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Long-term outcomes of lobectomy vs. sublobectomy for stage I lung invasive mucinous adenocarcinoma

中华医学杂志(英文版) 2024年第15期137卷 2024 Jun 24页

作者： Wang Lide z.ang Guochao zheng Chao z.ang Long Jia Jia xue Liyan Gao Shugeng Gao Yushun Tan Fengwei xue Qi Department of Thoracic Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China Department of Pathology National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China

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Ce变质铸造汽车用Az61镁合金的组织与力学性能

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热加工工艺 2024年第15期53卷 108-111页

作者：薛冰燕京理工学院工学院河北三河065201

对Az61镁合金进行了不同Ce添加量的变质铸造试验,通过OM、硬度测试、拉伸试验等手段研究了Ce变质处理对Az61镁合金组织与力学性能的影响。结果表明:未变质的Az61镁合金铸态组织由α-Mg相和粗大网状β-Mg17Al12相组成。随着Ce加入量的增... 详细信息

对Az61镁合金进行了不同Ce添加量的变质铸造试验,通过OM、硬度测试、拉伸试验等手段研究了Ce变质处理对Az61镁合金组织与力学性能的影响。结果表明:未变质的Az61镁合金铸态组织由α-Mg相和粗大网状β-Mg17Al12相组成。随着Ce加入量的增加,Az61镁合金中β-Mg17Al12相析出量逐渐减少,稀土相逐渐增多,β-Mg17Al12相由连续粗大网状逐渐转变为颗粒状,Ce添加量1.0wt%的Az61镁合金中β-Mg17Al12相最为细小。与未变质的Az61镁合金相比,经Ce变质的Az61镁合金的硬度、抗拉强度和伸长率均有了明显提高。随着Ce加入量的增加,Az61镁合金的硬度、抗拉强度和伸长率均先升高后降低,Ce添加量1.0wt%的Az61镁合金的力学性能最佳。

关键词： Az61镁合金 Ce元素变质处理显微组织力学性能

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Therapeutic Effectiveness of Leukocyte-and Platelet-rich Fibrin for Diabetic Foot Ulcers:A Retrospective Study

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Current Medical Science 2024年第3期44卷 568-577页

作者： Fen Wang Xiao-ling z.ang Jing z.ang Song GONG Jing TAO Hui XIang Xiao-qing FU Xu-na BIAN xue-feng YU An-hui XU Cheng-la YI Shi-ying SHAO Department of Endocrinology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Branch of National Clinical Research Center for Metabolic Diseases Wuhan430030China Department of Radiology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Department of Trauma Surgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China

Objective Diabetic foot ulcer(DFU)is one of the most serious complications of ***-and platelet-rich fibrin(L-PRF)is a second-generation autologous platelet-rich *** study aims to investigate the clinical effects of L-PRF in patients with diabetes in real clinical *** Patients with DFU who received L-PRF treatment and standard of care(SOC)from 2018 to 2019 in Tongji Hospital were *** clinical information including patient characteristics,wound evaluation(area,severity,infection,blood supply),SOC of DFU,and images of ulcers was retrospectively extracted and analyzed.L-PRF treatment was performed every 7±2 days until the ulcer exhibited complete epithelialization or an overall percent volume reduction(PVR)greater than 80%.Therapeutic effectiveness,including overall PVR and the overall and weekly healing rates,was *** Totally,26 patients with DFU were enrolled,and they had an ulcer duration of 47.0(35.0,72.3)*** severity and infection of ulcers varied,as indicated by the Site,Ischemia,Neuropathy,Bacterial Infection,and Depth(SINBAD)scores of 2–6,Wagner grades of 1–4,and the Perfusion,Extent,Depth,Infection and Sensation(PEDIS)scores of 2–*** initial ulcer volume before L-PRF treatment was 4.94(1.50,13.83)cm3,and the final ulcer volume was 0.35(0.03,1.76)*** median number of L-PRF doses was 3(2,5).A total of 11 patients achieved complete epithelialization after the fifth week of treatment,and 19 patients achieved at least an 80%volume reduction after the seventh *** overall wound-healing rate was 1.47(0.63,3.29)cm3/week,and the healing rate was faster in the first 2 weeks than in the remaining *** treatment did not change the percentage of complete epithelialization or healing *** Adding L-PRF to SOC significantly improved wound healing in patients with DFU independent of the ankle brachial index,SINBAD score,or Wagner grade,indicating that this method is appropriate for D

关键词： diabetic foot ulcer autologous platelet-rich plasma leukocyte-and platelet-rich fibrin standard of care percentage volume reduction

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Antitumor efficacy and potential mechanism of FAP-targeted radioligand therapy combined with immune checkpoint blockade

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Signal Transduction and Targeted Therapy 2024年第7期9卷 2936-2952页

作者： Liang zhao Yizhen Pang Yangfan zhou Jianhao Chen Hao Fu Wei Guo Weizhi Xu Xin xue Guoqiang Su Long Sun Hua Wu Jingjing z.ang zhanxiang Wang Qin Lin Xiaoyuan Chen Haojun Chen Department of Nuclear Medicine and Minnan PET Center Xiamen Key Laboratory of RadiopharmaceuticalsThe First Affiliated Hospital of Xiamen UniversitySchool of MedicineXiamen UniversityXiamenChina Departments of Diagnostic Radiology SurgeryChemical and Biomolecular Engineeringand Biomedical EngineeringYong Loo Lin School of Medicine and College of Design and EngineeringNational University of SingaporeSingaporeSingapore Clinical Imaging Research Centre Centre for Translational MedicineYong Loo Lin School of MedicineNational University of SingaporeSingaporeSingapore Department of Radiation Oncology Xiamen Cancer CenterXiamen Key Laboratory of Radiation OncologyThe First Affiliated Hospital of Xiamen UniversitySchool of MedicineXiamen UniversityXiamenChina Department of Colorectal Tumor Surgery Xiamen Cancer CenterXiamen Key Laboratory of Radiation OncologyThe First Affiliated Hospital of Xiamen UniversitySchool of MedicineXiamen UniversityXiamenChina Department of Cardiothoracic Surgery Zhongda HospitalSchool of MedicineSoutheast UniversityNanjingChina Nanomedicine Translational Research Program NUS Center for NanomedicineYong Loo Lin School of MedicineNational University of SingaporeSingaporeSingapore Department of Neurosurgery and Department of Neuroscience Fujian Key Laboratory of Brain Tumors Diagnosis and Precision TreatmentXiamen Key Laboratory of Brain Centerthe First Affiliated Hospital of Xiamen UniversitySchool of MedicineXiamen UniversityXiamenChina Institute of Molecular and Cell Biology Agency for ScienceTechnology and Research(A*STAR)SingaporeSingapore Xiamen Key Laboratory of Rare Earth Photoelectric Functional Materials Xiamen Institute of Rare Earth MaterialsHaixi InstituteChinese Academy of SciencesXiamenChina

Radiotherapy combined with immune checkpoint blockade holds great promise for synergistic antitumor *** radionuclide therapy delivers radiation directly to tumor ***1004 is a fibroblast activation protein(FAP)-targeting radiopharmaceutical,conjugated with the albumin binder Evans Blue,which has demonstrated enhanced tumor uptake and retention in previous preclinical and clinical ***,we demonstrate that^(68)Ga/^(177)Lu-labeled LNC1004 exhibits increased uptake and prolonged retention in MC38/NIH3T3-FAP and CT26/NIH3T3-FAP tumor *** therapy with^(177)Lu-LNC1004 induced a transient upregulation of PD-L1 expression in tumor *** combination of^(177)Lu-LNC1004 and anti-PD-L1 immunotherapy led to complete eradication of all tumors in MC38/NIH3T3-FAP tumor-bearing mice,with mice showing 100%tumor rejection upon ***,single-cell RNA sequencing(scRNA-seq),and TCR sequencing revealed that combination therapy reprogrammed the tumor microenvironment in mice to foster antitumor immunity by suppressing malignant progression and increasing cell-to-cell communication,CD8^(+)T-cell activation and expansion,M1 macrophage counts,antitumor activity of neutrophils,and T-cell receptor diversity.A preliminary clinical study demonstrated that^(177)Lu-LNC1004 was well-tolerated and effective in patients with refractory ***,scRNA-seq of peripheral blood mononuclear cells underscored the importance of addressing immune evasion through immune checkpoint blockade *** was emphasized by the observed increase in antigen processing and presentation juxtaposed with T cell *** conclusion,our data supported the efficacy of immunotherapy combined with^(177)Lu-LNC1004 for cancer patients with FAP-positive tumors.

关键词： immunity retention holds

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On the bilinear square Fourier multiplier operators and related multilinear square functions

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Science China Mathematics 2017年第8期60卷 1477-1502页

作者： SI zengYan xue QingYing YABUTA Kz School of Mathematics and Information Science Henan Polytechnic University School of Mathematical Sciences Beijing Normal UniversityLaboratory of Mathematics and Complex Systems Ministry of Education Research Center for Mathematical Sciences Kwansei Gakuin University

Let n 1 and Tm be the bilinear square Fourier multiplier operator associated with a symbol m,which is defined by Tm（f1, f2）（x） =（∫0^∞︱∫（Rn）^2）e^2πix·（ξ1＋ξ2））m（tξ1, tξ2）f1（ξ1）f2（ξ2）dξ1dξ2︱^2dt/t）^1/2.Let s be an integer with s ∈ [n ＋ 1, 2n] and p0 be a number satisfying 2n/s p0 2. Suppose that νω=∏i^2=1ω^i^p/p） and each ωi is a nonnegative function on Rn. In this paper, we show that under some condition on m, Tm is bounded from L^p1（ω1） × L^p2（ω2） to L^p（νω） if p0 〈 p1, p2 〈 ∞ with 1/p = 1/p1 ＋ 1/p2. Moreover,if p0 〉 2n/s and p1 = p0 or p2 = p0, then Tm is bounded from L^p1（ω1） × L^p2（ω2） to L^p,∞（νω）. The weighted end-point L log L type estimate and strong estimate for the commutators of Tm are also given. These were done by considering the boundedness of some related multilinear square functions associated with mild regularity kernels and essentially improving some basic lemmas which have been used before.

关键词： multilinear square functions Fourier multiplier operator multiple weights commutators

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Tailoring-compensated ferrimagnetic state and anomalous Hall effect in quaternary Mn–Ru–V–Ga Heusler compounds

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Chinese Physics B 2024年第7期33卷 595-603页

作者：梁瑾静郗学奎王文洪刘永昌 Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China Tiangong University Tianjin 300387China

Cubic Mn_(2)Ru_(x)Ga Heusler compound is a typical example of compensated ferrimagnet with attractive potential for high-density,ultrafast,and low-power spintronic *** the form of epitaxial thin films,Mn_(2)Ru_(x)Ga exhibits high spin polarization and high tunability of compensation temperature by freely changing the Ru content x in a broad range(0.3

关键词： compensated ferrimagnet anomalous Hall effect residual resistivity ratio

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基层应急管理中的组织协调——问题根源与解决思路

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行政论坛 2024年第4期031卷 91-100页

作者：薛澜王哲清华大学苏世民书院清华大学公共管理学院

随着我国全面深化改革进入深水区，国家治理体系和治理能力现代化不断推进，应急管理体系改革也从2018年起进入新的阶段，成立了应急管理部，形成了我国全面应对四类突发事件的统一协调指挥体系。在改革实施后，由于基层应急管理中仍然... 详细信息

随着我国全面深化改革进入深水区，国家治理体系和治理能力现代化不断推进，应急管理体系改革也从2018年起进入新的阶段，成立了应急管理部，形成了我国全面应对四类突发事件的统一协调指挥体系。在改革实施后，由于基层应急管理中仍然存在各部门之间组织协调不畅的问题，故而带来一定的风险隐患。结合基层应急管理组织协调的现实问题和相关理论，通过分析A市z县等相关案例，研究认为，基层应急管理组织协调的问题根源，一方面源于应急管理问题本身的特点；另一方面，也源于现有的权责机制和制度体系仍然不健全。聚焦问题根源，应加强党对应急管理工作的领导，根据应急管理工作的特点推进应急管理体系和能力现代化，并从制度建设、人才培养和监督机制等三个方面破解应急管理组织协调问题，加强应急管理体系和能力建设，推进中国应急管理事业的发展。

关键词：应急管理基层治理组织协调协同治理

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胶质母细胞瘤中免疫和小胶质/巨噬细胞的特异性高表达基因具有间充质亚型的特性

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中华神经外科疾病研究杂志 2024年第1期18卷 38-45页

作者：吕瑞姬昂薛小燕章翔毛星刚空军军医大学西京医院神经外科陕西西安710032 空军军医大学药学系药理学教研室陕西西安710032

目的研究胶质母细胞瘤(GBM)中免疫细胞,特别是小胶质细胞/巨噬细胞中高表达的特异性基因集合,从而加深对胶质瘤中免疫微环境结构和功能的认识.方法在正常和GBM组织中,分析不同类型细胞中的分子表达情况,并得到免疫细胞和/或小胶质细胞/... 详细信息

目的研究胶质母细胞瘤(GBM)中免疫细胞,特别是小胶质细胞/巨噬细胞中高表达的特异性基因集合,从而加深对胶质瘤中免疫微环境结构和功能的认识.方法在正常和GBM组织中,分析不同类型细胞中的分子表达情况,并得到免疫细胞和/或小胶质细胞/巨噬细胞(MM-Cells)中,特异性高表达的基因(MM-Genes).进一步研究MM-Genes在胶质瘤不同级别、不同分子亚型中的表达情况及对患者预后的影响.结果我们获得了一系列高度可靠的MM-Genes,包括CD74、HLA-DRB5、CCL3、NFAM1、DOCK8、LTC4S、GPR183、CCL4、SLAMF8、NCKAP1L、CD14、CD68、PLCB2.大部分MM-Genes在胶质瘤高表达,且随着级别而增加.另外,MM-Genes在GBM的间质亚型中高表达.其次,多数MM-Genes单个基因,以及MM-Genes的综合评分,均与患者预后相关,且高表达者预后差.结论MM-Genes与胶质瘤级别及GBM的间质亚型高度相关,且MM-Genes高表达者预后差,揭示了免疫调控与胶质瘤级别和分子亚型之间的关系.

关键词：胶质母细胞瘤胶质瘤免疫治疗巨噬细胞小胶质细胞免疫调控间质亚型

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Simultaneous characterization of multiple properties of solid and liquid phases in crystallization processes using NIR

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Particuology 2011年第6期9卷 589-597页

作者： Chao Y. Ma xue z. Wang Institute of Particle Science and Engineering School of Process Environmental and Materials Engineering University of Leeds Leeds LS2 9JT UK

Near infrared spectroscopy （NIR） is now probably the most popular process analytical technology （PAT） for pharmaceutical and some other industries. However, unlike mid-IR, NIR is known to have difficulties in monitoring crystallization or precipitation processes because the existence of solids could cause distortion of the spectra. This phenomenon, seen as unfavorable previously, is however an indication that NIR spectra contain rich information about both solids and liquids, giving the possibility of using the same instrument for multiple property characterization. In this study, transflectance NIR calibration data was obtained using solutions and slurries of varied solution concentration, particle size, solid concentration and temperature. The data was used to build calibration models for prediction of the multiple properties of both phases. Predictive models were developed for this challenging application using an approach that combines genetic algorithm （GA） and support vector machine （SVM）. GA is used for wavelength selection and SVM for mode building. The new GA-SVM approach is shown to outperform other methods including GA-PLS （partial least squares） and traditional SVM. NIR is thus successfully applied to monitoring seeded and unseeded cooling crystallization processes of L-glutamic acid.

关键词： Process analytical technology Near infrared spectroscopy Support vector machine Genetic algorithm Wavelength selection Cooling crystallization

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θ-型C-z算子与Lipschitz函数生成的交换子在齐次变指标Herz空间上的有界性

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数学的实践与认识 2024年第7期54卷 199-210页

作者：薛凤宇牡丹江师范学院数学系黑龙江牡丹江157011

证明了θ-型Calderon-zygmund算子与Lipschitz函数生成的交换子在具有三个变指标的齐次Herz空间K^(α(·),q^(·)/p^(·)(R^(n))上的有界性.

关键词： θ-型Calderon-zygmund算子交换子变指标Herz空间 Lipschitz函数

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