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玉米赤霉烯酮对小鼠胸腺上皮细胞的毒性作用

中国兽医学报 2009年第7期29卷 894-897页

作者：梁梓森许利娜马勇江邓衔柏李英范小龙李玉谷宁章勇华南农业大学兽医学院广东广州510642

采用台盼蓝计数、流式细胞仪分析等方法，离体研究玉米赤霉烯酮对小鼠胸腺上皮细胞增殖与细胞周期的影响，结果发现：不同质量浓度（1～25mg／L）玉米赤霉烯酮对小鼠胸腺上皮细胞的增殖均具有显著抑制作用（P〈0．05），并表现出与剂量... 详细信息

采用台盼蓝计数、流式细胞仪分析等方法，离体研究玉米赤霉烯酮对小鼠胸腺上皮细胞增殖与细胞周期的影响，结果发现：不同质量浓度（1～25mg／L）玉米赤霉烯酮对小鼠胸腺上皮细胞的增殖均具有显著抑制作用（P〈0．05），并表现出与剂量和处理时间依赖性关系。高剂量（10～25mg／L）ZEA使小鼠胸腺上皮细胞细胞周期显著阻滞于G2／M期（P〈0．05），并存在剂量依赖性关系。这些结果表明，玉米赤霉烯酮对小鼠胸腺上皮细胞有直接毒害作用。

关键词：玉米赤霉烯酮细胞增殖细胞周期胸腺上皮细胞小鼠

Efficacy and safety of LY01005 versus goserelin implant in Chinese patients with prostate cancer: A multicenter, randomized, open-label, phase III, non-inferiority trial

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Chinese Medical Journal 2023年第10期136卷 1207-1215页

作者： Chengyuan gu Zengjun Wang Tianxin lin Zhiyu liu Weiqing Han Xuhui Zhang Chao liang Hao liu Yang yu Zhenzhou Xu shuang liu Jingen Wang linghua Jia Xin Yao Wenfeng liao Cheng Fu Zhaohui Tan guohua He guoxi Zhu Rui fan Wenzeng Yang Xin Chen Zhizhong liu liqiang Zhong Benkang Shi Degang Ding Shubo Chen Junli Wei Xudong Yao ming Chen Zhanpeng Lu Qun Xie Zhiquan Hu Yinhuai Wang Hongqian guo Tiwu fan Zhaozhao liang Peng Chen Wei Wang Tao Xu Chunsheng li Jinchun Xing Hong liao Dalin He Zhibin Wu Jiandi yu Zhongwen Feng Mengxiang Yang Qifeng Dou Quan Zeng yuanwei li Xin Gou guangchen Zhou xiaofeng Wang Rujian Zhu Zhonghua Zhang bo Zhang Wanlong Tan xueling Qu Hongliang Sun Tianyi Gan Dingwei Ye Department of Urology Fudan University Shanghai Cancer CenterShanghai 200032China Department of Oncology Shanghai Medical CollegeFudan UniversityShanghai 200032China Department of Urology The First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsu 210029China Department of Urology Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhouGuangdong 510120China Department of Urology The Second Affiliated Hospital of Dalian Medical UniversityDalianLiaoning 116023China Department of Urology The Affiliated Cancer Hospital of Xiangya School of MedicineCentral South UniversityHunan Cancer CenterChangshaHunan 410013China Department of Urology First Hospital of Shanxi Medical UniversityTaiyuanShanxi 030000China Department of Urology Jiangxi Provincial People’s HospitalSchool of MedicineNanchang UniversityNanchangJiangxi 330006China Department of Urology Tianjin Medical University Cancer Institute and HospitalTianjin 300060China Department of Urology Cancer Hospital of China Medical UniversityLiaoning Cancer Hospital and InstituteShenyangLiaoning 110043China Department of Urology Inner Mongolia People’s HospitalHohhotInner Mongolia 010010China Department of Urinary Surgery Taizhou Hospital of Traditional Chinese MedicineTaizhouJiangsu 225300China Department of Urology Linfen People’s HospitalLinfenShanxi 041000China Department of Urology Zhengzhou Central Hospital Affiliated to Zhengzhou UniversityZhengzhouHenan 450006China Department of Urology The Affiliated Hospital of Hebei UniversityBaodingHebei 071000China Department of Urology Chifeng Municipal HospitalChifeng Clinical Medical College of Inner Mongolia Medical UniversityChifengInner Mongolia 024000China Department of Urology Baogang HospitalBaotouInner Mongolia 014010China Department of Oncology The Second People’s Hospital of YibinYibinSichuan 644000China Department of Urology Qilu Hospital of Shandong UniversityJinanShandong 250014China Department of Urology Henan Provincial People’s Hos

Background:LY01005(Goserelin acetate sustained-release microsphere injection)is a modified gonadotropin-releasing hormone(GnRH)agonist injected *** phase III trial study aimed to evaluated the efficacy and safety of LY01005 in Chinese patients with prostate ***:We conducted a randomized controlled,open-label,non-inferiority trial across 49 sites in *** study included 290 patients with prostate cancer who received either LY01005 or goserelin implants every 28 days for three *** primary efficacy endpoints were the percentage of patients with testosterone suppression≤50 ng/dL at day 29 and the cumulative probability of testosterone≤50 ng/dL from day 29 to ***-inferiority was prespecified at a margin of-10%.Secondary endpoints included significant castration(≤20 ng/dL),testosterone surge within 72 h following repeated dosing,and changes in luteinizing hormone,follicle-stimulating hormone,and prostate specific antigen ***:On day 29,in the LY01005 and goserelin implant groups,testosterone concentrations fell below medical-castration levels in 99.3%(142/143)and 100%(140/140)of patients,respectively,with a difference of-0.7%(95%confidence interval[CI],-3.9%to 2.0%)between the two *** cumulative probabilities of maintaining castration from days 29 to 85 were 99.3%and 97.8%,respectively,with a between-group difference of 1.5%(95%CI,-1.3%to 4.4%).both results met the criterion for *** endpoints were similar between *** treatments were ***01005 was associated with fewer injection-site reactions than the goserelin implant(0%vs.1.4%[2/145]).Conclusion:LY01005 is as effective as goserelin implants in reducing testosterone to castration levels,with a similar safety *** registration:***,NCT04563936.

关键词： Prostatic neoplasms LY01005 Gonadotropin-releasing hormone agonist Efficacy Safety

5G技术对新能源接入配电网继电保护的影响及优化

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制造业自动化 2023年第8期45卷 77-80页

作者：李凡齐蓬勃弋富国马效国陈玉明国网宁夏电力有限公司固原供电公司固原750003

新能源并网后,传统的继电保护技术适用性普遍降低。为此,分析5G技术对新能源并网后的继电保护所造成的影响,探究5G技术为新能源并网后的继电保护技术带来的优化作用。采用算例,分析在新能源并网的条件下,对比采用5G技术与不采用5G技术... 详细信息

新能源并网后,传统的继电保护技术适用性普遍降低。为此,分析5G技术对新能源并网后的继电保护所造成的影响,探究5G技术为新能源并网后的继电保护技术带来的优化作用。采用算例,分析在新能源并网的条件下,对比采用5G技术与不采用5G技术的继电保护的可靠性,并分析运用5G技术在新能源并网的继电保护所带来的优化效果。结果表明,5G技术较大地提升了配电网的安全性和可靠性,并使新能源并网的继电保护得到了适用性的优化。

关键词：新能源配电网继电保护技术 5G技术

新疆维吾尔族慢性乙型肝炎患者HBV基因型分布及其特点

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中华肝脏病杂志 2007年第4期15卷 241-244页

作者：鲁晓擘王晓岚邓国宏况雪梅阿曼古丽张跃新张建龙王宇明新疆医科大学第一附属医院感染科乌鲁木齐830054 第三军医大学西南医院全军感染病研究所重庆新疆医科大学基础医学院

目的探讨新疆维吾尔族慢性乙型肝炎患者HBV基因型分布及其特点。方法采用型特异性引物巢式PCR法对127例维吾尔族慢性乙型肝炎患者进行基因分型,并测序验证。结果基因D型占39．4%（50/127）,基因B型占22．0%（28/127）,基因C型占16．5%（... 详细信息

目的探讨新疆维吾尔族慢性乙型肝炎患者HBV基因型分布及其特点。方法采用型特异性引物巢式PCR法对127例维吾尔族慢性乙型肝炎患者进行基因分型,并测序验证。结果基因D型占39．4%（50/127）,基因B型占22．0%（28/127）,基因C型占16．5%（21/127）,基因BD混合型占9．4%（12/127）,基因CD混合型占8．7%（11/127）,基因BCD混合型占3．9%（5/127）; HBeAg阳性与HBeAg阴性的维吾尔族慢性乙型肝炎患者基因型分布,差异无统计学意义（x^2= 6．033,P＞0．05）;不同年龄维吾尔族慢性乙型肝炎患者HBV基因型分布差异无统计学意义（x^2= 3．137,P＞0．05）;不同性别维吾尔族慢性乙型肝炎患者HBV基因型分布差异亦无统计学意义（x^2= 8．058,P＞0．05）。结论新疆维吾尔族慢性乙型肝炎患者HBV基因型以D型占优势,其次可见B、C型及BD、CD、BCD混合型。同一疾病谱的慢性HBV感染者基因型分布可能与宿主HBeAg状态、年龄、性别无明显关系。

关键词：肝炎,乙型,慢性肝炎病毒,乙型基因型维吾尔族

Measurements of differential and angle-integrated cross sections for the 10B（n, α）7li reaction in the neutron energy range from 1.0 eV to 2.5 MeV

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Chinese Physics C 2019年第12期43卷 47-74页

作者： Haoyu Jiang Wei Jiang Huaiyong Bai Zengqi Cui guohui Zhang Ruirui fan HanYi Changjun Ning liang Zhou Jingyu Tang Qi An Jie Bao yu Bao Ping Cao Haolei Chen Qiping Chen Yonghao Chen yukai Chen Zhen Chen Changqing Feng Keqing Gao Minhao gu Changcai Han Zijie Han guozhu He Yongcheng He Yang Hong Hanxiong Huang Weiling Huang Xiru Huang xiaolu Ji Xuyang Ji Zhijie Jiang Hantao Jing ling Kang mingtao Kang bo li Chao li Jiawen li Lun li Qiang li xiao li Yang li Rong liu Shubin liu Xingyan liu guangyuan Luan Qili Mu Binbin Qi Jie Ren Zhizhou Ren Xichao Ruan Zhaohui Song Yingpeng Song Hong Sun Kang Sun xiaoyang Sun Zhijia Sun Zhixin Tan Hongqing Tang Xinyi Tang Binbin Tian lijiao Wang Pengcheng Wang Qi Wang Taofeng Wang Zhaohui Wang Jie Wen Zhongwei Wen Qingbiao Wu xiaoguang Wu Xuan Wu likun Xie Yiwei Yang li yu Tao yu Yongji yu linhao Zhang Qiwei Zhang Xianpeng Zhang yuliang Zhang Zhiyong Zhang yubin Zhao Luping Zhou Zuying Zhou Danyang Zhu Kejun Zhu Peng Zhu State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China Institute of High Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China Spallation Neutron Source Science Center Dongguan 523803China State Key Laboratory of Particle Detection and Electronics Department of Modem Physics University of Science and Technology of ChinaHefei 230026China Key Laboratory of Nuclear Data China Institute of Atomic EnergyBeijing 102413China Institute of Nuclear Physics and Chemistry China Academy of Engineering PhysicsMianyang 621900China Northwest Institute of Nuclear Technology Xi'an 710024China University of Chinese Academy of Sciences Beijing 100049China Department of Engineering and Applied Physics University of Science and Technology of ChinaHefei 230026China School of Physics Beihang UniversityBeijing 100083China

Differential and angle-integrated cross sections for the 10B(n,α)^7 li,10B(n,α0)^7 li and 10B(n,α1)^7 li^*reactions have been measured at CSNS Back-n white neutron *** enriched(90%)10B samples 5.0 cm in diameter and^85.0μg/cm^2 in thickness each with an aluminum backing were prepared,and back-to-back mounted at the sample *** charged particles were detected using the silicon-detector array of the light-charged Particle Detector Array(LPDA)*** neutron energy En was determined by TOF(time-of-flight)method,and the valid a events were extracted from the En-Amplitude two-dimensional *** 15 silicon detectors,the differential cross sections of a-particles were measured from 19.2°to 160.8°.Fitted with the Legendre polynomial series,the(n,a)cross sections were obtained through *** absolute cross sections were normalized using the standard cross sections of the 10B(n,α)^7 li reaction in the 0.3-0.5 MeV neutron energy *** measurement neutron energy range for the 10B(n,α)^7 li reaction is 1.0 eV≤Enli and10B(n,α1)^7 li^*reactions is 1.0 eV≤Ennance reaction mechanism and the level structure of the 11B compound system,and compared with existing measurements and evaluations.

关键词： 10B(n,α)^7li reaction cross sections LPDA CSNS Back-n white neutron source

Quafu-RL:The cloud quantum computers based quantum reinforcement learning

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Chinese Physics B 2024年第5期33卷 29-34页

作者：靳羽欣许宏泽王正安庄伟峰黄凯旋时运豪马卫国李天铭陈驰通许凯冯玉龙刘培陈墨李尚书杨智鹏钱辰马运恒肖骁钱鹏顾炎武柴绪丹普亚南张翼鹏魏世杰曾进峰李行龙桂鲁金贻荣于海峰范桁刘东胡孟军 Beijing Academy of Quantum Information Sciences Beijing 100193China State Key Laboratory of Low Dimensional Quantum Physics Department of PhysicsTsinghua UniversityBeijing 100084China Institute of Physics Chinese Academy of SciencesBeijing 100190China Frontier Science Center for Quantum Information Beijing 100184China School of Physical Sciences University of Chinese Academy of SciencesBeijing 100190China CAS Center for Excellence in Topological Quantum Computation University of Chinese Academy of SciencesBeijing 100190China School of Mathematical Sciences Nankai UniversityTianjin 300071China

With the rapid advancement of quantum computing,hybrid quantum–classical machine learning has shown numerous potential applications at the current stage,with expectations of being achievable in the noisy intermediate-scale quantum(NISQ)*** reinforcement learning,as an indispensable study,has recently demonstrated its ability to solve standard benchmark environments with formally provable theoretical advantages over classical ***,despite the progress of quantum processors and the emergence of quantum computing clouds,implementing quantum reinforcement learning algorithms utilizing parameterized quantum circuits(PQCs)on NISQ devices remains *** this work,we take the first step towards executing benchmark quantum reinforcement problems on real devices equipped with at most 136 qubits on the BAQIS Quafu quantum computing *** experimental results demonstrate that the policy agents can successfully accomplish objectives under modified conditions in both the training and inference ***,we design hardware-efficient PQC architectures in the quantum model using a multi-objective evolutionary algorithm and develop a learning algorithm that is adaptable to quantum *** hope that the Quafu-RL can be a guiding example to show how to realize machine learning tasks by taking advantage of quantum computers on the quantum cloud platform.

关键词： quantum cloud platform quantum reinforcement learning evolutionary quantum architecture search

超声造影在糖尿病肾脏疾病鉴别诊断中的价值研究

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中国实用内科杂志 2024年第3期44卷 204-209页

作者：凌晓晶范校周高卓余颖谷君辉单婧崔瑜吕小萌邱德俊李玥铭刘东空军特色医学中心肾脏病科北京100142 中国医科大学辽宁沈阳110031

目的探讨超声造影技术在糖尿病肾脏疾病(DKD)早期鉴别诊断中的临床价值。方法收集2021年8月到2022年10月在北京空军特色医学中心住院的慢性肾脏病(CKD)患者临床资料,包括CKD病因、超声参数以及实验室指标等,将患者分为非DKD组和DKD组... 详细信息

目的探讨超声造影技术在糖尿病肾脏疾病(DKD)早期鉴别诊断中的临床价值。方法收集2021年8月到2022年10月在北京空军特色医学中心住院的慢性肾脏病(CKD)患者临床资料,包括CKD病因、超声参数以及实验室指标等,将患者分为非DKD组和DKD组,比较两组患者超声参数差异并与临床指标进行相关性分析。结果 DKD组肾门动脉阻力指数(RI)(0.72±0.08)高于非DKD组(0.66±0.07)(t=-3.52,P0.05)。估算肾小球滤过率(eGFR)≥60mL/(min·1.73 m^(2))期间,DKD组肾门动脉(0.70±0.08)、段动脉(0.65±0.06)、叶间动脉(0.61±0.05)的RI明显较非DKD组肾门动脉(0.62±0.10)(t=-3.30,P0.05)。结论超声造影参数TTP联合叶间动脉、段动脉、肾门动脉RI对糖尿病肾脏疾病的早期鉴别诊断具有一定的临床价值。

关键词：糖尿病性肾脏疾病慢性肾脏病超声造影肾功能

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新西兰生物科技及产业现状及特点

中国生物工程杂志 2008年第10期28卷 5-7页

作者：范明杰付红波赵清华李玉洁李晓娟安道昌中国生物技术发展中心北京100081 中国中医科学院中药研究所北京100700 中国科学院植物研究所北京100093

新西兰生物产业的规模并不十分引人注目,但却是新西兰经济中不可忽视的组成部分,其生物科技方面的优势领域主要是农业生物技术和生物医学两方面,例如大型动植物、生物安全、环境保护、神经科学、心血管疾病、结核与哮喘、糖尿病和癌症... 详细信息

新西兰生物产业的规模并不十分引人注目,但却是新西兰经济中不可忽视的组成部分,其生物科技方面的优势领域主要是农业生物技术和生物医学两方面,例如大型动植物、生物安全、环境保护、神经科学、心血管疾病、结核与哮喘、糖尿病和癌症等研究领域。新西兰政府十分重视生物科技和产业的发展,在其2002年颁布的《创新增长框架》计划中,将生物技术列为未来的三大经济增长支柱之一,将加大对生物科技和产业的投入作为新西兰向高技术经济转型的重要举措。

关键词：生物科技产业现状新西兰农业生物技术经济增长心血管疾病生物产业组成部分

Measurement of the differential cross sections and angle-integrated cross sections of the ~6li(n,t)~4 He reaction from 1.0 eV to 3.0 MeV at the CSNS Back-n white neutron source

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Chinese Physics C 2020年第1期44卷 58-85页

作者： Huaiyong Bai Ruirui fan Haoyu Jiang Zengqi Cui Yiwei Hu guohui Zhang Zhenpeng Chen Wei Jiang Han Yi Jingyu Tang liang Zhou Qi An Jie Bao Ping Cao Qiping Chen Yonghao Chen Pinjing Cheng Changqing Feng Minhao gu Fengqin guo Changcai Han Zijie Han guozhu He Yongcheng He yuefeng He Hanxiong Huang Weiling Huang Xiru Huang xiaolu Ji Xuyang Ji Hantao Jing ling Kang mingtao Kang bo li Lun li Qiang li xiao li Yang li Yang li Rong liu Shubin liu Xingyan liu guangyuan Luan Yinglin Ma Changjun Ning Binbin Qi Jie Ren Xichao Ruan Zhaohui Song Hong Sun xiaoyang Sun Zhijia Sun Zhixin Tan Hongqing Tang Pengcheng Wang Qi Wang Taofeng Wang Yanfeng Wang Zhaohui Wang Zheng Wang Jie Wen Zhongwei Wen Qingbiao Wu xiaoguang Wu Xuan Wu likun Xie Yiwei Yang li yu Tao yu Yongji yu Jing Zhang linhao Zhang liying Zhang Qingmin Zhang Qiwei Zhang Xianpeng Zhang yuliang Zhang Zhiyong Zhang Yingtan Zhao Zuying Zhou Danyang Zhu Kejun Zhu Peng Zhu State Key Laboratory of Nuclear Physics and Technology Institute of Heavy Ion PhysicsSchool of PhysicsPeking UniversityBeijing 100871China Sate Key Laboratory of Particle Detection and Electronics Institute of High Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China Dongguan Neutron Science Center Dongguan 523803China Physics Department Tsinghua UniversityBeijing 100084China Department of Modern Physics University of Science and Technology of ChinaHefei 230026China Key Laboratory of Nuclear Data China Institute of Atomic EnergyBeijing 102413China Institute of Nuclear Physics and Chemistry China Academy of Engineering PhysicsMianyang 621900China University of South China Hengyang 421001China Northwest Institute of Nuclear Technology Xi’an 710024China Department of Engineering and Applied Physics University of Science and Technology of ChinaHefei 230026China Beihang University Beijing 100083China Xi’an Jiaotong University Xi’an 710049China

The^6 li(n,t)~4 He reaction was measured as the first experiment involving neutron-induced charged particle emission reactions at the CSNS(China Spallation Neutron Source)Back-n white neutron *** differential cross-sections of the^6 li(n,t)~4 He reaction at 15 detection angles ranging from 19.2°to 160.8°are obtained from 1.0 eV to 3.0 MeV at 80 neutron energy points;for 50 energy points below 0.1 MeV they are reported for the first *** results indicate that the anisotropy of the emitted tritium is noticeable above E_n=100 *** angle-integrated cross-sections are also *** present differential cross-sections agree in general with the previous evaluations,but there are some differences in the *** importantly,the present results indicate that the cross-sections of the^6 li(n,t)~4 He reaction might be overestimated by most evaluations in the 0.5-3.0 MeV region,although they are recommended as standards below 1.0 MeV.

关键词： ~6li(n,t)~4He reaction differential cross-section angle-integrated cross-section LPDA