[Research progress on the mechanism of acupuncture on depression based on signaling pathway regulation]

作     者：Min Xiao Xing-Ke Yan Peng-Fei Li Xue-Jiao Ma Chong-Bing Ma 

作者机构：College of Acupuncture-Moxibustion and Tuina Gansu University of Chinese Medicine Lanzhou 730000 China. Pain Department of Acupuncture and Moxibustion The Affiliated Hospital of Gansu University of Chinese Medicine Lanzhou 730000. College of Acupuncture-Moxibustion and Tuina Gansu University of Chinese Medicine Lanzhou 730000 China. mcbrain@***. 

出 版 物：《Zhen ci yan jiu = Acupuncture research》 (Acupuncture Research)

年 卷 期：2024年第49卷第10期

页      面：1100-1106页

核心收录：

学科分类：1005[医学-中医学] 100512[医学-针灸推拿学] 10[医学] 

基　　金：甘肃省针灸推拿临床医学中心开放基金项目(No.ZJKF2204) 甘肃中医药大学2020-2021年引进人才科研启动基金项目(No.2023YJRC-01) 甘肃中医药大学创新基金项目(No.2021KCYB-1) 

主　　题：Acupuncture Depression Molecular mechanism Signaling pathway 

摘      要：Depression is high in prevalence rate, recurrence rate and disability rate. Acupuncture is effective on depression. The paper reviewed the regulatory effect of acupuncture on five prominent signaling pathways, i.e. mitogen activated protein kinase (MAPK), Wnt/β-catenin, Notch, adenyl ate cyclase/cyclic adenosine phosphate/protein kinase (AC/cAMP/PKA) and NO/cyclic guanosine monophosphate (cGMP)； and elaborated the structure of each signaling pathway, the association with depression onset, and the relevant research progress of acupuncture in treatment of depression. In view of the regulation of signal pathways, acupuncture can up-regulate AC/cAMP/PKA and extracellular signal-regulated kinase (ERK), promote the expression of neurotrophic factors or Bcl-2, prevent from and repair neuronal damage, advance neurogenesis and improve synaptic plasticity； it can modulate the Wnt/β-catenin and Notch signal pathways to protect neurons and increase cell proliferation； and down-regulate JNK and up-regulate NO/cGMP signal pathways to inhibit stress that leads to abnormal apoptosis of neurosis and attenuate neurotoxicity and neuronal damage so that anti-depression of acupuncture is obtained. This review provides a new approach to the mechanism research of acupuncture in treatment of depression through regulating the relevant single pathways.