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Acta Mathematicae Applicatae Sinica 2021年第1期37卷 148-154页

作者： Xiao-ming PENG Ya-dong SHANG xue-qin wang School of Statistics and Mathematics Guangdong University of Finance and EconomicsGuangzhou 510320China School of Mathematics and Information Science Guangzhou UniversityGuangzhou 510006China College of Mathematics and Informatics South China Agricultural UniversityGuangzhou 510642China

This paper deals with an initial boundary value problem for a class of nonlinear wave equation with nonlinear damping and source terms whose solution may blow up in finite *** explicit lower bound for blow up time is ... 详细信息

关键词： lower bound blow up nonlinear wave equation nonlinear damping nonlinear source

Correlations of Active Galactic Nuclei with Microquasars

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Communications in Theoretical Physics 2006年第1X期46卷 187-192页

作者： YE Yong-Chun ZUO xue-qin wang Ding-Xiong Department of Physics Huazhong University of Science and Technology Wuhan 430074 China

Correlations of active galactic nuclei （AGNs） with microquasars are discussed based on the coexistence of the Blandford-Znajek （BZ） and magnetic coupling （MC） processes （CEBZMC） in black hole （BH） accretion disk. The proportions of several quantities of BH systems for both AGNs and microquasars are derived by combining the observational data with CEBZMC. It is shown that the square of the magnetic field at the BH horizon is inversely proportional to the BH mass, while the accretion rate of the disk is proportional to the BH mass. In addition, the very steep emissivity indexes from the recent XMM-Newton observations of the nearby bright Seyfert 1 galaxy MCG-6-30-15 and the microquasars XTE J1650-500 are well fitted by considering the MC effects on the disk radiation. These results suggest strongly the correlations of A GNs with microquasars.

关键词： accretion accretion disks MCG-6-30-15 4C+11.50 3C345 3C273 XTE J1650-500 GRO J1655-40 XTE J1550-564 GRS 1915+105

Possible Role of Mast Cells and Neuropeptides in the Recovery Process of Dextran Sulfate Sodium-induced Colitis in Rats

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Chinese Medical Sciences Journal 2013年第1期28卷 28-33页

作者： Ping Zhao Lei Dong Jin-yan Luo Hai-tao Guan Hui Ma xue-qin wang Department of Gastroenterology The Second Affiliated Hospital of Xi'an Jiaotong University Medical College

Objective To clarify the role of mast cells and neuropeptides substance P （SP）, somatostatin （SS）, and vasoactive intestinal peptide （VIP） in dextran sulfate sodium （DSS）-induced colitis in rats. Methods Experimental colitis was induced in Sprague-Dawley rats （180-200 g, n=20） by oral in- gestion of 4% （w/v） DSS in drinking water for 7 days. Control rats （n=5） drank water and were sacrificed on day 0. Mast cell number, histamine levels in whole blood and tissue, tissue levels of SP, SS and, VIP in the dis- tal colon of the rats were measured on day 8, day 13, and day 18 of experimentation. Results Oral administration of 4% DSS solution for 7 days resulted in surface epithelial loss and crypt loss in the distal colon. Mast cell count increased on day 8 （1.75±1.09/mm vs. 0.38±0.24/mm, P〈0.05） and day 13 （1.55±1.01/mm vs. 0.38±0.24/mm, P〈0.05） after DSS treatment. Whole blood his- tamine levels were increased on day 8 （266.93±35.62 ng/mL vs. 76.87±32.28 ng/mL, P〈0.01） and gradu- ally decreased by clay 13 and day 18 after DSS treatment. Histamine levels in the distal colon were decreased on day 8 （1.77±0.65 ng/mg vs. 3.06±0.87 ng/mg, P〈0.05） and recovered to control levels by day 13 after DSS treatment. SP level in the distal colon gradually increased and were raised significantly by day 13 （8777.14±3056.14 pg/mL vs. 4739.66±3299.81 pg/mL, P〈0.05） after DSS treatment. SS and VIP levels in the distal colon were not changed. Conclusions Mast cell degranulation followed by histamine release may play an important role in the pathogenesis of colitis induced by DSS. SP may be a significant substance in the progression of inflamma- tion and the recovery process of DSS-induced colitis.

关键词： dextran sulfate sodium colitis mast cell substance P

Microfluidics-based assay on the effects of microenvironmental geometry and aqueous flow on bacterial adhesion behaviors

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Journal of Pharmaceutical Analysis 2011年第3期1卷 175-183页

作者： Yang Liu Jian-Chun wang Li Ren qin Tu Wen-Ming Liu xue-qin wang Rui Liu Yan-Rong Zhang Jin-Yi wang College of Science Northwest A&F University Yangling Shaanxi 712100 China College of Veterinary Medicine Northwest A&F University Yangling Shaanxi 712100 China Shaanxi Key Laboratory of Molecular Biology .for Agriculture Northwest A&F University Yangling

Abstract A new microfluidic system with four different microchambers （a circle and three equilateral concave polygons） was designed and fabricated using poly（dimethylsiloxane）（PDMS） and the soft lithography method. Using this microfluidic device at six flow rates （5, 10, 20, 30, 40, and 50 μL/h）, the effects of microenvironmental geometry and aqueous flow on bacterial adhesion behaviors were investigated. Escherichia coli HB101 pGLO, which could produce a green fluorescent protein induced by L-arabinose, was utilized as the model bacteria. The results demonstrated that bacterial adhesion was significantly related to culture time, microenvironment geometry, and aqueous flow rates. Adhered bacterial density increased with the culture time. Initially, the adhesion occurred at the microchamber sides, and then the entire chamber was gradually covered with increased culture time. Adhesion densities in the side zones were larger than those in the center zones because of the lower shearing force in the side zone. Also, the adhesion densities in the complex chambers were larger than those in the simple chambers. At low flow rates, the orientation of adhered bacteria was random and disorderly. At high flow rates, bacterial orientation became close to the streamline and oriented toward the flow direction; All these results implied that bacterial adhesion tended to occur in complicated aqueous flow *** present study provided an on-chip flow system for physiological behavior of biological cells, as well as provided a strategic cue for the prevention of bacterial infection and biofilm formation.

关键词： Microfluidic device Escherichia coli Adhesion behaviors Geometry Aqueous flow

Challenges and Suggestions of Ethical Review on Clinical Research Involving Brain-Computer Interfaces

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Chinese Medical Sciences Journal 2024年第2期39卷 131-139页

作者： xue-qin wang Hong-Qiang Sun Jia-Yue Si Zi-Yan Lin Xiao-Mei Zhai Lin Lu Peking University Sixth Hospital Peking University Institute of Mental HealthNHC Key Laboratory of Mental Health(Peking University)National Clinical Research Center for Mental Disorders(Peking University Sixth Hospital)Chinese Academy of Medical Sciences Research Unit(No.2018RU006)Beijing 100191China Department of Psychology University of CaliforniaDavis 95616USA Department of Psychology University of TorontoToronto M5S 1A1Canada School of Population Medicine and Public Health Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China Academy for Advanced Interdisciplinary Studies Peking-Tsinghua Centre for Life Sciences and Peking University-International Development Group/McGovern Institute for Brain ResearchPeking UniversityBeijing 100871China

Brain-computer interface(BCI)technology is rapidly advancing in medical research and *** an emerging biomedical engineering technology,it has garnered significant attention in the clinical research of brain disease diagnosis and treatment,neurological rehabilitation,and mental ***,BCI also raises several challenges and ethical concerns in clinical *** this article,the authors investigate and discuss three aspects of BCI in medicine and healthcare:the state of international ethical governance,multidimensional ethical challenges pertaining to BCI in clinical research,and suggestive concerns for ethical *** the great potential of frontier BCI research and development in the field of medical care,the ethical challenges induced by itself and the complexities of clinical research and brain function have put forward new special fields for ethics in *** ensure"responsible innovation"in BCI research in healthcare and medicine,the creation of an ethical global governance framework and system,along with special guidelines for cutting-edge BCI research in medicine,is suggested.

关键词： brain-computer interface clinical research bioethics ethical governance ethical review

Reflux characteristics of 113 GERD patients with abnormal 24-h multichannel intraluminal impedance-pH tests

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2015年第9期16卷 805-810页

作者： Yuan-yuan NIAN Cheng FENG Fu-chun JING xue-qin wang Jun ZHANG Division of Gastroenterology the Second Affiliated Hospital of Xi'an Jiaotong University

Objective： To analyze reflux parameters by means of combined multichannel intraluminal impedance and pH （MII-pH） monitoring in patients with gastroesophageal reflux disease （GERD） symptoms off medication, and to find the reflux characteristics of Chinese GERD patients and the influences of gender, age, body posture, and body mass index （BMI） on gastroesophageal reflux （GER）. Methods： Between Dec. 2008 and May 2014, 125 patients with typical GERD symptoms were subjected to 24-h MII-pH monitoring. Twelve patients with normal MII-pH profiles were not considered for analysis. The reflux parameters of 113 GERD patients with abnormal Mll-pH results were analyzed. Results：（1） DeMeester scores were above the normal range in 46.90% （53/113） of GERD patients. Weakly acidic refluxes were prevalent in GERD patients, and the frequency of abnormal weakly acidic reflux was 75.22% （85/113）. The frequencies of abnormal symptom index （SI） and symptom association probability （SAP） were 19.47% （22/113） and 14.16% （16/113）, respectively. （2） The frequencies of DeMeester scores, the %time at pH〈4, and the numbers of reflux episodes and of long reflux episodes 〉5 min were significantly higher in male patients than in female patients. （3） The %time at pH〈4 was much higher during upright periods than during supine periods. During supine periods, 31.86% （36/113） of GERD patients had delayed bolus clearance time, compared with 19.47% （22/113） during upright periods. （4） The number of abnormal DeMeester scores, %time at pH〈4, and the number of acid refluxes during upright periods were significantly higher in obese GERD patients than in GERD patients with a normal BMI. Over- weight GERD patients also had many more acid refluxes during upright periods than GERD patients with a normal BMI Conclusions： Weakly acidic refluxes were prevalent in Chinese GERD patients. The factors male, gender, upright position, obesity （BMI〉25）, but not age, may increase the frequency and severity of GER.

关键词： Gastroesophageal reflux disease (GERD) Multichannel intraluminal impedance.pH (MII-pH) Reflux characteristics Off medication

Postprandial proximal gastric acid pocket and its association with gastroesophageal acid reflux in patients with short-segment Barrett’s esophagus

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2020年第7期21卷 581-589页

作者： Yuan-yuan NIAN Xian-mei MENG Jing WU Fu-chu JING xue-qin wang Tong DANG Jun ZHANG Department of Gastroenterology the Second Affiliated Hospital of Baotou Medical CollegeBaotou 014040China Department of Gastroenterology the Second Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710049China

Objective:To determine the characteristics of postprandial proximal gastric acid pockets(PPGAPs)and their association with gastroesophageal acid reflux in patients with Barrett’s esophagus(BE).Methods:Fifteen patients with BE(defined by columnar lined esophagus of≥1 cm)and 15 healthy individuals that were matched for age,gender,and body mass index,were *** fasting intragastric p H and the appearance time,length,lowest p H,and mean p H of the PPGAP were determined using a single p H electrode pull-through *** BE patients,a gastroesophageal reflux disease questionnaire(Gerd Q)was completed and esophageal 24-h p H monitoring was carried ***:The PPGAP was significantly longer(5(3,5)cm vs.2(1,2)cm)and the lowest p H(1.1(0.8,1.5)vs.1.6(1.4,1.9))was significantly lower in patients with short-segment BE than in healthy *** PPGAP started to appear proximally from the gastroesophageal p H step-up point to the esophageal *** acidity of the PPGAP was higher in the distal segment than in the proximal *** short-segment BE patients,there were significant correlations between the acidity and the appearance time and length of the *** length and acidity of the PPGAP were positively associated with gastroesophageal acid reflux *** acidity of the PPGAP was associated with the De Meester scores,the Gerd Q scores,and the fasting intragastric p ***:In patients with short-segment BE,a PPGAP is commonly *** length and acidity of PPGAP are associated with gastroesophageal acid reflux,the De Meester score,and the Gerd Q score in patients with short-segment BE.

关键词： Short-segment Barrett’s esophagus Postprandial proximal gastric acid pocket(PPGAP) Gastroesophageal acid reflux

Cross-sectional survey following a longitudinal study on mental health and insomnia of people with sporadic COVID-19

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World Journal of Psychiatry 2022年第8期12卷 1076-1087页

作者： Xiao-Jun Li Tian-Ze Guo Yan Xie Yan-Ping Bao Jia-Yue Si Zhe Li Yi-Ting Xiong Hui Li Su-Xia Li Lin Lu xue-qin wang Department of Psychiatry Peking University International HospitalBeijing 102206China Department of Bioengineering University of California San DiegoSan DiegoCA 92093United States Department of Psychology Peking University International HospitalBeijing 102206China Department of Epidemiology National Institute on Drug Dependence and Beijing Key laboratory of Drug DependencePeking UniversityBeijing 100191China University of California Davis DavisCA 95616United States Department of History University College LondonLondon WC1E 6BTUnited Kingdom Department of Psychiatry Peking University Sixth HospitalPeking University Institute of Mental HealthNHC Key Laboratory of Mental Health(Peking University)National Clinical Research Center for Mental Disorders(Peking University Sixth Hospital)Peking UniversityBeijing 100191China Department of Clinical Pharmacology National Institute on Drug Dependence and Beijing Key Laboratory of Drug DependencePeking UniversityBeijing 100191China Peking-Tsinghua Centre for Life Sciences and Peking University-International Development Group/McGovern Institute for Brain Research Peking UniversityBeijing 100091China

BACKGROUNDIn the post-pandemic era, the emergence of sporadic cases of coronavirus disease 2019 (COVID-19) and the scale of the pandemic are unpredictable. Therefore, the impact ofsporadic cases of COVID-19 and isolation measures on mental health and sleep in different groupsof people need to be *** clarify the severity of psychological problems and insomnia of staff and community residentsaround a hospital with sporadic cases of COVID-19, and their relationship with quarantinelocation and long-term *** cross-sectional survey was conducted on community residents and medical staff. Many of thesemedical staff had been subjected to different places of quarantine. Community residents did notexperience quarantine. Hospital anxiety and depression scale (HADS), acute stress disorder scale(ASDS) and insomnia severity index (ISI) were used to evaluate anxiety and depression, acutestress disorder symptoms, and the severity of insomnia. Additionally, we conducted a 1-yearfollow-up study on medical staff, with related scales measurement immediately after and one yearafter the 2-wk quarantine *** included 406 medical staff and 226 community residents. The total scores of ISI and subscale inHADS of community residents were significantly higher than that of medical staff. Furtheranalysis of medical staff who experienced quarantine showed that 134 were quarantined in hotels,70 in hospitals and 48 at home. Among all subjects, the proportions of HADS, ASDS and ISI scoresabove normal cutoff value were 51.94%, 19.17% and 31.11%, respectively. Multivariable logisticregression analysis found that subjects with higher total ASDS scores had a greater risk to developanxiety and depression. The total ISI score for medical staff in hotel quarantine was significantlyhigher than those in home quarantine. Total 199 doctors and nurses who completed the 1-yearfollow-up study. Compared with baseline, HADS and ASDS scores decreased significantly oneyear after the

关键词： COVID-19 Depression Anxiety Insomnia Quarantine

Efficacy of Huangma Ding or autologous platelet-rich gel for the diabetic lower extremity arterial disease patients with foot ulcers

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World Journal of Diabetes 2024年第5期15卷 923-934页

作者： xue-qin wang Dan-Lan Pu Wei-Ling Leng Xiao-Tian Lei Jiang Juan Zou La Ding Yao Jia-Zhuang Xi Li Jian Teng Miao Qi-Nan Wu Endocrinology Department The People’s Hospital of Yubei District of Chongqing CityChongqing 401120China Department of Endocrinology Chongqing Yubei District People’s HospitalChongqing 400030China Endocrinology Department The First Affiliated Hospital of the Army Medical UniversityChongqing 400038China Endocrinology and Nephrology Department Chongqing University Cancer Hospital and Chongqing Cancer Institute and Chongqing Cancer HospitalChongqing 400016China Department of Endocrinology Dazu Hospital of Chongqing Medical UniversityThe People’s Hospital of DazuChongqing 402360China

BACKGROUND Diabetes foot is one of the most serious complications of diabetes and an important cause of death and disability,traditional treatment has poor efficacy and there is an urgent need to develop a practical treatment *** To investigate whether Huangma Ding or autologous platelet-rich gel(APG)treatment would benefit diabetic lower extremity arterial disease(LEAD)patients with foot *** A total of 155 diabetic LEAD patients with foot ulcers were enrolled and divided into three groups:Group A(62 patients;basal treatment),Group B(38 patients;basal treatment and APG),and Group C(55 patients;basal treatment and Huangma Ding).All patients underwent routine follow-up visits for six *** follow-up,we calculated the changes in all variables from baseline and determined the differences between groups and the relationships between *** The infection status of the three groups before treatment was the ***(PCT)improved after APG and Huangma Ding treatment more than after traditional treatment and was significantly greater in Group C than in Group *** regression analysis revealed that PCT was positively correlated with total amputation,primary amputation,and minor amputation *** ankle-brachial pressure and the transcutaneous oxygen pressure in Groups B and C were greater than those in Group *** major amputation rate,minor amputation rate,and total amputation times in Groups B and C were lower than those in Group *** Our research indicated that diabetic foot ulcers(DFUs)lead to major amputation,minor amputation,and total amputation through local infection and poor microcirculation and *** Ding and APG were effective attreating *** clinical efficacy of Huangma Ding was better than that of autologous platelet gel,which may be related to the better control of local infection by Huangma *** finding suggested that in patients with DFUs combined with coinfection,controll

关键词： Diabetic foot ulcer Huangma Ding Autologous platelet-rich gel Ankle-brachial index Transcutaneous oxygen partial pressure

Haplotype-based association of two SNPs in miR-323b with unexplained recurrent spontaneous abortion in a Chinese Han population

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Haplotype-based association of two SNPs in miR-323b with une...