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国内外不同品种啤酒大麦萌发过程中蛋白质的变化

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中国食品添加剂 2011年第2期22卷 105-110页

作者：王特薛永常大连工业大学生物工程学院大连116034

采用9种国内外啤酒大麦为材料,以考马斯亮蓝G-250方法检测其萌发过程中清蛋白、球蛋白、醇溶蛋白和谷蛋白含量的动态变化,并进行SDS-PAGE电泳分析。结果表明:大麦萌发过程中,清蛋白含量逐渐升高,平均增加2.116倍;球蛋白含量先升高后降低... 详细信息

采用9种国内外啤酒大麦为材料,以考马斯亮蓝G-250方法检测其萌发过程中清蛋白、球蛋白、醇溶蛋白和谷蛋白含量的动态变化,并进行SDS-PAGE电泳分析。结果表明:大麦萌发过程中,清蛋白含量逐渐升高,平均增加2.116倍;球蛋白含量先升高后降低,萌发后比萌发前略高;醇溶蛋白和谷蛋白的含量逐渐降低,分别平均减少1.983和2.167倍。国内外不同品种啤酒大麦的清蛋白和球蛋白组成基本相同,醇溶蛋白存在显著的差异,谷蛋白也有一定的差别,因此醇溶蛋白可以作为鉴定大麦不同品种和品质的依据之一,谷蛋白也可以作为一种辅助的鉴别依据。

关键词：大麦蛋白质萌发 SDS-聚丙烯酰胺凝胶电泳

Using MsfNet to Predict the ISUP Grade of Renal Clear Cell Carcinoma in Digital Pathology Images

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Computers, Materials & Continua 2024年第1期78卷 393-410页

作者： Kun Yang Shilong chang Yucheng Wang Minghui Wang Jiahui Yang Shuang Liu Kun Liu Linyan xue College of Quality and Technical Supervision Hebei UniversityBaoding071002China National and Local Joint Engineering Research Center of Metrology Instrument and System Hebei UniversityBaoding071002China Hebei Technology Innovation Center for Lightweight of New Energy Vehicle Power System Hebei UniversityBaoding071002China

Clear cell renal cell carcinoma(ccRCC)represents the most frequent form of renal cell carcinoma(RCC),and accurate International Society of Urological Pathology(ISUP)grading is crucial for prognosis and treatment *** study presents a new deep network called Multi-scale Fusion Network(MsfNet),which aims to enhance the automatic ISUP grade of ccRCC with digital histopathology pathology *** MsfNet overcomes the limitations of traditional ResNet50 by multi-scale information fusion and dynamic allocation of channel *** model was trained and tested using 90 Hematoxylin and Eosin(H&E)stained whole slide images(WSIs),which were all cropped into 320×320-pixel patches at 40×*** achieved a micro-averaged area under the curve(AUC)of 0.9807,a macro-averaged AUC of 0.9778 on the test *** Gradient-weighted Class Activation Mapping(Grad-CAM)visually demonstrated MsfNet’s ability to distinguish and highlight abnormal areas more effectively than *** t-Distributed Stochastic Neighbor Embedding(t-SNE)plot indicates our model can efficiently extract critical features from images,reducing the impact of noise and redundant *** results suggest that MsfNet offers an accurate ISUP grade of ccRCC in digital images,emphasizing the potential of AI-assisted histopathological systems in clinical practice.

关键词： Renal cell carcinoma computer-aided diagnosis pathology image deep learning machine learning

Computed tomography-based multi-organ radiomics nomogram model for predicting the risk of esophagogastric variceal bleeding in cirrhosis

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World Journal of Gastroenterology 2024年第36期30卷 4044-4056页

作者： Yu-Jie Peng Xin Liu Ying Liu xue Tang Qi-Peng Zhao yong Du Department of Radiology The Affiliated Hospital of North Sichuan Medical CollegeNanchong 637000Sichuan ProvinceChina Department of Radiology The People’s Hospital of Chongqing Liang Jiang New AreaChongqing 401121China

BACKGROUND Radiomics has been used in the diagnosis of cirrhosis and prediction of its associated ***,most current studies predict the risk of esophageal variceal bleeding(EVB)based on image features at a single level,which results in incomplete *** studies have explored the use of global multi-organ radiomics for non-invasive prediction of EVB secondary to *** To develop a model based on clinical and multi-organ radiomic features to predict the risk of first-instance secondary EVB in patients with *** In this study,208 patients with cirrhosis were retrospectively evaluated and randomly split into training(n=145)and validation(n=63)*** areas were chosen as regions of interest for extraction of multi-organ radiomic features:The whole liver,whole spleen,and lower esophagus–gastric fundus *** the training cohort,radiomic score(Rad-score)was created by screening radiomic features using the inter-observer and intra-observer correlation coefficients and the least absolute shrinkage and selection operator *** clinical risk factors were selected using multivariate logistic regression *** radiomic features and clinical risk variables were combined to create a new radiomics-clinical model(RC model).The established models were validated using the validation *** Radiomics has been used in the diagnosis of cirrhosis and prediction of its associated ***,most current studies predict the risk of esophageal variceal bleeding(EVB)based on image features at a single level,which results in incomplete *** studies have explored the use of global multi-organ radiomics for non-invasive prediction of EVB secondary to *** To develop a model based on clinical and multi-organ radiomic features to predict the risk of first-instance secondary EVB in patients with *** In this study,208 patients with cirrhosis were retrospectively evaluated and randoml

关键词： Artificial intelligence Cirrhosis Radiomics Esophagogastric variceal bleeding

Flotation separation of feldspar from quartz using sodium fluosilicate as a selective depressant

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Rare Metals 2024年第3期43卷 1288-1300页

作者： Xin Hu Xian-Ping Luo Zi-Shuai Liu yong-Bing Zhang He-Peng Zhou Zhi-Zhao Yang xue-Kun Tang Faculty of Resource and Environmental Engineering Jiangxi University of Science and TechnologyGanzhou341000China Yichun Lithium New Energy Industry Research Institute Jiangxi University of Science and TechnologyYichun336000China

The physical and chemical properties of feldspar and quartz are highly similar,thus they cannot be easily separated *** this work,the flotation separation of feldspar from quartz using sodium fluosilicate(Na_(2)SiF_(6);SF)as a selective depressant was ***,the influence mechanism of SF on the selective flotation separation of feldspar and quartz was investigated via flotation tests,chemical analysis of flotation solution,Fourier transform infrared spectroscopy(FTIR),X-ray photoelectron spectroscopy(XPS)and contact angle *** results of the flotation tests show that feld spar and quartz without SF treatment have good *** SF treatment,feldspar still has good floatability,whereas quartz has significantly reduced *** solution chemical analysis shows that the functional group plays an important role in depressing the quartz is[SiF_(6)]^(2-).FTIR,XPS and contact angle analysis results show that[SiF_(6)]^(2-)is adsorbed only on the surface of ***,a thin hydrophilic SiOF layer is generated on the surface,which interferes with the adsorption of the collector on the surface of the *** phenomenon leads to a significant reduction in quartz's ***,SF has a good ability to separate feldspar from quartz by flotation.

关键词： Flotation separation Depressants Sodium fluorosilicate Quartz Feldspar

Skin supersoliditymatters the performance and functionality of water droplets

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Droplet 2024年第4期3卷 1-9页

作者： chang Q.Sun yong Zhou Hengxin Fang Biao Wang RISE and School of Materials Science&Engineering Dongguan University of TechnologyDongguanChina School of Physics&Sino-French Institute of Nuclear Engineering&Technology Sun Yat-Sen UniversityGuangzhouChina Guangdong Provincial Key Laboratory of Extreme Conditions DongguanChina

Even more fascinating than its bulk parent,a water droplet possesses extraordinary catalytic and hydro-voltaic capability,elastic adaptivity,hydrophobicity,sensitivity,thermal stability,etc.,but the underlying mechanism is still *** emphasize herewith that the H‒O bond follows the universal bond order‒length‒strength cor-relation and nonbonding electron polarization regulation and the hydrogen bond cooperativity and polarizability notion regulates the performance of the coupling hydrogen bond(O:H‒O).Computational and spectrometric evidence consistently shows that molecular undercoordination shortens the intramolecular H‒O bond by up to 10%while lengthening the intermolecular O:H nonbond by 20%cooperatively with an association of electron polarization,making the 0.3-nm thick droplet skin of a supersolid phase of *** supersolid skin dictates the performance and functionality of the droplet in chemical,dielectric,electrical,mechanical,optical,and thermal properties as well as the transport dynamics of electrons and *** amplification of these findings could deepen our insight into the undercoordi-nated aqueous systems,including bubbles and molecular clusters,and promote deep engineering of water and ice.

关键词： performance solid bonding

Tailoring-compensated ferrimagnetic state and anomalous Hall effect in quaternary Mn–Ru–V–Ga Heusler compounds

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Chinese Physics B 2024年第7期33卷 595-603页

作者：梁瑾静郗学奎王文洪刘永昌 Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China Tiangong University Tianjin 300387China

Cubic Mn_(2)Ru_(x)Ga Heusler compound is a typical example of compensated ferrimagnet with attractive potential for high-density,ultrafast,and low-power spintronic *** the form of epitaxial thin films,Mn_(2)Ru_(x)Ga exhibits high spin polarization and high tunability of compensation temperature by freely changing the Ru content x in a broad range(0.3

关键词： compensated ferrimagnet anomalous Hall effect residual resistivity ratio

Path analysis of desirable traits and evaluation of reproductive performance of Crassostrea sikamea in different ages

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Aquaculture and Fisheries 2024年第2期9卷 164-171页

作者： Guangqiu chang Sheng Liu Hongqiang Xu Minhai Liu Zhihua Lin Qinggang xue National Demonstration Center for Experimental Fisheries Science Education Shanghai Ocean UniversityShanghai201306China Ninghai Institute of Mariculture Breeding and Seed Industry Zhejiang Wanli UniversityNinghaiZhejiang Province315604China Key Laboratory of Aquatic Germplasm Resources of Zhejiang Zhejiang Wanli UniversityNingbo315100China

Kumamoto oysters(Crassostrea sikamea)are important marine aquaculture shellfish because of their taste and round shell *** to its small size,selective breeding is required to improve its market size,but there are no reports on traits suitable for direction selection and reproductive productivity of Kumamoto oysters of different *** this study,path analysis and one-way ANOVA were used to explore the influential indices of oyster body weight and *** results showed that shell height was the main factor affecting the body weight of Kumamoto oysters at one-year-old and two-year-old,followed by shell *** weight was the main factor influencing fecundity,and shell height showed a significant correlation with ***,shell height should be considered the first parameter for selection when selecting Kumamoto oysters for body weight as the direct selection *** one-year-old and two-year-old Kumamoto oysters were selected as parents from Xiangshan Bay,hatching parameters and growth parameters of F1 generation larvae were *** fecundity and egg diameters were 1.72×10^(6)and 46.60±3.62μm,respectively,which were significantly greater than one-aged oysters(5.86×10^(5),40.26±3.52μm).The hatching parameters(fertilized egg size,fertilization rate,and hatching rate)and larval growth performance(D-stage veliger and veliger)were similar and did not differ significantly(P>0.05),and after metamorphosis,there was also no significant difference in shell height size at 40 days of age(P>0.05).Therefore,there was no significant effect of age on reproduction,larval development,and the early growth of Kumamoto *** results could provide a basis for parental sources and proper traits for Kumamoto oyster selection,which is beneficial to developing and utilizing this excellent germplasm resource.

关键词： Crassostrea sikamea Path analysis Reproductive performance Growth traits

Comparative Study on the Immunogenicity and Efficacy of Different Post-exposure Intramuscular Rabies Vaccination Regimens in China

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Biomedical and Environmental Sciences 2024年第2期37卷 178-186页

作者： SONG Yun HE Ying LU xue Xin ZHANG Xiao Mei JIANG XIAO Lin SONG Qing HUANG xue yong MA Hong Xia YU Peng Cheng ZHU Wu Yang Henan Provincial Center for Disease Control and Prevention Infectious Disease Prevention and Control InstituteHenan Provincial Key Laboratory of Infectious Disease PathogensZhengzhou 450000HenanChina National Institute for Viral Disease Control and Prevention China CDCKey Laboratory of BiosafetyNational Health CommissionBeijing 102206China Shandong Provincial Center for Disease Control and Prevention Jinan 250014ShandongChina Qingdao Chengyang District Center for Disease Control and Prevention Qingdao 266108ShandongChina

Objective This study aimed to compare the current Essen rabies post-exposure immunization schedule(0-3-7-14-28)in China and the simple 4-dose schedule(0-3-7-14)newly recommended by the World Health Organization in terms of their safety,efficacy,and *** Mice were vaccinated according to different immunization schedules,and blood was collected for detection of rabies virus neutralizing antibodies(RVNAs)on days 14,21,28,35,and 120after the first ***,different groups of mice were injected with lethal doses of the CVS-11 virus on day 0,subjected to different rabies immunization schedules,and assessed for morbidity and death *** a clinical trial,185 rabies-exposed individuals were selected for post-exposure vaccination according to the Essen schedule,and blood was collected for RVNAs detection on days 28and 42 after the first *** A statistically significant difference in RVNAs between mice in the Essen and 0-3-7-14 schedule groups was observed on the 35th day(P0.05)in RVNAs levels at any time *** post-exposure immune protective test showed that the survival rate of mice in the control group was 20%,whereas that in the immunization groups was 40%.In the clinical trial,the RVNAs positive conversion rates on days 28(14 days after 4 doses)and 42(14 days after 5 doses)were both 100%,and no significant difference in RVNAs levels was observed(P>0.05).Conclusion The simple 4-dose schedule can produce sufficient RVNAs levels,with no significant effect of a delayed fourth vaccine dose(14–28 d)on the immunization potential.

关键词： Rabies Post-exposure immunization Essen regimen RVNAs

Citrinsorbicillin A,a novel homotrimeric sorbicillinoid isolated by LC-MS-guided with cytotoxic activity from the fungus Trichoderma citrinoviride HT-9

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Chinese Chemical Letters 2024年第8期35卷 299-303页

作者： Guo-Ping Yin Ya-Juan Li Li Zhang Ling-Gao Zeng xue-Mei Liu chang-Hua Hu Engineering Research Center of Coptis Development and Utilization(Ministry of Education) College of Pharmaceutical Sciences and Chinese MedicineSouthwest UniversityChongqing 400715China State Key Laboratory of Natural Medicines China Pharmaceutical UniversityNanjing 211198China NMPA Key Laboratory for Quality Monitoring of Narcotic Drugs and Psychotropic Substances Chongqing Institute for Food and Drug ControlChongqing 401121China

Citrinsorbicillin A(1),a novel homotrimeric sorbicillinoid,along with two new monomers citrinsor-bicillins B(2)and C(3),were isolated from the Coptis chinensis endophyte Trichoderma citrinoviride HT-9 by liquid chromatograph mass spectrometer(LC-MS)-guided strategy.1 was the first trimeric-example from terrestrial fungi,which possessed a unique carbon skeleton with two bicyclo[2.2.2]octanedione ring connected through an enolated carbon forming by[4+2]*** structures were elucidated by spectroscopic analysis and X-ray diffraction.1 exhibited moderate cytotoxicity against human colon cancer HT29 cells,and it induced significant cell cycle arrest by reducing the protein expression of cyclin D1.

关键词： Citrinsorbicillin A Trimeric sorbicillinoid Coptis chinensis endophyte Trichoderma citrinoviride [4+2]Cycloaddition Cytotoxic activity