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Dissolvable temporary barrier:a novel paradigm for flexible hydrogel patterning in organ-on-a-chip models

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Bio-Design and Manufacturing 2024年第2期7卷 153-166页

作者： Ding Wang Qinyu li Chenyang zhou Zhangjie li Kangyi Lu Yijun liu lian xuan Xiaolin Wang Department of Micro/Nano Electronics School of Electronic Information and Electrical EngineeringShanghai Jiao Tong UniversityShanghai 200240China Department of Ophthalmology LKS Faculty of MedicineThe University of Hong KongHong Kong 999077China Institute of Medical Robotics Shanghai Jiao Tong UniversityShanghai 200240China National Key Laboratory of Advanced Micro and Nano Manufacture Technology Shanghai Jiao Tong UniversityShanghai 200240China National Center for Translational Medicine(Shanghai)SHU Branch Shanghai UniversityShanghai 200444China

A combination of hydrogels and microfluidics allows the construction of biomimetic three-dimensional(3D)tissue models in vitro,which are also known as *** hydrogel patterningwith awell-controlled spatial distribution is typically achieved by embedding sophisticated microstructures to act as a ***,these physical barriers inevitably expose cells/tissues to a less physiologically relevant microenvironment than in vivo ***,we present a novel dissolvable temporary barrier(DTB)strategy that allows robust and flexible hydrogel patterning with great freedom of design and desirable flow stimuli for cellular *** key aspect of this approach is the patterning of a water-soluble rigid barrier as a guiding path for the hydrogel using stencil printing technology,followed by a barrier-free medium perfusion after the dissolution of the *** and multiple tissue compartments with different geometries can be established using either straight or curved DTB *** effectiveness of this strategy is further validated by generating a 3D vascular network through vasculogenesis and angiogenesis using a vascularized microtumor *** a new proof-of-concept in vasculature-on-a-chip,DTB enables seamless contact between the hydrogel and the culture medium in closed microdevices,which is an improved protocol for the fabrication ofmultiorgan ***,we expect it to serve as a promising paradigm for organ-on-a-chip devices for the development of tumor vascularization and drug evaluation in the future preclinical studies.

关键词： Dissolvable temporary barrier Hydrogel patterning Microfluidics Organ-on-a-chip Vascularization

Formal Modeling of Frame Selection in Asynchronous TSN Communications

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Chinese Journal of Electronics 2024年第2期33卷 549-563页

作者： Ershuai li xuan zhou Jinjing SUN Huagang XIONG Feng HE School of Electronic and Information Engineering Beihang University

The asynchronous time-sensitive networking(TSN) based on IEEE 802.1Qcr is expected to be a promising solution for the asynchronous transmissions of safety-critical flows without the support of clock *** the asynchronous traffic shaping(ATS) mechanism is adopted to meet the deadline requirements for transmissions of safety-critical flow, it is necessary to formally verify the real-time properties and corresponding network ***, it is still unclear how to build an efficient formal model to evaluate different frame selection methods during the ATS scheduling process, which originate from the dominations of priority or eligibility time. In this paper, we present a formal modeling framework to compare the impacts of different frame selection on transmission sequence under the ATS mechanism. According to the priority level(p ATS) or eligibility time(e ATS) for flows, two transmission selection methods in ATS are modeled and compared. Then, we verify the real-time properties of ATS. The result shows that the shaping-for-free property can be satisfied with the p ATS method but can not be fulfilled with the e ATS method. Besides, the timing analysis results illustrate that the e ATS method can provide more fairness than the p ATS method for the transmission of low-priority flows in TSN networks.

关键词： System recovery Real-time systems Delays Synchronization

Revealing the role of calcium ion intercalation of hydrated vanadium oxides for aqueous zinc-ion batteries

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Journal of Energy Chemistry 2024年第8期95卷 9-19,I0001页

作者： Tao zhou xuan Du Guo Gao Key Laboratory for Thin Film and Micro Fabrication of the Ministry of Education School of Sensing Science and EngineeringSchool of Electronic Information and Electrical EngineeringShanghai Jiao Tong UniversityShanghai 200240China

Exploring suitable high-capacity V_(2)O_(5)-based cathode materials is essential for the rapid advancement of aqueous zinc ion batteries(ZIBs).However,the typical problem of slow Zn^(2+)diffusion kinetics has severely limited the feasibility of such *** this work,unique hydrated vanadates(CaVO,BaVO)were obtained by intercalation of Ca^(2+)or Ba^(2+)into hydrated vanadium *** the CaVO//Zn and BaVO//Zn batteries systems,the former delivered up to a 489.8 mAh g^(-1)discharge specific capacity at 0.1 A g^(-1).Moreover,the remarkable energy density of 370.07 Wh kg^(-1)and favorable cycling stability yard outperform BaVO,pure V_(2)O_(5),and many reported cathodes of similar ionic intercalation *** addition,pseudocapacitance analysis,galvanostatic intermittent titration(GITT)tests,and Trasatti analysis revealed the high capacitance contribution and Zn^(2+)diffusion coefficient of CaVO,while an in-depth investigation based on EIS elucidated the reasons for the better electrochemical performance of ***,ex-situ XRD,XPS,and TEM tests further demonstrated the Zn^(2+)insertion/extraction and Zn-storage mechanism that occurred during the cycle in the CaVO//Zn battery *** work provides new insights into the intercalation of similar divalent cations in vanadium oxides and offers new solutions for designing cathodes for high-capacity aqueous ZIBs.

关键词： Aqueous zinc ion batteries Cathode materials Ion pre-intercalation Vanadium oxides Energy storage mechanism

HeterMM: applying in-DRAM index to heterogeneous memory-based key-value stores

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Frontiers of Computer Science 2024年第4期18卷 215-217页

作者： Yunhong JI Wentao HUANG xuan zhou School of Information Renmin University of ChinaBeijing 100872China School of Computing National University of SingaporeSingapore 117417Singapore School of Data Science and Engineering East China Normal UniversityShanghai 200062China

1 Introduction Emerging byte-addressable storage technologies,such as NVM(Non-Volatile Memory),provide a more cost-effective and larger-capacity alternative to DRAM(Dynamic Random Access Memory)[1],presenting new opportunities to address the high cost,limited capacity,and volatility of in-memory key-value(KV)*** efforts have been dedicated to redesigning conventional structures on ***,they were challenged by the substantial engineering cost and increased complexity to be integrated into existing ***,a general framework to apply existing indexes to KV stores on NVM becomes more attractive[2].

关键词： stores applying value

Engineering classification recycling of spent lithium-ion batteries through pretreatment:a comprehensive review from laboratory to scale-up application

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Rare Metals 2024年第3期43卷 915-941页

作者： Shu-xuan Yan You-zhou Jiang Xiang-Ping Chen Lu Yuan Ting-Ting Min Yu Cao Wan-li Peng Tao zhou Hunan Provincial Key Laboratory of Chemical Power Sources College of Chemistry and Chemical EngineeringCentral South UniversityChangsha 410083China College of Chemistry and Chemical Engineering Hunan Normal UniversityChangsha 410083China School of Public Policy and Management Tsinghua UniversityBeijing 100084China China Nonferrous Metal Industry's Foreign Engineering and Construction Co. LtdBeijing 100029China

The lithium-ion batteries(liBs)have been widely equipped in electric/hybrid electric vehicles(EVs/HEVs)and the portable electronics due to their excellent electrochemical ***,a large number of retired liBs that consist of toxic substances(e.g.,heavy metals,electrolytes)and valuable metals(e.g.,li,Co)will inevitably flow into the waste stream,and their incineration or landfill treatment will cause severe risks to ecosystem and human *** sustainable and efficient treatment or recycling of valuable resources from spent liBs should be fully recognized for environmental and resource *** one of the most important processes for spent liBs recycling,the pretreatment is an indispensable step,which is directly related to the subsequent metal extraction and separation *** considerable progresses have been made regarding the pretreatment technologies,there are few summarized reports concerning critical processes of spent liBs recycling,especially combination of currently available recycling technologies with industrialized applications during ***,comprehensive review of the current prevailing pretreatment technologies in laboratory to existing scale-up applications is quite necessary to reveal cutting-edge development in the field of *** this review,the current pretreatment technologies are systematically categorized and introduced,along with critical *** review focused on the various options for pretreatment processes itself,instead of general spent liBs recycling technologies without the focused topics that have been sophisticatedly reviewed by previous ***,the deactivation,discharge,dismantling,separation,liberation of active material and electrolyte treatment have been summarized with the in-depth discussion of the technology development and current status of each ***,current states of industrial development are also reviewed and discussed for the development of

关键词： Spent lithium-ion batteries(liBs) Recycling Pretreatment Valuable metals Cutting-edge technologies Industrialized application

Zinc lactate alleviates oxidative stress by modulating crosstalk between constitutive androstane receptor signaling pathway and gut microbiota profile in weaned piglets

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Animal Nutrition 2024年第1期16卷 23-33页

作者： Wenjie Tang xuan Xiang Houfu Wang Wentao zhou liuqin He Yulong Yin Tiejun li College of Animal Science and Technology Hunan Agricultural UniversityChangsha 410128China Hunan Provincial Key Laboratory of Animal Nutritional Physiology and Metabolic Process CAS Key Laboratory of Agro-Ecological Processes in Subtropical RegionNational Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry ProductionInstitute of Subtropical AgricultureChinese Academy of SciencesChangsha 410125China Hunan Provincial Key Laboratory of Animal Intestinal Function and Regulation Laboratory of Animal Nutrition and Human HealthCollege of Life SciencesHunan Normal UniversityChangsha 410081China College of Advanced Agricultural Science University of Chinese Academy of SciencesBeijing 100049China Sichuan Academy of Animal Sciences Animal Breeding and Genetics Key Laboratory of Sichuan ProvinceChengdu 610066China livestock and Poultry Biological Products Key Laboratory of Sichuan Province Sichuan Animtech Feed Co.LtdChengdu 610000China

This study aimed to determine the regulatory mechanism of dietary zinc lactate(ZL)supplementation on intestinal oxidative stress damage in a paraquat(PQ)-induced piglet ***-eight piglets(mean body weight 9.51±0.23 kg)weaned at 28 d of age were randomly divided into control,ZL,PQ,and ZL+PQ groups(n=7 in each group).The ZL-supplemented diet had little effect on growth performance under normal physiological ***,under PQ challenge,ZL supplementation significantly improved average daily gain(Pling(Pling and gut microbiota.

关键词： Zinc lactate Intestinal barrier Oxidative stress Inflammation Constitutive androstane receptor Gut microbiota

Accurate atomic scanning transmission electron microscopy analysis enabled by deep learning

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Nano Research 2024年第4期17卷 2971-2980页

作者： Tianshu Chu Lei zhou Bowei Zhang Fu-Zhen xuan Shanghai Key Laboratory of Intelligent Sensing and Detection Technology East China University of Science and TechnologyShanghai 200237China School of Mechanical and Power Engineering East China University of Science and TechnologyShanghai 200237China Key Laboratory of Pressure Systems and Safety of Ministry of Education East China University of Science and TechnologyShanghai 200237China

Currently,the machine learning(ML)-based scanning transmission electron microscopy(STEM)analysis is limited in the simulative stage,its application in experimental STEM is needed but ***,we built up a universal model to analyze the vacancy defects and single atoms accurately and rapidly in experimental STEM images using a full convolution *** our model,the unavoidable interference factors of noise,aberration,and carbon contamination were fully considered during the training,which were difficult to be considered in the *** toward the simultaneous identification of various vacancy types and low-contrast single atoms in the low-quality STEM images,our model showed rapid process speed(45 images per second)and high accuracy(>95%).This work represents an improvement in experimental STEM image analysis by ML.

关键词： deep learning low-dimensional materials atomic defects single atoms

Data-driven rational design of single-atom materials for hydrogen evolution and sensing

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Nano Research 2024年第4期17卷 3352-3358页

作者： Lei zhou Pengfei Tian Bowei Zhang Fu-Zhen xuan Shanghai Key Laboratory of Intelligent Sensing and Detection Technology East China University of Science and TechnologyShanghai 200237China School of Mechanical and Power Engineering East China University of Science and TechnologyShanghai 200237China Key Laboratory of Pressure Systems and Safety of Ministry of Education East China University of Science and TechnologyShanghai 200237China

Herein we proposed a data-driven high-throughput principle to screen high-performance single-atom materials for hydrogen evolution reaction(HER)and hydrogen sensing by combing the theoretical computations and a topology-based multi-scale convolution kernel machine learning *** the rational training by 25 groups of data and prediction of all 168 groups of single-atom materials for HER and sensing,respectively,a high prediction accuracy(>0.931 R^(2) score)was achieved by our *** show that the promising HER catalysts include Pt atoms in C_(4) and Sc atoms in C_(1)N_(3) coordination ***,Y atoms in C_(4) coordination environment and Cd atoms in C_(2)N_(2)-ortho coordination environment were predicted with great potential as hydrogen sensing *** method provides a way to accelerate the discovery of innovative materials by avoiding the time-consuming empirical principles in experiments.

关键词： machine learning single-atom materials sensing hydrogen evolution

Perturbation of autophagy pathways in murine alveolar macrophage by 2D TMDCs is chalcogen-dependent

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Journal of Environmental Sciences 2024年第1期135卷 97-107页

作者： Xiaofei zhou Weitao Jin Rui Zhang xuan Mao Jianbo Jia Hongyu zhou College of Science&Technology Hebei Agricultural UniversityHuanghua 061100China Institute of Environmental Research at Greater Bay Area Key Laboratory for Water Quality and Conservation of the Pearl River DeltaMinistry of EducationGuangzhou UniversityGuangzhou 510006China

Increasing risks of incidental and occupational exposures to two-dimensional transition metal dichalcogenides(2D TMDCs)due to their broad application in various areas raised their public health *** the composition-dependent cytotoxicity of 2D TMDCs has been well-recognized,how the outer chalcogenide atoms and inner transition metal atoms differentially contribute to their perturbation on cell homeostasis at non-lethal doses remains to be *** the present work,we compared the autophagy induction and related mechanisms in response to WS_(2),NbS_(2),WSe_(2)and Nb Se_(2)nanosheets exposures in MH-S murine alveolar *** these 2D TMDCs had comparable physicochemical properties,overall cytotoxicity and capability in triggering autophagy in MH-S cells,but showed outer chalcogen-dependent subcellular localization and activation of autophagy ***,WS_(2)and NbS_(2)nanosheets adhered on the cell surface and internalized in the lysosomes,and triggered m TOR-dependent activation of ***,WSe_(2)and Nb Se_(2)nanosheets had extensive distribution in cytoplasm of MH-S cells and induced autophagy in an m TOR-independent ***,the 2D TMDCs-induced perturbation on autophagy aggravated the cytotoxicity of respirable benzo[a]*** findings provide a deeper insight into the potential health risk of environmental 2D TMDCs from the perspective of homeostasis perturbation.

关键词： Chalcogen group Autophagy pathway Cell function Endosomal escape Inhalation toxicity