successful cloning of gene of protein interacting with p7 protein paves a way for the study of the physiological function of p7 protein and its assodated protein.

关键词： Hepatitis C virus p7 protein Interacting proteins Yeast two-hybrid system

Chronic Liver Failure after Treatment with Infliximab for Ankylosing Spondylitis in a Patient with Hepatitis B

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国际感染病学（电子版） 2013年第2期2卷 84-87页

作者： Yun-ru Li Feng-xin Chen xue-fei Duan xue-song gao Xiao-ling Fan Beijing Ditan Hospital China Capital Medical University

A 50-year-old man with ankylosing spondylitis was treated successfully with infliximab,who was also a HBV carrier for about twenty-five *** injection with infliximab for four times,he developed jaundice and HBV DNA was detectable in *** aminotransferase and total bilirubin levels were higher than *** he was hospitalized and treated with entacavir and Chinese herb *** his liver damage aggravated and was diagnosed as acute on chronic liver ***,liver transplantation was carried out and he was cured successfully.

关键词： Acute on chronic liver failure Hepatitis B Ankylosing spondylitis

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Observation of acoustic hybrid topological phases induced by the p-d orbital interactions

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 132-139页

作者： Xiao Xiang Feng gao Yu-Gui Peng Peng Wu Zong-Lin Li xue-Feng Zhu School of Physics and Innovation Institute Huazhong University of Science and Technology

In spinless systems,growing attention has recently been attracted to synthetic gauge fields,which redefine the fundamental crystal symmetries by utilizing the projective algebraic ***,synthetic gauge fields have been commonly investigated in single orbital systems,and explorations on hybrid orbitals remain elusive in ***,we report the experimental observation of hybrid topological phases induced by hybrid synthetic gauge flux,which is formed by the interaction between p and d orbitals embedded in acoustic *** breaking the translation symmetries of Lxand/or Ly,we unambiguously demonstrate the first-order M?bius edge states and higher-order corner *** work establishes a platform for seeking exotic topological phases induced by hybrid-orbitals interactions and initializing the framework of hybrid-orbitalsrelated topological *** applications can be anticipated in scenarios such as high-quality sensing and robust wave trapping due to the stepwise energy distribution of the hybrid topological phase.

关键词： topological insulator synthetic gauge field projective symmetry corner states

Revolutionizing breast cancer detection:Advances in fluorescent probe technology

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Nano Research 2025年第1期18卷 653-674页

作者： Qian gao Lin Tang Jun Zhan Yiyuan xue Feng Luo State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases West China Hospital of StomatologySichuan UniversityChengdu 610041China Emergency Obstetrics and Gynecology West China Second University HospitalSichuan UniversityChengdu 610041China Department of Obstetrics and Gynecology West China Second University HospitalSichuan UniversityChengdu 610041China Department of Prosthodontics West China School of StomatologySichuan UniversityChengdu 610041China

With the increasing incidence of breast cancer globally,there is an urgent demand for enhanced diagnostic and therapeutic *** comprehensive review explores advancements in fluorescent probe technology for breast cancer imaging and early *** probes offer unparalleled sensitivity and specificity in detecting cancer biomarkers,enabling early diagnosis and delineation of tumor margins during *** categorize these probes into molecular,nano,ratiometric,the second near-infrared window(NIR-II),and multifunctional varieties,each with unique capabilities for targeting specific cancer *** review highlights recent innovations in probe design,emphasizing their applications in pathogenesis studies,drug development,precision medicine,and fluorescence-guided *** their promising clinical potential,challenges such as safety,biomarker targeting accuracy,system compatibility,and clinical translation *** these hurdles is crucial for the integration of fluorescent probes into standard cancer care,aiming to improve treatment outcomes and patient quality of life.

关键词： breast cancer fluorescent probes imaging early diagnosis biomarker

Real-world evidence on the efficacy and safety of vonoprazanamoxicillin dual therapy for Helicobacter pylori treatment in elderly patients

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World Journal of Gastroenterology 2025年第1期31卷 68-78页

作者： Wen gao Jing-Wen Li Hui Ye xue-Zhi Zhang Jian-Xiang Liu Hong Cheng Department of Gastroenterology Peking University First HospitalBeijing 100034China School of Medicine Tsinghua MedicineTsinghua UniversityBeijing 100034China Department of Traditional Chinese Medicine and Integrative Medicine Peking University First HospitalBeijing 100034China

BACKGROUND A dual therapy regimen containing amoxicillin is a common treatment option for the eradication of Helicobacter pylori(***).While substantial research supports the efficacy and safety of vonoprazan and amoxicillin(VA)dual therapy in the general population,there is still a lack of studies specifically focusing on its safety in elderly *** To evaluate efficacy and safety of VA dual therapy as first-line or rescue treatment for *** in elderly *** As a real-world retrospective study,data were collected from elderly patients aged 60 years and above who accepted VA dual therapy(vonoprazan 20 mg twice daily+amoxicillin 1000 mg thrice daily for 14 days)for *** eradication in the Department of Gastroenterology at Peking University First Hospital between June 2020 and January *** status was evaluated by^(13)C-urease breath test 6 weeks after *** adverse events(AEs)during treatment were *** In total,401 cases were ***-one cases were excluded due to loss to follow-up,lack of re-examination,or unwillingness to take *** total of 380 included cases comprised 250 who received VA dual therapy as first-line treatment and 130 who received VA dual therapy as rescue *** was successfully eradicated in 239 cases(95.6%)in the first-line treatment group and 116 cases(89.2%)in the rescue treatment *** overall incidence of AEs was 9.5%for both ***,9.2%of patients experienced an AE in the first-line treatment group and 10.0%in the rescue treatment *** patients discontinued treatment due to AE,with a discontinuation rate of 1.3%.No serious AE *** The VA dual therapy regimen as a first-line treatment and a rescue therapy was effective and safe for elderly patients aged 60 and older.

关键词： Helicobacter pylori Vonoprazan Amoxicillin Dual therapy Elderly

非肝硬化期慢性病毒性肝炎合并骨质疏松症的研究进展

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世界华人消化杂志 2022年第11期30卷 491-497页

作者：王平高学松张耀南段雪飞首都医科大学附属北京地坛医院综合科北京市100015 北京医院骨科国家老年医学研究中心中国医学科学院老年医学研究院北京市100730

骨质疏松症是病毒性肝炎肝硬化的并发症之一,有大量研究阐述了肝硬化患者中骨质疏松症的发病机制及治疗方法,而未进展至肝硬化阶段的慢性病毒性肝炎是否同样存在并发骨质疏松症的风险则尚无定论,多数研究就两者的关系给出了肯定的答复,... 详细信息

骨质疏松症是病毒性肝炎肝硬化的并发症之一,有大量研究阐述了肝硬化患者中骨质疏松症的发病机制及治疗方法,而未进展至肝硬化阶段的慢性病毒性肝炎是否同样存在并发骨质疏松症的风险则尚无定论,多数研究就两者的关系给出了肯定的答复,但其发病机制和治疗等仍无系统的论断.本文回顾了近年来有关慢性病毒性肝炎及骨质疏松症的相关文献,就非肝硬化期慢性病毒性肝炎继发骨质疏松症的发生风险、可能的致病机制及治疗方案进行了系统的综述,以期明确两者的关系,提高临床医生关于本病的认识,并为临床诊治提供参考.

关键词：慢性病毒性肝炎骨质疏松症发病机制治疗

An efficient quantum proactive incremental learning algorithm

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 49-57页

作者： Lingxiao Li Jing Li Yanqi song Sujuan Qin Qiaoyan Wen Fei gao State Key Laboratory of Networking and Switching Technology Beijing University of Posts and Telecommunications School of Cyberspace Security Beijing University of Posts and Telecommunications

In scenarios where a large amount of data needs to be learned, incremental learning can make full use of old knowledge, significantly reduce the computational cost of the overall learning process, and maintain high performance. In this paper, taking the MaxCut problem as our example, we introduce the idea of incremental learning into quantum computing, and propose a Quantum Proactive Incremental Learning algorithm(QPIL). Instead of a one-off training of quantum circuit, QPIL contains a multi-phase training on gradually-increased subgraphs of all vertices, proactively reducing large-scale problems to smaller ones to solve in steps, providing an efficient solution for MaxCut. Specifically, some vertices and corresponding edges are randomly selected for training to obtain optimized parameters of the quantum circuit at first. Then, in each incremental phase, the remaining vertices and corresponding edges are gradually added and the parameters obtained from the previous phase are reused in the parameter initialization of the current phase. We perform experiments on 120 different small-scale graphs, and it shows that QPIL performs superior to prevalent quantum and classical baselines in terms of approximation ratio(AR), time cost, anti-forgetting, and solving stability. In particular, QPIL's AR surpasses 20% of mainstream quantum baselines, and the time cost is less than 1/5 of them. The idea of QPIL is expected to inspire efficient and high-quality solutions in large-scale Max Cut and other combinatorial optimization problems.

关键词： variational quantum algorithm incremental learning multi-phase training MaxCut quantum computing