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Convergent Neuroimaging and Molecular Signatures in Mild Cognitive Impairment and Alzheimer’s Disease:A Data-Driven Meta-Analysis with N=3,118

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Neuroscience Bulletin 2024年第9期40卷 1274-1286页

作者： Xiaopeng kang Dawei Wang Jiaji Lin Hongxiang Yao Kun Zhao Chengyuan Song Pindong Chen Yida Qu Hongwei Yang Zengqiang Zhang Bo Zhou Tong Han Zhengluan Liao Yan Chen Jie Lu Chunshui Yu Pan Wang Xinqing Zhang Ming Li Xi Zhang Tianzi Jiang Yuying Zhou Bing Liu Ying Han Yong Liu The Alzheimer’s Disease Neuroimaging Initiative The Multi-Center Alzheimer’s Disease Imaging(MCADI)Consortium School of Artificial Intelligence University of Chinese Academy of SciencesBeijing100049China Brainnetome Center and National Laboratory of Pattern Recognition Institute of AutomationChinese Academy of SciencesBeijing100190China Department of Radiology Qilu Hospital of Shandong UniversityJi’nan250063China Department of Neurology the Second Affiliated Hospital of Air Force Medical UniversityXi’an710032China Department of Radiology Chinese PLA General HospitalBeijing100853China Department of Radiology the Second Medical CentreNational Clinical Research Centre for Geriatric DiseasesChinese PLA General HospitalBeijing100853China School of Artificial Intelligence Beijing University of Posts and TelecommunicationsBeijing100191China Department of Neurology Qilu Hospital of Shandong UniversityJi’nan250063China Department of Radiology Xuanwu Hospital of Capital Medical UniversityBeijing100053China Branch of Chinese PLA General HospitalSanya572013China Department of Neurology the Second Medical CentreNational Clinical Research Centre for Geriatric DiseasesChinese PLA General HospitalBeijing100853China Department of Radiology Tianjin Huanhu HospitalTianjin300222China Department of Psychiatry People’s Hospital of Hangzhou Medical CollegeZhejiang Provincial People’s HospitalHangzhou310014China Department of Radiology Tianjin Medical University General HospitalTianjin300070China Department of Neurology Tianjin Huanhu HospitalTianjin300222China Department of Neurology Xuanwu Hospital of Capital Medical UniversityBeijing100053China Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences&Yunnan Province Kunming Institute of ZoologyChinese Academy of SciencesKunming650201YunnanChina State Key Lab of Cognition Neuroscience&Learning Beijing Normal UniversityBeijing100875China National Clinical Research Center for Geriatric Disorders Beijing100053China Center of Alzheimer’s Disease Beijing Institute for Brain DisordersBeijing1000

The current study aimed to evaluate the susceptibility to regional brain atrophy and its biological mechanism in Alzheimer’s disease(AD).We conducted data-driven meta-analyses to combine 3,118 structural magnetic resonance images from three datasets to obtain robust atrophy *** we introduced a set of radiogenomic analyses to investigate the biological basis of the atrophy patterns in *** results showed that the hippocampus and amygdala exhibit the most severe atrophy,followed by the temporal,frontal,and occipital lobes in mild cognitive impairment(MCI)and *** extent of atrophy in MCI was less severe than that in AD.A series of biological processes related to the glutamate signaling pathway,cellular stress response,and synapse structure and function were investigated through gene set enrichment *** study contributes to understanding the manifestations of atrophy and a deeper understanding of the pathophysiological processes that contribute to atrophy,providing new insight for further clinical research on AD.

关键词： Alzheimer’s disease Structural magnetic resonance imaging Meta-analysis Brain atrophy Gene set enrichment analysis

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信号交叉口行人空间分布与人车冲突行为分析

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山东科学 2017年第4期30卷 80-85页

作者：于瑞康赵晖北京交通大学交通运输学院北京100044

人车冲突是影响城市道路信号交叉口通行能力的重要因素。本文通过选取典型信号交叉口,分析了过街行人堆积与右转机动车之间的冲突行为。对北京市闹市口大街和宣武门西大街的交叉口高峰时段进行了全程录像,提取了行人等待和右转车辆的空... 详细信息

人车冲突是影响城市道路信号交叉口通行能力的重要因素。本文通过选取典型信号交叉口,分析了过街行人堆积与右转机动车之间的冲突行为。对北京市闹市口大街和宣武门西大街的交叉口高峰时段进行了全程录像,提取了行人等待和右转车辆的空间分布特征数据,并根据数据分析了影响机动车右转的相关因素,通过线性回归分析解释了各影响因素与机动车延误之间的关系。研究发现,过街行人堆积的数量对右转机动车延误的影响最大,二者存在较强的线性关系。在今后的交通管理控制中,减少或避免人车冲突具有现实意义。

关键词：城市交通人车冲突线性回归模型行人空间分布特征延误

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前驱期多系统萎缩的研究进展

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中华老年医学杂志 2024年第9期43卷 1191-1195页

作者：潘竞康佳王新海日罕陈彪内蒙古医科大学第二附属医院神经内科呼和浩特010010 首都医科大学宣武医院神经生物室/神经内科/老年医学北京100053

多系统萎缩(MSA)是一种进展迅速的神经系统退行性疾病,和帕金森病(PD)、路易体痴呆(DLB)同属于α-突触核蛋白病。由于同类疾病早期临床症状的重叠以及目前诊断标准对疾病早期缺乏敏感性,开展疾病早期修饰治疗药物的临床试验困难重重,疾... 详细信息

多系统萎缩(MSA)是一种进展迅速的神经系统退行性疾病,和帕金森病(PD)、路易体痴呆(DLB)同属于α-突触核蛋白病。由于同类疾病早期临床症状的重叠以及目前诊断标准对疾病早期缺乏敏感性,开展疾病早期修饰治疗药物的临床试验困难重重,疾病修饰治疗药物的研发以及诊断工具的开发和验证进展缓慢。因此,国际运动障碍协会(MDS)开发了新的MSA诊断标准,首次提出可能的前驱期MSA的定义和诊断标准。本综述介绍了可能的前驱期MSA诊断标准以及与其他前驱期α-突触核蛋白病鉴别诊断,以提高疾病在早期阶段诊断的准确性,有利于疾病早期研究的开展。

关键词：多系统萎缩 α突触核蛋白诊断,鉴别

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CCI和SNI神经病理性疼痛动物模型的认知功能研究进展

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神经疾病与精神卫生 2021年第11期21卷 761-764页

作者：康美美王蓉首都医科大学宣武医院中心实验室北京100053

神经病理性疼痛常伴有情感和认知障碍的合并症,但其内在机制并不清楚。神经病理性疼痛动物模型中坐骨神经慢性结扎(CCI)模型和坐骨神经分支选择性损伤(SNI)模型的行为和功能改变与临床神经病理性疼痛症状更为相似,且可以诱发疼痛晚期神... 详细信息

神经病理性疼痛常伴有情感和认知障碍的合并症,但其内在机制并不清楚。神经病理性疼痛动物模型中坐骨神经慢性结扎(CCI)模型和坐骨神经分支选择性损伤(SNI)模型的行为和功能改变与临床神经病理性疼痛症状更为相似,且可以诱发疼痛晚期神经精神障碍(焦虑样、抑郁样及认知障碍等),常被用于神经病理性疼痛认知功能的研究中。文章介绍两种动物模型的特点及其在神经病理性疼痛改变认知功能研究中的应用,旨在为神经病理性改变认知功能的病理机制和干预研究提供帮助。

关键词：神经病理性疼痛认知障碍动物模型坐骨神经慢性结扎坐骨神经分支选择性损伤

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乳腺癌手术中胸肌筋膜切除的抉择

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中国普外基础与临床杂志 2021年第1期28卷 125-129页

作者：于振超康骅首都医科大学宣武医院普外科甲状腺乳腺疾病诊疗中心北京100053

目的总结乳腺癌手术中胸肌筋膜的解剖及其作用,以及不同术式中胸肌筋膜切除与保留的抉择。方法通过PubMed、Web of Science、EBSCO、万方医学网、SinoMed等数据库检索有关胸肌筋膜与乳腺癌相关研究的文献,筛选符合本研究探讨目的的中外... 详细信息

目的总结乳腺癌手术中胸肌筋膜的解剖及其作用,以及不同术式中胸肌筋膜切除与保留的抉择。方法通过PubMed、Web of Science、EBSCO、万方医学网、SinoMed等数据库检索有关胸肌筋膜与乳腺癌相关研究的文献,筛选符合本研究探讨目的的中外文文献,阅读文献后进行系统的综述。结果在乳腺癌术后的乳房假体即刻乳房重建中,保留胸肌筋膜有利于乳房假体的完整覆盖,改善术后美容效果;在保乳手术中保留胸肌筋膜的脂肪组织更多是为了减少乳房体积的丢失、追求术后美容效果;目前已有保留胸肌筋膜肿瘤学安全性的研究报道,但肿瘤距胸肌筋膜的安全距离等问题尚无定论,目前的研究尚无法为保留胸肌筋膜提供足够的证据。结论有关乳腺癌手术中胸肌筋膜是否需要切除的问题尚存在争议,胸肌筋膜的保留更多的是为了更好的术后即刻乳房重建,但目前的循证医学证据尚不充分,临床医生有必要进行多中心、随机对照临床研究来完善证据。

关键词：乳腺癌胸肌筋膜保乳手术改良根治术乳房重建综述

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早期乳腺癌保乳手术的焦点问题

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国际外科学杂志 2020年第1期47卷 6-12页

作者：陈志强康骅首都医科大学宣武医院普外科甲状腺乳腺疾病诊疗中心北京100053

保乳手术已成为早期乳腺癌外科治疗的标准术式,但随着保乳手术的规范化推进,目前临床仍面临诸多焦点问题。首先,有关保乳手术的适应证,虽然总体达成一致,但有关年龄、肿瘤大小对保乳手术效果的影响仍值得关注;其次,如何确保切缘阴性以... 详细信息

保乳手术已成为早期乳腺癌外科治疗的标准术式,但随着保乳手术的规范化推进,目前临床仍面临诸多焦点问题。首先,有关保乳手术的适应证,虽然总体达成一致,但有关年龄、肿瘤大小对保乳手术效果的影响仍值得关注;其次,如何确保切缘阴性以及修复组织缺损进而达到较好乳房外形是保乳手术成功的关键;另外,术中切缘评估方法的改进、肿瘤整形技术、新辅助化疗、腋窝前哨淋巴活检、腔镜辅助技术及新型人工材料和3D打印技术在保乳手术中的运用均为保乳手术的发展提供了更好的前景。本文将对上述有关早期乳腺癌的焦点问题作一综述。

关键词：早期诊断乳腺肿瘤外科手术保乳手术焦点问题

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Prediction of treatment response to antipsychotic drugs for precision medicine approach to schizophrenia:randomized trials and multiomics analysis

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Military Medical Research 2024年第1期11卷 19-33页

作者： Liang-Kun Guo Yi Su Yu-Ya-Nan Zhang Hao Yu Zhe Lu Wen-Qiang Li Yong-Feng Yang Xiao Xiao Hao Yan Tian-Lan Lu Jun Li Yun-Dan Liao Zhe-Wei kang Li-Fang Wang Yue Li Ming Li Bing Liu Hai-Liang Huang Lu-Xian Lv Yin Yao Yun-Long Tan Gerome Breen Ian Everall Hong-Xing Wang Zhuo Huang Dai Zhang Wei-Hua Yue Institute of Mental Health Peking University Sixth HospitalBeijing 100191China National Clinical Research Center for Mental Disorders Peking University Sixth HospitalBeijing 100191China NHC Key Laboratory of Mental Health and Research Unit of Diagnosis and Treatment of Mood Cognitive Disorder(2018RU006) Chinese Academy of Medical SciencesBeijing 100191China Peking University Huilongguan Clinical Medical School Beijing Huilongguan HospitalBeijing 100096China Department of Psychiatry Jining Medical UniversityJining 272067ShandongChina Henan Key Lab of Biological Psychiatry the Second Affiliated Hospital of Xinxiang Medical UniversityXinxiang 435001HenanChina Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province Kunming Institute of ZoologyChinese Academy of SciencesKunming 650223China Institute of Psychiatry Psychology and NeuroscienceKing’s College LondonLondon WC2R 2LSUK State Key Laboratory of Cognitive Neuroscience and Learning Beijing Normal UniversityBeijing 100875China Analytic and Translational Genetics Unit Massachusetts General HospitalBostonMA 02114USA Stanley Center for Psychiatric Research the Broad Institute of MIT and HarvardCambridgeMA 02141USA Department of Medicine Harvard Medical SchoolBostonMA 02115USA Department of Biostatistics and Computational Biology School of Life SciencesFudan UniversityShanghai 200438China Department of Neurology Xuanwu HospitalCapital Medical UniversityBeijing 100053China State Key Laboratory of Natural and Biomimetic Drugs Key Laboratory for Neuroscience for Ministry of EducationSchool of Pharmaceutical SciencesPeking University Health Science CenterBeijing 100191China PKU-IDG/McGovern Institute for Brain Research Peking UniversityBeijing 100871China Chinese Institute for Brain Research Beijing 102206China

Background:Choosing the appropriate antipsychotic drug(APD)treatment for patients with schizophrenia(SCZ)can be challenging,as the treatment response to APD is highly variable and difficult to predict due to the lack of effective *** studies have indicated the association between treatment response and genetic and epigenetic factors,but no effective biomarkers have been ***,further research is imperative to enhance precision medicine in SCZ ***:Participants with SCZ were recruited from two randomized *** discovery cohort was recruited from the CAPOC trial(n=2307)involved 6 weeks of treatment and equally randomized the participants to the Olanzapine,Risperidone,Quetiapine,Aripiprazole,Ziprasidone,and Haloperidol/Perphenazine(subsequently equally assigned to one or the other)*** external validation cohort was recruited from the CAPEC trial(n=1379),which involved 8 weeks of treatment and equally randomized the participants to the Olanzapine,Risperidone,and Aripiprazole ***,healthy controls(n=275)from the local community were utilized as a genetic/epigenetic *** genetic and epigenetic(DNA methylation)risks of SCZ were assessed using the polygenic risk score(PRS)and polymethylation score,*** study also examined the genetic-epigenetic interactions with treatment response through differential methylation analysis,methylation quantitative trait loci,colocalization,and promoteranchored chromatin *** learning was used to develop a prediction model for treatment response,which was evaluated for accuracy and clinical benefit using the area under curve(AUC)for classification,R^(2) for regression,and decision curve ***:Six risk genes for SCZ(LINC01795,DDHD2,SBNO1,KCNG2,SEMA7A,and RUFY1)involved in cortical morphology were identified as having a genetic-epigenetic interaction associated with treatment *** developed and externally validated predictio

关键词： Schizophrenia Antipsychotic drug Treatment response Prediction model Genetics Epigenetics

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Epidemiological and clinical features,treatment status,and economic burden of traumatic spinal cord injury in China:a hospital-based retrospective study

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Neural Regeneration Research 2024年第5期19卷 1126-1132页

作者： Hengxing Zhou Yongfu Lou Lingxiao Chen Yi kang Lu Liu Zhiwei Cai David BAnderson Wei Wang Chi Zhang Jinghua Wang Guangzhi Ning Yanzheng Gao Baorong He Wenyuan Ding Yisheng Wang Wei Mei Yueming Song Yue Zhou Maosheng Xia Huan Wang Jie Zhao Guoyong Yin Tao Zhang Feng Jing Rusen Zhu Bin Meng Li Duan Zhongmin Zhang Desheng Wu Zhengdong Cai Lin Huang Zhanhai Yin Kainan Li Shibao Lu Shiqing Feng Department of Orthopedics The Second HospitalCheeloo College of MedicineShandong UniversityShandongChina Department of Orthopedics Shandong University Center for OrthopedicsQilu HospitalCheeloo College of MedicineShandong UniversityShandongChina Department of Orthopedics Tianjin Medical University General HospitalInternational Science and Technology Cooperation Base of Spinal Cord InjuryTianjin Key Laboratory of Spine and Spinal CordTianjinChina Faculty of Medicine and Health The Back Pain Research TeamSydney Musculoskeletal HealthThe Kolling InstituteUniversity of SydneySydneyNSWAustralia Department of Spine Surgery Honghui HospitalXi’an Jiaotong UniversityXi’anShaanxi ProvinceChina Department of Burns and Plastic Surgery The Fourth Medical Center of Chinese PLA General HospitalBeijingChina Faculty of Medicine and Health School of Health SciencesUniversity of SydneyNSWAustralia Sydney Spine Institute BurwoodSydneyNSWAustralia Laboratory of Epidemiology Tianjin Neurological InstituteDepartment of NeurologyTianjin Medical University General Hospital&Tianjin Neurological InstituteKey Laboratory of Post-Neuroinjury Neuro-repair and Regeneration in Central Nervous SystemMinistry of Education and Tianjin CityTianjinChina Department of Orthopedics Henan Provincial People’s HospitalZhengzhouHenan ProvinceChina Department of Spinal Surgery The Third Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina Department of Orthopedics The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina Department of Spine Surgery Zhengzhou Orthopedics HospitalZhengzhouHenan ProvinceChina Department of Orthopedic Surgery and Orthopedic Research Institute West China HospitalSichuan UniversityChengduSichuan ProvinceChina Department of Orthopedics Xinqiao HospitalArmy Medical UniversityChongqingChina Department of Orthopedics The First Affiliated Hospital of China Medical UniversityShenyangLiaoning ProvinceChina Department of Spinal Surgery Shengj

Traumatic spinal cord injury is potentially catastrophic and can lead to permanent disability or even *** has the largest population of patients with traumatic spinal cord *** studies of traumatic spinal cord injury in China have mostly been regional in scope;national-level studies have been *** the best of our knowledge,no national-level study of treatment status and economic burden has been *** retrospective study aimed to examine the epidemiological and clinical features,treatment status,and economic burden of traumatic spinal cord injury in China at the national *** included 13,465 traumatic spinal cord injury patients who were injured between January 2013 and December 2018 and treated in 30 hospitals in 11 provinces/municipalities representing all geographical divisions of *** epidemiological and clinical features,treatment status,and total and daily costs were *** in the percentage of traumatic spinal cord injuries among all hospitalized patients and among patients hospitalized in the orthopedic department and cost of care were assessed by annual percentage change using the Joinpoint Regression *** percentage of traumatic spinal cord injuries among all hospitalized patients and among patients hospitalized in the orthopedic department did not significantly change overall(annual percentage change,-0.5%and 2.1%,respectively).A total of 10,053(74.7%)patients underwent *** 2.8%of patients who underwent surgery did so within 24 hours of injury.A total of 2005(14.9%)patients were treated with high-dose(≥500 mg)methylprednisolone sodium succinate/methylprednisolone(MPSS/MP);615(4.6%)received it within 8 *** total cost for acute traumatic spinal cord injury decreased over the study period(-4.7%),while daily cost did not significantly change(1.0%increase).Our findings indicate that public health initiatives should aim at improving hospitals’ability to complete early surgery within 24 ho

关键词： China clinical features costs epidemiology methylprednisolone sodium succinate methylprednisolone retrospective study traumatic spinal cord injury treatment

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乳头样核特征的非浸润性甲状腺滤泡性肿瘤的病理特征及外科治疗:附33例报告

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中国普通外科杂志 2024年第11期33卷 1766-1774页

作者：蔡伟赵菁李开富赵烨王亚军康骅首都医科大学宣武医院甲状腺乳腺疾病诊疗中心北京100053

背景与目的:甲状腺乳头状癌发病呈明显上升趋势,因其治疗效果良好,对其降级治疗提升生活质量成为一种趋势。病理学家将包裹性滤泡亚型乳头状癌中生物学行为更为惰性的非浸润性包裹性滤泡亚型乳头状癌更名为具有乳头样核特征的非浸润性... 详细信息

背景与目的:甲状腺乳头状癌发病呈明显上升趋势,因其治疗效果良好,对其降级治疗提升生活质量成为一种趋势。病理学家将包裹性滤泡亚型乳头状癌中生物学行为更为惰性的非浸润性包裹性滤泡亚型乳头状癌更名为具有乳头样核特征的非浸润性甲状腺滤泡性肿瘤(NIFTP),为其治疗降级提供了理论基础。但此类疾病在实际临床病理诊断上还存在着一定的问题,目前大多数情况下仍按经典的甲状腺乳头状癌处理。本研究探讨NIFTP的临床病理诊断特点及临床手术治疗中面临的问题及降级治疗的前景。方法:回顾性分析首都医科大学宣武医院2017年11月—2022年12月期间入院,经最后石蜡病理证实为NIFTP的33例患者的临床资料。结果:33例NIFTP患者中,男11例,女22例;平均年龄50岁;肿瘤大小0.6~7.5 cm;单发NIFTP肿瘤31例,多发(均2处)2例;11例合并甲状腺乳头状癌(均为1处),其中4例与NIFTP同侧,7例位于对侧甲状腺。所有患者均行手术治疗,常规开放手术27例,腔镜手术6例。怀疑或不除外癌者均按甲状腺乳头状癌手术原则处理(病变侧腺叶全切+同侧中央区淋巴结清扫)。术前超声影像特点为结节主要为低回声、形态尚规则、边界尚清楚、常伴钙化、纵横比<1。超声的TI-RADS分级评估3级5例、4a级9例、4b及以上11例。术前行穿刺者29例,其中1例诊断为意义不明的细胞非典型病变或滤泡性病变(AUS/FLUS),12例诊断为滤泡性肿瘤或可疑滤泡性肿瘤(FN/SFN),12例诊断为可疑恶性肿瘤(SUS),4例考虑为甲状腺乳头状癌。25例患者术后行BRAFV600E检测,7例检测到突变,但均为合并甲状腺乳头状癌病例。结论:NIFTP概念的提出,对某些侵袭性较弱的甲状腺肿瘤的降级或个体化治疗提供了依据。但在实际的临床诊疗中,术前及术中NIFTP诊断目前仍比较困难。所以,使手术医师改变治疗决策还需要更加准确的术前诊断标准及诊断方法。

关键词：甲状腺肿瘤/诊断甲状腺肿瘤/治疗 NIFTP

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不同强度高级迭代重建算法在不同噪声水平下对图像质量的影响:体模研究

引用

中国医学影像技术 2019年第6期35卷 914-919页

作者：王苑丁康德强白玫杜祥颖李宏伟北京大学国际医院放射科北京102206 首都医科大学宣武医院放射科北京100053 首都医科大学宣武医院医学工程处北京100053 北京市卫戍区海淀第二十四离职干部休养所门诊部北京100039

目的采用Catphan500体模及改造后的套环体模,探讨2种体模噪声水平下高级迭代重建算法(ADMIRE)不同迭代强度对图像质量的影响。方法在12种不同扫描条件下对标准体模组和套环体模组分别进行扫描,采用滤波反投影法(FBPADMIRE0亚组)及不同... 详细信息

目的采用Catphan500体模及改造后的套环体模,探讨2种体模噪声水平下高级迭代重建算法(ADMIRE)不同迭代强度对图像质量的影响。方法在12种不同扫描条件下对标准体模组和套环体模组分别进行扫描,采用滤波反投影法(FBPADMIRE0亚组)及不同迭代强度ADMIRE1~5(ADMIRE1~5亚组)重建图像。测量图像的噪声、SNR、空间分辨率、密度分辨率,比较不同迭代强度图像间的差异。结果标准体模组:随迭代强度增高,噪声逐渐减低,SNR逐渐增高,空间分辨率无明显改变,密度分辨率逐渐升高,ADMIRE4、5亚组密度分辨率高于ADMIRE0~2亚组(P均<0.05)。套环体模组:随迭代强度增高,噪声逐渐减低,SNR逐渐增高,ADMIRE4、5亚组空间分辨率低于ADMIRE0~2亚组,密度分辨率逐渐升高,ADMIRE3~5亚组密度分辨率高于ADMIRE0~2亚组(P均<0.05)。结论标准体模图像噪声水平下,ADMIRE技术可提高密度分辨率而不降低空间分辨率;套环体模图像噪声水平下,ADMIRE技术可提高密度分辨率,但高级别ADMIRE技术会降低空间分辨率;推荐以ADMIRE3作为优选迭代强度级别。

关键词：体层摄影术,X线计算机迭代重建图像质量体模

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