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Effects of aniracetam on membrane fluidity and intracellular calcium in synaptosome of young mice brain with amyloid-beta protein 2.-3. treatment and aged mice brain

Effects of aniracetam on membrane fluidity and intracellular...

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中国神经科学学会第四次会员代表大会暨第七届全国学术会议

作者： ya LI~(1,2.3.,Jian-Jun WANG~3.Jing-Xia CAI~2.1 {3. of {2. sciences,Qufu normal University,Qufu 2.3.65 2.Kunming Institute of Zoology,Chinese Academy of sciences,Kunming 6502.3.3.{3. of {2. sciences,Nanjing University,Nanjing 2.0093

Both brain ageing and Amyloid beta protein(Aß) is known to be associated with the decrease of membrane fluidity and the overload of intracellular calcium([Ca]i).Aniracetam is a known nootropic drug,but the underlying mechanisms are not fully *** the present study,we observed the in vitro effects of aniracetam on membrane fluidity and intracellular calcium of synaptosome from hippocampus and frontal cortex of young mice brain with amyloid-beta protein(Aβ) treatment and of aged mice *** fluidity was measured by fluorescence anisotropy of the lipophilic probe 1,6-diphenyl-1,3.5-hexatriene(DPH).The synaptosomal free calcium concentrations([Ca]i) was measured by fluorescent spectrophotometry,and Fura 2.AM was used as an indicator for[Ca]*** results showed that the membrane fluidity of synaptosome in the frontal cortex and hippocampus of 14-months mice brain was significantly lower than that of 3.months mice brain.Aβ2.-3. at 1μmol/L significantly reduced the membrane fluidity of synaptosome in both observed brain regions,*** concentration-dependently enhanced the membrane fluidity of synaptosome in both of aged brain and Aβ2.-3. treated ***,the[Ca]i was significantly increased by Aβ2.-3., and aniracetam(1.0-4.0 mmol/L) can reverse the increased[Ca]i with a concentration-dependent *** suggested that the improvement of aniracetam on membrane dysfunction induced by aging and A(?)A treatment in synaptosomes was related to alteration of[Ca]i.

关键词： aniracetam membrane fluidity amyloid-βprotein 2.-3. synaptosome calcium mice

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Genome assembly of autotetraploid Actinidia arguta highlights adaptive evolution and enables dissection of important economic traits

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Plant Communications 2024年第6期5卷 173-192页

作者： xue-Mei Lu Xiao-Fen Yu Guo-Qiang Li Ming-Hao Qu Huan Wang Chuang Liu Yu-Ping Man Xiao-Han jiang Mu-Zi Li Jian Wang Qi-Qi Chen Rui Lei Cheng-Cheng {2. Yun-Qiu Zhou Zheng-Wang jiang Zuo-Zhou Li Shang Zheng Chang Dong Bai-Lin Wang yan-Xiang sun Hui-Qin Zhang Jie-Wei Li Quan-Hui Mo Ying Zhang Xin Lou Hai-Xu Peng ya-Ting Yi He-Xin Wang Xiu-Jun Zhang Yi-Bo Wang Dan Wang Li Li Qiong Zhang Wen-Xia Wang Yongbo Liu Lei Gao Jin-Hu Wu yan-Chang Wang CAS Key Laboratory of Plant Germplasm Enhancement and Specialty Agriculture Wuhan Botanical GardenChinese Academy of SciencesWuhanHubeiChina Key Laboratory of Western china’s Environmental Systems(Ministry of Education) College of Earth and Environmental SciencesLanzhou UniversityLanzhouGansuChina college of life {2.s University of Chinese Academy of SciencesBeijingChina Wuhan Frasergen Bioinformatics Co. LtdWuhanHubeiChina Institute of Soil and Fertilizer Anhui Academy of Agricultural SciencesHefeiChina college of Agricultural sciences Xichang UniversityXichangSichuanChina Department of Horticulture Heilongjiang Academy of Agricultural SciencesHarbinHeilongjiangChina college of life {2.s Langfang Normal UniversityLangfangHebeiChina Institute of Horticulture Zhejiang Academy of Agricultural SciencesHangzhouZhejiangChina Guangxi Institute of Botany Chinese Academy of SciencesGuilinGuangxiChina Xi’an Botanical Garden of Shaanxi Province Institute of Botany of Shaanxi ProvinceXi’anShaanxiChina Institute of Modern Agricultural Research Dalian UniversityDalianLiaoningChina Bioinformatics Center College of Plant Science and TechnologyBeijing University of AgricultureBeijingChina college of Agriculture Eastern Liaoning UniversityDandongLiaoningChina Dalian Institute of Chemical Physics Chinese Academy of SciencesDalianLiaoningChina State Environmental Protection Key Laboratory of Regional Eco-process and Function Assessment Chinese Research Academy of Environmental SciencesBeijingChina Hubei Hongshan Laboratory WuhanHubeiChina The New Zealand Institute for Plant and Food Research Limited AucklandNew Zealand

Actinidia arguta,the most widely distributed Actinidia species and the second cultivated species in the genus,can be distinguished from the currently cultivated Actinidia chinensis on the basis of its small and smooth fruit,rapid softening,and excellent cold *** evolution of tetraploid Actinidia species and the genetic basis of their important agronomic traits are still ***,we generated a chromosome-scale genome assembly of an autotetraploid male *** *** genome assembly was 2.77 Gb in length with a contig N50 of 9.97 Mb and was anchored onto 116 *** and clustering of 101 geographically representative accessions showed that they could be divided into two geographic groups,Southern and Northern,which first diverged 12.9 million years *** underwent two prominent expansions and one demographic bottleneck from the midPleistocene climate transition to the late *** genomics studies using paleoclimate data enabled us to discern the evolution of the species’adaptation to different historical *** genes(AaCEL1,AaPME1,and AaDOF1)related to flesh softening were identified by multi-omics analysis,and their ability to accelerate flesh softening was verified through transient expression assays.A set of genes that characteristically regulate sexual dimorphism located on the sex chromosome(Chr3.or autosomal chromosomes showed biased expression during stamen or carpel *** chromosome-level assembly of the autotetraploid *** genome and the genes related to important agronomic traits will facilitate future functional genomics research and improvement of ***.

关键词： kiwiberry dioecism adaptive evolution paleoclimate GEA rapid softening

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低盐压力下缢蛏血淋巴蛋白的比较蛋白质组学研究

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吉林农业大学学报 2004年第3期26卷 272-274,279页

作者：张鹭陈寅山彭宣宪齐齐哈尔大学生命科学院齐齐哈尔161005 福建师范大学生物工程学院福州350007 厦门大学生命科学院厦门361005

应用双向聚丙烯酰胺凝胶电泳技术及图像分析技术寻找缢蛏在低盐环境压力下血淋巴内40kD以下小分子蛋白质组差异,制成肽质指纹图谱,MALDI-TOF-MS测序,通过数据库检索快速鉴定蛋白质或多肽。研究结果表明:低盐压力下,缢蛏血淋巴内有多种... 详细信息

应用双向聚丙烯酰胺凝胶电泳技术及图像分析技术寻找缢蛏在低盐环境压力下血淋巴内40kD以下小分子蛋白质组差异,制成肽质指纹图谱,MALDI-TOF-MS测序,通过数据库检索快速鉴定蛋白质或多肽。研究结果表明:低盐压力下,缢蛏血淋巴内有多种蛋白质发生变化,共鉴定出包括磷脂酶A2.Phospho lipaseA2.、锌指蛋白(ZincFingerProtein)等6种蛋白或多肽,其功能涉及营养、基因表达及蛋白合成调控等方面,说明其血淋巴在缢蛏的防御体系中具有关键性作用。

关键词：缢蛏血淋巴双向电泳质谱低盐蛋白质

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Response of solar energy translation in chloroplast of rice seedings with different salt tolerance to salt stress

Response of solar energy translation in chloroplast of rice ...

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2.07中国植物生理学会全国学术会议

作者： Zhou Bin-Wei~(1*) Zhang ya~1 Wang Ren-Lei~(1,2.*) Liu Qin~1 Xu yan-Li~1 (1 {2. of life sciences,Nanjing normal University,Nanjing,jiangsu,2.0046) (2.jiangsn Food science {2.,Huaian,jiangsu,2.3.01,china)

＜正＞Response of solar energy translation in chloroplast of rice seedings（Pokkali,salt-tolerant and Peta,salt- sensitive）to salt stress were *** results showed that the net photosynthetic rate and the O2.evolution of chloroplast and contents of ATP in chloroplast decreased with the increasing of translation gradient and day of NaCl stress;Under the 100mmol/LNaCl,ATPase activity of chloroplast first boosted up and then

关键词： rice salt stress chloroplast solar energy translation

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Common Cuckoo(Cuculus canorus)nestlings adapt their begging behavior to the host signal system

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Avian Research 2024年第3期15卷 352-362页

作者： Sabah Mushtaq Puswal Guo Zhong xuan Zhang Longwu Wang Wei Liang Ministry of Education Key Laboratory for Ecology of Tropical Islands Key Laboratory of Tropical Animal and Plant Ecology of Hainan ProvinceCollege of Life SciencesHainan Normal UniversityHaikou571158China School of life sciences Guizhou Normal UniversityGuiyang550001China

Common Cuckoos(Cuculus canorus)dependent on parental care for post-hatching demonstrate an intriguing ability to modify their begging vocalizations to ensure maximum care and resources from their interspecific foster ***,we compared begging calls of the Common Cuckoo nestlings fed by four host species,the Grey Bushchat(Saxicola ferreus),Siberian Stonechat(Saxicola maurus),Daurian Redstart(Phoenicurus auroreus),and Oriental Magpie-robin(Copsychus saularis).Results showed that begging calls of the stonechat-,redstart-,and robin-cuckoo resemble those of host species'nestlings in various aspects like low frequency,high frequency,frequency bandwidth and peak frequency,while the bushchat-cuckoo chicks'begging calls were only comparable to their host species in terms of how long they lasted and their peak *** addition,cuckoo nestlings raised in different host nests displayed significant variations in their begging calls in low and peak *** study suggests that cuckoo nestlings do not mimic host species nestlings'begging calls throughout the nestling period,but may tune their begging calls according to host species,while begging calls vary with cuckoo and host species nestlings'*** research should study the parents'reactions to these calls in different host species for a better understanding of the mechanisms underlying such adaptations.

关键词： Acoustic tuning Begging call Brood parasitism Cuckoo Coevolution

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单分散纳米级胶体金的合成

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陕西师范大学学报（自然科学版） 2003年第2期31卷 71-73页

作者：杨文玉崔亚丽代丽君陕西师范大学化学与材料科学学院陕西西安710062

利用柠檬酸钠还原四氯合金酸的方法(简称Frens方法)制备了一系列单分散性、粒径小的胶体金,并应用透射电镜和紫外可见分光光度法对不同粒径纳米金进行了表征.结果表明,在0.01%四氯合金酸2.mL的条件下,应用不同体积的1%柠檬酸三钠作为... 详细信息

利用柠檬酸钠还原四氯合金酸的方法(简称Frens方法)制备了一系列单分散性、粒径小的胶体金,并应用透射电镜和紫外可见分光光度法对不同粒径纳米金进行了表征.结果表明,在0.01%四氯合金酸2.mL的条件下,应用不同体积的1%柠檬酸三钠作为还原剂,可得到粒径范围在10～45nm的胶体金,且随着粒度的增大,胶体金在可见区的最大吸收峰呈红移趋势.当还原剂用量减少至80μL时,得到的胶体金粒径不再均一,说明该法更容易制备粒径小于50nm的胶体金.

关键词：单分散纳米级胶体金合成纳米科技制备方法 Frens方法柠檬酸钠四氯合金酸

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The effects of perinatal exposure to bisphenol-A on NMDA receptor expression in hippocampus of male rat offspring

The effects of perinatal exposure to bisphenol-A on NMDA rec...

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中国神经科学学会第四次会员代表大会暨第八届全国学术会议

作者： Xiao-Hong XU~(1 2.*) ya-Min WANG~1 Jing ZHANG~1 Qing-Qing LUO~1 Yin-Ping YE~1 Qin RUAN~1 1 Chemistry and life {2.s college Zhejiang normal University Jinhua 3.0}004 china 2.Institute of Psychology Zhejiang normal University Jinhua 3.0}004 china

＜正＞Objective Bisphenol-A（BPA） is one of the most common environmental endocrine disrupters with mixed estrogen agonist/antagonist *** toxicity of BPA has been extensively evaluated in a variety of tests in rodents, including developmental and reproductive toxicity,and *** objective of the present investigation is to evaluate whether or not perinatal maternal exposure to BPA affects NMDA receptor（NMDAR） subunits,estrogen receptorβ（ERβ）,and aromatase cytochrome P450（P450arom） protein expressions of male rat offspring during postnatal *** After pregnancy,dams were orally（ig） exposed to BPA dissolved in sesame oil（2.0,50,5,or 0.5 mg/kg/d） or only sesame oil as a vehicle control from gestational day 7 through postnatal day（PND） *** male pups were sacrificed on PND 4,7,14,2.,and 56 *** hippocampus of the brain was *** expressions of NMDAR subunits NR1,NR2.,2.,ERβ,and P450arom were detected by Western blotting（n=5）.The Western blots intensity was determined by a computer image analysis ***（1） The expression of NMDAR subunits NR1, NR2.,2. in the hippocampus was increased gradually after birth and peaked during postnatal 2.3.weeks,then decreased *** exposure to BPA significantly affected the expression of NMDAR subunits during the developmental *** the lower dosage（0.05～50 mg/kg/d）,BPA dosage-dependently inhibited the expression of NMDAR subunits. However,the effects of BPA on these subunits were different at the higher dose（2.0 mg/kg/d）,with a strongest inhibition of NR1 expression（P＜0.01 or P＜0.001） and a slighter inhibition of NR2.,2. expression（P＜0.05 or P＜0.01） compared with the lower dosages of *** addition,BPA changed the component of NMDAR subunits in the *** rates of NR2.A/NR1,NR2./NR1 were increased by 2.0 mg/kg/d of BPA,but was decreased by the lower doses of BPA when compared with the control.（2. In the control,ERβprotein was expressed in the hippoc

关键词： Bisphenol-A NMDA receptor estrogen receptor beta aromatase cytochrome P450 hippocampus

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Zinc lactate alleviates oxidative stress by modulating crosstalk between constitutive androstane receptor signaling pathway and gut microbiota profile in weaned piglets

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Animal Nutrition 2024年第1期16卷 23-33页

作者： Wenjie Tang xuan Xiang Houfu Wang Wentao Zhou Liuqin He Yulong Yin Tiejun Li college of Animal science and Technology Hunan Agricultural UniversityChangsha 410128China Hunan Provincial Key Laboratory of Animal Nutritional Physiology and Metabolic Process CAS Key Laboratory of Agro-Ecological Processes in Subtropical RegionNational Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry ProductionInstitute of Subtropical AgricultureChinese Academy of SciencesChangsha 410125China Hunan Provincial Key Laboratory of Animal Intestinal Function and Regulation Laboratory of Animal Nutrition and Human HealthCollege of Life SciencesHunan Normal UniversityChangsha 410081China college of Advanced Agricultural science University of Chinese Academy of SciencesBeijing 100049China Sichuan Academy of Animal sciences Animal Breeding and Genetics Key Laboratory of Sichuan ProvinceChengdu 610066China Livestock and Poultry Biological Products Key Laboratory of Sichuan Province Sichuan Animtech Feed Co.LtdChengdu 610000China

This study aimed to determine the regulatory mechanism of dietary zinc lactate(ZL)supplementation on intestinal oxidative stress damage in a paraquat(PQ)-induced piglet ***-eight piglets(mean body weight 9.51±0.2. kg)weaned at 2. d of age were randomly divided into control,ZL,PQ,and ZL+PQ groups(n=7 in each group).The ZL-supplemented diet had little effect on growth performance under normal physiological ***,under PQ challenge,ZL supplementation significantly improved average {3.ly gain(P1(ZO-1)(P2.(P1)in PQ-induced piglets and altered the structure of the gut microbiota,especially by significantly increasing the abundance of beneficial gut microbes,including UCG_002.Ruminococcus,Rikenellaceae_RC9_gut_group,Christensenellaceae_R_7_group,Treponema,unclassified_Christensenellaceae,and unclassified_Erysipelotrichaceae(P2. and gut microbiota.

关键词： Zinc lactate Intestinal barrier Oxidative stress Inflammation Constitutive androstane receptor Gut microbiota

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Vitamin D status and its relationship between body composition and bone mass in central south Chinese postmenopausal women

Vitamin D status and its relationship between body compositi...

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中华医学会第六次全国骨质疏松和骨矿盐疾病学术会议暨中华医学会骨质疏松和骨矿盐疾病分会成立十周年

作者： Shuang Li~1,Zhimin Zhang~1,Hongbing Zhang~1,Zhifeng Sheng~(1,2.,Eryuan Liao~1 1 Institute of Metabolism and Endocrinology,the Second Xiang-ya Hospital,Central South University 2.Key Laboratory of Protein Chemistry and Developmental Biology of Education Ministry of {2.,college of life science,Hunan normal university

Aims This study aims to assess the vitamin D status and its relationship between body composition and bone mass in central south Chinese postmenopausal women. Methods 779 healthy central southern Chinese(2.°N)postmenopausal women(age 50-71 yrs) were involved in this cross-sectional *** X-ray absorptiometry was used to measure the

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大鼠前列腺素D合成酶在毕赤酵母中的表达及其在精子中的分布

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生物工程学报 2004年第6期20卷 896-900页

作者：陈德宇周开亚黄宇烽南京师范大学生命科学院南京军区总医院生殖遗传实验室南京210002

研究大鼠L PGDS在毕氏酵母中的表达 ,探讨L PGDS在大鼠精子中的分布。以大鼠睾丸mRNA为模板 ,经逆转录获得L PGDS全长和成熟基因片段。将该基因片段克隆到pPIC9载体上 ,将重组表达质粒转化巴斯德毕赤酵母 (Pichiapastoris)GS115 ,筛选mu... 详细信息

研究大鼠L PGDS在毕氏酵母中的表达 ,探讨L PGDS在大鼠精子中的分布。以大鼠睾丸mRNA为模板 ,经逆转录获得L PGDS全长和成熟基因片段。将该基因片段克隆到pPIC9载体上 ,将重组表达质粒转化巴斯德毕赤酵母 (Pichiapastoris)GS115 ,筛选mut+ 表型 ,经甲醇诱导实现L PGDS的分泌表达。用SDS PAGE分析L PGDS的分子量 ,用PAS反应鉴定糖链 ,用免疫组织化学法研究L PGDS的分布 ,用Westernblot分析重组L PGDS与精浆中L PGDS。筛选出 4株表达水平较高的酵母工程菌株 ,SDS PAGE分析表明 ,产物分子量约为 2.7kD ;L

关键词：前列腺素D合成酶毕赤酵母分布

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