检索结果-南通市图书馆

Gonadal dysgenesis in Turner syndrome with Y-chromosome mosaicism:Two case reports

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2020年第22期8卷 5737-5743页

作者： xue-Fei leng Ke Lei Yi Li Fei Tian Qin Yao Qing-Mei Zheng Zhi-Hong Chen Department of Pediatric Endocrinology Affiliated Hospital of Medical College Qingdao UniversityQingdao 266001Shandong ProvinceChina Department of Laboratory Medicine Affiliated Hospital of Medical College Qingdao UniversityQingdao 266001Shandong ProvinceChina Department of Gastrointestinal Surgery Affiliated Hospital of Medical College Qingdao UniversityQingdao 266001Shandong ProvinceChina Department of Gynecology Affiliated Hospital of Medical College Qingdao UniversityQingdao 266001Shandong ProvinceChina

BACKGROUND Turner syndrome(TS)has a variety of different karyotypes,with a wide range of phenotypic features,but the specific karyotype may not always predict the *** with Y chromosome mosaicism may have mixed gonadal dysgenesis,and the mosaicism is related to the potential for *** SUMMARY In this case report,we report two cases of TS with different karyotypes and gonadal *** 1 had obvious virilization,and was positive for the SRY gene,but her karyotype in peripheral blood lymphocytes was *** 2 had a mosaic karyotype,45X/46X,dic(Y:Y)(p11.3:p11.2),and the proportion of Y-bearing cells was 50%in peripheral blood lymphocytes,but the patient had normal female external genitalia and streaky gonads,with no genital *** tissues in the same TS individual may exhibit different ratios of *** gonadal determination and differentiation of mosaic TS are primarily dependent on the predominant cell line in the *** In TS patients with virilization,it is necessary to test at least two to three tissues to search for cryptic Y material.

关键词： Turner syndrome Gonadal dysgenesis Virilization Y chromosome mosaicism Gonadoblastoma Case report

中医院校“一主线三连接四协同”中西医结合桥梁课程体系建设模式探索

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

卫生职业教育 2024年第4期42卷 5-8页

作者：马艺鑫贾连群刘慧慧冷雪曹媛谷丽艳辽宁中医药大学中医脏象理论及应用教育部重点实验室辽宁沈阳110000

在中西医结合人才需求的大背景下,以中西医并重理念为根本,促进传统医学和现代医学更好结合,首次构建“一主线三连接四协同”的中西医结合桥梁课程体系建设模式,树立先进的育人理念,促进学生能力全面发展,努力打造知行合一、强化实践、... 详细信息

在中西医结合人才需求的大背景下,以中西医并重理念为根本,促进传统医学和现代医学更好结合,首次构建“一主线三连接四协同”的中西医结合桥梁课程体系建设模式,树立先进的育人理念,促进学生能力全面发展,努力打造知行合一、强化实践、科学素养、创新思维融为一体的高水平中西医结合专业人才培养模式,有效提升中西医结合人才培养质量。

关键词：中医院校人才培养中西医结合桥梁课程

面向“双创”教育的“一主体三维度”中医药院校本科生创新能力培养新模式探索

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

卫生职业教育 2024年第8期42卷 6-9页

作者：吕美君贾连群李宁杜莹冷雪王莹曹媛曲怡辽宁中医药大学中医脏象理论及应用教育部重点实验室辽宁沈阳110032

高等中医药院校在加强学生专业培养的同时,需响应国家“大众创业、万众创新”战略,着力培养高质量的创新创业人才。以重点实验室为依托,探索面向“双创”教育的“一主体三维度”中医药院校本科生创新能力培养新模式,为中医药院校培养高... 详细信息

高等中医药院校在加强学生专业培养的同时,需响应国家“大众创业、万众创新”战略,着力培养高质量的创新创业人才。以重点实验室为依托,探索面向“双创”教育的“一主体三维度”中医药院校本科生创新能力培养新模式,为中医药院校培养高质量的创新创业人才提供参考。

关键词： “双创”教育中医药院校本科生创新能力

基于“一课三融三化”六位一体专创融合课改研究——以基础化学课程为例

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

食品工业 2024年第4期45卷 245-248页

作者：高涵冷学苏波肖彦春蔡智军李文一辽宁农业职业技术学院营口115009

基于“专创融合”,改革专业课程教学模式,适应人才需求标准。以基础化学课程为例,建设以学习者为中心,以课程思政、双创竞赛、科学研究、考取X证和智慧平台为抓手的项目式混合教学模式,将创新精神、创业意识与课程深度融合,制定以成果... 详细信息

基于“专创融合”,改革专业课程教学模式,适应人才需求标准。以基础化学课程为例,建设以学习者为中心,以课程思政、双创竞赛、科学研究、考取X证和智慧平台为抓手的项目式混合教学模式,将创新精神、创业意识与课程深度融合,制定以成果为导向的多元课程考核标准,探索融思政、融双创、融产业、数字化、项目化、国际化的“一课三融三化”六位一体专创融合课改途径,真正落实将双创教育贯穿人才培养全过程,有效赋能学生优质就业与创业,培养学生终身学习能力的专创融合任务。

关键词：专创融合基础化学思政双创产教融合

Whole-genome sequencing in medicinal plants:current progress and prospect

在线全文

学校读者我要写书评

暂无评论

Science China(Life Sciences) 2024年第2期67卷 258-273页

作者： Yifei Pei Liang leng Wei Sun Baocai Liu xue Feng Xiwen Li Shilin Chen Institute of Chinese Materia Medica China Academy of Chinese Medical SciencesBeijing 100700China Institute of Herbgenomics Chengdu University of Traditional Chinese MedicineChengdu 611137China Innovative Institute of Chinese Medicine and Pharmacy Chengdu University of Traditional Chinese MedicineChengdu 611137China Institute of Agricultural Bioresource Fujian Academy of Agricultural SciencesFuzhou 350003China

Advancements in genomics have dramatically accelerated the research on medicinal plants,and the development of herbgenomics has promoted the“Project of 1K Medicinal Plant Genome”to decipher their genetic ***,it is difficult to obtain their high-quality whole genomes because of the prevalence of polyploidy and/or high genomic *** genomes of 123 medicinal plants were published until September *** published genome sequences were investigated in this review,covering their classification,research teams,ploidy,medicinal functions,and sequencing *** than 1,000 institutes or universities around the world and 50 countries are conducting research on medicinal plant *** species account for a majority of sequenced medicinal *** whole genomes of plants in the Poaceae family are the most *** 40%of the published papers studied species with tonifying,replenishing,and heat-cleaning medicinal *** plants are still in the process of domestication as compared with crops,thereby resulting in unclear genetic backgrounds and the lack of pure lines,thus making their genomes more difficult to *** addition,there is still no clear routine framework for a medicinal plant to obtain a high-quality whole ***,a clear and complete strategy has been originally proposed for creating a high-quality whole genome of medicinal ***,whole genome-based biological studies of medicinal plants,including breeding and biosynthesis,were *** also advocate that a research platform of model medicinal plants should be established to promote the genomics research of medicinal plants.

关键词： herbgenomics whole genome high throughput sequencing research strategy model species application

THE TYPES OF LAKE IN SONGNEN PLAIN AND THEIR REGIONAL CHARACTER

在线全文

学校读者我要写书评

暂无评论

Chinese Geographical Science 2000年第4期10卷 79-83页

作者： LU Jin-fu JIE Dong-mei LI Zhi-min leng xue-tian Geography Department Northeast Normal UniversityChangchun 130024P.R.China

The lake groups in the Songnen Plain are low plain lake groups, which are located in the temperate semihumid area in China. They are characterized by small area, shallow basin, thick density and various types. In the try for classifying comprehensively the lake groups, a classification system is developed based on three main factors, i.e. forming cause, water quantity and water quality. The most internal character can be concisely grasped through three principal indexes and three auxiliary indexes of three main factors. A sample of complicated changeable path is put forward for further analyzing and outlining these basic types, in the meantime, it’s linking up easily with the classification system of the single factor. According to the regional environment, the regional differences of the type composition and the principal types, the lake groups in the Songnen Plain can be divided into 6 sub-regions.

关键词： Songnen Plain types of lake regional character

睡美人创新研究在科学、技术及创新政策制定中的应用

在线全文

学校读者我要写书评

暂无评论

情报杂志 2019年第2期38卷 43-48页

作者：冷雪中国科学院文献情报中心北京100190 中国科学院大学北京100190

[目的/意义]睡美人创新是指被专利唤醒的睡美人文献,体现了论文与专利之间的知识扩散情况,论文与专利作为基础研究与应用研究最重要的产出,论文与专利之间的关系能够反映基础研究与应用研究之间的转化情况,为以基础研究与应用研究为政... 详细信息

[目的/意义]睡美人创新是指被专利唤醒的睡美人文献,体现了论文与专利之间的知识扩散情况,论文与专利作为基础研究与应用研究最重要的产出,论文与专利之间的关系能够反映基础研究与应用研究之间的转化情况,为以基础研究与应用研究为政策客体的科学、技术与创新政策提供定量依据。[方法/过程]首先梳理了推迟认可相关概念之间的关系,并对睡美人文献的研究现状从识别与机理两个方面进行了总结,归纳了睡美人创新的内涵,提出了睡美人创新研究的现状以及存在的不足与局限,最后结合政策实践指出睡美人创新在科学、技术与创新政策中的应用情况。[结果/结论]睡美人创新是科学计量学领域的最新研究热点,对睡美人创新进行研究不仅对科学计量学和科学学有着重要意义,而且也能为科学政策、技术政策和创新政策带来新的科学依据。

关键词：科学计量学创新政策睡美人创新睡美人文献

近十年我国档案学与图书馆学领域知识管理研究的计量分析

在线全文

学校读者我要写书评

暂无评论

档案学研究 2013年第6期 9-14页

作者：冷雪华东师范大学商学院上海200241

文章选取期刊研究论文,从文献量、来源期刊、作者情况、发文机构、高频关键词、主题分布和基金来源等角度对我国档案学和图书馆学领域知识管理研究的差距进行了计量分析,指出档案学领域应更加重视知识管理的研究,并从宏观、中观和微观... 详细信息

文章选取期刊研究论文,从文献量、来源期刊、作者情况、发文机构、高频关键词、主题分布和基金来源等角度对我国档案学和图书馆学领域知识管理研究的差距进行了计量分析,指出档案学领域应更加重视知识管理的研究,并从宏观、中观和微观三个层面为档案学知识管理研究给出了具体建议。

关键词：知识管理档案学图书馆学文献计量

Functional analysis of the novel mitochondrial tRNA^(Trp)and tRNA^(Ser(AGY))variants associated with type 2 diabetes mellitus

在线全文

学校读者我要写书评

暂无评论

World Journal of Diabetes 2024年第8期15卷 1753-1763页

作者： Yu Ding xue-Jiao Yu Qin-Xian Guo Jian-Hang leng Central Laboratory Hangzhou First People’s HospitalHangzhou 310006Zhejiang ProvinceChina Clinical Laboratory Quzhou People’s HospitalQuzhou 324000Zhejiang ProvinceChina

BACKGROUND Mutations in mitochondrial tRNA(mt-tRNA)genes that result in mitochondrial dysfunction play important roles in type 2 diabetes mellitus(T2DM).We previously reported a large Chinese pedigree with maternally inherited T2DM that harbors novel mt-tRNA^(Trp)A5514G and tRNA^(Ser(AGY))C12237T variants,however,the effects of these mt-tRNA variants on T2DM progression are largely *** To assess the potential pathogenicity of T2DM-associated m.A5514G and m.C12237T variants at genetic,molecular,and biochemical *** Cytoplasmic hybrid(cybrid)cells carrying both m.A5514G and m.C12237T variants,and healthy control cells without these mitochondrial DNA(mtDNA)variants were generated using trans-mitochondrial *** features,including mt-tRNA steady-state level,levels of adenosine triphosphate(ATP),mitochondrial membrane potential(MMP),reactive oxygen species(ROS),mtDNA copy number,nicotinamide adenine dinucleotide(NAD+)/NADH ratio,enzymatic activities of respiratory chain complexes(RCCs),8-hydroxy-deoxyguanine(8-OhdG),malondialdehyde(MDA),and superoxide dismutase(SOD)were examined in cell lines with and without these mt-tRNA *** Compared with control cells,the m.A5514G variant caused an approximately 35%reduction in the steady-state level of mt-tRNA^(Trp)(P<0.0001);however,the m.C12237T variant did not affect the mt-tRNA^(Ser(AGY))steady-state level(P=0.5849).Biochemical analysis revealed that cells with both m.A5514G and m.C12237T variants exhibited more severe mitochondrial dysfunctions and elevated oxidative stress than control cells:ATP,MMP,NAD+/NADH ratio,enzyme activities of RCCs and SOD levels were markedly decreased in mutant cells(P<0.05 for all measures).By contrast,the levels of ROS,8-OhdG and MDA were significantly increased(P<0.05 for all measures),but mtDNA copy number was not affected by m.A5514G and m.C12237T variants(P=0.5942).CONCLUSION The m.A5514G variant impaired mt-tRNA^(Trp)metabolism,which subsequent

关键词： Type 2 diabetes mellitus Mitochondrial tRNA genes Novel variants Oxidative stress Mitochondrial dysfunctions