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Exploring predictive markers for liver failure post-hepatectomy in hepatocellular carcinoma patients

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World Journal of Gastrointestinal Surgery 2024年第5期16卷 1482-1484页

作者： Shi-Yan Zhang Xiong-Jian Ma xue-xia Zhu Na Cai Department of Clinical Laboratory Fuding HospitalFujian University of Traditional Chinese MedicineFuding 355200Fujian ProvinceChina

This letter to the editor addresses the study titled“Predictive value of NLR,Fib4,and APRI in the occurrence of liver failure after hepatectomy in patients with hepatocellular carcinoma”by Kuang et al in the World Journal of Gastrointestinal *** study acknowledges the comprehensive patient data analysis while suggesting that there is a need for further discussion on the clinical applicability of these markers across diverse patient *** letter recommends prospective studies for validation and considers the influence of confounding *** finding underscores the significance of this study in improving hepatocellular carcinoma management.

关键词： Neutrophil-to-lymphocyte ratio Hepatocellular carcinoma Liver failure Hepatectomy Letter to the Editor Commentary

Pathological BBB Crossing Melanin-Like Nanoparticles as Metal-Ion Chelators and Neuroinflammation Regulators against Alzheimer’s Disease

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Research 2024年第1期6卷 687-706页

作者： Qianqian Huang Chaoqing Jiang xue xia Yufan Wang Chenxing Yan xiaorong Wang Ting Lei xiaotong Yang Wenqin Yang Guo Cheng Huile Gao Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry West China School of PharmacySichuan UniversityChengdu 610041P.R.China Laboratory of Molecular Translational Medicine Center for Translational MedicineKey Laboratory of Birth Defects and Related Diseases of Women and Children(Sichuan University)Ministry of EducationDepartment of PediatricsWest China Second University HospitalSichuan UniversityChengdu 610041P.R.China

Inflammatory responses,manifested in excessive oxidative stress and microglia overactivation,together with metal ion-triggered amyloid-beta(Aβ)deposition,are critical hallmarks of Alzheimer’s disease(AD).The intricate pathogenesis causes severe impairment of neurons,which,in turn,exacerbates Aβaggregation and facilitates AD ***,multifunctional melanin-like metal ion chelators and neuroinflammation regulators(named PDA@K)were constructed for targeted treatment of *** this platform,intrinsically bioactive material polydopamine nanoparticles(PDA)with potent metal ion chelating and ROS scavenging effects were decorated with the KLVFF peptide,endowing the system with the capacity of enhanced pathological blood–brain barrier(BBB)crossing and lesion site accumulation via Aβ*** vitro and in vivo experiment revealed that PDA@K had high affinity toward Aβand were able to hitch a ride on Aβto achieve increased pathological BBB *** engineered PDA@K effectively mitigated Aβaggregate and alleviated neuroinflammation.

关键词： oxidative aggregation chelating

NAD+associated genes as potential biomarkers for predicting the prognosis of gastric cancer

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Oncology Research 2024年第2期32卷 283-296页

作者： xiaNGDONG SUN HUIJUAN WEN FAZHAN LI IHTISHAM BUKHARI FEIFEI REN xia xue PENGYUAN ZHENG YANG MI Henan Key Laboratory for Helicobacter Pylori&Microbiota and GI Cancer Marshall Medical Research CenterThe Fifth Affiliated Hospital of Zhengzhou UniversityZhengzhouChina Department of Gastroenterology The Fifth Affiliated Hospital of Zhengzhou UniversityZhengzhouChina

Nicotinamide adenine dinucleotide(NAD+)plays an essential role in cellular metabolism,mitochondrial homeostasis,inflammation,and ***,the role of NAD+-regulated genes,including coding and long non-coding genes in cancer development is poorly *** constructed a prediction model based on the expression level of NAD+metabolism-related genes(NMRGs).Furthermore,we validated the expression of NMRGs in gastric cancer(GC)tissues and cell lines;additionally,β-nicotinamide mononucleotide(NMN),a precursor of NAD+,was used to treat the GC cell lines to analyze its effects on the expression level of NMRGs lncRNAs and cellular proliferation,cell cycle,apoptosis,and senescence-associated secretory phenotype(SASP).A total of 13 NMRGs-related lncRNAs were selected to construct prognostic risk signatures,and patients with high-risk scores had a poor *** immune checkpoint genes were upregulated in the high-risk *** addition,cell cycle,epigenetics,and senescence were significantly downregulated in the high-risk ***,we found that the levels of immune cell infiltration,including CD8 T cells,CD4 naïve T cells,CD4 memory-activated T cells,B memory cells,and naïve B cells,were significantly associated with risk ***,the treatment of NMN showed increased proliferation of AGS and MKN45 *** addition,the expression of SASP factors(IL6,IL8,IL10,TGF-β,and TNF-α)was significantly decreased after NMN *** conclude that the lncRNAs associated with NAD+metabolism can potentially be used as biomarkers for predicting clinical outcomes of GC patients.

关键词： NAD+ LncRNAs Cancer Cell infiltration Prognosis Tumor microenvironment

Combination losartan with hyaluronic acid modified diethyldithiocarbamate loaded hollow copper sulfide nanoparticles for the treatment of breast cancer and metastasis

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Chinese Chemical Letters 2024年第3期35卷 406-414页

作者： Haili Hu Weiwei Zhang Lei Lei Fan Tong Huilin Zhang Yiwei Zhang Wenqin Yang Yilu Tang Ruyi Lin xue xia Jiamei Li Shiyong Song Huile Gao Key Laboratory of Drug Targeting and Drug Delivery Systems West China School of PharmacySichuan UniversityChengdu 610041China School of Pharmacy Henan UniversityKaifeng 475004China Department of Public Health Chengdu Medical CollegeChengdu 610500China

The application of photothermal therapy(PTT)is greatly limited by the low accumulation of photothermal agents,uneven photothermal distribution,and heat endurance of cancer *** still,despite PTT enhances immunogenicity,the anti-tumor immune efficacy is still unsatisfactory due to the inefficient immunogenic cell death(ICD)induction and poor infiltration of immune *** solve the above problems of PTT,we developed hyaluronic acid(HA)modified hollow copper sulfide nanoparticles encapsulating diethyldithiocarbamate(DDTC)to construct a breast tumor targeting and near infrared(NIR)photo-responsive drug delivery system(D-HCuS@HA),which further combined with losartan to improve the accumulation and penetration in the tumor *** irradiation,D-HCuS@HA realized enhanced PTT and released cytotoxic Cu(DDTC)_(2)to eliminate heat endurance tumor cells,thereby enhancing antitumor effect and inducing effective ***,the combination with losartan could remodel the tumor microenvironment,allowing more T cells to infiltrate into the tumor,and significantly inhibiting the occurrence and development of metastatic *** vitro/vivo results revealed the great potential of D-HCuS@HA combined with losartan,which provides a new paradigm for anti-tumor and anti-metastases.

关键词： Targeted drug delivery system Hollow copper sulfide nanoparticles Photothermal therapy Hyaluronic acid Breast cancer Anti-metastasis

家属互助办福利:“一五”期间工房托儿站在上海

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安徽史学 2024年第2期 147-157页

作者：夏雪复旦大学马克思主义学院上海200433

在高积累低消费的“一五”期间,国家无法全力承担起全部女职工的托儿责任,因而鼓励职工家属用团结互助的办法解决自己的困难。观察“一五”期间以女工为主要生产者的上海纺织工厂用家属互助办工房托儿站来处理再生产的方式,可以清晰地看... 详细信息

在高积累低消费的“一五”期间,国家无法全力承担起全部女职工的托儿责任,因而鼓励职工家属用团结互助的办法解决自己的困难。观察“一五”期间以女工为主要生产者的上海纺织工厂用家属互助办工房托儿站来处理再生产的方式,可以清晰地看到:基于劳动的性别化分工,以家庭妇女居多的职工家属成为工厂企业集体托儿福利事业的主要承担者。这种做法不仅提高了女工的生产效率,减轻了国家和女工们的经济负担,为国家工业化作出了一定贡献,而且有着妇女解放的重要意涵。在当下,仍不失为一种值得考虑的解决幼有所育的可能方法。

关键词：家属互助 “一五”计划上海工房托儿站

Fatal multiple acyl-CoA dehydrogenase deficiency caused by ETFDH gene mutation:A case report

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World Journal of Clinical Cases 2024年第23期12卷 5422-5430页

作者： xue-xia Li xiao-Nan Yang Hu-Dan Pan Liang Liu State Key Laboratory of Quality Research in Chinese Medicine Macao University of Science and TechnologyMacao 999078China State Key Laboratory of Traditional Chinese Medicine Syndrome The Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510006Guangdong ProvinceChina

BACKGROUND Multiple acyl-CoA dehydrogenase deficiency(MADD)is a disease of rare autosomal recessive *** are three types of *** I is a neonatalonset form with congenital *** II is a neonatal-onset form without congenital *** III is considered to a milder form and usually responds to ***,late-onset form could also be fatal and not responsive to *** SUMMARY We report a severe case of a young man with onset type III MADD induced by drugs and strenuous exercise characterized by rhabdomyolysis and liver *** analysis indicated 12 out of 70 kinds of organic acids like glutaric acid-2 were *** analysis in genetic metabolic diseases revealed 24 out of 43 tested items were abnormal,revealing the elevation of several acylcarnitines and the reduction of carnitine in the *** next generation sequencing technology for gene sequencing related to fatty acid oxidation and carnitine cycle defects,a rare ETFDH gene variant was identified:NM_004453:4:C.1448C>T(***483 Leu).The patient was diagnosed with lateonset *** was not responsive to riboflavin and progressively worsened into multiple organ failure that finally led to *** Type III MADD can also be fatal and not responsive to treatments.

关键词： Electron transfer flavoprotein dehydrogenase mutation Multiple acyl-CoA dehydrogenase deficiency Multiple organ failure Case report

基于改进YOLOv8算法的实时细粒度植物病害检测

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中国农机化学报 2024年第5期45卷 188-194页

作者：薛霞刘鹏周文运城学院数学与信息技术学院山西运城044000 山西农业大学信息科学与工程学院山西晋中030800 中国科学院计算技术研究所计算机体系结构国家重点实验室北京市100190

为解决现有识别方法在植物病害检测中遇到的密集分布、不规则形态、多尺度目标类别、纹理相似性等障碍,提出一种高性能的实时细粒度植物病害检测框架。首先,在YOLOv8主干网络和颈部设计两个新的残差块,增强特征提取和降低计算成本;其次... 详细信息

为解决现有识别方法在植物病害检测中遇到的密集分布、不规则形态、多尺度目标类别、纹理相似性等障碍,提出一种高性能的实时细粒度植物病害检测框架。首先,在YOLOv8主干网络和颈部设计两个新的残差块,增强特征提取和降低计算成本;其次,引入DenseNet层,并使用Hard-Swish函数作为主要激活函数,以提高模型的准确性;最后,设计PANet网络,用于保留细粒度的局部信息和改善特征融合。在不同的复杂环境下,对番茄植株的四种不同病害进行检测。试验结果表明,所提改进模型在检测准确性和速度上均优于现有模型的检测模型。当检测速度为71.23 FPS时,所提改进模型精确度为92.58%,召回率为97.59%,F_(1)分数为93.64%。为精准农业自动化提供有效的技术手段。

关键词：植物病害检测改进YOLOv8 实时目标检测深度神经网络残差网络

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融媒体时代宁夏主流媒体抖音号融合发展现状及优化路径

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北方民族大学学报（哲学社会科学版） 2024年第2期 127-134页

作者：张学霞北方民族大学文学与新闻传播学院宁夏银川750021

宁夏主流媒体抖音号短时期内呈现出规模化发展态势,但同时也面临着区域媒体原创性内容供给不足、账号尚未形成品牌和口碑、与用户无法建立强连接和深互动等结构性难题。要想成为意识形态的主阵地、舆论宣传的主战场和区域媒体发展的领跑... 详细信息

宁夏主流媒体抖音号短时期内呈现出规模化发展态势,但同时也面临着区域媒体原创性内容供给不足、账号尚未形成品牌和口碑、与用户无法建立强连接和深互动等结构性难题。要想成为意识形态的主阵地、舆论宣传的主战场和区域媒体发展的领跑者,宁夏主流媒体抖音号需要借鉴其他媒体抖音号的成功经验,深度融合抖音短视频平台的规则,实现硬新闻内容和短视频视觉化、故事化、情感化等软传播的兼容发展。

关键词：宁夏主流媒体抖音号视频化表达差异化传播深度融合

清中叶至民国时期东洋参在中国的流通药用考析

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中华医史杂志 2024年第2期54卷 90-97页

作者：夏雪李铁华上海中医药大学科技人文研究院上海201203

东洋参,是将高丽参、西洋参引种至日本并形成一定规模化种植的人参。自清代中叶至民国初年,东洋参借助价格优势以辽参、高丽参替代品的外来参形象广泛流通于进补文化浓厚的江南地区,并逐渐在中国参市站稳脚跟。随着东洋参的流通和药用演... 详细信息

东洋参,是将高丽参、西洋参引种至日本并形成一定规模化种植的人参。自清代中叶至民国初年,东洋参借助价格优势以辽参、高丽参替代品的外来参形象广泛流通于进补文化浓厚的江南地区,并逐渐在中国参市站稳脚跟。随着东洋参的流通和药用演变,清中叶至民国时期的医药界对其分类、作伪、药性与药用等研究逐渐深入,并在近代生药学的发展下,最终确定其与辽参、高丽参在药用价值上的替代关系。但随着近代中日民族矛盾的上升,东洋参在全国性抵制日货运动中销量锐减,其在中国的药用逐渐衰落。

关键词：东洋参市场流通分类演变作伪鉴别药用价值