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医学信息素养教育中的游戏教学法实践研究

吉林医药学院学报 2025年第1期46卷 71-73,76页

作者：焦雪冯超杨影吉林医药学院文献检索教研室吉林吉林132013

在医学生信息素养教学中,以“文献检索”课程为例,从“理论讲授”和“实践操作”两部分探索医学院校信息素养教育的游戏式教学。首先,通过调研了解学生对游戏教学的认知;然后,分析出医学文献检索互动教学游戏的设计要素以及游戏教学中... 详细信息

在医学生信息素养教学中,以“文献检索”课程为例,从“理论讲授”和“实践操作”两部分探索医学院校信息素养教育的游戏式教学。首先,通过调研了解学生对游戏教学的认知;然后,分析出医学文献检索互动教学游戏的设计要素以及游戏教学中的典型案例;最后,结合课堂实践提出了游戏教学策略优化方案。实践表明以学生为中心,游戏互动的教学设计提高了学生的学习积极性、培养学生的自主学习和团队合作能力。

关键词：医学教育游戏教学信息素养

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中药标准化发展研究及对策建议

中国标准化 2025年第4期 60-65页

作者：于钟怡阎雪姣辽宁省标准化研究院

中医药标准化是我国中医药事业发展中一项基础性、战略性、全局性工作。近年来,我国标准化能力显著提升,标准化支撑和服务中医药高质量发展的作用日益凸显。本文通过对中药标准化发展情况的研究,构建中药标准体系框架,并提出对中药产业... 详细信息

中医药标准化是我国中医药事业发展中一项基础性、战略性、全局性工作。近年来,我国标准化能力显著提升,标准化支撑和服务中医药高质量发展的作用日益凸显。本文通过对中药标准化发展情况的研究,构建中药标准体系框架,并提出对中药产业标准化发展的建议,为推动我国中医药标准化事业发展提供有力的技术支撑。

关键词：中药标准化标准体系

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基于双目视觉和改进YOLOv8n的火灾检测及测距方法

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陕西科技大学学报 2025年第1期43卷 152-160页

作者：刘振董绍江罗家元孙世政潘学娇重庆交通大学机电与车辆工程学院重庆400074

针对火灾检测出现的漏检误检、模型参数量大及定位困难的问题,基于双目视觉和改进YOLOv8n提出了一种轻量化火灾检测及测距方法.通过双目相机拍摄图片,使用改进的检测算法YOLOv8n-AEM和现有的测距算法SGBM进行检测和测距.首先,在主干网... 详细信息

针对火灾检测出现的漏检误检、模型参数量大及定位困难的问题,基于双目视觉和改进YOLOv8n提出了一种轻量化火灾检测及测距方法.通过双目相机拍摄图片,使用改进的检测算法YOLOv8n-AEM和现有的测距算法SGBM进行检测和测距.首先,在主干网络中引入可变核卷积AKConv和EMA注意力机制,通过构建不规则卷积核有效提取火灾的特征;然后,在颈部网络中构建C2f-SCConv模块,通过特征重组降低模型参数,提高检测速度;其次,基于最小点距离改进损失函数,解决火源与光源重叠导致的漏检与误检问题;最后,增加小目标检测头,提高对小火苗的检测能力.实验结果表明,改进后的检测算法P、R、mAP分别为83.6%、76.4%、83.6%,分别提高了2.5%、3.6%、4.8%;参数量和模型大小分别为2.54 M和5.1 MB,分别降低了15.3%和15%;测距精度误差不超过2.5%,证明改进的方法能准确完成火灾的检测及测距.

关键词：火灾检测双目视觉测距 YOLOv8n 轻量化

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儿童和青少年2型糖尿病患者饮食管理的最佳证据总结

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护理学杂志 2025年第1期40卷 99-104,110页

作者：温敬冬岳小林杨旻星薛姣叶赟常州市第一人民医院内分泌代谢科江苏常州213000 常州市第一人民医院护理部江苏常州213000

目的检索、评价并整合国内外儿童和青少年2型糖尿病患者饮食管理的最佳证据,为临床护理提供参考。方法系统检索指南网站、专业协会网站和数据库中关于儿童和青少年2型糖尿病患者饮食管理的证据,包括临床决策、最佳实践、指南、专家共识... 详细信息

目的检索、评价并整合国内外儿童和青少年2型糖尿病患者饮食管理的最佳证据,为临床护理提供参考。方法系统检索指南网站、专业协会网站和数据库中关于儿童和青少年2型糖尿病患者饮食管理的证据,包括临床决策、最佳实践、指南、专家共识、系统评价等,检索时限为2014年1月至2024年5月,由2名研究者对纳入文献进行方法学质量评价,对符合标准的文献进行资料提取和证据汇总。结果共纳入15篇文献,包括临床决策1篇,指南5篇,专家共识9篇。从管理目标、评估、体质量管理、营养素推荐、运动的饮食管理、团队合作与教育6个方面汇总38条最佳证据。结论本研究总结了儿童和青少年2型糖尿病患者饮食管理的最佳证据,可为护理人员开展临床实践提供参考。医护人员可以结合临床情景,个性化地应用相关证据,促进患者的科学管理。

关键词：儿童青少年 2型糖尿病饮食管理营养素体质量健康教育证据总结

Runchangningshen paste activates NLRP6 inflammasome-mediated autophagy to stimulate colonic mucin-2 secretion and modulates mucosal microbiota in functional constipation

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World Journal of Gastroenterology 2025年第9期31卷 100-134页

作者： Liu, xue-jiao Ye-Er-tai, Ye-Li-Ya Jia, Yue-Bo Wu, Chen-Heng Wang, Xiang-Xiang Yang, Ke-Ming Yao, Xuan Ling, Jiang-Hong Department of Gastroenterology Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine Shanghai 200021 China School of Traditional Chinese Medicine Shanghai University of Traditional Chinese Medicine Shanghai 201203 China Department of Gastroenterology Shenzhen Traditional Chinese Medicine Hospital Guangdong Province Shenzhen 518033 China Guangdong Shaxi Pharmaceutical Co. Ltd Guangdong Province Zhongshan 528471 China

BACKGROUND Runchangningshen paste (RCNSP) is a paste made of four medicinal and edible homologous Chinese medicine mixed with honey. It is known for its ability to nourish yin and blood as well as to loosen the bowel to relieve constipation. The pathophysiology of functional constipation (FC) is associated with a reduction in mucin-2 (MUC2) secretion and microbial dysbiosis. AIM To investigate the underlying mechanism of RCNSP against FC through MUC2 and the gut mucosal microbiota. METHODS Ultra-performance liquid chromatography tandem mass spectrometry characterized RCNSP composition to elucidate the material basis of action. FC model was induced via loperamide gavage (16 mg/kg) twice daily for 7 days. Applying defecation function and gastrointestinal motility to assess constipation severity. Hematoxylin and eosin and Alcian blue-periodic acid-schiff staining analyzed colonic mucosal morphology. Transmission electron microscope was used to observe the ultrastructure of goblet cells (GCs). Immunofluorescence colocalization, quantitative PCR, and western blot assessed the impact of RCNSP on gene and protein expression within the NLRP6/autophagy pathway. 16S rDNA was employed to sequence the gut mucosal microbiota. RESULTS RCNSP contained 12 components with potential laxative effects. It enhanced defecation function, accelerated gastrointestinal motility, and maintained colonic mucosal integrity. RCNSP treatment significantly increased GC abundance and MUC2 production while preserving GC ultrastructure. At the molecular level, RCNSP enhanced the colocalized expression of key regulatory proteins and modulated mRNA and protein expressions in the NLRP6/autophagy pathway. Through 16S rDNA sequencing analysis, RCNSP significantly altered the mucosal microbiota composition. Specifically, it increased beneficial bacterial strains while reducing harmful ones. Simultaneously, RCNSP reduced butyrate-producing bacteria like Proteobacteria, Enterobacteriaceae, Blautia, and Eubact

关键词： Autophagy Functional constipation Goblet cells Mucin Mucosal microbiota NLRP6 Traditional Chinese medicine

Microcrack-and microvoid-related impact damage and ignition responses for HMX-based polymer-bonded explosives at high temperature

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Defence Technology（防务技术） 2022年第9期18卷 1602-1621页

作者： Hai-jiao xue Yan-qing Wu Kun Yang Yi Wu State Key Laboratory of Explosion Science and Technology Beijing Institute of TechnologyBeijing100081China School of Aerospace Engineering Beijing Institute of TechnologyBeijing100081China

Investigating the damage and ignition behaviors of polymer-bonded explosive(PBX) under a coupled impact and high-temperature loading condition is required for the safe use of charged PBXs. An improved combined microcrack and microvoid model(CMM) was developed for better describing the thermal effects of deformation, damage, and ignition responses of PBXs. The main features of the model under typical dynamic loadings(i.e. uniaxial tension and compression, and lateral confinement) at different initial temperature were first studied. And then the effects of temperature on impact-shear sensitivity of HMX-based PBXs were investigated. The results showed that the ignition threshold velocity of shear-crack hotspots exhibits an increase from 260 to 270 to 315-325 m/s when initial temperature increases from 301 to 348 K;and then the threshold velocity decreases to 290-300 m/s with the initial temperature continually increasing to 378 K. The predicted ignition threshold velocity level of the explosives under coupled impact and high temperature loading conditions were consistent with the experimental data.

关键词： PBX Thermal-mechanical coupling Numerical simulation Impact Sensitivity

Bifidobacterium and Lactobacillus for preventing necrotizing enterocolitis in very-low-birth-weight preterm infants:a systematic review and meta-analysis

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World Journal of Pediatrics 2020年第2期16卷 135-142页

作者： xue jiao Meng-Di Fu Ya-Yun Wang Jiang xue Yuan Zhang School of Medicine Shandong UniversityJinanChina Department of Neonatology Second Hospital of Shandong University247#Beiyuan RoadJinanChina Center of Evidence-Based Medicine Institute of Medical SciencesSecond Hospital of Shandong University247#Beiyuan RoadJinanChina School of Public Health Shandong UniversityJinanChina

Background The therapeutic effect of Bifidobacterium and Lactobacillus on necrotizing enterocolitis(NEC)in very-low-birth-weight preterm infants was controversial,and we aimed to explore the exact impact of the two *** The PubMed,EMBASE,Web of Science and Cochrane Library were systematically searched for studies published from January 1,2010 to February 28,*** were combined with fixed-effect model or random-effect model with specific *** analysis was conducted by the trim-and-fill method,and the Begger's and Egger's test were used to measure publication *** The meta-analysis included 16 original articles with 4632 very-low-birth-weight preterm *** respect to the intervention of Bifidobacterium,we estimated non-significant decrease in the morbidity of NEC with a risk ratio(RR)of 0.75[95%confidence internal(CI)0.56-1.01,P=0.06].Regarding the effect of Lactobacillus,there was no evidence of significant lower risk in the incidence of NEC(RR=0.67,95%CI 0.39-1.17,P=0.16).The use of mixture of probiotics(Bifidobacterium and Lactobacillus)reduced the risk of NEC in the probiotics group(RR=0.45,95%CI 0.25-0.80,P=0.007).Conclusion The mixture of Bifidobacterium and Lactobacillus could prevent the morbidity of NEC in very-low-birth-weight preterm *** Bifidobacterium or Lactobacillus alone did not show this effect.

关键词： Bifidobacterium Lactobacillus Necrotizing enterocolitis Preterm infants

Studies of surface plasmon resonance sensor using bi-beam differential measurement approach

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2007年第12期8卷 2027-2031页

作者： ZENG Han-rong WANG Xiao-ping ZHANG xue-jiao Department of Optical Engineering Zhejiang University Hangzhou 310027 China

In this paper, a low-cost measurement approach with bi-beam was presented, which can be used for real-time detection and online analysis of solution refractive index, based on systematical analysis and experiments of conventional detection methods on surface plasmon resonance sensor. This novel method was analyzed theoretically and based on it a sensor system set was established. The factors that affect the sensor's sensitivity and working range were discussed. The angular adjustment setup was simplified, errors produced by movable components were avoided and the maneuverability was enhanced with this new method. The noiseproof feature and stability of the sensor system were greatly improved as well.

关键词： Kretschmann prism structure Light intensity Bi-beam measurement Light differential Surface plasmon resonance

Arginine Vasopressin-Aquaporin-2 Pathway-Mediated Dehydration Effects of Electroacupuncture in Guinea Pig Model of AVP-Induced Endolymphatic Hydrops

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Chinese Journal of Integrative Medicine 2019年第10期25卷 763-769页

作者： JIANG Li-yuan HE jiao-jun CHEN Xi-xi SUN xue-jiao WANG xue-zhong ZHONG Shan CHEN Hua-de Departm ent of Acupuncture and Moxibustion the Third Clinical Medical College of Zhejiang Chinese Medical University Hangzhou (310053) China Department of Acupuncture and Rehabilitation Guangxing Hospital Affiliated to Zhejiang Chinese Medical University Hangzhou (310007) China

Objective: To investigate the effects of electroacupuncture(EA) on endolymphatic hydrops(EH) and the regulation of arginine vasopressin(AVP)-aquaporin-2(AQP2) pathway in guinea pigs. Methods: EH was induced in male guinea pigs by an intraperitoneal injection of AVP. For the treatment, EA was delivered to Baihui(GV 20) and Tinggong(SI 19) acupoints, once per day for 10 consecutive days. In histomorphological studies, cochlear hydrops degree was evaluated by hematoxylin-eosin(HE) staining, and then the ratio of scala media(SM) area to SM + scala vestibuli(SV) area(R value) was calculated. In mechanical studies, a comparison of plasma AVP(p-AVP) concentrations, cyclic adenosine monophosphate(cAMP) levels, vasopressin type 2 receptor(V2R) and AQP2 mRNA expressions in the cochlea were compared among groups. Results: EA significantly reduced cochlear hydrops in guinea pigs(P=0.001). EA significantly attenuated the AVPinduced up-regulation of p-AVP concentrations(P=0.006), cochlear c AMP levels(P=0.003) and AQP2 mRNA expression(P=0.016), and up-regulated the expression of V2R mRNA(P=0.004) in the cochlea. Conclusion: The dehydrating effect of EA might be associated with its inhibition of AVP-AQP2 pathway activation.

关键词： endolymphatic hydrops electroacupuncture arginine vasopressin (AVP)-aquaporin-2 (AQP2) pathway Meniere's disease