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Hepatocellular carcinoma:An analysis of the expression status of stress granules and their prognostic value

World Journal of Gastrointestinal Oncology 2024年第6期16卷 2571-2591页

作者： Qing-Shuai Ren Qiu Sun Shu-Qin Cheng Li-Ming Du Ping-xuan guo Department of Cardiovascular Surgery North China University of Science and Technology Affiliated HospitalTangshan 063000Hebei ProvinceChina Department of Hepatobiliary Kailuan General HospitalTangshan 063000Hebei ProvinceChina Department of Gastroenterology and Hepatology Tianjin Medical University General HospitalTianjin Institute of Digestive DiseasesTianjin Key Laboratory of Digestive DiseasesTianjin 300000China Department of Traditional Chinese Medicine Kailuan General HospitalTangshan 063000Hebei ProvinceChina Department of Anesthesiology Kailuan General HospitalNorth China University of Science and TechnologyTangshan 063000Hebei ProvinceChina

BACKGROUND Hepatocellular carcinoma(HCC)is a global popular malignant tumor,which is difficult to cure,and the current treatment is *** To analyze the impacts of stress granule(SG)genes on overall survival(OS),survival time,and prognosis in *** The combined The Cancer Genome Atlas-Liver Hepatocellular Carcinoma(TCGA-LIHC),GSE25097,and GSE36376 datasets were utilized to obtain genetic and clinical *** hub gene numbers and corresponding coefficients were determined using the Least absolute shrinkage and selection operator model approach,and genes for constructing risk scores and corresponding correlation coefficients were calculated according to multivariate Cox regression,*** prognostic model’s receiver operating characteristic(ROC)curve was produced and plotted utilizing the time ROC software *** models were constructed to predict the outcomes at 1,3,and 5-year OS prognostications with good prediction *** We identified seven SG genes(DDX1,DKC1,BICC1,HNRNPUL1,CNOT6,DYRK3,CCDC124)having a prognostic significance and developed a risk score *** findings of Kaplan-Meier analysis indicated that the group with a high risk exhibited significantly reduced OS in comparison with those of the low-risk group(P<0.001).The nomogram model’s findings indicate a significant enhancement in the accuracy of OS prediction for individuals with HCC in the TCGA-HCC *** Ontology and Gene Set Enrichment Analysis suggested that these SGs might be involved in the cell cycle,RNA editing,and other biological *** Based on the impact of SG genes on HCC prognosis,in the future,it will be used as a biomarker as well as a unique therapeutic target for the identification and treatment of HCC.

关键词： Stress granule genes Hepatocellular carcinoma Gastrointestinal neoplasms Bioinformatics prognosis Prognostic value

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A widely used nonionic surfactant with desired functional groups as aqueous electrolyte additives for stabilizing Zn anode

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Rare Metals 2024年第8期43卷 3692-3701页

作者： Yue-Xian Song Xiao-Feng Wang Cai-Bin Liu Kai-xuan guo Xu-Huan guo Xiao-Bin Zhong Yao-Hui Zhang Kai Wang Hui-Juan guo Li-Xin Zhang Jun-Fei Liang School of Energy and Power Engineering North University of ChinaTaiyuan 030051China Key Laboratory of Green Chemical Process of Ministry of Education Hubei Key Laboratory of Novel Chemical Reactor and Green Chemical TechnologySchool of Chemical Engineering and PharmacyWuhan Institute of TechnologyWuhan 430073China Shanxi Provincial Key Laboratory for High Performance Battery Materials and Devices Taiyuan 030051China

Aqueous Zn-ion batteries(AZIBs) have emerged as potential candidates for Li-ion batteries due to their intrinsic safety and high ***,metallic Zn anodes encounter dendrite growth and water-induced corrosion,rendering poor stability and severe irreversibility at the electrode/electrolyte interface during *** stabilize the Zn anode,we report a low-cost and effective nonionic surfactant,Tween-20 polymer,as an electrolyte additive for *** Tween-20,sequential oxyethylene groups tended to be preferentially adsorbed on the Zn electrode to form a shielding layer for regulating uniform Zn ***,the hydrophobic hendecyl chains prevented H_(2)O-induced corrosion on the Zn anode *** from the desired functional groups,when only trace amounts of Tween-20(0.050 g·L^(-1)) were used,the Zn anode displayed good cycling stability over 2170 h at10 mA·cm^(-2) and a high average Coulombic efficiency of98.94% over 1000 *** Tween-20 polymer can also be effectively employed in MnO_(2)/Zn full *** their toxicity,price and amount of usage,these surfactant additives provide a promising strategy for realizing the stability and reversibility of high-performance Zn anodes.

关键词： Zn anode Dendrite growth Tween-20 polymer Surfactant additive Aqueous electrolyte

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Gossypol acetic acid regulates leukemia stem cells by degrading LRPPRC via inhibiting IL-6/JAK1/STAT3 signaling or resulting mitochondrial dysfunction

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World Journal of Stem Cells 2024年第4期16卷 444-458页

作者： Cheng-Jin Ai Ling-Juan Chen Li-xuan guo Ya-Ping Wang Zi-Yi Zhao Department of Laboratory Medicine Hospital of Chengdu University of Traditional Chinese MedicineChengdu 641000Sichuan ProvinceChina Department of Ophthalmology Hospital of Chengdu University of Traditional Chinese MedicineChengdu 641000Sichuan ProvinceChina Central Laboratory Hospital of Chengdu University of Traditional Chinese MedicineChengdu 641000Sichuan ProvinceChina Traditional Chinese Medicine Regulating Metabolic Diseases Key Laboratory of Sichuan Province Chengdu University of Traditional Chinese MedicineChengdu 641000Sichuan ProvinceChina

BACKGROUND Leukemia stem cells(LSCs)are found to be one of the main factors contributing to poor therapeutic effects in acute myeloid leukemia(AML),as they are protected by the bone marrow microenvironment(BMM)against conventional *** acetic acid(GAA),which is extracted from the seeds of cotton plants,exerts anti-tumor roles in several types of cancer and has been reported to induce apoptosis of LSCs by inhibiting *** To investigate the exact roles of GAA in regulating LSCs under different microenvironments and the exact *** In this study,LSCs were magnetically sorted from AML cell lines and the CD34+CD38-population was *** expression of leucine-rich pentatricopeptide repeat-containing protein(LRPPRC)and forkhead box M1(FOXM1)was evaluated in LSCs,and the effects of GAA on malignancies and mitochondrial RESULTS LRPPRC was found to be upregulated,and GAA inhibited cell proliferation by degrading *** induced LRPPRC degradation and inhibited the activation of interleukin 6(IL-6)/janus kinase(JAK)1/signal transducer and activator of transcription(STAT)3 signaling,enhancing chemosensitivity in LSCs against conventional chemotherapies,including L-Asparaginase,Dexamethasone,and *** was also found to downregulate FOXM1 indirectly by regulating ***,GAA induced reactive oxygen species accumulation,disturbed mitochondrial homeostasis,and caused mitochondrial *** inhibiting IL-6/JAK1/STAT3 signaling via degrading LRPPRC,GAA resulted in the elimination of ***,GAA induced oxidative stress and subsequent cell damage by causing mitochondrial *** Taken together,the results indicate that GAA might overcome the BMM protective effect and be considered as a novel and effective combination therapy for AML.

关键词： Leukemia stem cells Gossypol acetic acid Reactive oxygen species Mitochondrial dysfunction Interleukin 6/janus kinase 1/signal transducer and activator of transcription 3 signaling

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《洪武正韵》在朝鲜朝汉语官话“正音”教学中的地位及影响

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吉林大学社会科学学报 2024年第2期64卷 88-99,238页

作者：张辉郭璇璇延边大学文学院延吉133002 厦门大学中文系厦门361005

朝鲜朝(1392—1910)引进和翻译中国韵书,积极推行以《洪武正韵》为汉语官话“正音”标准的中文教育。朝鲜朝从官方层面将《洪武正韵》列入蒙童学习书目及科举考试科目,翻译《洪武正韵》,刊行《洪武正韵译训》,构建汉语官话“正音”韵书... 详细信息

朝鲜朝(1392—1910)引进和翻译中国韵书,积极推行以《洪武正韵》为汉语官话“正音”标准的中文教育。朝鲜朝从官方层面将《洪武正韵》列入蒙童学习书目及科举考试科目,翻译《洪武正韵》,刊行《洪武正韵译训》,构建汉语官话“正音”韵书编撰的标准范式。《洪武正韵》曾对朝鲜半岛的汉语官话“正音”教学产生过深刻影响,推动了朝鲜本土化汉语“正音”韵书的刊行,是汉语国际教育史研究中值得关注的问题。

关键词：《洪武正韵》《洪武正韵译训》朝鲜朝汉语教育 “正音”

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中国重要农业文化遗产的空间分布特征及其差异性管理策略

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Journal of Geographical Sciences 2024年第3期34卷 483-498页

作者：郭旋闵庆文焦雯珺 Institute of Geographic Sciences and Natural Resources Research CASBeijing100101China University of Chinese Academy of Sciences Beijing100049China Tourism College of Beijing Union University Beijing100101China

Climate change and rapid urbanization pose significant challenges to the conservation and management of agricultural heritage systems,including decline in agricultural land,loss of labor,and ecosystem *** existing studies have proposed general strategies with theoretical guidance and specific strategies for particular systems to promote the conservation of agricultural heritage systems,there remains a large knowledge gap in effective and differentiated management strategies at the regional *** is especially so in China because of the clear regional differences in the natural and socioeconomic conditions of the widely distributed China Nationally Important Agricultural Heritage Systems(China-NIAHS).In this study,we integrated multi-source data and spatial analysis to reveal the distribution characteristics of existing China-NIAHS and proposed differentiated management *** show that there are four clustering distribution zones of China-NIAHS,i.e.,the northwest clustering zone west of the Heihe-Tengchong Line(ZoneⅠ),the clustering belt with‘Northeast-Hebei-Shandong'as core(ZoneⅡ),the Yangtze River Delta clustering zone(ZoneⅢ),and the Hunan-Chongqing-Yunnan-Guizhou clustering zone(ZoneⅣ).Different management strategies are proposed for the China-NIAHS in each clustering ***,ZoneⅠshould focus on maintaining their ecological functions and services,while ZoneⅡshould aim for livelihood supply,sustainable resource use,and ecological *** ZoneⅢ,rapid urbanization could become a positive driving force for China-NIAHS conservation through sustainable tourism and reasonable urban ***Ⅳshould emphasize the mutual support between characteristic product development and the brand effect of the *** findings will help establish regional and targeted management strategies for China-NIAHS and provide a reference for the conservation of agricultural heritage systems in other countries.

关键词： China Nationally Important Agricultural Heritage Systems(China-NIAHS) spatial distribution characteristics differentiated management strategies clustering zone ecological functions and services synergistic development with the socio-economy

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A potential giant gallium deposit hosted in the tailing dam of the Fankou Zn-Pb deposit in northern Guangdong Province, South China

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China Geology 2024年第1期7卷 157-160页

作者： Peng-peng Yu Zhao-bin Hu Yi Zheng Lan-xuan guo Shi-yuan Ouyang Gui-qiang Yuan Shang-zhou Chen Cheng-ming Wang Xi Chen School of Earth Sciences and Geological Engineering Sun Yat-sen UniversityGuangzhou 510275China Guangdong Provincial Key Lab of Geological Process and Mineral Resources Survey Sun Yat-sen UniversityGuangzhou 510275China Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai) Zhuhai 519000China Zhongjin Lingnan Nonfemet Co. LtdShenzhen 518000China

*** The Fankou giant zinc(Zn)-lead(Pb)deposit in Guangdong Province is well-known for its huge reserves of over 10 Mt(million ton)Zn+Pb metals and high ore-grade with Zn+Pb exceeding 15%(Guangdong Fankou Deposit Investigation Group,1980;Zhu XY et al.,2017).After 60 years of exploration and exploitation,the deposit has accumulated millions of tons of *** interesting question is that what components are hosted in these tailings,and whether some key and critical metals such as gallium and germanium are extremely enriched and worth further comprehensive *** motivated us to conduct an integrated set of field investigation,sampling,major-trace element analyses and reserve assessments about the Fankou *** this contribution,we discover that the tailings contain a variety of metal elements such as zinc,lead and gallium with comprehensive utilization *** data can act as a scientific guidance for further exploration and utilization of the Fankou tailings,and aid to enhance the utilization efficiency of the key mineral resource in *** study also provide demonstration for future green mine construction in China.

关键词： deposit comprehensive Guangdong

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考虑中频变压器非理想几何结构的通用漏感解析模型

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电力自动化设备 2024年第2期44卷 211-217页

作者：郭轩郑泽东李驰清华大学电力系统及大型发电设备安全控制与仿真国家重点实验室北京100084

中频变压器非理想几何结构引起的畸变磁场对漏感解析计算精度有较大影响,进而影响变压器设计及变换器运行特性和效率特性。首先针对副边绕组为非理想几何结构的漏感解析计算问题,基于叠加定理和洛氏高度等效方法,将传统只考虑纵向漏磁... 详细信息

中频变压器非理想几何结构引起的畸变磁场对漏感解析计算精度有较大影响,进而影响变压器设计及变换器运行特性和效率特性。首先针对副边绕组为非理想几何结构的漏感解析计算问题,基于叠加定理和洛氏高度等效方法,将传统只考虑纵向漏磁场的一维模型,改进为综合考虑纵向和横向漏磁场的二维模型,显著提升计算精度,并依据此模型提出一种通用漏感优化方法。进一步,针对原副边均为非理想几何结构情况,引入洛氏叠加区域,将原副边非正交且耦合的横向漏磁场能量考虑在内,提出一种计及中频变压器非理想几何因素的通用解析模型,计算误差在7.5%以下。仿真和实验验证了模型的准确性和通用性。

关键词：中频变压器非理想几何结构漏感解析模型

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论习近平对马克思世界历史理论的创新性发展

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河南师范大学学报（哲学社会科学版） 2024年第4期51卷 1-8页

作者：李妍郭璇中国矿业大学(北京)马克思主义学院北京100083

习近平对马克思世界历史理论的创新性发展,是在马克思主义世界历史理论宝库中汲取营养,赓续中华优秀传统文化,并传承中国共产党历届领导人百年来对世界历史理论拓展的基础上,对当今世界之变、历史之变、时代之变和中国之变深刻思考的结... 详细信息

习近平对马克思世界历史理论的创新性发展,是在马克思主义世界历史理论宝库中汲取营养,赓续中华优秀传统文化,并传承中国共产党历届领导人百年来对世界历史理论拓展的基础上,对当今世界之变、历史之变、时代之变和中国之变深刻思考的结果,是理论、历史与实践逻辑的统一,是马克思主义世界历史理论的中国化和时代化。习近平对马克思世界历史理论创新性发展主要表现在“构建人类命运共同体是世界各国人民前途所在”“推动建设相互尊重、公平正义、合作共赢的新型国际关系”“中国式现代化,是一种全新的人类文明形态”等一系列重要论述上。深入领会和把握习近平对马克思世界历史理论的创新性发展,对当今中国增强“四个自信”、挖掘和发挥东方大国在“两个变局”中的发展优势,坚持应变而动、正确应对全球化进程中的逆全球化浪潮,胸怀全球视野、提高中国特色社会主义的世界历史站位,具有重要的时代价值。

关键词：习近平世界历史内在逻辑时代价值

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综合考虑材料热各向异性与多种传热方式的磁性元件热阻网络精准模型

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电工技术学报 2024年第6期39卷 1806-1817页

作者：郭轩肖云昊李驰郑泽东电力系统及大型发电设备安全控制与仿真国家重点实验室(清华大学) 北京100084

磁性元件正在向高频化、小型化、高功率密度的方向发展,随着功率密度的提高,散热已成为影响器件可靠运行的关键因素,因此对磁性元件的热分析提出更高的要求。传统的热分析模型存在运算时间长、传热方式单一等问题,该文引入已有研究中提... 详细信息

磁性元件正在向高频化、小型化、高功率密度的方向发展,随着功率密度的提高,散热已成为影响器件可靠运行的关键因素,因此对磁性元件的热分析提出更高的要求。传统的热分析模型存在运算时间长、传热方式单一等问题,该文引入已有研究中提出的三轴九热阻网络模型,在此基础上添加热对流与热辐射两种传热方式,综合考虑材料热各向异性与热传导、热对流、热辐射。并通过精细划分元件温度计算子区域、实际器件损耗场分析、热电耦合迭代提高模型的计算精度,提出一种更加完善的三轴十五热阻网络模型,基于该模型对实际磁性器件建模,验证了该模型的准确性,并于最后提出一种通用的针对EE、EI、UU等典型磁心构成的磁性元件的热阻网络建模方法。

关键词：磁性元件材料热各向异性多种传热方式实际损耗分布集总参数热阻网络

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基于异步合作更新的LSTM-MADDPG多智能体协同决策算法

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吉林大学学报（工学版） 2024年第3期54卷 797-806页

作者：高敬鹏王国轩高路哈尔滨工程大学信息与通信工程学院哈尔滨150001 北京航天长征飞行器研究所试验物理与计算数学国家级重点实验室北京100076

针对完全合作型任务中,多智能体深度确定性策略梯度(MADDPG)算法存在信度分配以及训练稳定性差的问题,提出了一种基于异步合作更新的LSTM-MADDPG多智能体协同决策算法。基于差异奖励和值分解思想,利用长短时记忆(LSTM)网络提取轨迹序列... 详细信息

针对完全合作型任务中,多智能体深度确定性策略梯度(MADDPG)算法存在信度分配以及训练稳定性差的问题,提出了一种基于异步合作更新的LSTM-MADDPG多智能体协同决策算法。基于差异奖励和值分解思想,利用长短时记忆(LSTM)网络提取轨迹序列间特征,优化全局奖励划分方法,实现各智能体的动作奖励分配;结合算法联合训练需求,构建高质量训练样本集,设计异步合作更新方法,实现LSTM-MADDPG网络的联合稳定训练。仿真结果表明,在协作捕获场景中,本文算法相较于QMIX的训练收敛速度提升了20.51%;所提异步合作更新方法相较于同步更新,归一化奖励值均方误差减小了57.59%,提高了算法收敛的稳定性。

关键词：人工智能多智能体协同决策深度强化学习信度分配异步合作更新

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