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Preoperative prediction of perineural invasion of rectal cancer based on a magnetic resonance imaging radiomics model:A dual-center study

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World Journal of Gastroenterology 2024年第16期30卷 2233-2248页

作者： Yan Liu Bai-Jin-Tao Sun Chuan Zhang Bing Li xiao-xuan Yu Yong Du Department of Radiology The Affiliated Hospital of North Sichuan Medical CollegeNanchong 637000Sichuan ProvinceChina Department of Radiology The Affiliated Hospital of North Sichuan Medical CollegeNanchong 637000Sichuan ProvinceChina.duyong@***

BACKGROUND Perineural invasion(PNI)has been used as an important pathological indicator and independent prognostic factor for patients with rectal cancer(RC).Preoperative prediction of PNI status is helpful for individualized treatment of ***,several radiomics studies have been used to predict the PNI status in RC,demonstrating a good predictive effect,but the results lacked *** preoperative prediction of PNI status is still challenging and needs further *** To establish and validate an optimal radiomics model for predicting PNI status preoperatively in RC *** This retrospective study enrolled 244 postoperative patients with pathologically confirmed RC from two independent *** patients underwent preoperative high-resolution magnetic resonance imaging(MRI)between May 2019 and August *** radiomics features were extracted and selected from oblique axial T2-weighted imaging(T2WI)and contrast-enhanced T1WI(T1CE)*** radiomics signatures were constructed using logistic regression analysis and the predictive potential of various sequences was compared(T2WI,T1CE and T2WI+T1CE fusion sequences).A clinical-radiomics(CR)model was established by combining the radiomics features and clinical risk *** internal and external validation groups were used to validate the proposed *** area under the receiver operating characteristic curve(AUC),DeLong test,net reclassification improvement(NRI),integrated discrimination improvement(IDI),calibration curve,and decision curve analysis(DCA)were used to evaluate the model *** Among the radiomics models,the T2WI+T1CE fusion sequences model showed the best predictive performance,in the training and internal validation groups,the AUCs of the fusion sequence model were 0.839[95%confidence interval(CI):0.757-0.921]and 0.787(95%CI:0.650-0.923),which were higher than those of the T2WI and T1CE sequence *** CR model constructed by combinin

关键词： Rectal cancer Perineural invasion Magnetic resonance imaging Radiomics Nomogram

Ablation behaviour and mechanical performance of ZrB_(2)-ZrC-SiC modified carbon/carbon composites prepared by vacuum infiltration combined with reactive melt infiltration

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新型炭材料（中英文） 2024年第4期39卷 633-644页

作者： ZHANG Jia-ping SU xiao-xuan LI Xin-gang WANG Run-ning FU Qian-gang Shaanxi Key Laboratory of Fiber Reinforced Light Composite Materials Northwestern Polytechnical UniversityXi’an 710072China

The development of advanced aircraft relies on high performance thermal-structural materials,and carbon/carbon com-posites(C/C)composited with ultrahigh-temperature ceramics are ideal ***,the traditional routes of compositing are either inefficient and expensive or lead to a non-uniform distribution of ceramics in the *** with the traditional C/C-ZrC-SiC composites prepared by the reactive melt infiltration of ZrSi_(2),C/C-ZrB_(2)-ZrC-SiC composites prepared by the vacuum infiltration of ZrB_(2) combined with reactive melt infiltration have the higher content and more uniform distribution of the introduced ceramic *** mass and linear ablation rates of the C/C-ZrB_(2)-ZrC-SiC composites were respectively 68.9%and 29.7%lower than those of C/C-ZrC-SiC composites prepared by reactive melt *** ablation performance was improved because the volatilization of B_(2)O_(3),removes some of the heat,and the more uniformly distributed ZrO_(2),that helps produce a ZrO2-SiO2 continu-ous protective layer,hinders oxygen infiltration and decreases ablation.

关键词： C/C composites ZrB_(2)-ZrC-SiC Vacuum filtration Reactive melt infiltration Ablation.

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明清戏曲疑难字词例释

语言研究 2024年第1期44卷 104-108页

作者：吴小萱浙江财经大学人文与传媒学院浙江杭州310018

明清戏曲中有很多疑难字词未得其解,它们多与俗写讹变有关。文章以俗字学理论为指导,在比勘异文的基础上,结合戏曲的自身特点,对■“■”“发详”“穵灭/挖灭/挖密”“一身太守”等的词义作了细致深入的考辨。

关键词：明清戏曲疑难字词考释

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沉浸与编织:对歌套路与跨日对歌的持续

南京艺术学院学报（音乐与表演版） 2024年第3期 13-18,I0002页

作者：肖璇中国音乐学院北京100101

在民间跨日对歌套路丰富的地方知识和文化表征下,中国两性对歌的思维导图、行为规范、音素资源和礼唱过程等集体歌唱要素值得关注。作为“时间空间化”的歌唱诗性智慧,除了不同时段“歌路”和歌书、叙事歌、歌牌、典故组成的歌套交织的... 详细信息

在民间跨日对歌套路丰富的地方知识和文化表征下,中国两性对歌的思维导图、行为规范、音素资源和礼唱过程等集体歌唱要素值得关注。作为“时间空间化”的歌唱诗性智慧,除了不同时段“歌路”和歌书、叙事歌、歌牌、典故组成的歌套交织的纵横经纬线,对歌时间跨度还与“以和为继”“群己平衡”的循循之礼有关。而对歌套路具有唱腔模式化意义不仅促发视、听、唱、思多感官加入,也是民间即兴两性对歌“声声不息”的传统人声资源。

关键词：两性对歌跨日对歌对歌套路歌唱礼俗

Diagnosis and management of benign recurrent intrahepatic cholestasis and psychosocial stressors in an adolescent:A case report

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World Journal of Clinical Cases 2024年第20期12卷 4427-4433页

作者： Ya-Xin Xu xiao-xuan Niu Bei-Li Xu Yuan Ji Qun-Yan Yao Department of General Practice Zhongshan HospitalFudan UniversityShanghai 200032China Department of Nutrition Zhongshan HospitalFudan UniversityShanghai 200032China Department of Gastroenterology and Hepatology Zhongshan HospitalFudan UniversityShanghai 200032China Department of Pathology Zhongshan HospitalFudan UniversityShanghai 200032China

BACKGROUND Benign recurrent intrahepatic cholestasis(BRIC)is a rare autosomal recessive disorder,characterized by episodes of intense pruritus,elevated serum levels of alkaline phosphatase and bilirubin,and near-normal-glutamyl *** episodes may persist for weeks to months before spontaneously resolving,with patients typically remaining asymptomatic between *** entails the evaluation of clinical symptoms and targeted genetic *** BRIC is recognized as a benign genetic disorder,the triggers,particularly psychosocial factors,remain poorly *** SUMMARY An 18-year-old Chinese man presented with recurrent jaundice and pruritus after a cold,which was exacerbated by self-medication involving vitamin B and *** and laboratory evaluations revealed elevated levels of bilirubin and liver enzymes,in the absence of viral or autoimmune liver *** excluded biliary and pancreatic abnormalities,and liver biopsy demonstrated centrilobular cholestasis,culminating in a BRIC diagnosis confirmed by the identification of a novel ATP8B1 gene *** assessment of the patient unveiled stress attributable to academic and familial pressures,regarded as potential triggers for *** relief was observed with ursodeoxycholic acid and cetirizine,followed by an adjustment of the treatment regimen in response to elevated liver *** patient's condition significantly improved following a stress-related episode,thanks to a comprehensive management approach that included psychosocial support and medical *** Our research highlights genetic and psychosocial influences on BRIC,emphasizing integrated diagnostic and management strategies.

关键词： Benign recurrent intrahepatic cholestasis Genetic testing Psychosocial factors ATP8B1 gene mutation Cholestasis Jaundice Pruritus Case report

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试析英国学位学徒制的兴起与发展

成人教育 2024年第5期44卷 88-93页

作者：丁晓轩王辉河北师范大学石家庄050024 河北省职业技术教育研究所石家庄050031

围绕英国学位学徒制概念界定、发展历程、勃兴之源等方面进行研究,试图厘清英国高等职业教育新兴人才培养模式——学位学徒制在不同时期的发展脉络,同时从内、外两个维度,分析学位学徒制的兴起原因,着力探究学位学徒制人才培育模式特色... 详细信息

围绕英国学位学徒制概念界定、发展历程、勃兴之源等方面进行研究,试图厘清英国高等职业教育新兴人才培养模式——学位学徒制在不同时期的发展脉络,同时从内、外两个维度,分析学位学徒制的兴起原因,着力探究学位学徒制人才培育模式特色及优势。研究英国学位学徒制,有利于将其运用于我国现代学徒制的发展进程之中,从而更好地推进职业本科教育进程,为中国特色职业教育体系添砖加瓦,以促进职业教育高质量发展。

关键词：英国学位学徒制现代学徒制高等职业教育职业本科教育人才培养

Network pharmacology investigation of the mechanism underlying the therapeutic action of Shikang granules in retinal ischemia-reperfusion injuries

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Integrative Medicine Discovery 2024年第17期8卷 1-8页

作者： xiao-xuan Wang Cong-Ying Wang Chi Zhang Fang-Yuan Zheng Long-Hui Han Ming-Lian Zhang Hebei Eye Hospital Hebei Provincial Key Laboratory of OphthalmologyHebei Provincial Clinical Research Center for Eye DiseasesXingtai 054000China

Background:Retinal ischemia/reperfusion(I/R)injury often results in vision loss,and effective clinical management options are currently *** granules(SKG)are traditional Chinese medicine-based preparations commonly used in clinical practice for treating optic ***:Despite decades of clinical use,the precise mechanism of action(MoA)of SKG remains ***,we employ a network pharmacological approach to elucidate its MoA by identifying active ingredients and relevant targets using the Traditional Chinese Medicine System Pharmacology Database and Analytical *** associated with retinal I/R injury were sourced from GeneCards,Online Mendelian Inheritance in Man,and *** software facilitated the identification of intersecting targets,which were then subjected to gene ontology functional analysis and Kyoto Encyclopedia of Genes and Genomes pathway *** validate the protective effect and explore the MoA of SKG in retinal I/R injuries,we conducted experiments using rat ***:Our animal experiments demonstrated that SKG mitigated apoptosis following retinal I/R injury by upregulating the expression of the anti-apoptotic protein Bcl-2 and downregulating the expression of BAX,Caspase-9,Caspase-3,PARP,and cytochrome ***,SKG was found to increase the expression of PI3K and ***:SKG may exert its protective effects by inhibiting apoptosis through modulation of pro-apoptotic and anti-apoptotic protein expression,as well as activation of the PI3K/AKT pathway.

关键词： retinal ischemia-reperfusion injury Shikang granules apoptosis PI3K/AKT pathway

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“印太战略”视域下美国太平洋岛国政策论析

亚太经济 2024年第1期 108-119页

作者：丑则静郭晓萱国际关系学院国际政治系北京100091 南开大学周恩来政府管理学院天津300350

美国“印太战略”出台与全面强化后,太平洋岛国的战略价值被不断抬升。美国从安全、经济与意识形态多领域系统加强了对太平洋岛国的争夺,其政策体系趋于完善。在大国竞争回归背景下,中国在太平洋岛国地区的存在与影响力上升引发了美国... 详细信息

美国“印太战略”出台与全面强化后,太平洋岛国的战略价值被不断抬升。美国从安全、经济与意识形态多领域系统加强了对太平洋岛国的争夺,其政策体系趋于完善。在大国竞争回归背景下,中国在太平洋岛国地区的存在与影响力上升引发了美国等西方发达国家的战略焦虑,美国正将太平洋岛国视作“印太战略”与对华战略竞争的重点推进地区。然而,在“竞赢”中国、霸权护持战略目标支配下的美国太平洋岛国政策,表现出对地区和平稳定、发展繁荣及应对气候变化等核心关切的漠视,在导致太平洋岛国地区阵营化、大国竞争化与意识形态化风险上升的同时,其政策限度不断显现。

关键词： “印太战略” 美国太平洋岛国政策政策限度

政府赋能、企业国际合作与出海企业高质量发展

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经济问题 2024年第8期 103-110页

作者：时晓萱赵雨菡浙江大学历史学院浙江杭州310058 浙江财经大学管理学院浙江杭州310018

高水平对外开放不仅是中国经济持续快速发展的重要动力,同时也是推进企业高质量发展的不竭源泉。然而,当前国际政治、经济格局存在高度不确定性,出海企业在国际化过程中面临重重阻碍。对此,政府、企业应通力合作,共同推进企业高质量发... 详细信息

高水平对外开放不仅是中国经济持续快速发展的重要动力,同时也是推进企业高质量发展的不竭源泉。然而,当前国际政治、经济格局存在高度不确定性,出海企业在国际化过程中面临重重阻碍。对此,政府、企业应通力合作,共同推进企业高质量发展。政府应从制度、市场、技术三个维度入手,通过结构赋能、心理赋能、要素赋能助力出海企业实现高质量发展,实现与世界经济的互联互通,构建人类命运共同体。而企业应在此基础上,重视并充分利用好国际合作网络,强化政府的赋能作用。

关键词：政府赋能出海企业高质量发展