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Enhanced tensile plasticity of a CuZr-based bulk metallic glass composite induced by ion irradiation

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Journal of Materials Science & Technology 2019年第10期35卷 2221-2226页

作者： peng xue Simon Pauly Weimin Gan Songshan Jiang Hongbo Fan Zhiliang Ning Yongjiang Huang Jianfei Sun State Key Laboratory of Advanced Welding and Joining Harbin Institute of TechnologyHarbin 150001China School of Materials Science and Engineering Harbin Institute of TechnologyHarbin 150001China IFW Dresden Institute for Complex MaterialsHelmholtzstraβe 20D-01069 DresdenGermany German Engineering Materials Science Centre(GEMS)at Heinz Maier-Leibnitz Zentrum(MLZ) Helmholtz-Zentrum Geesthacht GmbHGarchingGermany Key Laboratory of Micro-systems and Microstructures Manufacturing(Harbin Institute of Technology) Ministry of EducationHarbinChina

N^+ ion irradiation is utilized to tune the structure and mechanical properties of a Cu48Zr47.2Al4Nb0.8 bulk metallic glass composite(BMGC). Ion irradiation increases the disorder near the surface, as probed by neutron diffraction, and, moreover, causes the phase transformation from B2Cu Zr to B19’ CuZr martensitic phase in the studied BMGC. The tensile plasticity of the BMGC is dramatically improved after ion irradiation, which results from multiple shear banding on the surface and the martensitic transformation of the B2 to B19’ Cu Zr martensitic phase. The experimental results are strongly corroborated by complementary molecular dynamic simulations.

关键词： Bulk metallic glass composite Ion irradiation Neutron diffraction Molecular dynamics simulation Mechanical properties

Temperature Dependence of Chain Conformation and Local Rigidity of Isomerized Polyimides in Dimethyl Formamide

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Chemical Research in Chinese Universities 2013年第5期29卷 1022-1028页

作者： LIU Gui-hua QIU xue-peng SIDDIQ Mohammad BO Shu-qin JI Xiang-ling State Key Laboratory of Polymer Physics and Chemistry Changchun 130022 P. R. China Polymer Composites and Engineering Laboratory Changehun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022 P. R. China Department of Chemistry Quaid-i-Azam University Islamabad 45320 Pakistan

Temperature dependence of chain conformation and local rigidity of two soluble isomerized polyimides （PIs）, poly（hexafluorodianhydride/3,3＇-dimethylbenzidine）[poly（6FDA/3,3＇-DMB）] and poly（hexafluorodianhy- dride/2,2＇-dimethylbenzidine）[poly（6FDA/2,2＇-DMB）] were investigated by dilute solution viscosity, size exclusion chromatography（SEC） coupled with multi-angle laser light scattering, viscometer, and refractive index detector in dimethylformamide（DMF） with either 0.1 mol/L LiBr or 3.1 mmol/L tetrabutylammonium bromide（TBAB） in the temperature range of 30 to 50 ~C. The scaling relationships of [t/]=K^M~ and Rg=KgMv obtained are employed to in- vestigate the temperature dependence of chain conformation for the two polyimides. The values of a and v are in the range of 0.66--0.69 and 0.53--0.56, respectively, for poly（6FDA/3,3＇-DMB）, meanwhile they are in the range of 0.64--0.68 and 0.53--0.56, respectively, for poly（6FDAJ2,2＇-DMB）. These results reveal that random coil conforma- tions for both Pls are not affected visibly with increasing temperature from 30 ~C to 50 ~C. However, values of more exact intrinsic viscosity from dilute solution measurement indicate there is only tiny coil extension or shrinkage for both PIs with temperature rising. Parameters related to chain flexibility of polymer, including persistence length lp, shift factor ME（relative molecular weight per unit contour length） and backbone diameter d are estimated from the relationship between intrinsic viscosity and molecular weight for the continuous wormlike cylinder model, which indicates that two samples are flexible chains, only the chain of poly（6FDA/3,3＇-DMB） is stiffer than that of poly（6FDA/2,2＇-DMB） slightly.

关键词： Isomerized polyimide Chain conformation Temperature dependence Wormlike chain Persistence length

Indocyanine Green-Conjugated Magnetic Prussian Blue Nanoparticles for Synchronous Photothermal/Photodynamic Tumor Therapy

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Nano-Micro Letters 2018年第4期10卷 324-338页

作者： peng xue Ruihao Yang Lihong Sun Qian Li Lei Zhang Zhigang Xu Yuejun Kang Faculty of Materials and Energy Institute for Clean Energy and Advanced Materials Southwest University Chongqing Engineering Research Center for Micro-Nano Biomedical Materials and Devices State Key Laboratory of Silkworm Genome Biology Southwest University

Indocyanine green(ICG) is capable of inducing a photothermal effect and the production of cytotoxic reactive oxygen species for cancer therapy. However, the major challenge in applying ICG molecules for antitumor therapy is associated with their instability in aqueous conditions and rapid clearance from blood circulation,which causes insufficient bioavailability at the tumor ***, we conjugated ICG molecules with Prussian blue nanoparticles enclosing a Fe_3O_4 nanocore, which was facilitated by cationic polyethyleneimine via electrostatic adsorption. The nanocarrier-loaded ICG formed stable aggregates that enhanced cellular uptake and prevented fluorescence quenching. Moreover, the strong superparamagnetism of the Fe_3O_4 core in the obtained nanocomposites further improved cellular internalization of the drugs guided by a localized magnetic field. The therapeutic efficacy of this nanoplatform was evaluated using tumor models established in nude mice, which demonstrated remarkable tumor ablation in vivo due to strong photothermal/photodynamic effects. This study provides promising evidence that this multifunctional nanoagent might function as an efficient mediator for combining photothermal and photodynamic cancer therapy.

关键词： Combination therapy Prussian blue nanoparticles Photothermal therapy Photodynamic therapy Indocyanine green

An in-depth analysis of proteomics expression profiling in rat glomeruli utilizing LC-MS

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Chinese Science Bulletin 2010年第20期55卷 2142-2151页

作者： HONG Quan xue peng LU Yang CHEN XiangMei QI Ka WU Di Kidney Department & Institute of Nephrology Division of Clinical Internal Medicine Chinese PLA General Hospital Beijing 100853 China Laboratory of Proteomics Institute of Biophysics Chinese Academy of Sciences Beijing 100101 China

Glomeruli are an essential functional element of renal *** majority of renal diseases caused by glomerular sclerosis or fibrosis may result in renal dysfunction.A fomulate protein profile,a comprehensive analysis of glomeruli of normal rats was conducted in this study via protein *** annotation and classification of these proteins were performed and it was found that 26 had the same glomerule(endothelial cells,podocytes and mesangial cells)markers with proteins.

关键词：蛋白质组学肾小球大鼠 MS法 LC 作者内皮细胞肾功能不全

Detection of Ultra Trace Amount Gossypol with Chemiluminescence Using Capillary Electrophoresis as Injection Techniques

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Chinese Chemical Letters 2005年第12期16卷 1649-1651页

作者： Er Bao LIU Min ZHANG Bing Chun xue peng Xiang ZHAO Yin LIU School of Chemistry and Life Sciences Tianjin Normal University Tianjin 300074

Detection of ultra trace amount gossypol is reported. It is based on luminolhexacyanoferrate（Ⅲ） chemiluminescence reaction with gossypol as a sensitizer. The detection limit （3 σ ）of gossypol reaches 5.21 × 10^... 详细信息

关键词： Capillary electrophoresis chemiluminescence gossypol

DNA polymerase beta overexpression correlates with poor prognosis in esophageal cancer patients

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Chinese Science Bulletin 2013年第26期58卷 3274-3279页

作者： ZHENG Hong xue peng LI Min ZHAO JiMin DONG ZiMing ZHAO GuoQiang Department of Pathophysiology Medical College of Henan University School of Basic Medical Sciences Zhengzhou University

Gene of DNA polymerase beta (pol ) plays an important role in base excision repair, DNA replication and translesion synthesis. This study aims to investigate the expression and prognostic significance of DNA pol in esophageal cancer. DNA pol expression was analyzed using real-time quantitative PCR (RT-qPCR) and immunohistochemical staining on tissue samples from a consecutive series of 114 esophageal squamous carcinoma patients who underwent resections between 2002 and 2006. Pol expression was investigated on its correlation to clinico-pathological factors and survival. RT-qPCR results showed higher expression of DNA pol mRNA in tumor tissue than in its matched adjacent non-tumor tissue sample, different expression of DNA pol mRNA was noticed with significance between tumors with and without lymph node metastasis. Immunohistochemistry staining results indicated the pol strong-positive rate was 44.73% (51/114) in tumor tissue samples and 0.00% in matched adjacent non-tumor tissue samples, with significant difference. Kaplan-Meier survival curves revealed that high expression of pol was associated with tumor metastasis and poor prognosis in esophageal cancer patients. Our data suggests that pol plays an important role in tumor progression and that high pol expression predicts an unfavorable prognosis in esophageal squamous carcinoma patients.

关键词： DNA聚合酶β 食管癌预后患者过表达免疫组化染色肿瘤组织鳞状细胞癌

Improvement in the Hit Ratio of the Yield Strength of HRB400D Reinforced Bar

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Journal of Iron and Steel Research International 2014年第S1期21卷 28-33页

作者： Dong-feng HE peng xue Jin-bao CHANG Shuang-wu LI You-bing XIANG State Key Laboratory of Advanced Metallurgy University of Science and Technology Beijing School of Metallurgy and Ecology Engineering University of Science and Technology Beijing Tangshan Iron and Steel Company of Hebei Iron and Steel Group

The hit ratio of the yield strength of HRB400 D reinforced bar(Tangshan Iron and Steel Co.) is low. In this study, the effects of [C], [Mn], [Si], and [V] on the yield strength and mechanism were investigated. The HRB400 D reinforced bar with a specification of 22 spiral was chosen. A narrow composition control was achieved by reducing the lower limit of the Mn content and the amount of the alloying elements; moreover, the hit ratio of the reinforced bar yield strength increased from 65.54% to 96.27%, enhancing product stability. The cost of the steel alloy reduced by 8.86 RMB/ton, improving the market competitiveness of the product.

关键词： HRB400D narrow composition control yield strength hit ratio

Diagnosis and guidance of treatment of breast cancer cutaneous metastases by multiple needle biopsy: A case report

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World Journal of Clinical Cases 2022年第1期10卷 345-352页

作者： Zhong-Hui Li Fang Wang Ping Zhang peng xue Shi-Jie Zhu Department of Oncology Wangjing HospitalChina Academy of Chinese Medical SciencesBeijing 100102Beijing ProvinceChina Department of Pathology Wangjing HospitalChina Academy of Chinese Medical SciencesBeijing 100102Beijing ProvinceChina

BACKGROUND Breast cancer patients have a high skin metastasis ***,reports on treatment of cutaneous metastases of breast cancer are *** SUMMARY We report the treatment process for one breast cancer case with bone,lung,and skin *** patient was a 43-year-old woman with advanced breast cancer and skin *** underwent pathological diagnosis by needle biopsy to guide the *** the disease progressed,a new pathological diagnosis was determined by needle biopsy to guide the *** patient received chemotherapy,endocrine therapy,and photodynamic dynamic therapy,followed by sonodynamic *** Repeated puncture should be performed for advanced breast cancer with skin metastasis,in order to obtain the pathology and directly determine diagnosis when the disease *** treatment should focus on controlling the systemic metastasis,rather than the local disease.

关键词： Breast cancer Cutaneous metastases Needle biopsy Exemestane and everolimus Case report

Rigorous Running Time Analysis of a Simple Immune-Based Multi-Objective Optimizer for Bi-Objective Pseudo-Boolean Functions

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Journal of Shanghai Jiaotong university(Science) 2018年第6期23卷 827-833页

作者： ZHOU Shiyuan peng xue WANG Yinglin XIA Xiaoyun School of Information Management and Engineering Shanghai University of Finance and EconomicsShanghai 200433China School of Mathematics and Systems Science Guangdong Polytechnic Normal UniversityGuangzhou 510665China Office of Budget and Finance Jiaxing UniversityJiaxing 314001ZhejiangChina College of Mathematics Physics and Information EngineeringJiaxing UniversityJiaxing 314001ZhejiangChina

A simple immune-based multi-objective optimizer(IBMO) is proposed, and a rigorous running time analysis of IBMO on three proposed bi-objective pseudo-Boolean functions(Bi-Trap, Bi-Plateau and Bi-Jump) is presented. The running time of a global simple evolutionary multi-objective optimizer(GSEMO) using standard bit mutation operator with IBMO using somatic contiguous hypermutation(CHM) operator is compared with these three functions. The results show that the immune-based hypermutation can significantly beat standard bit mutation on some well-known multi-objective pseudo-Boolean functions. The proofs allow us to understand the relationship between the characteristics of the problems and the features of the algorithms more deeply. These analysis results also give us a good inspiration to analyze and design a bio-inspired search heuristics.

关键词： evolutionary algorithm running time analysis somatic contiguous hypermutation