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Hard magnetic properties of melt-spun nanocomposite Y_(16)Fe_(78)b_(6)ribbons

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Rare Metals 2023年第2期42卷 602-605页

作者： Liang Sun Kuo-She Li Hong-Wei Li Dun-bo Yu Yang luo Jin-Ling Jin Shuo lu Ning-Tao Quan GRIREM Advanced Materials Ltd General Research Institute for Nonferrous MetalsBeijing100088China

Melt-spun Y_(16)Fe_(78)b_(6)ribbons were prepared by the melt-spinning technique with pure elements Y,Fe and Fe-b alloy n *** ribbons are mainly composed of Y_(2)Fe_(14)b,YFe_(2)andα-Fe *** phase appears at the wheel velocity of>35 m·s^(-1).For the ribbons prepared at optimum wheel velocity and heat treatments,the coercivity,remanence and maximum energy product are239.5 kA·m^(-1),0.61 T and 32.7 kJ·m-3,*** an investigation of Henkel plots of ribbons,it is found that intergrain exchange coupling leads to the enhancement of *** coercivity mechanism of ribbons prepared at 35 m·s^(-1)is mainly controlled by inhomogeneous pinning of domain *** phase component and magnetic properties change with annealing temperature and *** optimum magnetic properties are obtained with the ribbon quenched at 35 m·s^(-1)and annealed at 700℃for10 min.

关键词： Melt spinning Permanent magnets Y-Fe-b alloys Magnetic hardening

circ_LAS1L调控SFRP5抑制心肌细胞铁死亡

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宁夏医科大学学报 2024年第7期46卷 656-662,684页

作者：别自东鲁佳佳张焰蓬李文正王竟靖山东医学高等专科学校附属费县人民医院心血管内科临沂273400 宁夏医科大学总医院心血管内科宁夏医科大学第一临床医学院银川750004

目的探讨心肌缺血-再灌注损伤进展中circ_LAS1L调控分泌型卷曲相关蛋白5(SFRP5)表达的潜在机制和circ_LAS1L/SFRP5通路在大鼠心肌细胞铁死亡中的作用。方法传代培养大鼠胚胎心肌细胞株H9c2细胞,H9c2心肌细胞分别转染或共转染circ_LAS1L... 详细信息

目的探讨心肌缺血-再灌注损伤进展中circ_LAS1L调控分泌型卷曲相关蛋白5(SFRP5)表达的潜在机制和circ_LAS1L/SFRP5通路在大鼠心肌细胞铁死亡中的作用。方法传代培养大鼠胚胎心肌细胞株H9c2细胞,H9c2心肌细胞分别转染或共转染circ_LAS1L过表达载体、circ_LAS1L siRNA、miR-125b mimic、miR-125b siRNA和SFRP5 siRNA,然后进行缺氧/复氧处理。RT-qPCR检测circ_LAS1L和miR-125b的表达,RT-qPCR和Western blot检测SFRP5和GPX4的表达,电镜观察线粒体结构变化,CCK-8法检测细胞存活力,同时检测乳酸脱氢酶(LDH)、活性氧(ROS)、Fe^(2+)和丙二醛(MDA)含量。结果circ_LAS1L-O可增加SFRP5的mRNA和蛋白表达,而抑制circ_LAS1L表达可降低SFRP5的mRNA和蛋白表达(P均b mimic抑制而miR-125b siRNA促进SFRP5的RNA和蛋白表达,circ_LAS1L-O能减弱miR-125b mimic调控SFRP5表达的作用(P均b siRNA对SFRP5的表达调控(P均b能抑制SFRP5的表达,且减弱circ_LAS1L调控SFRP5表达的作用。

关键词：心肌细胞 circ_LAS1L miR-125b 分泌型卷曲相关蛋白5 铁死亡

Menthol-modified casein nanoparticles loading 10-hydroxycamptothecin for glioma targeting therapy

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Acta Pharmaceutica Sinica b 2019年第4期9卷 843-857页

作者： Caifang Gao Jianming Liang Ying Zhu Chengli Ling Zhekang Cheng Ruixiang Li Jing Qin Weigen lu Jianxin Wang Department of Pharmaceutics School of PharmacyFudan University&Key Laboratory of Smart Drug DeliveryMinistry of EducationShanghai 201203China Shanghai Institute of Pharmaceutical Industry China State Institute of Pharmaceutical IndustryShanghai 201203China Guangzhou University of Chinese Medicine Guangzhou 510006China School of Pharmacy Chengdu University of Traditional Chinese MedicineChengdu 611137China School of Pharmacy Minzu University of ChinaBeijing 100081China

Chemotherapy outcomes for the treatment of glioma remains unsatisfactory due to the inefficient drug transport across the blood–brain barrier(bbb) and insufficient drug accumulation in the tumor region. Although many approaches, including various nanosystems, have been developed to promote the distribution of chemotherapeutics in the brain tumor, the delivery efficiency and the possible damage to the normal brain function still greatly restrict the clinical application of the ***, it is urgent and necessary to discover more safe and effective bbb penetration and gliomatargeting strategies. In the present study, menthol, one of the strongest bbb penetration enhancers screened from traditional Chinese medicine, was conjugated to casein, a natural food protein with brain targeting capability. Then the conjugate self-assembled into the nanoparticles to load anti-cancer *** nanoparticles were characterized to have appropriate size, spheroid shape and high loading drug capacity. Tumor spheroid penetration experiments demonstrated that penetration ability of mentholmodified casein nanoparticles(M-CA-NP) into the tumor were much deeper than that of unmodified nanoparticles. In vivo imaging further verified that M-CA-NPs exhibited higher brain tumor distribution than unmodified nanoparticles. The median survival time of glioma-bearing mice treated with HCPT-MCA-NPs was significantly prolonged than those treated with free HCPT or HCPT-CA-NPs. HE staining ofthe organs indicated the safety of the nanoparticles. Therefore, the study combined the advantages of traditional Chinese medicine strategy with modern delivery technology for brain targeting, and provide a safe and effective approach for glioma therapy.

关键词： Glioma Casein Menthol Nanoparticles brain targeting blood–brain barrier 10-Hydroxycamptothecin

Rdh13 deficiency weakens carbon tetrachloride-induced liver injury by regulating Spotl4 and Cyp2e1 expression levels

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Frontiers of Medicine 2019年第1期13卷 104-111页

作者： Xiaofang Cui benting Ma Yan Wang Yan Chen Chunling Shen Ying Kuang Jian Fei lungen lu Zhugang Wang State Key Laboratory of Medical Genomics Research Center for Experimental MedicineRuijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200025China Shanghai Research Center for Model Organisms Shanghai 201203China Department of Gastroenterology Shanghai First People s HospitalShanghai Jiao Tong UniversityShanghai 200080China

Mitochondrion-localized retinol dehydrogenase 13 (Rdh13) is a short-chain dehydrogenase/reductase involved in vitamin A metabolism in both humans and mice. We previously generated Rdh13 knockout mice and showed that Rdh13 deficiency causes severe acute retinal light damage. In this study, considering that Rdh13 is highly expressed in mouse liver, we further evaluated the potential effect of Rdh13 on liver injury induced by carbon tetrachloride (CC14). Although Rdh13 deficiency showed no significant effect on liver histology and physiological functions under regular culture, the Rdh13^-/- mice displayed an attenuated response to CCl4-induced liver injury. Their livers also exhibited less histological changes and contained lower levels of liver-related metabolism enzymes compared with the livers of wild-type (WT) mice. Furthermore, the Rdhl3 1 mice had Rdh13 deficiency and thus their liver cells were protected from apoptosis, and the quantity of their proliferative cells became lower than that in WT after CC14 exposure. The ablation of Rdhl3 gene decreased the expression levels of thyroid hormone-inducible nuclear protein 14 (Spot14) and cytochrome P450 (Cyp2el) in the liver, especially after CC14 treatment for 48 h. These data suggested that the alleviated liver damage induced by CC14 in Rdh13^-/- mice was caused by Cyp2el enzymes, which promoted reductive CC14 metabolism by altering the status of thyroxine metabolism. This result further implicated Rdhl3 as a potential drug target in preventing chemically induced liver injury.

关键词： retinol dehydrogenase 13 carbon tetrachloride acute liver injury Cyp2el Spot14

Systematic review and meta-analysis of the efficacy and safety of immunosuppressive pulse therapy in the treatment of paraquat poisoning

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Journal of Zhejiang University-Science b(biomedicine & biotechnology) 2019年第7期20卷 588-597页

作者： Ying-ge XU Yuan-qiang lu Department of Emergency Medicine the First Affiliated Hospital School of Medicine Zhejiang University

Paraquat(PQ),a highly effective herbicide,is widely used *** poisoning can cause multiple organ failure,in which the lung is the primary target *** PQ poisoning,the patient mortality rate is as high as 90%,and there is currently no specific *** main clinical treatment is the use of glucocorticoids and cyclophosphamide for pulse therapy,but its effectiveness and safety are still *** investigated the effectiveness and safety of immunosuppressive pulse therapy with glucocorticoids and cyclophosphamide to evaluate the treatment value in patients with acute PQ *** meta-analysis,combined with seven trials that enrolled a total of 426 patients,showed that immunosuppressive pulse therapy with glucocorticoids and cyclophosphamide for PQ poisoning significantly reduced mortality of the study group(59.3%,134/226) compared with the control group(81.0%,162/200).There was no significant difference of hepatitis or renal failure between the control and study groups,indicating that immunosuppressive pulse therapy was relatively *** patients were reported to have leukopenia and returned to normal after 1-2 weeks without any *** cases of non-fatal sepsis were reported and considered to be a side effect of the immunosuppressive pulse ***,immunosuppressive pulse therapy can efficiently reduce the mortality of PQ poisoning and it is relatively safe.

关键词： Paraquat Glucocorticoids Cyclophosphamide Immunosuppressive pulse therapy Meta-analysis

TAZ inhibits osteoclastogenesis by attenuating TAK1/NF-κb signaling

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bone Research 2021年第3期9卷 375-384页

作者： Wanlei Yang Xuanyuan lu Tan Zhang Weiqi Han Jianlei Li Wei He Yewei Jia Kangxian Zhao An Qin Yu Qian Department of Orthopaedics Shaoxing People’s Hospital(Shaoxing HospitalZhejiang University School of Medicine)ShaoxingZhejiangPR China Department of Orthopedic Surgery Shanghai Key Laboratory of Orthopedic ImplantsShanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghaiChina

Osteoporosis is an osteolytic disorder commonly associated with excessive osteoclast *** coactivator with PDZ-binding motif(TAZ)is a key downstream effector of the Hippo signaling pathway;it was suggested to be involved in the regulation of bone ***,the exact role of TAZ in osteoclasts has not yet been *** this study,we demonstrated that global knockout and osteoclast-specific knockout of TAZ led to a low-bone mass phenotype due to elevated osteoclast formation,which was further evidenced by in vitro osteoclast formation ***,the overexpression of TAZ inhibited RANKL-induced osteoclast formation,whereas silencing of TAZ reduced ***,TAZ bound to TGF-activated kinase 1(TAK1)and reciprocally inhibited NF-κb signaling,suppressing osteoclast ***,our findings highlight an essential role of TAZ in the regulation of osteoclastogenesis in osteoporosis and its underlying mechanism.

关键词： osteoclast inhibited elevated

考虑软化效应的滨海软土区基桩受力与变形特性分析

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中外公路 2024年第2期44卷 1-8页

作者：王飞闫宇焦立冬申奉歧陈璐刘建华中化学建设投资集团有限公司北京市102300 长沙理工大学公路工程教育部重点实验室湖南长沙410114

为探讨水平荷载作用下滨海软土区基桩受力与变形性能,首先根据滨海软土区基桩受荷特点建立相应的简化受力模型;其次,考虑滨海软土的软化效应,对现有的p‑y曲线模型进行修正;据此导出滨海软土区基桩挠曲微分方程,并通过传递矩阵法对其内... 详细信息

为探讨水平荷载作用下滨海软土区基桩受力与变形性能,首先根据滨海软土区基桩受荷特点建立相应的简化受力模型;其次,考虑滨海软土的软化效应,对现有的p‑y曲线模型进行修正;据此导出滨海软土区基桩挠曲微分方程,并通过传递矩阵法对其内力及位移进行求解,获得考虑软化效应的滨海软土区基桩非线性计算方法;最后,结合相关工程案例,分析软化参数、桩径和桩体弹性模量对基桩水平承载性能的影响。研究结果表明:采用传递矩阵法对软土区水平受荷桩进行受力分析精度较高,计算效率也高,可为相关工程提供参考;软化参数每增加0.3,地面处桩身水平位移分别减小24.12%和43.04%;桩径每增加0.7 m,地面处桩身水平位移分别减小62.63%和79.65%,桩体位移及内力的影响深度随桩径增大而增大;桩体弹性模量由25.5 GPa增加到36.0 GPa时,桩身变形量分别减小了6.25%和23.06%。

关键词：桩基础软土软化效应水平承载特性 p‑y曲线

The effects of borneol on the pharmacokinetics and brain distribution of tanshinone IIA,salvianolic acid b and ginsenoside Rg1 in Fufang Danshen preparation in rats

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Chinese Journal of Natural Medicines 2021年第2期19卷 153-160页

作者： ZHANG Jie LIU Sheng-Lan WANG Hui SHI Li-Ying LI Jin-Ping JIA lu-Juan XIE bao-Ping The Third Xiangya hospital Central South UniversityChangsha 410013China The Fourth Hospital of Changsha Changsha 410013China The Central Hospital of Taian Taian 271000China Xiangya School of Pharmaceutical Sciences Central South UniversityChangsha 410013China Gannan Medical University Gannan341000China

Fufang Danshen preparation(FDP)is consisted of Salviae Miltiorrhizar Radix et Rhizoma(Danshen),Notoginseng Radix et Rhizoma(Sanqi)and borneolum Syntheticum(borneol).FDP is usually used to treat myocardial ischemia hypoxia,cerebral ischemia and alzheimer’s disease,*** the treatment of cerebrovascular diseases,borneol is usually used to promote the absorption and distribution of the bioactive components to proper organs,especially to the *** purpose of this study is investigating the effects of borneol on the pharmacokinetics and brain distribution of tanshinone IIA(TS IIA),salvianolic acid b(SAb)and ginsenoside Rg1 in *** healthy Sprague-Dawley(SD)rats were given Danshen extracts,Sanqi extracts(Panax notoginseng saponins)or simultaneously administered Danshen extracts,Sanqi extracts and *** and brain samples were collected at different points in *** concentration of TS IIA,SAb and Rg1 was determined by UPLC-MS/MS *** main pharmacokinetics parameters of plasma and brain tissue were calculated by using Phoenix WinNolin 6.1 *** comparison with Danshen and Sanqi alone,there were significant differences in pharmacokinetic parameters of TS IIA,SAb and Rg1,and the brain distribution of SAb and TS IIA when Danshen,Sanqi and borneol were administrated *** statistically significant shortened tmax of TS IIA,SAb and Rg1 in plasma and brain,increased the bioavaiability of Rg1,inhibited metabolism of Rg1 and enhanced the transport of TS IIA and SAb to *** results indicated that borneol could affect the multiple targets components and produce synergistic *** accelerating the intestinal absorption and brain distribution,borneol caused the effective ingredients of Danshen and Sanqi to play a quicker therapeutic role and improved the therapeutic effect.

关键词： borneol Fufang Danshen preparation Tanshinone IIA Salvianolic acid b Ginsenoside Rg1 Pharmacokinetics

基于猪模型和腔镜模拟训练器的3D腔镜系统对比评价

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中国医院建筑与装备 2024年第7期25卷 27-32页

作者：卢如意孙静金以勒毛彬张倩冯靖祎浙江大学医学院附属第一医院医学工程与物资部杭州310003 浙江大学医学院附属第一医院浙江省医疗器械临床评价技术研究重点实验室杭州310003

基于文献分析、小组讨论、德尔菲法(专家咨询法)等方法,确定了3D腔镜系统评价指标,制定了评价标准及专家评价表,邀请多家医院、多个研究领域的临床专家对品牌A和品牌b两款产品基于猪模型以及腔镜模拟训练器进行对比评价。在该研究样本量... 详细信息

基于文献分析、小组讨论、德尔菲法(专家咨询法)等方法,确定了3D腔镜系统评价指标,制定了评价标准及专家评价表,邀请多家医院、多个研究领域的临床专家对品牌A和品牌b两款产品基于猪模型以及腔镜模拟训练器进行对比评价。在该研究样本量下,结果显示:在动物实验中品牌A共计25项指标中的24项指标评分结果与品牌b没有显著性差异,在立体感这一指标上显著优于品牌b;在腔镜模拟训练器下,品牌A的视野、清晰度、景深等15项指标的评分结果与品牌b差异无统计学意义,但分辨能力、抗反光能力、图像保真性、视疲劳以及总体印象这5项指标的评分与品牌b差异有统计学意义。该研究采用t检验统计学方法分别对比了在动物实验研究中以及腔镜模拟训练器下,专家对品牌A和品牌b各项指标的评分结果以及参评专家对两款设备的总体表现、景深等方面发表的个人建议,可为企业在设备功能和性能改进方面提供参考。

关键词： 3D腔镜系统猪模型腔镜模拟训练器医疗设备评价

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