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Retrospective analysis of pathological types and imaging features in pancreatic cancer: A comprehensive study

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 121-129页

作者： Yang-Gang Luo mei wu Hong-Guang Chen Pathology Department Xuanhan County People’s HospitalDazhou 636150Sichuan ProvinceChina

BACKGROUND Pancreatic cancer remains one of the most lethal malignancies worldwide,with a poor prognosis often attributed to late *** the correlation between pathological type and imaging features is crucial for early detection and appropriate treatment *** To retrospectively analyze the relationship between different pathological types of pancreatic cancer and their corresponding imaging *** We retrospectively analyzed the data of 500 patients diagnosed with pancreatic cancer between January 2010 and December 2020 at our *** types were determined by histopathological examination of the surgical spe-cimens or biopsy *** imaging features were assessed using computed tomography,magnetic resonance imaging,and endoscopic *** analyses were performed to identify significant associations between pathological types and specific imaging *** There were 320(64%)cases of pancreatic ductal adenocarcinoma,75(15%)of intraductal papillary mucinous neoplasms,50(10%)of neuroendocrine tumors,and 55(11%)of other rare *** imaging features were identified in each pathological *** ductal adenocarcinoma typically presents as a hypodense mass with poorly defined borders on computed tomography,whereas intraductal papillary mucinous neoplasms present as characteristic cystic lesions with mural *** tumors often appear as hypervascular lesions in contrast-enhanced *** analysis revealed significant correlations between specific imaging features and pathological types(P<0.001).CONCLUSION This study demonstrated a strong association between the pathological types of pancreatic cancer and imaging *** findings can enhance the accuracy of noninvasive diagnosis and guide personalized treatment approaches.

关键词： Pancreatic cancer Pathological types Imaging features Retrospective analysis Diagnostic accuracy

Clinical and etiological characteristics of community-acquired pneumonia at high altitudes in Tibet, China

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Chinese Medical Journal 2021年第6期134卷 749-751页

作者： Qucuo meilang Ran Li xue-mei wu Ying Shang Pu Ning Jing Bao Qiongda Bianba Zhuoga Pubu Li-Ping Huang Zhan-Cheng Gao Department of Respiratory Medicine Tibet Autonomous Region People’s HospitalLhasaTibet 850000China Department of Respiratory and Critical Care Medicine Peking University People’s HospitalBeijing 100044China

To the Editor:Community-acquired pneumonia(CAP)is one of the most common infectious diseases,causing high morbidity and *** altitudes are characterized by a hypoxic environment with low barometric pressure,increased ultraviolet radiation,and low *** can disturb normal homeostasis of the immune system,especially impairing the function of the T lymphocytes,leading to an increased susceptibility to bacterial *** respiratory symptoms of CAP at high altitudes are similar to that of high-altitude pulmonary edema.

关键词： pneumonia altitude homeostasis

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翼状胬肉对人工晶状体度数测算的影响

中国现代医学杂志 2021年第2期31卷 87-91页

作者：吴雪梅吴沂旎陕西省中医医院眼科陕西西安710000

目的通过对比不同大小翼状胬肉手术前后角膜曲率和理论人工晶状体(IOL)度数的差异,探讨翼状胬肉大小对IOL度数测算的影响。方法选取2016年6月—2017年12月于陕西省中医医院行手术治疗的单眼原发性鼻侧翼状胬肉患者94例(94眼),根据翼状... 详细信息

目的通过对比不同大小翼状胬肉手术前后角膜曲率和理论人工晶状体(IOL)度数的差异,探讨翼状胬肉大小对IOL度数测算的影响。方法选取2016年6月—2017年12月于陕西省中医医院行手术治疗的单眼原发性鼻侧翼状胬肉患者94例(94眼),根据翼状胬肉长度和宽度分为A组、B组、C组,A组长度3.5 mm~5.0 mm或宽度>7.0 mm。分别于手术前及术后3个月检查各组患者裸眼视力、矫正视力、眼轴长度、前房深度、平均角膜曲率、角膜散光和理论IOL度数。结果随着翼状胬肉大小的增加,各组裸眼视力、矫正视力和角膜散光呈上升趋势(P3.5 mm~5.0 mm或宽度>7.0 mm时,IOL度数测算误差较大。

关键词：翼状胬肉角膜白内障

Circular RNA CiRS-7 promotes propagation of Cryptosporidium parvum in HCT-8 cells via sponging miR-1270 to active NF-κB signaling pathway

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Circular RNA CiRS-7 promotes propagation of Cryptosporidium ...

Brain region-specific roles of brain-derived neurotrophic factor in social stress-induced depressive-like behavior

2021中国畜牧兽医学会兽医寄生虫学分会第16次学术研讨会

作者： Yan-Ling Yin Ting-Li Liu Qian Yao Yu-Xin Wang xue-mei wu xue-Ting Wang Xin Yang Jun-Ke Song Guang-Hui Zhao

Cryptosporidium parvum is an important zoonotic pathogen responsible for severe enteric diseases in humans and ***,the underly molecular mechanisms of Cryptosporidium infection are not *** studies confirmed that *** can alternate the expression of ncRNAs(e.g.,long non-coding RNAs and micro RNAs) of hosts during infection,and some of these ncRNAs played a vital role in regulating cellular responses to Cryptosporidium *** this study,we found that *** infection caused great alterations of the expression profiles of circRNAs in HCT-8 *** them,the significantly up-regulated ciRS-7 was chosen for further *** starBase v2.0 database and luciferase reporter assays,we predicted and verified that ciRS-7 sponged miR-1270 and miR-1270 targeted ***-PCR and western blot assays revealed that *** infection decreased miR-1270 expression,while induced RelA ***,we confirmed that ciRS-7 may act as a ceRNA to relieve miR-1270-mediated suppression on RelA in HCT-8 cells following *** ***,the upregulation of ciRS-7 was involved in enhancing the expression of NF-κB signal downstream molecules of NOS2 and CXCL2,while miR-1270 mimics attenuated the ***,overexpression of ciRS-7 promoted the parasite burden,while induction of miR-1270 could reverse the effect of ciRS-7 on parasite *** conclusion,our results unveiled that ciRS-7 was beneficial to *** proliferation via regulating miR-1270/RelA axis and activating the NF-κB signal pathway.

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Neural Regeneration Research 2025年第1期20卷 159-173页

作者： Man Han Deyang Zeng Wei Tan Xingxing Chen Shuyuan Bai Qiong wu Yushan Chen Zhen Wei Yufei mei Yan Zeng Brain Science and Advanced Technology Institute Wuhan University of Science and TechnologyWuhanHubei ProvinceChina Geriatric Hospital Affiliated to wuhan University of Science and Technology WuhanHubei ProvinceChina School of Public Health Wuhan University of Science and TechnologyWuhanHubei ProvinceChina

Brain-derived neurotrophic factor is a key factor in stress adaptation and avoidance of a social stress behavioral *** studies have shown that brain-derived neurotrophic factor expression in stressed mice is brain region–specific,particularly involving the corticolimbic system,including the ventral tegmental area,nucleus accumbens,prefrontal cortex,amygdala,and *** how brain-derived neurotrophic factor participates in stress processing in different brain regions will deepen our understanding of social stress *** this review,we discuss the expression and regulation of brain-derived neurotrophic factor in stress-sensitive brain regions closely related to the pathophysiology of *** focused on associated molecular pathways and neural circuits,with special attention to the brain-derived neurotrophic factor–tropomyosin receptor kinase B signaling pathway and the ventral tegmental area–nucleus accumbens dopamine *** determined that stress-induced alterations in brain-derived neurotrophic factor levels are likely related to the nature,severity,and duration of stress,especially in the above-mentioned brain regions of the corticolimbic ***,BDNF might be a biological indicator regulating stress-related processes in various brain regions.

关键词： amygdala chronic mild stress chronic social defeat stress corticolimbic system depression hippocampus medial prefrontal cortex nucleus accumbens social stress models ventral tegmental area

Serum metabolomics in chickens infected with Cryptosporidium baileyi

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Serum metabolomics in chickens infected with Cryptosporidium...

2021中国畜牧兽医学会兽医寄生虫学分会第二届青年科学家学术论坛

作者： xue-mei wu Xin Yang Xian-Cheng Fan Xi Chen Yu-Xin Wang Long-Xian Zhang Jun-Ke Song Guang-Hui Zhao

Cryptosporidium baileyi is an important zoonotic pathogen causing serious respiratory symptoms in chickens,but no effective measures are available to control *** ***,increasing evidence indicates the novelty and usefulness of metabolomics to understand interaction between pathogens and hosts,and to search new diagnostic or pharmacological biomarkers of complex *** present study aimed to reveal the impact of *** infection on the serum metabolism of chickens,and to search several metabolites as potential diagnostic biomarkers for *** *** the present study,the ultra performance liquid chromatography-mass spectrometry(UPLC-MS) and subsequent multivariate statistical analysis were applied to investigate the metabolomics profiles in the serum samples of chickens infected with ***,and to identify potential metabolites that can be used to distinguish chickens infected with *** from non-infected *** statistics identified 138 differential serum metabolites between mock and infected chickens at 5 days post infection(dpi),including 115 up-regulated and 23 down-regulated *** metabolites were significantly enriched into 6 pathways,and 2 pathways associated with energy and lipid metabolism were the most enriched,namely glycerophospholipid metabolism and sphingolipid ***,some important immune-related pathways were also significantly enriched,including intestinal immune network for IgA production,autophagy,and cellular ***,9 potential *** responsive metabolites were identified,including choline,sirolimus,all-trans-Retinoic acid,PC(14:0/22:1(13 Z)),PC(15:0/22:6(4 Z,7 Z,10 Z,13 Z,16 Z,19 Z)),PE(16:1(9 Z)/24:1(15 Z)),phosphocholine,SM(d18:0/16:1(9 Z)(OH)) and *** is the first report on serum metabolic profilings of chickens during *** early infection,and the findings in the present study provide novel insights for revealing pathop

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基于数字信号处理器的指数加减速算法仿真

系统仿真学报 2003年第5期15卷 678-680页

作者：康健陶涛梅雪松吴序堂西安交通大学机械工程学院西安710049

通过对指数加减速原理分析,建立了离散时间域的软件加减速公式,并改进了算法,实际应用于自行开发的基于数字信号处理器(DSP)的多轴运动控制器。通过测量运动控制器输出电压以及与MATLAB的数值仿真结果比较,证明了改进的指数加减速算法... 详细信息

通过对指数加减速原理分析,建立了离散时间域的软件加减速公式,并改进了算法,实际应用于自行开发的基于数字信号处理器(DSP)的多轴运动控制器。通过测量运动控制器输出电压以及与MATLAB的数值仿真结果比较,证明了改进的指数加减速算法公式在数控加工中具有实际意义。

关键词：指数加减速数控数值仿真数字信号处理器

模块多变量预测控制及其在羰基合成反应器中的应用

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石油化工 2002年第6期31卷 459-463页

作者：张志刚薛美盛吴刚孙德敏中国科学技术大学自动化系安徽合肥230026

提出了一种模块多变量预测控制算法 ,实现了两个并列运行的羰基合成反应器的约束控制 ,使两个反应器出口的CO分压都保持在工艺约束范围内 ,同时将反应器进料配比控制在反应器在线操作优化软件给出的最佳值附近。运行结果表明 ,这种控制... 详细信息

提出了一种模块多变量预测控制算法 ,实现了两个并列运行的羰基合成反应器的约束控制 ,使两个反应器出口的CO分压都保持在工艺约束范围内 ,同时将反应器进料配比控制在反应器在线操作优化软件给出的最佳值附近。运行结果表明 ,这种控制方案具有很大的灵活性和优秀的控制品质。

关键词：模块多变量预测控制羰基合成反应器应用约束控制多目标优化

丹参川芎嗪注射液治疗非动脉炎性前部缺血性视神经病变临床分析

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国际眼科杂志 2019年第9期19卷 1563-1565页

作者：张武锋王芳吴沂旎吴雪梅冀璐韩治华中国江苏省泰州市第四医院眼科 225300 空军军医大学西京医院眼科中国陕西省西安市710032 陕西省中医医院眼科中国陕西省西安市710003

目的:回顾性研究丹参川芎嗪在非动脉炎性前部缺血性视神经病变(NAION)中的疗效及作用机制。方法:随机选取NAION患者60例,对照组(30例)给予口服醋酸泼尼松片加颞浅动脉旁皮下注射复方樟柳碱注射液治疗;试验组(30例)加用丹参川芎嗪注射液... 详细信息

目的:回顾性研究丹参川芎嗪在非动脉炎性前部缺血性视神经病变(NAION)中的疗效及作用机制。方法:随机选取NAION患者60例,对照组(30例)给予口服醋酸泼尼松片加颞浅动脉旁皮下注射复方樟柳碱注射液治疗;试验组(30例)加用丹参川芎嗪注射液治疗,疗程14d。采用ELISA检测两组患者血浆中IL-1β和TNF-α水平,采用Western blot检测两组患者血浆中Bcl-2和Caspase-3蛋白表达水平。结果:两组患者最佳矫正视力均有提高;试验组患者治疗后血浆中IL-1β和TNF-α水平均比对照组降低(P<0.05);试验组患者血浆Bcl-2、Caspase-3的表达与治疗前相比有差异(P<0.05),且两组间两个蛋白表达有统计学差异(P<0.05)。结论:丹参川芎嗪通过降低体内的炎性水平,抑制细胞凋亡,促进视功能的恢复。

关键词：丹参川芎嗪非动脉炎性前部缺血性视神经病变 IL-1β TNF-α Bcl-2 Caspase-3