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Bioinformatics Analysis and Identification of Potential Genes Associated with Pathogenesis and Prognosis of Gastric Cancer

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Current Medical Science 2022年第2期42卷 357-372页

作者： Dan-wen WANG fei SU li-jie YANG li-wen SHI Tie-cheng YANG Hua-qiao WANG xuan-fei li Mao-hui FENG Department of Gastrointestinal Surgery Zhongnan Hospital of Wuhan UniversityWuhan443071China Clinical Medical Research Center of Peritoneal Cancer of Wuhan Wuhan443071China Clinical Cancer Study Center of Hubei Provence Wuhan443071China Hubei Key Laboratory of Tumor Biological Behaviors Wuhan443071China Department of Oncology the First Hospital of Lanzhou UniversityLanzhou730000China

Objective Gastric cancer(GC)is a deadly cancer and a challenging public health problem *** study aimed to analyze potential genes associated with pathogenesis and prognosis of gastric *** This work selected the overlapping differentially expressed genes(DEGs)in GC from four datasets,the GSE29272,GSE29998,GSE54129 and GSE118916 Gene Expression Omnibus *** DEGs were used to carry out comprehensive bioinformatic analysis to analyze the related functions and pathways enriched,the relative expression levels and immune infiltrates,the prognostic characteristics and the interaction *** In total,55 DEGs increased while 98 decreased in their expression *** those DEGs with increased expression,they were mostly concentrated on“focal adhesion”and“ECM-receptor interaction”,whereas DEGs with decreased expression were mostly associated with“gastric acid secretion”and“drug metabolism cytochrome P450”.MCODE and ClueGO results were then integrated to screen 10 hub genes,which were FN1,COL1A1,COL3A1,BGN,TIMP1,COL1A2,LUM,VCAN,COL5A2 and *** analysis revealed that higher expression of the ten hub genes significantly predicted lower overall survival of GC ***1 was most significantly related to neutrophils,CD8+T cells,as well as dendritic cells,while LUM was most significantly related to *** Immunohistochemistry results and functional testing showed that the expression of COL5A2 was elevated in GC and that it might be a key gene in GC tumorigenesis.

关键词： gastric cancer differentially expressed genes bioinformatics analysis prognosis immune infiltrate

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Overexpression of eRF3a Promotes Cell Proliferation and Migration in liver Cancer

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Current Medical Science 2022年第1期42卷 100-107页

作者： Yi-qing XI li-hua XU li-jie YANG Hua-qiao WANG Tie-cheng YANG Zhi li Wei XIE Jing-wei ZHANG xuan-fei li Mao-hui FENG Department of Gastrointestinal Surgery Zhongnan Hospital of Wuhan UniversityWuhan 430071China Clinical Medical Research Center of Peritoneal Cancer of Wuhan 430071 China Clinical Cancer Study Center of Hubei Province Wuhan 430071China Hubei Key Laboratory of Tumor Biological Behaviors Wuhan 430071China

Objective:The eukaryotic release factor 3a(eRF3a),a member of the eukaryotic peptide chain release factor family,is overexpressed in several types of *** study aims to investigate the biological role and mechanism of ... 详细信息

关键词： eukaryotic release factor 3a liver cancer migration invasion

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Identification and Validation of SLC9A2 as A Potential Tumor Suppressor in Colorectal Cancer:Integrating Bioinformatics Analysis with Experimental Confirmation

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Current Medical Science 2024年第3期44卷 529-544页

作者： Yan-min liU Tie-cheng YANG Xiao-chang FANG li-jie YANG li-wen SHI Hua-qiao WANG Ting-ting DOU lin SHU Tian-liang CHEN Jun HU Xiao-ming YU xuan-fei li Department of Gastroenterology the Central Hospital of WuhanKey Laboratory for Molecular Diagnosis of Hubei ProvinceTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430014China Department of Gastrointestinal Surgery Zhongnan Hospital of Wuhan UniversityWuhan430071China Clinical Medical Research Center of Peritoneal Cancer of Wuhan Wuhan430071China Hubei Provincial Clinical Research Center for Cancer Hubei Key Laboratory of Tumor Biological Behavi Wuhan430071China Department of General Surgery Taihe HospitalHubei University of MedicineShiyan442000China Department of Gastrointestinal Surgery Huangshi Central HospitalAffiliated Hospital of Hubei Polytechnic UniversityWuhan435001China

Objective To uncover the mechanisms underlying the development of colorectal cancer(CRC),we applied bioinformatic analyses to identify key genes and experimentally validated their possible roles in CRC onset and *** We performed Gene Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway analysis on differentially expressed genes(DEGs),constructed a protein-protein interaction(PPI)network to find the top 10 hub genes,and analyzed their expression in colon adenocarcinoma(COAD)and rectum adenocarcinoma(READ).We also studied the correlation between these genes and immune cell infiltration and prognosis and validated the expression of SLC9A2 in CRC tissues and cell lines using qRT-PCR and Western *** experiments were conducted in vitro to investigate the effects of SLC9A2 on tumor growth and *** We found 130 DEGs,with 45 up-regulated and 85 down-regulated in *** analysis indicated that these DEGs were primarily enriched in functions related to the regulation of cellular pH,zymogen granules,and transmembrane transporter *** pathway analysis revealed that the DEGs played pivotal roles in pancreatic secretion,rheumatoid arthritis,and the IL-17 signaling *** identified 10 hub genes:CXCL1,SLC26A3,CXCL2,MMP7,MMP1,SLC9A2,SLC4A4,CLCA1,CLCA4,and *** enrichment analysis showed that these hub genes were predominantly involved in the positive regulation of *** expression analysis revealed that CXCL1,CXCL2,MMP1,and MMP7 were highly expressed in CRC,whereas CLCA1,CLCA4,SLC4A4,SLC9A2,SLC26A3,and ZG16 were expressed at lower *** analysis revealed that 5 key genes were significantly associated with the prognosis of *** mRNA and protein expression levels of SLC9A2 were markedly reduced in CRC tissues and cell ***,SLC9A2 overexpression in SW480 cells led to a notable inhibition of cell proliferation,migration,and *** blotting analysis revealed tha

关键词： SLC9A2 colorectal cancer bioinformatic analysis biomarkers immune infiltrate

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GSPT1 Functions as a Tumor Promoter in Human liver Cancer

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Current Medical Science 2023年第1期43卷 104-114页

作者： Yi-qing XI Jing-bo GAO xuan-fei li li-hua XU Zhi-li li-jie YANG Jing WANG Hua-qiao WANG Xiao-chang FANG Si-rui HUANG Wei XIE Mao-hui FENG Jing-wei ZHANG Department of Breast and Thyroid Surgery Zhongnan Hospital of Wuhan UniversityWuhan430071China Department of Gastrointestinal Surgery Zhongnan Hospital of Wuhan UniversityWuhan430071China Hubei Cancer Clinical Study Center Wuhan UniversityWuhan430071China Institute of Hydrobiology Chinese Academy of SciencesWuhan430071China

Objective This study analyzed the role of G1 to S phase transition 1 protein(GSPT1)in promoting progression of liver cancer *** A bioinformatics database was used to analyze the expression levels of GSPT1 in liver cancer tissues and the prognosis of ***,Western blotting and quantitative PCR were used to verify the expression levels of GSPT1 between normal hepatocytes and hepatoma *** used a CRISPR/Cas9 system to construct knockouts of GSPT1 in HepG2 and HCCLM9 liver cancer *** effect of GSPT1 on liver cancer cell migration and invasion was analyzed using flow cytometry,migration,and tumor formation *** The Cancer Genome Atlas liver Hepatocellular Carcinoma dataset indicated that GSPT1 expression was upregulated in liver cancer cell lines,and patients with liver cancer had poor *** of GSPT1 in cells significantly inhibited tumor proliferation,cell migration,and growth in *** In this study,we found that GSPT1 promotes the migration and invasion of liver cancer cells.

关键词： Gl to S phase transition I protein liver cancer migration invasion

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Cell polarization in ischemic stroke: molecular mechanisms and advances

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Neural Regeneration Research 2025年第3期20卷 632-645页

作者： Yuanwei li Xiaoxiao Xu xuan Wu Jiarui li Shiling Chen Danyang Chen Gaigai li Zhouping Tang Department of Neurology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

Ischemic stroke is a cerebrovascular disease associated with high mortality and disability rates. Since the inflammation and immune response play a central role in driving ischemic damage, it becomes essential to modulate excessive inflammatory reactions to promote cell survival and facilitate tissue repair around the injury site. Various cell types are involved in the inflammatory response, including microglia, astrocytes, and neutrophils, each exhibiting distinct phenotypic profiles upon stimulation. They display either proinflammatory or anti-inflammatory states, a phenomenon known as ‘cell polarization.’ There are two cell polarization therapy strategies. The first involves inducing cells into a neuroprotective phenotype in vitro, then reintroducing them autologously. The second approach utilizes small molecular substances to directly affect cells in vivo. In this review, we elucidate the polarization dynamics of the three reactive cell populations(microglia, astrocytes, and neutrophils) in the context of ischemic stroke, and provide a comprehensive summary of the molecular mechanisms involved in their phenotypic switching. By unraveling the complexity of cell polarization, we hope to offer insights for future research on neuroinflammation and novel therapeutic strategies for ischemic stroke.

关键词： astrocyte polarization immune regulation inflammation ischemic injury microglia polarization neutrophil polarization signaling pathways stroke

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Epigenetic regulation of the inflammatory response in stroke

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Neural Regeneration Research 2025年第11期20卷 3045-3062页

作者： Jingyi liang fei Yang Zixiao li Qian li School of Basic Medical Sciences Capital Medical UniversityBeijingChina Department of Neurobiology School of Basic Medical SciencesCapital Medical UniversityBeijingChina Laboratory for Clinical Medicine Beijing Key Laboratory of Neural Regeneration and RepairCapital Medical UniversityBeijingChina Department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina China National Clinical Research Center for Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina National Center for Healthcare Quality Management in Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Chinese Institute for Brain Research BeijingChina Research Unit of Artificial Intelligence in Cerebrovascular Disease Chinese Academy of Medical SciencesBeijingChina Beijing Engineering Research Center of Digital Healthcare for Neurological Diseases BeijingChina Department of Biochemistry and Molecular Biology School of Basic Medical SciencesCapital Medical UniversityBeijingChina Beijing Key Laboratory of Cancer Invasion and Metastasis Research Capital Medical UniversityBeijingChina

Stroke is classified as ischemic or hemorrhagic,and there are few effective treatments for either *** mechanisms play a critical role in secondary brain injury following a stroke,which manifests as cytokine release,blood–brain barrier disruption,neuronal cell death,and ultimately behavioral *** the inflammatory response has been shown to mitigate this cascade of events in experimental stroke ***,in clinical trials of anti-inflammatory agents,longterm immunosuppression has not demonstrated significant clinical benefits for *** may be attributable to the dichotomous roles of inflammation in both tissue injury and repair,as well as the complex pathophysiologic inflammatory processes in *** acute harmful inflammatory responses or inducing a phenotypic shift from a pro-inflammatory to an anti-inflammatory state at specific time points after a stroke are alternative and promising therapeutic *** agents that can modulate inflammation requires a detailed understanding of the inflammatory processes of ***,epigenetic reprogramming plays a crucial role in modulating post-stroke inflammation and can potentially be exploited for stroke *** this review,we summarize current findings on the epigenetic regulation of the inflammatory response in stroke,focusing on key signaling pathways including nuclear factor-kappa B,Janus kinase/signal transducer and activator of transcription,and mitogen-activated protein kinase as well as inflammasome *** also discuss promising molecular targets for stroke *** evidence to date indicates that therapeutic targeting of the epigenetic regulation of inflammation can shift the balance from inflammation-induced tissue injury to repair following stroke,leading to improved post-stroke outcomes.

关键词： DNA methylation histone modification intracerebral hemorrhage ischemic stroke neuroinflammation neuroprotection non-coding RNA RNA methylation subarachnoid hemorrhage treatment

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An efficient quantum proactive incremental learning algorithm

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 49-57页

作者： lingxiao li Jing li Yanqi Song Sujuan Qin Qiaoyan Wen fei Gao State Key Laboratory of Networking and Switching Technology Beijing University of Posts and Telecommunications School of Cyberspace Security Beijing University of Posts and Telecommunications

In scenarios where a large amount of data needs to be learned, incremental learning can make full use of old knowledge, significantly reduce the computational cost of the overall learning process, and maintain high performance. In this paper, taking the MaxCut problem as our example, we introduce the idea of incremental learning into quantum computing, and propose a Quantum Proactive Incremental Learning algorithm(QPIL). Instead of a one-off training of quantum circuit, QPIL contains a multi-phase training on gradually-increased subgraphs of all vertices, proactively reducing large-scale problems to smaller ones to solve in steps, providing an efficient solution for MaxCut. Specifically, some vertices and corresponding edges are randomly selected for training to obtain optimized parameters of the quantum circuit at first. Then, in each incremental phase, the remaining vertices and corresponding edges are gradually added and the parameters obtained from the previous phase are reused in the parameter initialization of the current phase. We perform experiments on 120 different small-scale graphs, and it shows that QPIL performs superior to prevalent quantum and classical baselines in terms of approximation ratio(AR), time cost, anti-forgetting, and solving stability. In particular, QPIL's AR surpasses 20% of mainstream quantum baselines, and the time cost is less than 1/5 of them. The idea of QPIL is expected to inspire efficient and high-quality solutions in large-scale Max Cut and other combinatorial optimization problems.

关键词： variational quantum algorithm incremental learning multi-phase training MaxCut quantum computing

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From blocker to booster:Harnessing garnet surface chemistry for advanced solid-state electrolytes

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Nano Research 2025年第1期18卷 323-331页

作者： Jun Cheng xuan Zhou Hongqiang Zhang Zhen Zeng Yuanyuan li Yulong Zhu Yingsheng liao lijie Ci Deping li State Key Laboratory of Precision Welding and Joining of Materials and Structures School of Materials Science and EngineeringHarbin Institute of Technology(Shenzhen)Shenzhen 518055China

Garnet electrolytes with high ionic conductivity and electrochemical stability are widely used as fillers to fabricate composite solid electrolytes(CPEs)within polymer ***,the performance of CPEs is significantly influenced by the surface characteristics of the garnet ***,the impact of garnet surface characteristics on CPEs was systematically investigated and a conversion from a typically unstable and Lewis basic surface to a more stable Lewis acidic surface was realized,which is shown to be more conductive to the improved performance of *** simultaneously removing the li_(2)CO_(3)layer and applying a li-Al-O coating,the influence of surface characteristics on CPEs was *** Lewis acid li-Al-O surface coating not only promotes lithium salt dissociation,improving the ionic conductivity and ionic transfer number,but also prevents the reformation of the passive Lewis basic li_(2)CO_(3)*** to garnet with a Lewis basic li_(2)CO_(3)surface,the garnet modified with a Lewis acid li-Al-O coating enhances CPEs,which exhibit an improved critical current density of 1.0 mA·cm^(-2)and highly stable lithium symmetric cell cycling for 400 h at 0.2 mA·cm^(-2).This research highlights the importance of surface chemistry in the design of high-performance solid-state batteries and presents a strategic modification approach for garnetbased CPEs.

关键词： garnet electrolyte composite solid electrolyte surface chemistry all-solid-state batteries

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川中地区下二叠统白云岩储层特征及发育主控因素

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大庆石油地质与开发 2017年第4期36卷 1-8页

作者：李祖兵欧加强陈轩李飞王小蓉谭先锋复杂油气田勘探开发重庆市重点实验室重庆401331 西南油气田分公司川中油气矿勘探开发研究所四川遂宁629000 长江大学油气资源与勘探技术教育部重点实验室湖北武汉430100

为进一步深化对川中地区下二叠统白云岩储层特征及发育主控因素的认识,利用研究区茅口组的岩心、岩屑、薄片鉴定、扫描电镜、碳氧同位素、阴极发光及流体包裹体分析等资料,采用地质分析与地化分析相结合的方法,从岩石学、岩石地球化学... 详细信息

为进一步深化对川中地区下二叠统白云岩储层特征及发育主控因素的认识,利用研究区茅口组的岩心、岩屑、薄片鉴定、扫描电镜、碳氧同位素、阴极发光及流体包裹体分析等资料,采用地质分析与地化分析相结合的方法,从岩石学、岩石地球化学及储集空间发育特征等方面进行研究。研究结果表明:茅口组白云岩主要发育砂糖状白云岩、中—细晶白云石、角砾白云岩及少量灰质白云岩,储集空间以溶孔和溶洞为主,溶缝和粒内溶孔次之,白云岩形成过程几乎不受埋深的影响,没有或很少有淡水参与,主要形成于构造—热液环境;储层的岩性组成、白云化作用、构造作用及溶蚀作用是茅口组白云岩储层发育的主控因素,储层的岩性组成是白云岩储层发育的物质基础,适度白云化作用是储层发育的必要条件,构造作用是储层最终发育和空间展布的关键,溶蚀作用是白云岩储层空间展布的重要因素。

关键词：川中地区茅口组白云岩储层主控因素

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Activation of adult endogenous neurogenesis by a hyaluronic acid collagen gel containing basic fibroblast growth factor promotes remodeling and functional recovery of the injured cerebral cortex

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Neural Regeneration Research 2025年第10期20卷 2923-2937页

作者： Yan li Peng Hao Hongmei Duan fei Hao Wen Zhao Yudan Gao Zhaoyang Yang Kwok-Fai So Xiaoguang li Department of Neurobiology School of Basic Medical SciencesCapital Medical UniversityBeijingChina China Rehabilitation Science Institute China Rehabilitation Research CenterBeijing Key Laboratory of Neural Injury and RehabilitationBeijingChina Center of Neural Injury and Repair Beijing Institute for Brain DisordersBeijingChina Beijing Key Laboratory for Biomaterials and Neural Regeneration School of Engineering MedicineBeihang UniversityBeijingChina Guangdong-HongKong-Macao Institute of CNS Regeneration Ministry of Education CNS Regeneration Collaborative Joint LaboratoryJinan UniversityGuangzhouGuangdong ProvinceChina Bioland Laboratory(Guangzhou Regenerative Medicine and Health Guangdong Laboratory) GuangzhouGuangdong ProvinceChina Department of Ophthalmology and State Key Laboratory of Brain and Cognitive Sciences The University of Hong KongHong Kong Special Administration RegionChina Center for Brain Science and Brain-Inspired Intelligence Guangdong-HongKong-Macao Greater Bay AreaGuangzhouGuangdong ProvinceChina Co-innovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Department of Biomedical Engineering School of Biological Science and Medical EngineeringBeihang UniversityBeijingChina

The presence of endogenous neural stem/progenitor cells in the adult mammalian brain suggests that the central nervous system can be repaired and regenerated after ***,whether it is possible to stimulate neurogenesis and reconstruct cortical layers II to VI in non-neurogenic regions,such as the cortex,remains *** this study,we implanted a hyaluronic acid collagen gel loaded with basic fibroblast growth factor into the motor cortex immediately following traumatic *** findings reveal that this gel effectively stimulated the proliferation and migration of endogenous neural stem/progenitor cells,as well as their differentiation into mature and functionally integrated ***,these new neurons reconstructed the architecture of cortical layers II to VI,integrated into the existing neural circuitry,and ultimately led to improved brain *** findings offer novel insight into potential clinical treatments for traumatic cerebral cortex injuries.

关键词： adult endogenous neurogenesis basic fibroblast growth factor-hyaluronic acid collagen gel cortical remodeling functional recovery migration motor cortex injury neural circuits neural stem cells newborn neurons proliferation

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