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[Research progress on the mechanism of acupuncture on depression based on signaling pathway regulation]

Zhen ci yan jiu = Acupuncture research 2024年第10期49卷 1100-1106页

作者： Min Xiao Xing-Ke Yan Peng-Fei Li xue-jiao ma Chong-Bing ma College of Acupuncture-Moxibustion and Tuina Gansu University of Chinese Medicine Lanzhou 730000 China. Pain Department of Acupuncture and Moxibustion The Affiliated Hospital of Gansu University of Chinese Medicine Lanzhou 730000. College of Acupuncture-Moxibustion and Tuina Gansu University of Chinese Medicine Lanzhou 730000 China. mcbrain@***.

Depression is high in prevalence rate, recurrence rate and disability rate. Acupuncture is effective on depression. The paper reviewed the regulatory effect of acupuncture on five prominent signaling pathways, i.e. mitogen activated protein kinase (maPK), Wnt/β-catenin, Notch, adenyl ate cyclase/cyclic adenosine phosphate/protein kinase (AC/cAMP/PKA) and NO/cyclic guanosine monophosphate (cGMP)； and elaborated the structure of each signaling pathway, the association with depression onset, and the relevant research progress of acupuncture in treatment of depression. In view of the regulation of signal pathways, acupuncture can up-regulate AC/cAMP/PKA and extracellular signal-regulated kinase (ERK), promote the expression of neurotrophic factors or Bcl-2, prevent from and repair neuronal damage, advance neurogenesis and improve synaptic plasticity； it can modulate the Wnt/β-catenin and Notch signal pathways to protect neurons and increase cell proliferation； and down-regulate JNK and up-regulate NO/cGMP signal pathways to inhibit stress that leads to abnormal apoptosis of neurosis and attenuate neurotoxicity and neuronal damage so that anti-depression of acupuncture is obtained. This review provides a new approach to the mechanism research of acupuncture in treatment of depression through regulating the relevant single pathways.

关键词： Acupuncture Depression Molecular mechanism Signaling pathway

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Flexible,high-density,laminated ECoG electrode array for high spatiotemporal resolution foci diagnostic localization of refractory epilepsy

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Bio-Design and manufacturing 2024年第4期7卷 388-398页

作者： Yafeng Liu Zhouheng Wang Yang jiao Ying Chen Guangyuan Xu Yinji ma xue Feng Applied Mechanics Laboratory Department of Engineering MechanicsTsinghua UniversityBeijing 100084China Laboratory of Flexible Electronics Technology Tsinghua UniversityBeijing 100084China College of Artificial Intelligence Southwest UniversityChongqing 400715China Institute of Flexible Electronics Technology of THU Jiaxing 314000China Qiantang Science and Technology Innovation Center Hangzhou 310016China School of Artificial Intelligence Beijing University of Posts and TelecommunicationsBeijing 100876China

High spatiotemporal resolution brain electrical signals are critical for basic neuroscience research and high-precision focus diagnostic localization,as the spatial scale of some pathologic signals is at the submillimeter or micrometer *** entails connecting hundreds or thousands of electrode wires on a limited *** study reported a class of flexible,ultrathin,highdensity electrocorticogram(ECoG)electrode *** challenge of a large number of wiring arrangements was overcome by a laminated structure design and processing technology *** flexible,ultrathin,high-density ECoG electrode array was conformably attached to the cortex for reliable,high spatial resolution electrophysiologic *** minimum spacing between electrodes was 15μm,comparable to the diameter of a single *** hundred electrodes were prepared with an electrode density of 4444 mm^(-2).In focal epilepsy surgery,the flexible,high-density,laminated ECoG electrode array with 36 electrodes was applied to collect epileptic spike waves inrabbits,improving the positioning accuracy of epilepsy lesions from the centimeter to the submillimeter *** flexible,high-density,laminated ECoG electrode array has potential clinical applications in intractable epilepsy and other neurologic diseases requiring high-precision electroencephalogram acquisition.

关键词： Electrocorticogram(ECoG)electrode Epilepsy High density High resolution Laminated structure

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Synthesis of uniform two-dimensional MoS_(2) films via thermal evaporation

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Nano Research 2024年第4期17卷 3217-3223页

作者： xue-Wei Lu Zhewei Li Chen-Kai Yang Weijia Mou Liying jiao Key Laboratory of Organic Optoelectronics and Molecular Engineering of the Ministry of Education Department of ChemistryTsinghua UniversityBeijing 100084China

Two-dimensional(2D)molybdenum disulfide(MoS_(2))holds great potential for various applications such as electronic devices,catalysis,lubrication,anti-corrosion and so *** evaporation is a versatile thin film deposition technique,however,the conventional thermal evaporation techniques face challenges in producing uniform thin films of MoS_(2) due to its high melting temperature of 1375℃.As a result,only thick and rough MoS_(2) films can be obtained using these *** address this issue,we have designed a vacuum thermal evaporation system specifically for large-scale preparation of MoS_(2) thin *** using K2MoS4 as the precursor,we achieved reliable deposition of uniform polycrystalline MoS_(2) thin films with a size of 50 mm×50 mm and controllable thickness ranging from 0.8 to 2.4 *** approach also allows for patterned deposition of MoS_(2) using shadow masks and sequential deposition of MoS_(2) and tungsten disulfide(WS_(2)),similar to conventional thermal evaporation ***,we have demonstrated the potential applications of the obtained MoS_(2) thin films in field effect transistors(FETs),memristors and electrocatalysts for hydrogen evolution reaction(HER).

关键词： thermal evaporation molybdenum disulfide two-dimensional memristors hydrogen evolution reaction

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A review of vehicle detection methods based on computer vision

Journal of Intelligent and Connected Vehicles

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Journal of Intelligent and Connected Vehicles 2024年第1期7卷 1-18页

作者： Changxi ma Fansong xue School of Traffic and Transportation Lanzhou Jiaotong UniversityLanzhou 730070China Key Laboratory of Railway Industry on Plateau Railway Transportation Intelligent management and Control Lanzhou 730070China

With the increasing number of vehicles,there has been an unprecedented pressure on the operation and maintenance of intelligent transportation systems and transportation *** order to achieve faster and more accurate identification of traffic vehicles,computer vision and deep learning technology play a vital role and have made significant *** study summarizes the current research status,latest findings,and future development trends of traditional detection algorithms and deep learning-based detection *** the detection algorithms based on deep learning,this study focuses on the representative convolutional neural network ***,it examines the two-stage and one-stage detection algorithms,which have been extensively utilized in the field of intelligent transportation *** to traditional detection algorithms,deep learning-based detection algorithms can achieve higher accuracy and *** single-stage detection algorithm is more efficient for real-time detection,while the two-stage detection algorithm is more accurate than the single-stage detection *** the follow-up research,it is important to consider the balance between detection efficiency and detection ***,vehicle missed detection and false detection in complex scenes,such as bad weather and vehicle overlap,should be taken into *** will ensure better application of the research findings in engineering practice.

关键词： intelligent transportation system computer vision deep learning vehicle detection object detection algorithm

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Effect of heat treatment on the microstructure,mechanical properties and fracture behaviors of ultra-high-strength SiC/Al-Zn-Mg-Cu composites

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International Journal of Minerals,Metallurgy and materials 2024年第10期31卷 2233-2243页

作者： Guonan ma Shize Zhu Dong Wang Peng xue BolüXiao Zongyi ma Shi-changxu Innovation Center for Advanced materials Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China Centre of Excellence for Advanced materials Dongguan 523808China

A high-zinc composite,12vol%SiC/Al-13.3 Zn-3.27 Mg-1.07Cu(wt%),with an ultra-high-strength of 781 MPa was success-fully fabricated through a powder metallurgy method,followed by an extrusion *** effects of solid-solution and aging heat treat-ments on the microstructure and mechanical properties of the composite were extensively *** with a single-stage sol-id-solution treatment,a two-stage solid-solution treatment(470℃/1 h+480℃/1 h)exhibited a more effective solid-solution strengthen-ing owing to the higher degree of solid-solution and a more uniform *** to the aging hardness curves of the com-posite,the optimized aging parameter(100℃/22 h)was *** the aging temperature and time resulted in finer and more uniform nanoscale precipitates but only yielded a marginal increase in tensile *** fractography analysis revealed that intergranu-lar cracking and interface debonding were the main fracture mechanisms in the ultra-high-strength SiC/Al-Zn-Mg-Cu *** regions,such as the SiC/Al interface containing numerous compounds and the precipitate-free zones at the high-angle grain boundaries,were identified as significant factors limiting the strength enhancement of the *** compounds,including MgO,MgZn2,and Cu5Zn8,reduced the interfacial bonding strength,leading to interfacial debonding.

关键词： metal matrix composites heat treatment interfacial reaction mechanical properties fracture mechanism

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Radial growth in Qinghai spruce is most sensitive to severe drought in the Qilian Mountains of Northwest China

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Journal of Forestry Research 2024年第3期35卷 73-86页

作者： Xuge Wang Liang jiao Ruhong xue Peng Zhang Dashi Du Mengyuan Wei Qian Li College of Geography and Environmental Science Northwest Normal UniversityNo.967Anning East RoadLanzhou 730070People's Republic of China Key Laboratory of Resource Environment and Sustainable Development of Oasis Northwest Normal UniversityLanzhou 730070Gansu ProvincePeople's Republicof China

Global warming and frequent extreme drought events lead to tree death and extensive forest decline,but the underlying mechanism is not *** drought years,cambial development is more sensitive to climate change,but in different phenological stages,the response rela-tionship is ***,the dynamic relationship between tree radial growth and climatic/environmental fac-tors needs to be *** thus continuously monitored radial growth of Qinghai spruce(Picea crassifolia Kom.)and environmental factors from January 2021 to November 2022 using point dendrometers and portable meteorological weather stations in the central area of the Qilian *** relationship and stability between the radial growth of Qinghai spruce and environmental factors were compared for different levels of drought in 2021 and *** year 2022 had higher temperatures and less precipitation and was drier than *** with 2021,the growing period in 2022 for Qinghai spruce was 10 days shorter,maximum growth rate(Grmax)was 4.5μm·d^(-1) slower,and the initiation of growth was 6 days *** of Qinghai spruce was always restricted by drought,and the stem radial increment(SRI)was more sensitive to precipitation and air relative *** changes in cumulative radial growth were divided into four phenological stages according to the time of growth onset,cessation,and maximum growth rate(Grmax)of Qinghai *** responses of SRI to climate change were stronger in Stage 3 and Stage 4 of 2021 and stronger in Stage 1(initiation growth stage)and Stage 3 of *** results provide important information on the growth of the trees in response to drought and for specific managing forests as the climate warms.

关键词： Picea crassifolia Radial growth dynamics Severe drought Response stability Point dendrometer

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Low-temperature graphitization of lignin via Co-assisted electrolysis in molten salt

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Green Energy & Environment 2024年第9期9卷 1449-1458页

作者： Shijie Li Wei-Li Song xue Han Qingqing Cui Yan-li Zhu Shuqiang jiao Institute of Advanced Structure Technology Beijing Institute of Technology State Key Laboratory of Advanced Metallurgy University of Science and Technology Beijing State Key Laboratory of Explosion Science and Technology Beijing Institute of Technology

The ever-growing energy demand and environmental issues have stimulated the development of sustainable energy ***,an efficient and environmentally friendly electrochemical transformation technology was proposed to prepare highly graphitized carbon materials from an abundant natural resource-lignin （LG）.The preparation process mainly includes pyrolytic carbonization of raw LG material and electrochemical conversion of amorphous carbon ***,with the assistance of Co catalyst,the graphitization degree of the products was significantly improved,in which the mechanism was the removal of heteroatoms in LG and the rearrangement of carbon atoms into graphite ***,tunable microstructures （nanoflakes） under catalytic effects could also be observed by controlling the electrolytic *** with the products CN1 （without catalyst） and CN5 （with 10%catalyst）,the specific surface area are 158.957 and202.246 m2g-1,*** used as the electrode material for lithium-ion batteries,CN5 delivered a competitive specific capacity of～350 m Ah g-1（0.5 C） compared with commercial *** strategy proposed in this work provides an effective way to extract value-added graphite materials from lignin and can be extended to the graphitization conversion of any other amorphous carbon precursor materials.

关键词： Lignin Graphitic carbon Electrochemical conversion Lithium-ion batteries

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Inner-shell ionization cross sections of atoms by positron impact

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Communications in Theoretical Physics 2024年第6期76卷 142-147页

作者： Yuan-Cheng Wang Jia ma Li-Guang jiao Stephan Fritzsche College of Physical Science and Technology Shenyang Normal UniversityShenyang 110034China Helmholtz-Institut Jena D-07743 JenaGermany GSI Helmholtzzentrum für Schwerionenforschung GmbH D-64291 DarmstadtGermany College of Science Shenyang Aerospace UniversityShenyang 110136China College of Physics Jilin UniversityChangchun 130012China Theoretisch-Physikalisches Institut Friedrich-Schiller-Universität Jena07743 JenaGermany

The relativistic binary-encounter-Bethe model with Wannier-type threshold law is employed to obtain the inner-shell ionization cross sections of multi-electron atoms(Ni,Cu,Y,Ag,Au,Yb,Ta,and Pb)for positron impact energies from the thresholds up to 105ke *** is good agreement between the present calculations and the experimental *** constant in the acceleration term derived from the Wannier law is determined to be 0.2 and 0.5 for the K-and L-shells,respectively.

关键词： positron scattering ionization cross section binary-encounter-Bethe model

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Carbon dots-derived three-dimensional-ordered macroporous host with high penetrability and catalytic activity for LSBs under lean electrolyte

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Rare Metals 2024年第6期43卷 2560-2573页

作者： jiao-Zi Duan Hua-Yu Pei Quan Yang xue Li Xin Ba xue Yong Jun-Ling Guo Si-Yu Lu Green Catalysis Center College of ChemistryZhengzhou UniversityZhengzhou 450001China Country State Center for International Cooperation On Designer Low-Carbon&Environmental materials School of Materials Science and EngineeringZhengzhou UniversityZhengzhou 450001China Hubei Institute of Quality Supervision Inspection Wuhan 430061China Department of Chemistry University of SheffieldSheffeld S37HFUK

The practical energy density of lithium-sulfur batteries(LSBs)is seriously limited by the high electrolyte-to-sulfur ratios(E/S).The E/S can be reduced by employing hosts with easy-to-infiltrate structure that ensures the uniform distribution of a lean electrolyte and high catalytic activity that can suppress"shuttle effect"via accelerating the slow conversion of soluble poly sulfides to insoluble *** the easy-to-infiltrate structures,the three-dimensional-ordered macroporous(3DOM)structure is easier to scale preparation and more suitable for the existing industrial ***,it is difficult to obtain the 3DOM with(1)high penetrability due to the high viscosity of frequently-used organic polymer precursors and(2)high catalytic activity due to the low confinement effect,meaning that uniformly dispersed small-sized catalytic materials are difficult to load on ***,using carbon dots(CDs)with both organic and inorganic properties as a precursor and aggregation limiting agent,a 3DOM host with high penetrability and homodispersed Ni particles of small sizes(Ni-CDs-3DOM)was *** this host:(1)CDs precursor with suitable viscosity can improve the penetrability.(2)CDs can effectively inhibit the agglomeration of Ni particles.(3)Uniformly dispersed small-size Ni particles offer high-efficiency catalytic activity toward sulfur ***,the Ni-CDs-3DOM/sulfur cathode exhibits high sulfur utilization and stable cycling performance even under high sulfur loading(5.5 mg·cm^(-2))and low E/S(6.5μl·mg^(-1)).This work indicates the usefulness of CDs in constructing hosts for LSBs with high energy density.

关键词： Lithium-sulfur batteries Carbon dots Catalytic action Easy-to-infiltrate structure Lean electrolyte

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Elevation response of above-ground net primary productivity for Picea crassifolia to climate change in Qilian Mountains of Northwest China based on tree rings

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Journal of Geographical Sciences 2024年第1期34卷 146-164页

作者： WU Xuan jiao Liang DU Dashi xue Ruhong WEI Mengyuan ZHANG Peng College of Geography and Environment Science Northwest Normal UniversityLanzhou 730070China Key Laboratory of Resource Environment and Sustainable Development of Oasis Northwest Normal UniversityLanzhou 730070China

Current ecosystem models used to simulate global terrestrial carbon balance generally suggest that terrestrial landscapes are stable and mature,but terrestrial net primary productivity(NPP)data estimated without accounting for disturbances in species composition,environment,structure,and ecological characteristics will reduce the accuracy of the global carbon ***,the steady-state assumption and neglect of elevation-related changes in forest NPP is a *** Qilian Mountains are located in continental climate zone,and vegetation is highly sensitive to climate *** quantified aboveground biomass(AGB)and aboveground net primary productivity(ANPP)sequences at three elevations using field-collected tree rings of Picea crassifolia in Qilian Mountains of Northwest *** results showed that(1)There were significant differences between AGB and ANPP at the three elevations,and the growth rate of AGB was the highest at the low elevation(55.99 t ha^(–1)10a^(–1)).(2)There are differences in the response relationship between the ANPP and climate factors at the three elevations,and drought stress is the main climate signal affecting the change of ANPP.(3)Under the future climate scenario,drought stress intensifies,and the predicted decline trend of ANPP at the three elevations from mid-century to the end of this century is–0.025 t ha^(–1)10a^(–1),respectively;–0.022 t ha^(–1)10a^(–1);At–0.246 t ha^(–1)10a^(–1),the level of forest productivity was significantly *** results reveal the elevation gradient differences in forest productivity levels and provide key information for studying the carbon sink potential of boreal forests.

关键词： global climate change tree ring aboveground net primary productivity aboveground biomass drought stress Qilian Mountains

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