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International Journal of Minerals,Metallurgy and Materials 2021年第5期28卷 816-825页

作者： Yi-shuang Yu Bin Hu Min-liang Gao Zhen-jia Xie xue-quan rong Gang Han Hui Guo Cheng-jia Shang Collaborative Innovation Center of Steel Technology University of Science and Technology BeijingBeijing 100083China Institute of Advanced Materials and Technology University of Science and Technology BeijingBeijing 100083China State Key Laboratory of Metal Material for Marine Equipment and Application Anshan 114021China

Here we present a novel approach of intercritical heat treatment for microstructure tailoring,in which intercritical annealing is introduced between conventional quenching and *** induced a heterogeneous microstructure consisting of soft intercritical ferrite and hard tempered martensite,resulting in a low yield ratio(YR)and high impact toughness in a high-strength low-alloy *** initial yielding and subsequent work hardening behavior of the steel during tensile deformation were modified by the presence of soft intercritical ferrite after intercritical annealing,in comparison to the steel with full martensitic *** increase in YR was related to the reduction in hardness difference between the soft and hard phases due to the precipitation of nano-carbides and the recovery of dislocations during *** excellent low-temperature toughness was ascribed not only to the decrease in probability of microcrack initiation for the reduction of hardness difference between two phases,but also to the increase in resistance of microcrack propagation caused by the high density of high angle grain boundaries.

关键词： heterogeneous microstructure yield ratio impact toughness intercritical heat treatment high-strength low-alloy steel

Effects of exogenous human leptin on heat shock protein 70 expression in MCF-7 breast cancer cells and breast carcinoma of nude mice xenograft model

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Chinese Medical Journal 2012年第4期125卷 680-686页

作者： xue rong-quan Gu Jun-chao Yu Wei Wang Yu Zhang Zhong-tao Ma xue-mei Capital Med Univ Beijing Friendship Hosp Dept Gen Surg Beijing 100050 Peoples R China Capital Med Univ Beijing Tiantan Hosp Dept Gen Surg Beijing 100050 Peoples R China

Background It is important to identify the multiple sites of leptin activity in obese women with breast *** this study,we examined the effect of exogenous human leptin on heat shock protein 70 （HSP70） expression in MCF-7 human breast cancer cells and in a breast carcinoma xenograft model of nude *** We cultured MCF-7 human breast cancer cells and established nude mice bearing xenograffs of these cells,and randomly divided them into experimental and control *** experimental group was treated with human leptin,while the control group was treated with the same volume of normal saline.A real-time reverse transcriptase-polymerase chain reaction （RT-PCR） assay was developed to quantify the mRNA expression of HSP70 in the MCF-7 human breast cancer cells and in tumor *** blotting analysis was applied to quantify the protein expression of HSP70 in the MCF-7 *** staining was done to assess the positive rate of HSP70 expression in the tumor *** Leptin activated HSP70 in a dose-dependent manner in vitro：leptin upregulated significantly the expression of HSP70 at mRNA and protein levels in MCF-7 human breast cancer cells （P 〈0.001）.There was no significant difference in expression of HSP70 mRNA in the implanted tumors between the leptin-treated group and the control group （P〉0.05）.Immunohistochemical staining revealed no significant difference in tumor HSP70 expression between the leptin-treated group and the control group （P〉0.05）.Conclusions A nude mouse xenograft model can be safely and efficiently treated with human leptin by subcutaneous injections around the ***70 may be target of leptin in breast *** can significantly upregulate the expression of HSP70 in a dose-dependent manner in vitro.

关键词： human leptin breast cancer xenografi model heat shock protein 70

Lentivirus-mediated RNA interference targeting the ObR gene in human breast cancer MCF-7 cells in a nude mouse xenograft model

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Chinese Medical Journal 2012年第9期125卷 1563-1570页

作者： xue rong-quan GU Jun-chao DU Song-tao YU Wei WANG Yu ZHANG Zhong-tao BAI Zhi-gang MA xue-mei Department of General Surgery Beijing Friendship Hospital Capital Medical University Beijing 100050 China Department of General Surgery Beijing Tiantan Hospital Capital Medical University Beijing 100050 China

Background There is a significant association between obesity and breast cancer, which is possibly due to the expression of leptin. Therefore, it is important to clarify the role of leptin/ObR （leptin receptor） signaling during the progression of human breast cancer. Methods Nude mice with xenografts of MCF-7 human breast cancer cells were administered recombinant human leptin subcutaneous via injection around the tumor site. Mice in the experimental group were intratumorally injected with ObR-RNAi-lentivirus, while negative control group mice were injected with the same dose of negative-lentivirus. Tumor size was blindly measured every other day, and mRNA and protein expression levels of ObR, estrogen receptor a （ERa）, and vascular endothelial growth factor （VEGF） for each group were determined.Results Knockdown of ObR-treated xenografted nude mice with a high leptin microenvironment was successfully established. Local injection of ObR-RNAi-lentivirus significantly suppressed the established tumor growth in nude mice. ObR level was significantly lower in the experimental group than in the negative control group, while the amounts of ERα and VEGF expression were significantly lower in the leptin group than in the control group （P 〈0.01 for all）.Conclusions Inhibition of leptin/ObR signaling is essential to breast cancer proliferation and possible crosstalk between ObR and ERa, and VEGF, and may lead to novel therapeutic treatments aiming at targeting ObR in breast cancers.

关键词： RNA interference breast neoplasms xenografi model leptin receptor estrogen receptor α vascular endothelial growth factor

匹罗卡品对正常眼压老年人眼前段结构变化的影响

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眼科新进展 2009年第2期29卷 121-123页

作者：孙怡艾育德薛荣泉内蒙古医学院附属医院眼科内蒙古呼和浩特市010050 内蒙古医院普外科内蒙古呼和浩特市010017

目的探讨匹罗卡品对正常眼压老年人眼前段结构变化影响的作用机制,进一步对比窄前房角和宽前房角老年人眼前段结构的形态特征。方法根据房角镜检查,选取具有窄前房角的患者21例(32眼)和宽前房角的正常志愿者20例(30眼),眼压均在正常范围... 详细信息

目的探讨匹罗卡品对正常眼压老年人眼前段结构变化影响的作用机制,进一步对比窄前房角和宽前房角老年人眼前段结构的形态特征。方法根据房角镜检查,选取具有窄前房角的患者21例(32眼)和宽前房角的正常志愿者20例(30眼),眼压均在正常范围内,使用超声生物显微镜对2组滴10g·L-1匹罗卡品滴眼液前后房角结构指标进行观察并运用专用软件给予测量。结果窄角眼滴匹罗卡品后表现前房深度减小,虹膜厚度变小,小梁虹膜角增加,房角开放距离增加,睫状体厚度增加,虹膜晶状体接触距离增加。宽角眼滴匹罗卡品后表现前房深度减小,虹膜厚度变小,小梁虹膜角减小,房角开放距离减小,睫状体厚度增加,虹膜晶状体接触距离增加。滴匹罗卡品滴眼液前后,2组前房深度、小梁虹膜角、房角开放距离变化差异有显著统计学意义(P0.05)。结论匹罗卡品可以引起窄角眼前房角增宽,其对房角的改变依靠于滴药前房角的状况,它对正常眼压老年人的窄角眼的治疗是有效的。

关键词：超声生物显微镜眼前段老年人眼压匹罗卡品

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正常眼压老年人眼前段超声生物显微镜的研究

中国实用眼科杂志 2006年第11期24卷 1127-1130页

作者：孙怡艾育德周炜薛荣全内蒙古医学院附属医院眼科呼和浩特010050 南宁市第一医院眼科内蒙古医院普外科

目的对比窄前房角和宽前房角老年人眼前段结构的形态特征。方法选取59-73岁正常眼压老年人41名(62眼)作为观察对象。根据房角镜检查分为窄房角组(32只眼)和宽房角组(30只眼),分别用A超及超声生物显微镜(UBM)检测前房深度、晶体厚度、眼... 详细信息

目的对比窄前房角和宽前房角老年人眼前段结构的形态特征。方法选取59-73岁正常眼压老年人41名(62眼)作为观察对象。根据房角镜检查分为窄房角组(32只眼)和宽房角组(30只眼),分别用A超及超声生物显微镜(UBM)检测前房深度、晶体厚度、眼轴长度、晶体相对位置测量,睫状体厚度、房角开放距离、小梁虹膜角、虹膜厚度、虹膜晶体接触距离,并且对比点1%匹罗卡品滴眼液前后眼前段结构的变化。结果与宽角眼相比,窄角眼前房浅、晶体厚度较大、相对晶体位置前移、睫状体薄、小梁虹膜角窄,房角开放距离小、虹膜厚度小、虹膜晶体接触距离较大;睫状体厚度与晶体厚度呈负相关(r1=-0.53,p0.05)。结论老年人窄前房角的眼前段结构预示,他们可能是发生闭角青光眼的高危人群。

关键词：超声生物显微镜眼前段老年人眼压

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可食性包装膜的研究进展

食品科技 2002年第4期27卷 4-6页

作者：汪学荣阚建全陈宗道西南农业大学食品科学学院重庆400716

可食性包装膜主要有多糖类可食性包装膜、蛋白质类可食性包装膜、微生物共聚聚酯可食性包装膜和多糖、蛋白质、脂肪酸复合型包装膜。

关键词：可食性包装膜研究进展食品包装 EPF

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铈掺杂二氧化钛的化学态分析

人工晶体学报 2015年第5期44卷 1383-1388,1415页

作者：荣雪荃严继康易健宏杜景红康昆勇甘国友昆明理工大学材料科学与工程学院昆明650093 昆明理工大学稀贵及有色金属先进材料教育部重点实验室昆明650093 昆明理工大学云南省新材料制备与加工重点实验室昆明650093 昆明理工大学昆明市稀贵及有色金属先进材料重点实验室昆明650093

采用溶胶-凝胶法制备纯TiO2粉末和5mol%Ce掺杂TiO2粉末,利用X射线衍射仪(XRD)、X射线光电子能谱仪(XPS)和紫外-可见分光光度计(UV-Vis)表征样品的相变过程和化学态变化,主要探讨了Ce掺杂对TiO2相变温度、物相组成、化学态及吸收光谱范... 详细信息

采用溶胶-凝胶法制备纯TiO2粉末和5mol%Ce掺杂TiO2粉末,利用X射线衍射仪(XRD)、X射线光电子能谱仪(XPS)和紫外-可见分光光度计(UV-Vis)表征样品的相变过程和化学态变化,主要探讨了Ce掺杂对TiO2相变温度、物相组成、化学态及吸收光谱范围的影响。结果表明:掺杂Ce抑制了TiO2的相转变和晶粒长大。随着热处理温度升高,Ce掺杂TiO2的晶格氧峰增强而吸附氧峰降低,而且Ti2p3/2结合能减小,Ce3+逐渐被氧化为Ce4+。掺杂Ce拓宽了TiO2的可见光谱吸收范围。

关键词：溶胶-凝胶法二氧化钛铈掺杂化学态

RNA干扰技术在乳腺癌基因治疗中的研究进展

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肿瘤研究与临床 2011年第9期23卷 643-646页

作者：薛荣泉(综述) 谷俊朝(审校) 首都医科大学附属北京友谊医院普外科 100050

RNA干扰技术作为一种简单、有效的代替基因敲除的手段为肿瘤的基因治疗提供了新思路，文章综述RNA干扰的机制、特点及在乳腺癌基因治疗等方面的应用进展。

关键词： RNA干扰乳腺肿瘤基因疗法

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超声生物显微镜对窄角眼房角的观察

内蒙古医学杂志 2005年第8期37卷 697-700页

作者：孙怡艾育德薛荣全内蒙古医学院附属医院眼科内蒙古呼和浩特010050 内蒙古医学院2002级研究生内蒙古呼和浩特010059

目的:了解窄角眼房角结构的解剖形态特征,分析其形成原因。方法:选取门诊窄房角患者21例(32只眼);宽角30眼作为对照,分别采用A超测厚仪及超声生物显微镜(UBM)对研究对象及正常对照组分别进行观察并运用专用软件给与测量。结果:与宽角眼... 详细信息

目的:了解窄角眼房角结构的解剖形态特征,分析其形成原因。方法:选取门诊窄房角患者21例(32只眼);宽角30眼作为对照,分别采用A超测厚仪及超声生物显微镜(UBM)对研究对象及正常对照组分别进行观察并运用专用软件给与测量。结果:与宽角眼相比,窄角眼具有浅前房、晶体厚度增加、眼轴缩短、相对晶体位置前移、睫状体变薄、小梁虹膜角变窄,房角开放距离变小、虹膜厚度缩小、虹膜晶体接触距离增大等解剖特点;晶体厚度和前房深度与睫状体厚度测量位置1与位置2有明显相关性。结论:窄角眼具有前房浅、晶体厚,晶状体相对位置偏前、眼轴变短、睫状体位置前移、小梁虹膜角变窄、房角开放距离变小、虹膜厚度缩小、虹膜晶体接触距离增大等解剖特点;窄角眼中睫状体变薄是晶体前移,厚度增加,前房变浅的重要相关因素之一。

关键词：超声生物显微镜窄角睫状体

The Numerical Simulation of the Flow Field around a Propelled Hull Including Free Surface Influence

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The Numerical Simulation of the Flow Field around a Propelle...