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Chemical Research in Chinese Universities 2013年第4期29卷 611-616页

作者： LI Yang-xue xue ming HUANG lin CHEN Si-ru QIU Shi-lun State Key Laboratory of Inorganic Synthesis and Preparative Chemistry Jilin University Changchun 130012 P. R. China

Two 3D multifunctional lanthanide metal-organic frameworks（MOFs）, Pr（HTCPS）（H20）·2DMF·C2H2OH·5H2O（JUC-93） and Pr3（TCPS）2（NO3）（H2O）4（DMA）2.2DMA.C2H5OH.3H2O（JUC-94）[H4TCPS=tetrakis（4-carboxyphenyl）- silane, DMF=N,N＇-dimethylformamide, DMA=N,N＇-dimethylacetamide and JUC=Jilin University China] were synthe- sized by the self-assembly of a rigid silicon-centered tetrahedral carboxylate ligand H4TCPS and Pr（III） ions in different solvothermal reactions. X-Ray crystallography revealed that they exhibited a rare CaFE topology framework, constructed from the 4-connected tetrahedral TCPS unit with the 8-connected dinuclear praseodymium cluster unit and trinuclear praseodymium cluster unit, respectively. In addition, the luminescent and magnetic properties of the two compounds were investigated.

关键词： Metal-organic framework Tetrakis(4-carboxyphenyl)silane CaF2 topology Magnetic property Fluores- cence

Vasectomy reversal in China during the recent decade:insights from a multicenter retrospective investigation

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Asian Journal of Andrology 2023年第3期25卷 416-420页

作者： Li-Juan Ren Rui-Zhi xue Zi-Qiang Wu Er-Lei Zhi Wei Li Liang Huang Xu-Yu Xiang Dao-Yuan Li xue-ming lin Department of Urology First Hospital of Shanxi Medical UniversityTaiyuan 030000China Department of Urology Xiangya Hospital of Central South UniversityChangsha 410000China Department of Urology Shanghai General HospitalShanghai 200000China Department of Urology Second Hospital of Tianjin Medical UniversityTianjin 300000China Department of Urology Zhujiang Hospital of Southern Medical UniversityGuangzhou 510000China Department of Urology First Affiliated Hospital of Nanchang UniversityNanchang 330000China Department of Urology Hainan General HospitalHaikou 570100China

To date,there is little information about the demography of vasectomy reversal(VR)patients or the factors currently influencing VR effectiveness in China,especially after the universal two-child policy was released in *** this research,demographic data and perioperative medical records of VR patients were extracted from seven major hospitals in different provinces or municipalities of ***,a telephone survey of the patients was conducted to collect follow-up ***,448 VR cases from the past 13 years were *** results were analyzed by stratified comparison to investigate factors that can influence postoperative vas deferens patency and pregnancy *** statistical methods were used,and all of the protocols were approved by the Ethics Committees of the institutes in this *** results showed that the annual operation volume of VR quadrupled after the two-child policy was *** and a long duration of vasectomy were significantly associated with a lower patency rate.A follow-up survey showed that the general postoperative pregnancy rate was 27.2%.For female partners over the age of 35 years,the postoperative pregnancy rate showed a more severe decline,but only 35.5%of them had been given a fertility examination before their husbands’VR *** work revealed that more patients in China have been demanding VR in recent ***-quality microsurgery and a short duration of vasectomy are crucial for restoring patency by *** andrologists should perform a preoperative fertility evaluation of the patients’female partners.

关键词： demography microsurgery multicenter vasectomy reversal

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低成本高性能永磁同步电机控制器的研制

微电机 2005年第5期38卷 98-100,81页

作者：薛利明北京迈克罗迈帝克机械有限公司北京100041

介绍低压大电流永磁同步电机(PM SM)的控制。针对霍尔波形的特点,通过M/T法测速,使低压大电流PM SM的控速精度达到±1%。虽然未进行电流控制,但控制器仍具有较高的动态性能。

关键词：永磁同步电动机霍尔传感器 M/T测速法控制器

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Observation of acoustic hybrid topological phases induced by the p-d orbital interactions

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 132-139页

作者： Xiao Xiang Feng Gao Yu-Gui Peng Peng Wu Zong-lin Li xue-Feng Zhu School of Physics and Innovation Institute Huazhong University of Science and Technology

In spinless systems,growing attention has recently been attracted to synthetic gauge fields,which redefine the fundamental crystal symmetries by utilizing the projective algebraic ***,synthetic gauge fields have been commonly investigated in single orbital systems,and explorations on hybrid orbitals remain elusive in ***,we report the experimental observation of hybrid topological phases induced by hybrid synthetic gauge flux,which is formed by the interaction between p and d orbitals embedded in acoustic *** breaking the translation symmetries of Lxand/or Ly,we unambiguously demonstrate the first-order M?bius edge states and higher-order corner *** work establishes a platform for seeking exotic topological phases induced by hybrid-orbitals interactions and initializing the framework of hybrid-orbitalsrelated topological *** applications can be anticipated in scenarios such as high-quality sensing and robust wave trapping due to the stepwise energy distribution of the hybrid topological phase.

关键词： topological insulator synthetic gauge field projective symmetry corner states

Revolutionizing breast cancer detection:Advances in fluorescent probe technology

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Nano Research 2025年第1期18卷 653-674页

作者： Qian Gao lin Tang Jun Zhan Yiyuan xue Feng Luo State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases West China Hospital of StomatologySichuan UniversityChengdu 610041China Emergency Obstetrics and Gynecology West China Second University HospitalSichuan UniversityChengdu 610041China Department of Obstetrics and Gynecology West China Second University HospitalSichuan UniversityChengdu 610041China Department of Prosthodontics West China School of StomatologySichuan UniversityChengdu 610041China

With the increasing incidence of breast cancer globally,there is an urgent demand for enhanced diagnostic and therapeutic *** comprehensive review explores advancements in fluorescent probe technology for breast cancer imaging and early *** probes offer unparalleled sensitivity and specificity in detecting cancer biomarkers,enabling early diagnosis and delineation of tumor margins during *** categorize these probes into molecular,nano,ratiometric,the second near-infrared window(NIR-II),and multifunctional varieties,each with unique capabilities for targeting specific cancer *** review highlights recent innovations in probe design,emphasizing their applications in pathogenesis studies,drug development,precision medicine,and fluorescence-guided *** their promising clinical potential,challenges such as safety,biomarker targeting accuracy,system compatibility,and clinical translation *** these hurdles is crucial for the integration of fluorescent probes into standard cancer care,aiming to improve treatment outcomes and patient quality of life.

关键词： breast cancer fluorescent probes imaging early diagnosis biomarker

Zoledronate-loaded aluminum salt nanovaccines amplify cellular immune response by enhancing cross-presentation

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Nano Research 2025年第1期18卷 559-571页

作者： Chunting He Penghui He xue Tang Shuting Bai ming Qin Yunting Zhang Zhaofei Guo Guangsheng Du Xun Sun Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry West China School of PharmacySichuan UniversityChengdu 610041China

Being a Th2 stimulator,classic aluminum salt-based adjuvants only stimulate weak cellular immune responses that are required for vaccination against intracellular viruses or cancerous *** a thirdgeneration bisphosphonate,zoledronate(ZOL)can enhance antigen crosspresentation by inhibiting key enzymes of the mevalonate ***,we developed the subunit antigen ovalbumin(OVA)and ZOL co-loaded aluminum hydroxide nanoparticles(APN-OVA-ZOL)and investigated their capacity for inducing cellular immune responses against the *** results showed that the developed nanovaccines could successfully encapsulate OVA and ZOL,and enabled efficient lymph node *** by the mevalonate pathway inhibition effect of ZOL,APN-OVA-ZOL significantly promoted *** a result,APN-OVA-ZOL induced robust cellular immunity,including the activation of T and B *** a EG7-OVA tumor-bearing murine model,APN-OVA-ZOL significantly inhibited the tumor growth and prolonged mice *** work provided a strong empirical foundation indicating that zoledronate-loaded aluminum salt nanovaccines had a strong potency for cancer immunotherapy.

关键词： zoledronate(ZOL) mevalonate pathway antigen cross-presentation cellular immune responses

NOX4 exacerbates Parkinson's disease pathology by promoting neuronal ferroptosis and neuroinflammation

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Neural Regeneration Research 2025年第7期20卷 2038-2052页

作者： Zhihao lin Changzhou Ying Xiaoli Si Naijia xue Yi Liu Ran Zheng Ying Chen Jiali Pu Baorong Zhang Department of Neurology The Second Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang ProvinceChina

Parkinson's disease is primarily caused by the loss of dopaminergic neurons in the substantia nigra ***,a novel form of regulated cell death characterized by iron accumulation and lipid peroxidation,plays a vital role in the death of dopaminergic ***,the molecular mechanisms underlying ferroptosis in dopaminergic neurons have not yet been completely *** oxidase 4 is related to oxidative stress,however,whether it regulates dopaminergic neuronal ferroptosis remains *** aim of this study was to determine whether NADPH oxidase 4 is involved in dopaminergic neuronal ferroptosis,and if so,by what *** found that the transcriptional regulator activating transcription factor 3 increased NADPH oxidase 4 expression in dopaminergic neurons and astrocytes in an 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine-induced Parkinson's disease *** oxidase 4 inhibition improved the behavioral impairments observed in the Parkinson's disease model animals and reduced the death of dopaminergic ***,NADPH oxidase 4 inhibition reduced lipid peroxidation and iron accumulation in the substantia nigra of the Parkinson's disease model ***,we found that NADPH oxidase 4 interacted with activated protein kinase Cαto prevent ferroptosis of dopaminergic ***,by lowering the astrocytic lipocalin-2 expression,NADPH oxidase 4 inhibition reduced 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine-induced *** findings demonstrate that NADPH oxidase 4 promotes ferroptosis of dopaminergic neurons and neuroinflammation,which contribute to dopaminergic neuron death,suggesting that NADPH oxidase 4 is a possible therapeutic target for Parkinson's disease.

关键词： dopaminergic neuron ferroptosis NADPH oxidase 4(NOX4) neuroinflammation Parkinson's disease

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Burden of mental disorders and risk factors in the Western Pacific region from 1990 to 2021

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World Journal of Psychiatry 2025年第1期15卷 93-105页

作者： Ya-Xin Xu Xiao-Xuan Niu Wen-Chang Jia Jing Wen xue-lin Cheng Yan Han ming-Hui Peng Jing Zhou Yao Liu Sun-Fang Jiang Xiao-Pan Li Department of Health Management Centre Zhongshan HospitalFudan UniversityShanghai 200030China Department of General Practice Zhongshan HospitalFudan UniversityShanghai 200030China Department of Nutrition Zhongshan HospitalFudan UniversityShanghai 200032China School of Public Health Fudan UniversityShanghai 200032China

BACKGROUND The burden of mental disorders(MD)in the Western Pacific Region(WPR)re-mains a critical public health concern,with substantial variations across demogra-phics and *** To analyze the burden of MD in the WPR from 1990 to 2021,along with associated risk factors,to reveal changing trends and emerging *** We used data from the Global Burden of Disease 2021,analyzing prevalence,incidence,and disability-adjusted life years(DALYs)of MD from 1990 to *** methods included age-standardisation and uncertainty analysis to address variations in population structure and data *** Between 1990 and 2021,the prevalence of MD rose from 174.40 million cases[95%uncertainty interval(UI):160.17-189.84]to 234.90 million cases(95%UI:219.04-252.50),with corresponding DALYs increasing from 22.8 million(95%UI:17.22-28.79)to 32.07 million(95%UI:24.50-40.68).During this period,the burden of MD shifted towards older age *** and anxiety disorders were predominant,with females showing higher DALYs for depressive and anxiety disorders,and males more affected by conduct disorders,attention-deficit hyperactivity disorder,and autism spectrum ***,New Zealand,and Malaysia reported the highest burdens,whereas Vietnam,China,and Brunei Darussalam reported the ***,childhood sexual abuse and bullying,and intimate partner violence emerged as significant risk *** This study highlights the significant burden of MD in the WPR,with variations by age,gender,and *** coronavirus disease 2019 pandemic has exacerbated the situation,emphasizing the need for a coordinated response.

关键词： Mental disorders Western pacific region Global Burden of Disease Risk factors Disability-adjusted life years

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生姜蛋白酶和生姜汁对猪肉嫩化效果的比较

山东农业大学学报（自然科学版） 2003年第1期34卷 15-18,23页

作者：唐晓珍黄雪松王明林马明李坤山东农业大学食品科学与工程学院

本文研究了生姜蛋白酶及生姜汁对猪肉的嫩化效果 ,对其用量、pH值、预处理温度进行了测试对比。结果表明 :生姜蛋白酶及生姜汁对猪肉的嫩化效果十分显著 (P≤ 0 .0 1) ,生姜蛋白酶最佳用量为 0 .0 1% ,姜汁最佳用量 5 % ,最佳pH都为 7.... 详细信息

本文研究了生姜蛋白酶及生姜汁对猪肉的嫩化效果 ,对其用量、pH值、预处理温度进行了测试对比。结果表明 :生姜蛋白酶及生姜汁对猪肉的嫩化效果十分显著 (P≤ 0 .0 1) ,生姜蛋白酶最佳用量为 0 .0 1% ,姜汁最佳用量 5 % ,最佳pH都为 7.0 ,最佳预处理温度生姜蛋白酶为 30℃ ,生姜汁为 4 0℃ ;并且生姜蛋白酶及生姜汁对猪肉的嫩化效果极为相似 ,可以证明。

关键词：生姜蛋白酶生姜汁猪肉嫩化效果巯醇蛋白酶

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Role of nutrition in diabetes mellitus and infections

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World Journal of Clinical Cases 2025年第3期13卷 1-8页

作者： xue-Lu Yu Li-Yun Zhou Xiao Huang Xin-Yue Li ming-Ke Wang Ji-Shun Yang Naval Medical Center of PLA Naval Medical UniversityShanghai 200052China

In this editorial,we have commented on the article that has been published in the recent issue of World Journal of Clinical *** authors have described a case of unilateral thyroid cyst and have opined that the acute onset of infection may be linked to diabetes mellitus(DM).We have focused on the role of nutrition in the association between DM and *** with DM are at a high risk of infection,which could also be attributed to nutrition-related *** interventions for patients with diabetes are mainly based on a low-calorie diet,which can be achieved by adhering to a low-carbohydrate ***,dietary fiber supplementation is recommended to maintain the diversity of the gut ***,high-quality protein can prevent the increased risk of infection due to *** of vitamins C,vitamins A,vitamins D,and folic acid improves blood sugar control and facilitates immune *** deficiencies augment the risk of infection,but the relationship with diabetes is mostly U-shaped and a good intake should be maintained.

关键词： Diabetes mellitus Infection Macronutrients Vitamins Minerals