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Regulating macrophage-MSC interaction to optimize BMP-2-induced osteogenesis in the local microenvironment

Bioactive Materials 2023年第7期25卷 307-318页

作者： Fei Jiang xuanyu qi Xiaolin Wu Sihan Lin Junfeng Shi Wenjie Zhang Xinquan Jiang Department of Prosthodontics Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineNo.639Zhizaoju RoadShanghai200011China College of Stomatology Shanghai Jiao Tong UniversityNational Center for StomatologyNational Clinical Research Center for Oral DiseasesShanghai Key Laboratory of StomatologyShanghai Engineering Research Center of Advanced Dental Technology and MaterialsNo.639Zhizaoju RoadShanghai200011China Jiangsu Key Laboratory of Oral Diseases Jiangsu Province Engineering Research Center of Stomatological Translational MedicineNanjing Medical UniversityNo.140Han Zhong RoadNanjing210029China Department of General Dentistry Affiliated Hospital of StomatologyNanjing Medical UniversityNo.136Han Zhong RoadNanjing210029China

Bone morphogenetic protein(BMP-2)has been approved by the FDA to promote bone regeneration,but uncertain osteogenic effect and dose-dependent side effects may occur.Osteoimmunomodulation plays an important role in growth factor-based osteogenesis.Here,we explored how proinflammatory signals affect the dose-dependent osteogenic potential of BMP-2.We observed that the expression level of local IL-1βdid not increase with the dose of BMP-2 in the mouse osteogenesis model.A low dose of BMP-2 could not promote new bone formation,but trigger the release of IL-1βfrom M1 macrophages.As the dose of BMP-2 increased,the IL-1βexpression and M1 infiltration in local microenvironment were inhibited by IL-1Ra from MSCs under osteogenic differentiation induced by BMP-2,and new bone tissues formed,even excessively.Anti-inflammatory drugs(Dexamethasone,Dex)promoted osteogenesis via inhibiting M1 polarization and enhancing BMP-2-induced MSC osteo-differentiation.Thus,we suggest that the osteogenic effect of BMP-2 involves macrophage-MSC interaction that is dependent on BMP-2 dose and based on IL-1R1 ligands,including IL-1βand IL-1Ra.The dose of BMP-2 could be reduced by introducing immunoregulatory strategies.

关键词： BMP-2 Osteogenesis IL-1β IL-1Ra Macrophage-MSC interaction

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Biomineralization inspired 3D printed bioactive glass nanocomposite scaffolds orchestrate diabetic bone regeneration by remodeling micromilieu

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Bioactive Materials 2023年第7期25卷 239-255页

作者： Zeqian Xu xuanyu qi Minyue Bao Tian Zhou Junfeng Shi Zhiyan Xu Mingliang Zhou Aldo R.Boccaccini Kai Zheng Xinquan Jiang Department of Prosthodontics Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineNo.639 Zhizaoju RoadShanghai200011People’s Republic of China College of Stomatology Shanghai Jiao Tong UniversityNo.639 Zhizaoju RoadShanghai200011People’s Republic of China National Center for Stomatology No.639 Zhizaoju RoadShanghai200011People’s Republic of China National Clinical Research Center for Oral Diseases No.639 Zhizaoju RoadShanghai200011People’s Republic of China Shanghai Key Laboratory of Stomatology No.639 Zhizaoju RoadShanghai200011People’s Republic of China Shanghai Engineering Research Center of Advanced Dental Technology and Materials No.639 Zhizaoju RoadShanghai200011People’s Republic of China Department of Oral Maxillofacial-Head and Neck Oncology Shanghai Ninth People’s HospitalCollege of StomatologyShanghai Jiao Tong University School of MedicineShanghai200023People’s Republic of China Institute of Biomaterials University of Erlangen-NurembergCauerstrasse 691058ErlangenGermany Jiangsu Province Engineering Research Center of Stomatological Translational Medicine Nanjing Medical UniversityNanjing210029People’s Republic of China Jiangsu Key Laboratory of Oral Diseases Nanjing Medical UniversityNanjing210029People’s Republic of China

TypeⅡdiabetes mellitus(TIIDM)remains a challenging clinical issue for both dentists and orthopedists.By virtue of persistent hyperglycemia and altered host metabolism,the pathologic diabetic micromilieu with chronic inflammation,advanced glycation end products accumulation,and attenuated biomineralization severely impairs bone regeneration efficiency.Aiming to“remodel”the pathologic diabetic micromilieu,we 3D-printed bioscaffolds composed of Sr-containing mesoporous bioactive glass nanoparticles(Sr-MBGNs)and gelatin methacrylate(GelMA).Sr-MBGNs act as a biomineralization precursor embedded in the GelMA-simulated extracellular matrix and release Sr,Ca,and Si ions enhancing osteogenic,angiogenic,and immunomodulatory properties.In addition to angiogenic and anti-inflammatory outcomes,this innovative design reveals that the nanocomposites can modulate extracellular matrix reconstruction and simulate biomineralization by activating lysyl oxidase to form healthy enzymatic crosslinked collagen,promoting cell focal adhesion,modulating osteoblast differentiation,and boosting the release of OCN,the noncollagenous proteins(intrafibrillar mineralization dependent),and thus orchestrating osteogenesis through the Kindlin-2/PTH1R/OCN axis.This 3D-printed bioscaffold provides a multifunctional biomineralization-inspired system that remodels the“barren”diabetic microenvironment and sheds light on the new bone regeneration approaches for TIIDM.

关键词： Biomineralization TypeⅡDiabetes mellitus 3D printing Sr-containing mesoporous bioactive glass nanoparticles Enzymatic cross-links

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Defect engineered nickel hydroxide nanosheets for advanced pseudocapacitor electrodes

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Nano Research 2024年第6期17卷 5233-5242页

作者： Yaohang Gu Yuxuan Zhang xuanyu Wang Ateer Bao Bo Ni Haijun Pan Xiaoyan Zhang Xiwei qi School of Materials Science and Engineering Northeastern UniversityShenyang 110189China College of Metallurgy and Energy North China University of Science and TechnologyTangshan 063210China Key Laboratory of Dielectric and Electrolyte Functional Material Hebei Province School of Resources and MaterialsNortheastern University at QinhuangdaoQinhuangdao 066004China School of Resources and Materials Northeastern University at QinhuangdaoQinhuangdao 066004China

While the past years have witnessed great achievement in pseudocapacitors,the inauguration of electrode materials of high-performance still remains a formidable challenge.Moreover,the capacity and rate capability of the electrode depends largely on its electrical conductivity,which ensures fast charge transfer kinetics in both the grain bulk and grain boundaries.Here,nickel hydroxides with oxygen vacancies are facilely fabricated via a hydrothermal method.The active materials exhibit a high specific capacitance of 3250 F·g^(−1)and a high areal of capacitance of 14.98 F·cm^(−2)at 4.6 mA·cm^(−2).The asymmetric supercapacitor device based on our material delivers a high energy density of~71.6 Wh·kg^(−1)and a power density of~17,300 W·kg^(−1)and could retain~95%of their initial capacitance even after 30,000 cycles.In addition,the defect-rich hydroxides demonstrate higher electrical conductivity as well as dielectric constant,which is responsible for the superior pseudocapacitive performance.Our new scientific strategy in terms of taking the advantages of oxygen vacancies might open up new opportunities for qualified pseudocapacitive materials of overall high performances not only for nickel hydroxides but also for other metal hydroxides/oxides.

关键词： pseudocapacitors nickel hydroxides oxygen vacancies electrical conductivity

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考虑网损的电力系统节点边际碳势理论研究与建模

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中国电力 2024年第6期57卷 215-224页

作者：吴静刘轩宇李响齐笑言李成俊张忠国网辽宁省电力有限公司电力科学研究院辽宁沈阳110006 大连理工大学电气工程学院辽宁大连116024

用于电力系统碳排放计算的宏观核算法和碳流分析法未考虑网损、阻塞因素对电网边际碳排放的影响。为实现电网碳排放指标的精细化分析,建立考虑网损的电力系统节点边际碳势分析模型。考虑火电机组煤耗特性建立了机组的边际碳势模型;基于... 详细信息

用于电力系统碳排放计算的宏观核算法和碳流分析法未考虑网损、阻塞因素对电网边际碳排放的影响。为实现电网碳排放指标的精细化分析,建立考虑网损的电力系统节点边际碳势分析模型。考虑火电机组煤耗特性建立了机组的边际碳势模型;基于交流潮流模型,建立电网网损灵敏度模型;进而提出电力系统节点边际碳势的计算方法,并考虑网络阻塞因素进一步改进了该方法。采用IEEE 14节点系统和某500 kV实际系统算例验证了所建模型的合理性和适用性,分别分析了低碳和非低碳调度模式下节点碳势的变化规律;发现考虑网损后节点的正、负向边际碳势存在一定差异;网损因素也使得电网各节点边际碳势各异,考虑网损的模型可提供更为准确的节点边际碳势信息,可用于开展较为精准的实时碳排放分析。

关键词：边际碳势网损间接碳排放边际理论碳流理论灵敏度分析

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Enhancing electrical conductivity of single-atom doped Co_(3)O_(4) nanosheet arrays at grain boundary by phosphor doping strategy for efficient water splitting

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Nano Research 2022年第10期15卷 9511-9519页

作者： Yaohang Gu xuanyu Wang Ateer Bao Liang Dong Xiaoyan Zhang Haijun Pan Wenquan Cui Xiwei qi School of Materials Science and Engineering Northeastern UniversityShenyang 110189China College of Metallurgy and Energy North China of Science and TechnologyTangshan 063210China School of Resources and Materials Northeastern University at QinhuangdaoQinhuangdao 066004China Key Laboratory of Dielectric and Electrolyte Functional Material Hebei Province Northeastern University at QinhuangdaoQinhuangdao 066004China College of Chemical Engineering Hebei Provincial Key Laboratory of Environmental Photocatalytic and Electrocatalytic MaterialsNorth China University of Science and TechnologyTangshan 063210China

High electrical conductivity guarantees a rapid electron transfer and thus plays an important role in electrocatalysis.In particular,for the single atom catalysts(SACs),to facilitate interaction between the single atom and supports,precisely engineering the conductivity represents a promising strategy to design SACs with high electrochemical efficiency.Here we show rhodium(Rh)SAC anchored on Co_(3)O_(4) nanosheets arrays on nickel foam(NF),which is modified by a facile phosphorus(P-doped Rh SACCo_(3)O_(4)/NF),possessing an appropriate electronic structure and high conductivity for electrocatalytic reaction.With the introduction of P atom in the lattice,the electrocatalyst demonstrates outstanding alkaline oxygen evolution reaction(OER)activity with 50 mA·cm^(−2) under overpotential of 268 mV,6 times higher than that of Ir/C/NF.More interestingly,the P-doped Rh SAC-Co_(3)O_(4)/NF can get 50 mA·cm^(−2) at only 1.77 V for overall water splitting.Both electrical conductivity studies and density functional theory(DFT)calculations reveal that the high conductivity at grain boundary improves the charge transfer efficiency of the Rh catalytic center.Furthermore,other noble-metal(Ir,Pd,and Ru)doped Co_(3)O_(4) nanosheets arrays are prepared to exhibit the general efficacy of the phosphorus doping strategy.

关键词： overall water splitting electrical conductivity single atom electrocatalyst phosphor doping strategy

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Decision making framework for autonomous vehicles driving behavior in complex scenarios via hierarchical state machine

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Autonomous Intelligent Systems 2021年第1期1卷 135-146页

作者： xuanyu Wang Xudong qi Ping Wang Jingwen Yang School of Electronics and Control Engineering Chang’an UniversityXi’an 710064China

With the development of autonomous car,a vehicle is capable to sense its environment more precisely.That allows improved drving behavior decision strategy to be used for more safety and effectiveness in complex scenarios.In this paper,a decision making framework based on hierarchical state machine is proposed with a top-down structure of three-layer finite state machine decision system.The upper layer classifies the driving scenario based on relative position of the vehicle and its surrounding vehicles.The middle layer judges the optimal driving behavior according to the improved energy efficiency function targeted at multiple criteria including driving efficiency,safety and the grid-based lane vacancy rate.The lower layer constructs the state transition matrix combined with the calculation results of the previous layer to predict the optimal pass way in the region.The simulation results show that the proposed driving strategy can integrate multiple criteria to evaluate the energy efficiency value of vehicle behavior in real time,and realize the selection of optimal vehicle driving strategy.With popularity of automatic vehicles in future,the driving strategy can be used as a reference to provide assistance for human drive or even the real-time decision-making of autonomous driving.

关键词： Decision making Autonomous Car Energy efficiency function State machine

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反应中断及转移法干预孤独症谱系障碍者重复刻板行为的实证研究综述

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中国特殊教育 2022年第9期 55-65页

作者：张轩瑜杜学元郭玲陈琪西华师范大学教育学院南充637009 乐山师范学院特殊教育学院乐山614000 四川师范大学四川文化教育高等研究院成都610066 武汉大学教育科学研究院武汉430072

重复刻板行为是孤独症谱系障碍(ASD)患者的核心症状之一,反应中断及转移法(RIRD)是一种以行为主义理论为基础的干预方法。国外的实证研究表明,该方法可以有效干预ASD患者的重复刻板行为。本文对反应中断及转移法产生以来(2007—2022年)... 详细信息

重复刻板行为是孤独症谱系障碍(ASD)患者的核心症状之一,反应中断及转移法(RIRD)是一种以行为主义理论为基础的干预方法。国外的实证研究表明,该方法可以有效干预ASD患者的重复刻板行为。本文对反应中断及转移法产生以来(2007—2022年)的实证研究进行系统梳理,从干预对象、实验设计、干预情境、干预目标、干预手段与干预结果等方面进行分析,明晰反应中断及转移法干预ASD患者重复刻板行为的研究进展,为我国今后相关实践与研究的开展提供启示。

关键词：反应中断及转移法孤独症谱系障碍重复刻板行为

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债务结构优化与企业创新——基于企业债券融资视角的研究

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金融研究 2021年第4期 131-149页

作者：江轩宇贾婧刘琪中央财经大学会计学院/中国管理会计研究与发展中心北京100081 清华大学经济管理学院北京100081

本文在我国保持宏观杠杆率基本稳定及实施创新驱动发展战略的现实背景下,从债券融资的视角,探讨债务结构优化对企业创新的影响。研究发现,债券融资与企业创新之间显著正相关,表明债券融资优化企业债务结构、提升企业创新能力的积极作用... 详细信息

本文在我国保持宏观杠杆率基本稳定及实施创新驱动发展战略的现实背景下,从债券融资的视角,探讨债务结构优化对企业创新的影响。研究发现,债券融资与企业创新之间显著正相关,表明债券融资优化企业债务结构、提升企业创新能力的积极作用占据主导地位。进一步研究表明:(1)债券融资能够通过降低整体债务融资成本并延长整体债务期限促进企业创新;(2)债券融资对于银行贷款存在溢出效应,即企业通过债券融资,还能降低银行贷款利率、延长银行贷款期限,进而促进企业创新;(3)产品市场竞争和代理问题会在一定程度上削弱债券融资对企业创新的促进作用;(4)不同类型的债券对企业创新能力的作用存在异质性,债券发行的便利性是其影响企业创新的一个重要因素。

关键词：债券融资企业创新债务融资成本债务期限结构溢出效应

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“因势利导”思想在疫病中的应用探讨

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环球中医药 2023年第1期16卷 8-12页

作者：卢轩禹卢云北京中医药大学中医学院 100029 成都中医药大学附属医院急诊科

“因势利导”在中医学中有丰富的内涵。自《黄帝内经》始,“因势利导”思想一直指导并影响着临床治疗,并在疫病的防治实践中发挥着巨大作用。本文从病邪性质、位置之势而利导和传变之势而利导两方面,结合经典古籍和现代研究,探讨其在临... 详细信息

“因势利导”在中医学中有丰富的内涵。自《黄帝内经》始,“因势利导”思想一直指导并影响着临床治疗,并在疫病的防治实践中发挥着巨大作用。本文从病邪性质、位置之势而利导和传变之势而利导两方面,结合经典古籍和现代研究,探讨其在临床诊治中的应用。针对疫病来势凶猛、传变迅速、病机复杂的特点,因病位表里上下及病性寒热虚实的不同,注重“通”“透”之法,透邪外达,通至邪出,除尽疫邪;审机度势,平衡祛邪与扶正之法,顺人体之势扶正以先安未受邪之地,防邪深入。因势利导,以祛邪为要,注重扶正,往往事半功倍,以期为疫病的临床诊治提供参考。

关键词：因势利导疫病透邪外达通法新型冠状病毒肺炎临床应用

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经营杠杆影响企业创新吗

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南开管理评论 2021年第6期24卷 163-173,I0031,I0032页

作者：朱琳江轩宇伊志宏潘琦无锡太湖学院会计学院苏南资本市场研究中心中央财经大学中国管理会计研究与发展中心中央财经大学会计学院中国人民大学商学院中国国际贸易促进委员会商品贸易处

本文结合我国经济增长放缓及实施创新驱动发展战略的现实背景,探讨了经营杠杆是否以及如何对企业创新能力产生影响。研究发现,经营杠杆与企业创新之间存在显著的负向关系,即经营杠杆的降低能有效促进企业创新能力的提升。进一步的研究表... 详细信息

本文结合我国经济增长放缓及实施创新驱动发展战略的现实背景,探讨了经营杠杆是否以及如何对企业创新能力产生影响。研究发现,经营杠杆与企业创新之间存在显著的负向关系,即经营杠杆的降低能有效促进企业创新能力的提升。进一步的研究表明:(1)经营杠杆对企业创新的抑制作用仅在企业销售收入下滑时显著;(2)经营杠杆伴随的风险压力及高昂的调整成本是其抑制企业创新的重要机制;(3)经营杠杆与企业创新的负向关系仅在非国有企业及创新型企业中显著;(4)经营杠杆的提高并未导致企业的投资在创新项目内部转移,而是促使其减少了所有类型的创新活动。

关键词：企业创新经营杠杆风险压力调整成本

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