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Non-cell autonomous role of astrocytes in axonal degeneration of cortical projection neurons in hereditary spastic paraplegias

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Neural Regeneration Research 2022年第6期17卷 1265-1266页

作者： xue-jun li Department of Biomedical Sciences University of Illinois College of Medicine RockfordRockfordILUSA Department of Bioengineering University of Illinois at ChicagoChicagoILUSA

Impai red axonal deve lopment and degeneration underlie many debilitating diseases,including hereditary spastic paraplegia(HSP).HSPs are a heterogeneous group of neurogenetic disorders characterized by axonopathy of cortical motor neurons(Fink,2006;Blackstone et al.,2010).The axonal degeneration of these cortical projection neurons(PNs)in HSP patients disrupts the signals from brain to spinal motor neurons,leading to muscle weakness and *** the discovery of the first HSP gene(SPAST)in 1999,over 80 distinct genetic loci associated with HSP have been *** the mutations of these divergent genes specifically result in axonal degeneration of cortical PNs remains largely unclear,which contributes to the lack of effective treatment to ameliorate,stop,or reverse axonal defects in HSPs.

关键词： degeneration axonal projection

Rescue axonal defects by targeting mitochondrial dynamics in hereditary spastic paraplegias

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Neural Regeneration Research 2019年第4期14卷 574-577页

作者： Yongchao Mou xue-jun li Department of Biomedical Sciences University of Illinois College of Medicine Rockford Department of Bioengineering University of Illinois at Chicago

Impaired axonal development and degeneration underlie debilitating neurodegenerative diseases including hereditary spastic paraplegia, a large group of inherited diseases. Hereditary spastic paraplegia is caused by retrograde degeneration of the long corticospinal tract axons, leading to progressive spasticity and weakness of leg and hip muscles. There are over 70 subtypes with various underlying pathophysiological processes, such as defective vesicular trafficking, lipid metabolism, organelle shaping, axonal transport, and mitochondrial dysfunction. Although hereditary spastic paraplegia consists of various subtypes with different pathological characteristics, defects in mitochondrial morphology and function emerge as one of the common cellular themes in hereditary spastic paraplegia. Mitochondrial morphology and function are remodeled by mitochondrial dynamics regulated by several key fission and fusion mediators. However, the role of mitochondrial dynamics in axonal defects of hereditary spastic paraplegia remains largely unknown. Recently, studies reported perturbed mitochondrial morphology in hereditary spastic paraplegia neurons. Moreover, downregulation of mitochondrial fission regulator dynamin-related protein 1, both pharmacologically and genetically, could rescue axonal outgrowth defects in hereditary spastic paraplegia neurons, providing a potential therapeutic target for treating these hereditary spastic paraplegia. This mini-review will describe the regulation of mitochondrial fission/fusion, the link between mitochondrial dynamics and axonal defects, and the recent progress on the role of mitochondrial dynamics in axonal defects of hereditary spastic paraplegia.

关键词： hereditary spastic paraplegia axonal degeneration mitochondrial dynamics fission fusion dynamin-related protein 1 mitochondrial dysfunction induced pluripotent stem cells

Future Strategies on Glioma Research:From Big Data to the Clinic

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Genomics, Proteomics & Bioinformatics 2017年第4期15卷 263-265页

作者： Hang Cao Feiyifan Wang xue-jun li Department of Neurosurgery Xiangya HospitalCentral South UniversityChangsha 410008China

Glioma, as the most common and aggressive malignant central nervous system （CNS） tumor with generally poor prognosis, has been attracting much attention in the last decade [1]. Temozolomide was firstly available in the United States in 1999 as a chemotherapy drug for treating brain cancers and remains as the first-line treatment for glioma. The World Health Organization （WHO） classified glioma into four main grades according to the degree of malignancy in 2007, which were updated in 2016 with the introduction of significant molecular alternations. Also in 2016, the Chinese Glioma Cooperative Group （CGCG） published the first guideline for adult diffuse gliomas [2], representing the only national consensus for the diagnosis and treatment of adult gliomas up till nOW.

关键词： From Big Data to the Clinic Future Strategies on Glioma Research GBM IDH

Investigation of Induced Unbalance Magnitude on Dynamic Characteristics of High-speed Turbocharger with Floating Ring Bearings

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Chinese Journal of Mechanical Engineering 2018年第5期31卷 99-109页

作者： Guang-Fu Bin Yuan Huang Shuai-Ping Guo xue-jun li Gang Wang Health Maintenance for Mechanical Equipment Key Lab of Hunan Province Hunan University of Science and Technology Xiangtan 411201 China Department of Mechanical and Aerospace Engineering The University of Alabama in Huntsville AL 35899 USA

Due to operational wear and uneven carbon absorption in compressor and turbine wheels, the unbalance(me) vibration is induced and could lead to sub?synchronous vibration accidents for high?speed turbocharger(TC). There are very few research works that focus on the magnitude e ects on such induced unbalance vibration. In this paper, a finite element model(FEM) is developed to characterize a realistic automotive TC rotor with floating ring bearings(FRBs). The nonlinear dynamic responses of the TC rotor system with di erent levels of induced unbalance magni?tude in compressor and turbine wheels are calculated. From the results of waterfall and response spectral intensity plots, the bifurcation and instability phenomena depend on unbalance magnitude during the startup of TC. The sub?synchronous component 0.12× caused rotor unstable is the dominant frequency for small induced unbalance. The nonlinear e ects of induced unbalance in the turbine wheel is obvious stronger than the compressor wheel. As the unbalance magnitude increases from 0.05 gbration 1·mm to 0.2 g·mm, the vibration component changes from mainly 0.12× to synchronous vi×. When unbalance increases continuously, the rotor vibration response amplitude is rapidly growing and the 1× caused by the large unbalance excitation becomes the dominant frequency. A suitable un?balance magnitude of turbine wheel and compressor wheel for the high?speed TC rotor with FRBs is proposed: the value of induced un?balance magnitude should be kept around 0.2 g·mm.

关键词： High?speed TC with FRBs Induced unbalance magnitude Nonlinear dynamic response Sub?synchronous vibration Stability

Metabolic Regulation of Mammary Gland Epithelial Cells of Dairy Cow by Galactopoietic Compound Isolated from Vaccariae segetalis

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Agricultural Sciences in China 2011年第7期10卷 1106-1116页

作者： TONG Hui-li GAO xue-jun li Qing-zhang liU Jie li Nan WAN Zhong-ying Key Laboratory of Dairy Science Ministry of Education/Life College Northeast Agricultural University Harbin 150030 P.R.China

In previous experiment, we isolated a compound dibutyl phthalate （DBP） from Vaccaria segetalis which had galactopoietic function on mammary gland epithelial cells of dairy cow （DCMECs）. In this experiment, we ascertained the metabolic regulation function of DBP on DCMECs. Many genes related to lactation including Stat5, AMPK, b-casein, Glut1, SREBP-1, PEPCK, and ACC were detected by real-time PCR. Furthermore, Stat5 and AMPK were detected by Western blot and immunofluorescence co-localization, respectively. The results showed that DBP stimulates the expression of Stat5 and p-Stat5, thus activates Stat5 cell signal transduction pathway and stimulates b-casein synthesis. DBP also raises the activities of Glut1 and AMPK to stimulate glucose uptake and glycometabolism and activates the expression of AMPK downstream target genes PEPCK and ACC and expression of SREBP-1 to stimulate milk fat synthesis. In addition, the activities of HK, G-6-PDH, ICDH, ATPase, and energy charges were stimulated by DBP to increase the energy metabolism level of DCMECs. The results showed DBP stimulates energy metabolism related to galactopoietic function in DCMECs.

关键词： Vaccaria segetalis DBP dairy cow mammary gland epithelial cell metabolic regulation

Microbiome changes in esophageal cancer:implications for pathogenesis and prognosis

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Cancer Biology & Medicine 2024年第2期21卷 163-174页

作者： Yi li Bing Wei Xia xue Hongle li jun li Department of Molecular Pathology Clinical Pathology CenterAffiliated Cancer Hospital of Zhengzhou University and Henan Cancer HospitalZhengzhou 450003China Henan Key Laboratory of Molecular Pathology Zhengzhou 450003China Henan Key Laboratory of Helicobacter pylori&Microbiota and Gastrointestinal Cancer Marshall Medical Research CenterThe Fifth Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China

Esophageal cancer(EC)is an aggressive malignancy with a poor *** factors,including dietary habits,and antacid and antibiotic use,have been shown to influence the esophageal ***,enrichment and diversity of the esophageal microbiome can also impact its *** studies have revealed prevalent changes in the esophageal microbiome among patients with EC,thus suggesting the potential contribution of the esophageal microbiome to EC ***,distinct microbiome compositions have been observed in patients with different responses to radiotherapy and chemotherapy,indicating the role of the esophageal microbiome in modulating treatment *** this review,we have examined previous studies on the esophageal microbiome in healthy individuals and patients with EC or other esophageal diseases,with a focus on identifying microbial communities associated with EC pathogenesis and *** the role of the microbiome in EC may aid in early detection and optimized treatment strategies,ultimately leading to better outcomes for patients.

关键词： Esophageal cancer microbiome dysbiosis microenvironment carcinogenesis

Unraveling role of double-exchange interaction in electrochemical water oxidation by external magnetic field

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Rare Metals 2024年第1期43卷 289-297页

作者： jun li jun-Ming li Hong Hong Dong-xue liu Qing-Qi Cao Dun-Hui Wang National Laboratory of Solid State Microstructures and Jiangsu Provincial Key Laboratory for Nanotechnology Nanjing UniversityNanjing 210093China School of Electronics and Information Hangzhou Dianzi UniversityHangzhou 310018China

Double-exchange(DE) interaction plays an important role in electrocatalytic oxygen evolution reaction(OER).However,precise achievement of DE interaction often requires foreign dopants or vacancy engineering,leading to destabilization of the catalysts and deterioration of *** contrast,the utilization of environmentally friendly,contactless,and continuously adjustable magnetic fields to study the OER process is profitable to avoid aforementioned interference factors and further elucidate the direct relationship_(0.5)between DE interaction and OER ***,by using cobalt hydroxide carbonate(Co(OH)(CO_(3))·xH_(2)O,CoHC) nanostructures as a proof-of-concept study,external magnetic fields are carefully implemented to verify the role of DE interaction during water oxidation *** studies reveal that external magnetic fields effectively enhance the reaction rate of the catalyst,the overpotential decreases from 386 to 355 mV(100 mA·cm^(-2)),while Tafel slopes drastically decline from 93 to 67 mV·dec^(-1)(1.0 T).Moreover,magnetic field increment exhibits robust *** in situ Raman and impedance measurements under external field,it can be found that magnetic field promotes the electron migration between Co^(2+) and Co^(3+) in the CoHC catalysts with the assistance of DE interactions,thus boosting the OER efficiency.

关键词： Magnetic field Double-exchange(DE)interaction Electrocatalysis Oxygen evolution reaction(OER) Cobalt hydroxide carbonate

Modeling axonal defects in hereditary spastic paraplegia with human pluripotent stem cells

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Frontiers in Biology 2016年第5期11卷 339-354页

作者： Kyle R. Denton Chongchong Xu Harsh Shah xue-jun li Department of Neuroscience University of Connecticut Health Center Farmington CT 06030 USA Department of Biomedical Sciences University of Illinois College of Medicine at Rockford IL 61107 USA MD program College of Medicine at Rockford IL 61107 USA MD program College of Medicine at Rockford IL 61107 USA Department of Btoengmeertng University of Illinois at Chicago IL 60607 USA

BACKGROUND： Cortical motor neurons, also known as upper motor neurons, are large projection neurons whose axons convey signals to lower motor neurons to control the muscle movements. Degeneration of cortical motor neuron axons is implicated in several debilitating disorders including hereditary spastic paraplegia （HSP）. Since the discovery of the first HSP gene, SPASTthat encodes spastin, over 70 distinct genetic loci associated with HSP have been identified. How the mutations of these functionally diverse genes result in axonal degeneration and why certain axons are affected in HSP remain largely unknown. The development of induced pluripotent stem cell （iPSC） technology has provided researchers an excellent resource to generate patient-specific human neurons to model human neuropathological processes including axonal defects. METHODS： In this article, we will first review the pathology and pathways affected in the common forms of liSP subtypes by searching the PubMed database. We will then summarize the findings and insights gained from studies using iPSC-based models, and discuss challenges and future directions. RESULTS： HSPs, a heterogeneous group of genetic neurodegenerative disorders, exhibit similar pathological changes that result from retrograde axonal degeneration of cortical motor neurons. Recently, iPSCs have been generated from several common forms of HSP including SPG4, SPG3A, and SPG11 patients. Neurons derived from HSP iPSCs exhibit impaired neurite outgrowth, increased axonal swellings, and reduced axonal transport, recapitulating disease-specific axonal defects. CONCLUSIONS： These patient-derived neurons offer a unique tool to study the pathogenic mechanisms and explore the treatments for rescuing axonal defects in HSP, as well as other diseases involving axonopathy.

关键词： HSP axonal degeneration pluripotent stem cells spastin atlastin-1

Toward a fundamental understanding of the heterogeneous multiphysics behaviors of silicon monoxide/graphite composite anodes

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Carbon Energy 2024年第1期6卷 142-158页

作者： Xiang Gao Suli li Jiachen xue Dianyang Hu jun Xu Department of Mechanical Engineering and Engineering Science University of North Carolina at CharlotteCharlotteNorth CarolinaUSA Vehicle Energy and Safety Laboratory(VESL) Battery ComplexityAutonomous Vehicleand Electrification(BATT CAVE)Research CenterUniversity of North Carolina at CharlotteCharlotteNorth CarolinaUSA Zhuhai CosMX Battery Co.Ltd. ZhuhaiGuangdongChina School of Data Science University of North Carolina at CharlotteCharlotteNorth CarolinaUSA

Silicon monoxide(SiO)(silicon[Si]mixed with silicon dioxide[SiO_(2)])/graphite(Gr)composite material is one of the most commercially promising anode materials for the next generation of high-energy-density lithium-ion *** major bottleneck for SiO/Gr composite anode is the poor cyclability arising from the stress/strain behaviors due to the mismatch between two heterogenous materials during the lithiation/delithiation *** date,a meticulous and quantitative understanding of the highly nonlinear coupling behaviors of such materials is still ***,an electro–chemo–mechanics-coupled detailed model containing particle geometries is *** underlying mechanism of the regulation between SiO and Gr components during electrochemical cycling is quantitatively *** discover that increasing the SiO weight percentage(wt%)reduces the utilization efficiency of the active materials at the same 1C rate charging and enhances the hindering effects of stress-driven flux on *** addition,the mechanical constraint demonstrates a balanced effect on the overall performance of cells and the local behaviors of *** study provides new insights into the fundamental interactions between SiO and Gr materials and advances the investigation methodology for the design and evaluation of next-generation high-energydensity batteries.

关键词： interactions lithium-ion batteries mechanical constraint multiphysics modeling Si-based anode