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Effect of perioperative chemotherapy on resection of isolated pulmonary metastases from colorectal cancer:A single center experience

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World Journal of Gastrointestinal Oncology 2024年第8期16卷 3457-3470页

作者： Zhao Gao xuan Jin ying-Chao Wu Shi-Jie Zhang Shi-Kai Wu Xin Wang Department of Medical Oncology Peking University First HospitalBeijing 10000China Department of General Surgery Peking University First HospitalBeijing 10000China Department of Thoracic Surgery Peking University First HospitalBeijing 10000China

BACKGROUND Numerous studies have assessed surgical resection as a standard treatment option for patients with colorectal cancer(CRC)and resectable pulmonary metastases(PM).However,the role of perioperative chemotherapy after complete resection of isolated PM from patients with CRC patients remains *** hypothesize that perioperative chemotherapy does not provide significant survival benefits for patients undergoing resection of PM from *** To determine whether perioperative chemotherapy affects survival after radical resection of isolated PM from *** We retrospectively collected demographic,clinical,and pathologic data on patients who underwent radical surgery for isolated PM from *** survival(CSS)and disease-free survival were calculated using Kaplan-Meier ***-group differences were compared using the log-rank *** multivariate analysis,Cox regression was utilized when *** This study included 120 patients with a median age of 61.6 *** 5-year CSS rate was 78.2%,with 36.7% experiencing *** resection for isolated PM resulted in a 5-year CSS rate of 50.0% for second *** chemotherapy(P=0.079)did not enhance survival *** associated with improved survival included fewer metastatic lesions[hazard ratio(HR):2.51,P=0.045],longer disease-free intervals(HR:0.35,P=0.016),and wedge lung resections(HR:0.42,P=0.035).Multiple PM predicted higher recurrence risk(HR:2.22,P=0.022).The log-rank test showed no significant difference in CSS between single and repeated metastasectomy(P=0.92).CONCLUSION Perioperative chemotherapy shows no survival benefit post-PM resection in ***-free intervals and fewer metastatic lesions predict better *** metastasectomy is warranted for eligible patients.

关键词： Pulmonary metastasis Colorectal cancer Perioperative chemotherapy Survival Repeated pulmonary metastasectomy

Guiding function of positron emission tomographycomputed tomography examination in the diagnosis and treatment of ocular adnexal mucosa associated lymphoid tissue lymphoma

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International Journal of Ophthalmology(English edition) 2024年第4期17卷 693-699页

作者： xuan Zhang Qi-Han Guo Rui Liu Jing Li ying-Chao Li Jian-Min Ma Beijing Ophthalmology and Visual Sciences Key Laboratory Beijing Tongren Eye CenterBeijing Tongren HospitalCapital Medical UniversityBeijing 100005China Tai’an City Central Hospital Qingdao UniversityTai’an 271000Shandong ProvinceChina

AIM:To explore the role of positron emission tomographycomputed tomography(PET-CT)examination in the diagnosis and treatment of ocular adnexal mucosa associated lymphoid tissue lymphoma(OAML).METHODS:The general clinical data,postoperative PET-CT results,treatment regimens,and the prognosis of 21 histopathologically confirmed OAML patients between October 2017 and September 2021 were *** the 21 patients,five patients underwent surgical treatment alone,13 patients underwent surgical treatment combined with radiotherapy,and three patients underwent surgical treatment combined with ***:The follow-up period ranged from 8 to 79mo,with four cases of recurrence and no *** PETCT examination,two patients exhibited both local ocular metabolic elevation and systemic metastasis,and one of these patients had cervical lymph node metastasis,while the other had submandibular and parotid gland *** patients showed only local ocular metabolic elevation,while 10 patients had no abnormal metabolic activity ***:PET-CT examination plays a crucial role in detecting residual lesions and recurrence following tumor resection,aiding in precise disease staging,and facilitating the development of personalized treatment plans,ultimately improving patient prognosis.

关键词： ocular adnexal mucosa associated lymphoid tissue lymphoma positron emission tomographycomputed tomography ocular tumors

Quantum Confinement in GaAs Microcrystallites Embedded in SiO_(2) Thin Film

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Chinese Physics Letters 1996年第10期13卷 797-800页

作者： SHI Wang-zhou LIN Kui-xun LIN xuan-ying QI Zhen-zhong Institute of Material Science Shantou UniversityShantou 515063 Centre of Information Storage Shanghai Jiaotong UniversityShanghai 200030

Semiconductor GaAs microcrystallites were embedded in SiO_(2) thin films by magnetron rf cosputtering *** of the thin films were characterized by transmission electron microscopy,x-ray diffraction and x-ray photoelectron *** size of microcrystallites,depending on the substrate temperature during deposition,is *** spectra of the films were *** shift of absorption edge was observed and discussed according to quantum confinement effect.

关键词： technique. Quantum Embedded

Antimony oxides-protected ultrathin Ir-Sb nanowires as bifunctional hydrogen electrocatalysts

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Nano Research 2024年第3期17卷 1042-1049页

作者： Bingyan Xu xuan Huang Shangheng Liu Zhiwei Hu Cheng-Wei Kao Ting-Shan Chan Hongbo Geng ying Zhang Xiaoqing Huang Country State Key Laboratory of Physical Chemistry of Solid Surfaces College of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China Max Planck Institute for Chemical Physics of Solids Dresden 01187Germany “National Synchrotron Radiation Research Center” Hsinchu 30076TaiwanChina School of Materials Engineering Changshu Institute of TechnologyChangshu 215500China Institute for Carbon Neutralization College of Chemistry and Materials EngineeringWenzhou UniversityWenzhou 325035China

Developing electrocatalysts with fast kinetics and long-term stability for alkaline hydrogen oxidation reaction(HOR)and hydrogen evolution reaction(HER)is of considerable importance for the industrial production of green and sustainable ***,an ultrathin Ir-Sb nanowires(Ir-Sb NWs)protected by antimony oxides(SbO_(x))was synthesized as an efficient bifunctional catalyst for both HOR and HER under alkaline *** from the much higher mass activities of Ir-Sb nanowires than those of Ir nanowires(Ir NWs)and commercial Pt/C,the SbO_(x) protective layer also contributes to the maintenance of morphology and anti-CO poisoning ability,leading to the long-term cycling performance in the presence of ***,the Ir-Sb NW/SbO_(x) exhibits the highest catalytic activities,which are about 3.5 and 4.8 times to those of Ir NW/C and commercial Pt/C toward HOR,*** work provides that the ultrathin morphology and H_(2)O-occupied Sb sites can exert the intrinsic high activity of Ir and effectively optimize the absorption of OH*both in alkaline HER/HOR electrolysis.

关键词： Ir nanowire amorphous antimony oxides bifunctional mechanism hydrogen evolution reaction hydrogen oxidation reaction

Gingipain from Porphyromonas gingivalis causes insulin resistance by degrading insulin receptors through direct proteolytic effects

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International Journal of Oral Science 2024年第3期16卷 539-552页

作者： Fen Liu Bofeng Zhu ying An Zhifei Zhou Peiying Xiong xuan Li Yang Mi Tongqiang He Faming Chen Buling Wu Shenzhen Stomatology Hospital(Pingshan) Southern Medical UniversityShenzhenChina Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research Laboratory Center of StomatologyDepartment of Paediatric DentistryCollege of StomatologyXi’an Jiaotong UniversityXi’anChina State Key Laboratory of Oral&Maxillofacial Reconstruction and Regeneration National Clinical Research Center for Oral DiseasesShaanxi International Joint Research Center for Oral DiseasesDepartment of PeriodontologySchool of StomatologyThe Fourth Military Medical UniversityXi’anChina Guangzhou Key Laboratory of Forensic Multi-Omics for Precision Identification School of Forensic MedicineSouthern Medical UniversityGuangzhouChina Microbiome Medicine Center Department of Laboratory MedicineZhujiang HospitalSouthern Medical UniversityGuangzhouChina Department of Stomatology General Hospital of Tibetan Military CommandLhasaChina Department of Stomatology Center Shenzhen HospitalSouthern Medical UniversityShenzhenChina Department of Obstetrics Northwest Women’s and Children’s HospitalXi’anChina

Periodontitis is a critical risk factor for the occurrence and development of *** gingivalis may participate in insulin resistance(IR)caused by periodontal inflammation,but the functional role and specific mechanisms of *** in IR remain *** the present study,clinical samples were analysed to determine the statistical correlation between *** and IR *** culturing of hepatocytes,myocytes,and adipocytes,and feeding mice *** orally,the functional correlation between *** and IR occurrence was further studied both in vitro and in *** data suggested that the amount of *** isolated was correlated with the Homeostatic Model Assessment for IR *** vitro studies suggested that coculture with *** decreased glucose uptake and insulin receptor(INSR)protein expression in hepatocytes,myocytes,and *** fed *** tended to undergo *** was detectable in the liver,skeletal muscle,and adipose tissue of experimental *** distribution sites of gingipain coincided with the downregulation of *** proteolysed the functional insulin-binding region of *** with *** significantly decreased the INSR–insulin binding *** out gingipain from *** alleviated the negative effects of *** on IR in *** together,these findings indicate that distantly migrated *** may directly proteolytically degrade INSR through gingipain,thereby leading to *** results provide a new strategy for preventing diabetes by targeting periodontal pathogens and provide new ideas for exploring novel mechanisms by which periodontal inflammation affects the systemic metabolic state.

关键词： gingivalis inflammation resistance

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酮连氮法制肼高盐废水离子膜电解前处理工艺

广州化工 2024年第5期52卷 140-143页

作者：樊燕钰赵有政陈秋霞刘自成赵选英杨峰何习宝安徽南新环保科技有限公司安徽安庆246000 江苏省盐城环境监测中心江苏盐城224002 安庆高新技术产业开发区管理委员会安徽安庆246000 江苏南大华兴环保科技股份公司江苏盐城224051 南京大学盐城环保技术与工程研究院江苏盐城224051

采用“两级活性炭吸附-电催化氧化-光催化氧化”工艺处理酮连氮法制水合肼高盐废水,考察了活性炭吸附对后续氧化处理的影响。实验结果表明:两级活性炭吸附通过预去除废水中部分难氧化污染物而大幅缩短后续氧化处理时间,吸附出水依次经... 详细信息

采用“两级活性炭吸附-电催化氧化-光催化氧化”工艺处理酮连氮法制水合肼高盐废水,考察了活性炭吸附对后续氧化处理的影响。实验结果表明:两级活性炭吸附通过预去除废水中部分难氧化污染物而大幅缩短后续氧化处理时间,吸附出水依次经电催化氧化和光催化氧化可分别实现深度脱氮和除碳。在各级吸附出水总体积为80 BV、电催化氧化电流密度为50 mA/cm^(2)和反应时间为30 min、光催化氧化反应时间为60 min的条件下,废水TOC和TN去除率分别为99.2%和97.3%。最终处理出水中TOC<10 mg/L,TN<4 mg/L,达到离子膜电解入槽盐水水质要求。

关键词：高盐废水水合肼离子膜电解活性炭光催化氧化

The rs2227481 C>T Polymorphism in the IL22 Gene Promoter Significantly Reduces the Risk of Liver,Lung,and Gastric Cancer in a Han Chinese Population

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Biomedical and Environmental Sciences 2021年第7期34卷 572-576页

作者： CHAI Long Long XIAO ying xuan MENG Ling Han WANG Huan FENG Xian Hong GU Xiu Li LI Qi Chang XIONG Qian Tao CHEN Bi Feng Department of Biological Science and Technology School of ChemistryChemical Engineering and Life SciencesWuhan University of TechnologyWuhan 430070HubeiChina Department of Biotechnology Institute of WUT-AMUWuhan University of TechnologyWuhan 430070HubeiChina Clinical Laboratory Wuhan Xinzhou District People's HospitalWuhan 430400HubeiChina Center of Reproductive Medicine Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430074HubeiChina Department of Reproductive Genetics Wuhan Tongji Reproductive Medicine HospitalWuhan 430010HubeiChina Department of Laboratory Maternal and Child Health Hospital of Hubei ProvinceWuhan 430070HubeiChina

Cancer is a serious threat to public health and the economy *** data from the World Health Organization(WHO)in 2018 have demonstrated that lung cancer is the most commonly diagnosed cancer(11.6%of the total cases)and the leading cause of cancer death(18.4%of the total cancer deaths),closely followed bygastric cancer(5.7%and 8.2%),and liver cancer(4.7%and 8.2%).

关键词： IL22 Cancer Gastric

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Ta-10W合金材料切削加工技术研究

机械工程与自动化 2024年第4期 126-128页

作者：史团乐刘前峰寇景玲马映璇王宪龙姚凌波河南航天精工制造有限公司河南信阳464000 中国科学院上海硅酸盐研究所上海200000

Ta-10W合金由于其优异的耐高温、抗腐蚀等性能被广泛应用于航空航天、化工等领域,但其性能特殊,具有导热性差、易加工硬化等特点,切削加工性能较差。针对钽钨合金的性能分析了影响其切削加工性的主要因素,并通过选择合适的切削刀具和工... 详细信息

Ta-10W合金由于其优异的耐高温、抗腐蚀等性能被广泛应用于航空航天、化工等领域,但其性能特殊,具有导热性差、易加工硬化等特点,切削加工性能较差。针对钽钨合金的性能分析了影响其切削加工性的主要因素,并通过选择合适的切削刀具和工艺参数设置,有效改善了钽钨合金的切削加工性。

关键词： Ta-10W合金切削加工刀具耐用度

Shuxuening Injection Inhibits Apoptosis and Reduces Myocardial Ischemia-Reperfusion Injury in Rats through PI3K/AKT Pathway

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Chinese Journal of Integrative Medicine 2024年第5期30卷 421-432页

作者： YUE Tong-tong CAO ying-jie CAO Ya-xuan LI Wei-xia WANG Xiao-yan SI Chun-ying XIA Han ZHU Ming-jun TANG Jin-fa WANG He The First Clinical Medical College of Henan University of Chinese Medicine Zhengzhou 450046China Department of Pharmacy the First Affiliated Hospital of Henan University of Chinese MedicineZhengzhou 451200China Department of Cardiovascular Diseases the First Affiliated Hospital of Henan University of Chinese MedicineZhengzhou 451200China

Objective: To investigate the main components and potential mechanism of Shuxuening Injection(SXNI) in the treatment of myocardial ischemia-reperfusion injury(MIRI) through network pharmacology and in vivo research. Methods: The Traditional Chinese Medicine Systems Pharmacology(TCMSP) and Pharm Mapper databases were used to extract and evaluate the effective components of Ginkgo biloba leaves, the main component of SXNI. The Online Mendelian Inheritance in Man(OMIM) and Gene Cards databases were searched for disease targets and obtain the drug target and disease target intersections. The active ingredient-target network was built using Cytoscape 3.9.1 software. The STRING database, Metascape online platform, and R language were used to obtain the key targets and signaling pathways of the anti-MIRI effects of SXNI. In order to verify the therapeutic effect of different concentrations of SXNI on MIRI in rats, 60 rats were first divided into 5 groups according to random number table method: the sham operation group, the model group, SXNI low-dose(3.68 mg/kg), medium-dose(7.35 mg/kg), and high-dose(14.7 mg/kg) groups, with 12 rats in each group. Then, another 60 rats were randomly divided into 5 groups: the sham operation group, the model group, SXNI group(14.7 mg/kg), SXNI+LY294002 group,and LY294002 group, with 12 rats in each group. The drug was then administered intraperitoneally at body weight for 14 days. The main biological processes were validated using in vivo testing. Evans blue/triphenyltetrazolium chloride(TTC) double staining, hematoxylin-eosin(HE) staining, terminal deoxynucleotidyl transferase d UTP nick end labeling(TUNEL) assay, enzyme-linked immunosorbent assay(ELISA), and Western blot analysis were used to investigate the efficacy and mechanism of SXNI in MIRI rats. Results: Eleven core targets and 30 Kyoto Encyclopedia of Genes and Genomes(KEGG) pathways were selected. Among these, the phosphoinositide 3-kinase(PI3K)/protein kinase B(AKT) pathway was

关键词： myocardial ischemia reperfusion injury PI3K/AKT signaling pathway Shuxuening Injection apoptosis Ginkgo biloba leaves