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Improving the detecting efficiency of suspected gastrointestinal tumors with dual-time-point 18F-FDG PET/CT

Nuclear Science and Techniques 2017年第10期28卷 23-30页

作者： Jian-Hua Song Jin-Hua Zhao xue-qian xie Yan Xing Xiang Chen Wen-Li Qiao Chang-Cun Liu Tai-Song Wang Department of Nuclear Medicine Shanghai General HospitalShanghai Jiao Tong University School of Medicine100 Haining Rd.Shanghai 200080China Department of Radiology Shanghai General HospitalShanghai Jiao Tong University School of Medicine100 Haining Rd.Shanghai 200080China

We conducted a retrospective analysis of 221 subjects with 256 suspected gastrointestinal lesions from2007 to 2015 to explore the detecting efficiency of dualtime-point fluorine-18 fludeoxyglucose(^(18)F-FDG) positron emission tomography/computed tomography(PET/CT)and pathology examination. The abdominal delayed PET/CT was performed within 45 min of the conventional *** change in maximum standardized uptake value(ASUV_(max)) and morphological features of the suspected lesions between the conventional and dual-time-point PET/CT were compared. The sensitivity, specificity, positive predictive value, and negative predictive value(NPV) of conventional PET/CT were 81.6%(84/103), 56.2%(86/153), 55.6%(84/151), and 81.9%(86/105), *** of dual-time-point PET/CT were 94.1%(97/103),78.4%(120/153), 74.6%(97/130), and 95.2%(120/126),respectively. There was a significant difference between the conventional and dual-time-point PET/CT(P < 0.005).The SUV_(early) and the %△SUV_(max) could not present more information in differential diagnoses, but the rate of tumors with increased SUVdelay accounted for 79.6%(82/103) and more than that of nonneoplastic lesions(15.5%, 29/187)(x^2= 115.5, P < 0.01). Therefore, the dual-time-point^(18)F-FDG PET/CT had a higher sensitivity and NPV than the conventional PET/CT to detect gastrointestinal *** constant morphology and increased SUV_(delay) help to detect the tumors and adding delayed imaging on the locality will be an effective method when we accidentally find a suspected gastrointestinal tumor on the conventional PET/CT images.

关键词：胃肠道肿瘤 CT检测检测效率 PET 肠肿瘤计算机断层扫描正电子发射断层扫描形态特征

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Combined analysis of imaging tumor capsule with imaging tumor size guides the width of resection margin for solitary hepatocellular carcinoma

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Hepatobiliary & Pancreatic Diseases International 2022年第6期21卷 551-558页

作者： Jia-Shuo Chao Qi Zhu De-Sheng Chen Gui-Ming Chen xue-qian xie Ai-Qun Liu Sen-Lin Zhao Hong-Cheng Sun Department of General Surgery Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 200080China Department of Radiology Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 200080China Department of Colorectal Surgery Fudan University Shanghai Cancer CenterShanghai 200032China

Background:The optimal width of resection margin(RM)for hepatocellular carcinoma(HCC)remains *** study aimed to investigate the value of imaging tumor capsule(ITC)and imaging tu-mor size(ITS)in guiding RM width for patients with ***:Patients who underwent hepatectomy for HCC in our center were retrospectively ***(complete/incomplete)and ITS(≤3 cm/>3 cm)were assessed by preoperative magnetic resonance imaging(MRI).Using subgroup analyses based on ITC and ITS,the impact of RM width[narrow RM(3 cm and complete ITC,the narrow RM group exhibited comparable RFS,OS,and incidence of RM recurrence with the wide RM group(P=0.606,0.916,and 0.649,respectively).However,in patients with ITS>3 cm and incomplete ITC,the wide RM group showed better RFS and OS and a lower incidence of RM recurrence compared with the narrow RM group(P=0.037,0.018,and 0.046,respectively).Conclusions:As MRI-based preoperative markers,conjoint analysis of ITC with ITS aids in determining RM width for solitary HCC *** RM is applicable in patients with ITS≤3 cm regardless of ITC status and in those with ITS>3 cm and complete *** RM is preferred in those with ITS>3 cm and incomplete ITC.

关键词： Hepatocellular carcinoma Resection Hepatectomy Magnetic resonance imaging Preoperative imaging

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涤棉府绸风格的研究

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棉纺织技术 1986年第5期 9-12页

作者：汪学骞谢维源安徽机电学院上海纺织科学研究院

本文对涤棉府绸风格进行研究,设立了涤棉府绸的综合风格计算式。利用计算式能对比各种涤棉府绸的风格,评定其风格的优劣。

关键词：贴近度涤棉府绸小子样标准差计算式正态分布 Gauss 分布仿毛织物仿真织物序列压缩弹性率

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Trends of alkaline phosphatase to prealbumin ratio in patients with hepatitis B linked to hepatocellular carcinoma development

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World Journal of Gastroenterology 2025年第2期31卷 42-51页

作者： Wen-Chong Zhen Jing Sun xue-Ting Bai qian Zhang Zi-Han Li Yi-Xin Zhang Rong-Xuan Xu Wei Wu Zhi-Han Yao Chun-Wen Pu Xiao-Feng Li School of Public Health Dalian Medical UniversityDalian 116044Liaoning ProvinceChina Graduate School Dalian Medical UniversityDalian 116044Liaoning ProvinceChina Dalian Public Health Clinical Center Dalian Municipal Research Institute for Public HealthDalian 116001Liaoning ProvinceChina Department of Epidemiology and Health Statistics Dalian Medical UniversityDalian 116044Liaoning ProvinceChina

BACKGROUND Chronic hepatitis B often progresses silently toward hepatocellular carcinoma(HCC),a leading cause of mortality *** detection of HCC is crucial,yet *** To investigate the role of dynamic changes in alkaline phosphatase to prealbumin ratio(APR)in hepatitis B progression to *** Data from 4843 patients with hepatitis B(January 2015 to January 2024)were *** incidence rates in males and females were compared using the log-rank *** were evaluated using Kaplan–Meier *** Linear Mixed-Effects Model was applied to track the fluctuation of APR levels over ***,Joint Modeling of Longitudinal and Survival data was employed to investigate the temporal relationship between APR and HCC *** The incidence of HCC was higher in *** ensure the model’s normality assumption,this study applied a logarithmic transformation to APR,yielding *** levels were higher in females(t=5.26,P<0.01).A 1-unit increase in ratio correlated with a 2.005-fold higher risk of HCC in males(95%CI:1.653-2.431)and a 2.273-fold higher risk in females(95%CI:1.620-3.190).CONCLUSION Males are more prone to HCC,while females have higher APR *** no baseline APR link,rising APR indicates a higher HCC risk.

关键词： Alkaline phosphatase to prealbumin ratio Chronic hepatitis B patients Hepatocellular carcinoma Retrospective cohort study Linear Mixed-Effect Mode Joint Modelling of Longitudinal and Survival data

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扬子板块西南缘早前寒武纪地质演化:来自撮科元古宙变沉积岩碎屑锆石U-Pb年龄、Hf-O同位素的制约

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岩石学报 2025年第1期41卷 304-320页

作者：高嘉敏谢士稳刘倩王舫陶鹏龙涛中国地质大学(北京)地球科学与资源学院北京100083 中国地质科学院地质研究所北京离子探针中心北京100037 山东省第四地质矿产勘查院潍坊261021

扬子板块的太古宙-古元古代基底出露十分有限,制约了对扬子早前寒武纪地质演化的认识。本次研究对扬子板块西南缘撮科地区的大红山群和昆阳群变沉积岩开展了碎屑锆石原位U-Pb年龄、Hf-O同位素及微量元素研究。测年结果显示,大红山群谐... 详细信息

扬子板块的太古宙-古元古代基底出露十分有限,制约了对扬子早前寒武纪地质演化的认识。本次研究对扬子板块西南缘撮科地区的大红山群和昆阳群变沉积岩开展了碎屑锆石原位U-Pb年龄、Hf-O同位素及微量元素研究。测年结果显示,大红山群谐和锆石年龄分布于3092~1786Ma之间,最年轻碎屑锆石年龄为1786Ma,限定大红山群最大沉积时代为古元古代晚期。昆阳群谐和锆石年龄分布于2874~1031Ma之间,最年轻碎屑锆石年龄为1031Ma,表明昆阳群最大沉积时代为中元古代晚期。除少量较年轻锆石(<1.75Ga)外,昆阳群和大红山群具有相似的年龄分布特征,两个主要的年龄峰为2.0~1.85Ga和2.4~2.2Ga。尽管古元古代碎屑锆石的年龄峰与撮科地区已报道的古元古代岩浆活动期次一致,但仅有少部分碎屑锆石的Hf-O同位素特征与撮科古元古代岩浆岩相似,大多数碎屑锆石Hf-O同位素组成与加拿大Rae克拉通古元古代变沉积岩中碎屑锆石相似,暗示古元古代碎屑物质可能仅少部分来自撮科地区已识别的古元古代岩浆岩,而大部分可能来自与Rae克拉通发育的古元古岩浆岩相似的源区。大红山群和昆阳群中1.9~1.03Ga的碎屑锆石可能来自扬子西南缘发育的古元古代晚期-中元古代晚期岩浆岩。结合前人的资料,我们认为我国撮科和越南北部的Phan Si Pan带经历了与加拿大Rae克拉通相似的古元古代演化过程,支持2.4~2.3Ga扬子西南缘卷入Arrowsmith造山事件,并与Rae克拉通一起参与哥伦比亚超大陆聚合过程的认识。

关键词：扬子西南缘撮科地区哥伦比亚超大陆大红山群和昆阳群碎屑锆石

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First detection and complete genome of Soybean chlorotic mottle virus naturally infecting soybean in China by deep sequencing

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Journal of Integrative Agriculture 2019年第11期18卷 2664-2667页

作者： HU qian-qian LIU xue-jian HAN xue-dong LIU Yong JIANG Jun-xi xie Yan State Key Laboratory of Rice Biology Institute of BiotechnologyZhejiang UniversityHangzhou 310058P.R.China Hunan Plant Protection Institute Changsha 410125P.R.China College of Agriculture Jiangxi Agricultural UniversityNanchang 330000P.R.China

Soybean chlorotic mottle virus(SbCMV)was first detected from soybean plants in Jiangxi Province of China by high throughput sequencing and was confirmed by *** complete nucleotide sequence of NC113 was determined to be 8210 nucleotides,and shared the highest similarity(91.7%)with sequences of SbCMV that was only reported in *** encodes nine putative open reading frames(ORFs Ia,Ib and Ⅱ-Ⅷ),and contains a large intergenic region located at nucleotide 5976-6512 between ORFs VI and *** analysis and phylogenetic tree indicated that NC113 is an isolate of SbCMV,and is more related to the soymoviruses Blueberry red ringspot virus(BRRSV),Peanut chlorotic streak virus(PCSV)and Cestrum yellow leaf curling virus(CmYLCV)than to other representative members in the Caulimoviridae *** survey of 472 legume plants from Jiangxi and Zhejiang provinces showed SbCMV was only detected from soybean in Nanchang City with a low incidence *** is the first report of Soybean chlorotic mottle virus identified in China.

关键词： Soybean chlorotic mottle virus Soymovirus genome sequence sequence analysis

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Pharmacological targeting cGAS/STING/NF-κB axis by tryptanthrin induces microglia polarization toward M2 phenotype and promotes functional recovery in a mouse model of spinal cord injury

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Neural Regeneration Research 2025年第11期20卷 3287-3301页

作者： Ziwei Fan Mengxian Jia Jian Zhou Zhoule Zhu Yumin Wu Xiaowu Lin Yiming qian Jiashu Lian Xin Hua Jianhong Dong Zheyu Fang Yuqing Liu Sibing Chen Xiumin xue Juanqing Yue Minyu Zhu Ying Wang Zhihui Huang Honglin Teng Department of Orthopedics(Spine Surgery) the First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina School of Pharmacy Hangzhou Normal UniversityHangzhouZhejiang ProvinceChina Department of Neurology The First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina Department of Pathology Affiliated Hangzhou First People’s HospitalSchool of MedicineWestlake UniversityHangzhouZhejiang ProvinceChina Department of Clinical Research Center Affiliated Hangzhou First People’s HospitalSchool of MedicineWestlake UniversityHangzhouZhejiang ProvinceChina

The M1/M2 phenotypic shift of microglia after spinal cord injury plays an important role in the regulation of neuroinflammation during the secondary injury phase of spinal cord *** of shifting microglia polarization from M1(neurotoxic and proinflammatory type)to M2(neuroprotective and anti-inflammatory type)after spinal cord injury appears to be *** possesses an anti-inflammatory biological ***,its roles and the underlying molecular mechanisms in spinal cord injury remain *** this study,we found that tryptanthrin inhibited microglia-derived inflammation by promoting polarization to the M2 phenotype in *** promoted M2 polarization through inactivating the cGAS/STING/NF-κB ***,we found that targeting the cGAS/STING/NF-κB pathway with tryptanthrin shifted microglia from the M1 to M2 phenotype after spinal cord injury,inhibited neuronal loss,and promoted tissue repair and functional recovery in a mouse model of spinal cord ***,using a conditional co-culture system,we found that microglia treated with tryptanthrin suppressed endoplasmic reticulum stress-related neuronal *** together,these results suggest that by targeting the cGAS/STING/NF-κB axis,tryptanthrin attenuates microglia-derived neuroinflammation and promotes functional recovery after spinal cord injury through shifting microglia polarization to the M2 phenotype.

关键词： cGAS/STING functional recovery microglia neuroinflammation neuroprotection nuclear factor-κB polarization spinal cord injury tryptanthrin

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Consensus Analysis of Fractional Multi-Agent Systems with Delayed Distributed PI Controller

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Journal of Systems Science & Complexity 2023年第1期36卷 205-221页

作者： xie Yingkang MA qian School of Automation Nanjing University of Science and TechnologyNanjing 210094China

The consensus problem for fractional multi-agent systems(MASs)with time delay is *** distributed fractional proportional-integral(PI)-type controller is designed so that the consensus of the proposed systems is ***,explicit condition to determine the crossing directions is *** results show that with the increase of time delay,the closed-loop system has two different dynamic characteristics:From consensus to nonconsensus and consensus ***,delay margin within which consensus of MASs will always hold is *** results should provide useful guidelines in the consensus analysis and in the analytical design of the distributed controllers.

关键词： Consensus switching crossing direction fractional multi-agent systems fractional PI controller time delay

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Climate Projections of Spatial Variations in Coastal Storm Surges Along the Gulf of Mexico and *** Coast

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Journal of Ocean University of China 2017年第1期16卷 1-7页

作者： YAO Zhigang xue Zuo HE Ruoying BAO Xianwen xie Jun GE qian Key Laboratory of Physical Oceanography Ocean University of ChinaQingdao 266100P.R.China Department of Marine Earth and Atmospheric SciencesNorth Carolina State UniversityRaleighNC 27695USA Department of Oceanography and Coastal Sciences Louisiana State UniversityBaton Rouge 70803USA Center for Computation and Technology Louisiana State UniversityBaton Rouge 70803USA Coastal Studies Institute Louisiana State UniversityBaton Rouge 70803USA College of Oceanic and Atmospheric Sciences Ocean University of ChinaQingdao 266100P.R.China Second Institute of Oceanography State Oceanic AdministrationHangzhou 310012P.R.China

Using statistically downscaled atmospheric forcing, we performed a numerical investigation to evaluate future climate's impact on storm surges along the Gulf of Mexico and U.S. east coast. The focus is on the impact of climatic changes in wind pattern and surface pressure while neglecting sea level rise and other factors. We adapted the regional ocean model system(ROMS) to the study region with a mesh grid size of 7–10 km in horizontal and 18 vertical layers. The model was validated by a hindcast of the coastal sea levels in the winter of 2008. Model's robustness was confirmed by the good agreement between model-simulated and observed sea levels at 37 tidal gages. Two 10-year forecasts, one for the IPCC Pre-Industry(PI) and the other for the A1 FI scenario, were conducted. The differences in model-simulated surge heights under the two climate scenarios were analyzed. We identified three types of responses in extreme surge heights to future climate: a clear decrease in Middle Atlantic Bight, an increase in the western Gulf of Mexico, and non-significant response for the remaining area. Such spatial pattern is also consistent with previous projections of sea surface winds and ocean wave heights.

关键词： storm surge sea surface winds climate change regional ocean

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AZD1775 synergizes with SLC7A11 inhibition to promote ferroptosis

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Science China Life Sciences 2025年第01期 204-218页

作者： Chen Xiong Hong Ling Yingdan Huang Hanzhi Dong Bangxiang xie qian Hao Xiang Zhou Fudan University Shanghai Cancer Center and Institutes of Biomedical Sciences Fudan University Department of Oncology Shanghai Medical CollegeFudan University Department of Breast Surgery Fudan University Shanghai Cancer CenterFudan University Department of Oncology First Affiliated Hospital of Nanchang University Beijing Institute of Hepatology Beijing Youan HospitalCapital Medical University Beijing Engineering Research Center for Precision Medicine and Transformation of Hepatitis and Liver Cancer Key Laboratory of Breast Cancer in Shanghai Fudan University Shanghai Cancer CenterFudan University Shanghai Key Laboratory of Medical Epigenetics International Co-laboratory of Medical Epigenetics and Metabolism (Ministry of Science and Technology)Institutes of Biomedical SciencesFudan University

Tumor suppressor p53-mediated cell cycle arrest and DNA damage repair may exert cytoprotective effects against cancer therapies, including WEE1 inhibition. Considering that p53 activation can also lead to multiple types of cell death, the role of this tumor suppressor in WEE1 inhibitor-based therapies remains disputed. In this study, we reported that nucleolar stress-mediated p53 activation enhanced the WEE1 inhibitor AZD1775-induced ferroptosis to suppress lung cancer growth. Our findings showed that AZD1775 promoted ferroptosis by blocking cystine uptake, an action similar to that of Erastin. Meanwhile, inhibition of WEE1 by the WEE1 inhibitors or si RNAs induced compensatory upregulation of SLC7A11, which conferred resistance to ferroptosis. Mechanistically, AZD1775 prevented the enrichment of H3K9me3, a histone marker of transcriptional repression, on the SLC7A11 promoter by repressing the expression of the histone methyltransferase SETDB1, thereby enhancing NRF2-mediated SLC7A11 transcription. This finding was also validated using the H3K9me3 inhibitor BRD4770. Remarkably, we found that the nucleolar stress-inducing agent Actinomycin D(Act. D) inhibited SLC7A11 expression by activating p53, thus augmenting AZD1775-induced ferroptosis. Moreover, the combination of AZD1775 and Act. D synergistically suppressed wild-type p53-harboring lung cancer cell growth both in vitro and in vivo. Altogether, our study demonstrates that AZD1775 promotes ferroptosis by targeting cystine uptake but also mediates the adaptive activation of SLC7A11 through the WEE1-SETDB1 cascade and NRF2-induced transcription, and inhibition of SLC7A11 by Act. D boosts the anti-tumor efficacy of AZD1775 by enhancing ferroptosis in cancers with wild-type p53.

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