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Anti-inflammatory effects of Solanum procumbens on a low dose complete Freund's adjuvant-induced arthritis rat model

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Asian Pacific Journal of Tropical Biomedicine 2023年第5期13卷 214-221页

作者： xuan-hai Do Trong Nghia nguyen Thanh Chung Dang Thi Thanh Mai nguyen Trung Nhan nguyen Van Nhat Truong Do Huu Tho Le xuan hai nguyen Hoang Phu Dang Giang-Linh nguyen Dinh-Khanh Hoang Van-Quan Le Van-Mao Can Department of Practical and Experimental Surgery Vietnam Military Medical UniversityHanoi 10000Vietnam Department of Reconstructive and Microsurgery Craniofacial and Reconstructive Surgery CentreMilitary Central Hospital 108Hanoi 10000Vietnam Department of Anatomic Pathology Military Hospital 103Vietnam Military Medical UniversityHanoi 10000Vietnam Faculty of Chemistry University of ScienceVietnam National University Ho Chi Minh CityHo Chi Minh City 70000Vietnam Faculty of Medicine University of Medicine and PharmacyVietnam National UniversityHanoi 10000Vietnam Department of Ultrasound Imaging Diagnostics CentreMilitary Hospital 103Vietnam Military Medical UniversityHanoi 10000Vietnam Department of Functional Diagnostics Military Hospital 103Vietnam Military Medical UniversityHanoi 10000Vietnam Department of Pathophysiology Vietnam Military Medical UniversityHanoi 10000Vietnam

Objective:To investigate the anti-inflammatory and analgesic effects of Solanum procumbens on complete Freund’s adjuvantinduced arthritis rat ***:We isolated and identified five compounds in the ethanolsoluble Solanum procumbens extract(SP)with anti-inflammatory effects,including ursolic acid,β-sitosterol,hexadecanoic acid,cisvaccenic acid,and vanillic ***,we investigated the anti-inflammatory effects of SP on rheumatoid arthritis symptoms,including paw volumes,local temperatures,withdrawal latency,and mechanical withdrawal threshold at the hind paw and white blood cell(WBC)number from complete Freund’s adjuvant-induced arthritis rat ***:We have successfully established a complete Freund’s adjuvant-induced arthritis rat model at a low dose(1 mg/mL).SP extract significantly reduced paw volumes(P<0.05),prolonged withdrawal latencies(P<0.05),decreased local temperature,and increased the mechanical withdrawal threshold(P<0.05),but only SP extract at the dose of 300 mg/kg significantly decreased WBC ***:SP extract could be a potential medication candidate with anti-inflammatory effects for arthritis,but it requires further investigation into the mechanism of the SP and its effectiveness on other models as well as clinical trials.

关键词： Solanum procumbens Arthritis Anti-inflammation Complete Freund's adjuvant Rats

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From Imperfection to Perfection: Advanced 3D Facial Reconstruction Using MICA Models and Self-Supervision Learning

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Computer Modeling in Engineering & Sciences 2025年第2期142卷 1459-1479页

作者： Thinh D.Le Duong Q.nguyen Phuong D.nguyen H.nguyen-xuan CIRTECH Institute HUTECH UniversityHo Chi Minh City72308Viet Nam

Research on reconstructing imperfect faces is a challenging *** this study,we explore a data-driven approach using a pre-trained MICA(MetrIC fAce)model combined with 3D printing to address this *** propose a training strategy that utilizes the pre-trained MICA model and self-supervised learning techniques to improve accuracy and reduce the time needed for 3D facial structure *** results demonstrate high accuracy,evaluated by the geometric loss function and various statistical *** showcase the effectiveness of the approach,we used 3D printing to create a model that covers facial *** findings indicate that our method produces a model that fits well and achieves comprehensive 3D facial *** technique has the potential to aid doctors in treating patients with facial injuries.

关键词： 3D face reconstruction self-supervised learning face defect 3D printed prototypes

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Investigation on cost-effective composites for CO_(2) adsorption from post-gasification residue and metal organic framework

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Journal of Environmental Sciences 2025年第2期148卷 174-187页

作者： Hong Nam nguyen Thu Phuong nguyen Phuong Thu Le Quang Minh Tran Thi hai Do Trung Dung nguyen Phuong Lan Tran-nguyen Toshiki Tsubota Thi Mai Thanh Dinh University of Science and Technology of Hanoi Vietnam Academy of Science and Technology18 Hoang Quoc VietCau GiayHanoi 100000Vietnam Institute for Tropical Technology Vietnam Academy of Science and Technology18 Hoang Quoc VietCau GiayHanoi 100000Vietnam Faculty of Basic Science Hanoi University of Mining and Geology18 Pho VienDuc ThangNam Tu LiemHanoi 100000Vietnam Faculty of Physical and Chemical Engineering Le Quy Don Technical University236 Hoang Quoc VietBac Tu LiemHanoi 100000Vietnam Department of Mechanical Engineering Can Tho University3/2 streetCan Tho City 94000Vietnam Department of Engineering Graduate School of EngineeringKyushu Institute of Technology1-1 SensuichoTobata-kuKitakyushuFukuoka 804-8550Japan

Cost-effective CO_(2) adsorbents are gaining increasing attention as viable solutions for mitigating climate *** this study,composites were synthesized by electrochemically combining the post-gasification residue of Macadamia nut shell with copper benzene-1,3,5-tricarboxylate(CuBTC).Among the different composites synthesized,the ratio of 1:1 between biochar and CuBTC(B 1:1)demonstrated the highest CO_(2) adsorption *** controlled laboratory conditions(0°C,1 bar,without the influence of ambient moisture or CO_(2) diffusion limitations),B 1:1 achieved a CO_(2) adsorption capacity of 9.8 mmol/g,while under industrial-like conditions(25℃,1 bar,taking into account the impact of ambient moisture and CO_(2) diffusion limitations within a bed of adsorbent),it reached 6.2 mmol/*** values surpassed those reported for various advanced CO_(2) adsorbents investigated in previous *** superior performance of the B 1:1 composite can be attributed to the optimization of the number of active sites,porosity,and the preservation of the full physical and chemical surface properties of both ***,the composite exhibited a notable CO_(2)/N_(2) selectivity and improved stability under moisture *** favorable characteristics make B 1:1 a promising candidate for industrial applications.

关键词： Biochar-based composites CO_(2)adsorption CuBTC Metal organic framework Post-gasification residue

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Self-reporting hypoxia-responsive supramolecular phototheranostic nanomaterials based on AIEgen and azocalixarene

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Science China Chemistry 2025年

作者： Xiao-Wen Han Guo-Ling Zhang Pu Chen Jing Zhang Guo-Gang Shan Chun-xuan Qi Ben-Zhong Tang hai-Tao Feng AIE Research Center Shaanxi Key Laboratory of Phytochemistry College of Chemistry and Chemical Engineering Baoji University of Arts and Sciences National & Local United Engineering Laboratory for Power Batteries Department of Chemistry Northeast Normal University School of Science and Engineering Shenzhen Institute of Aggregate Science and Technology The Chinese University of Hong KongShenzhen (CUHK-Shenzhen)

Hypoxia is a significant feature in most of solid tumors. Hence, developing hypoxia-responsive phototheranostic system is still a challenge. In this contribution, a supramolecular assembly strategy based on sulfonate-functionalized azocalix[4]arene(SAC4A)and cationic aggregation-induced emission photosensitizer(namely TPA-H) was proposed for hypoxia-responsive bioimaging and photodynamic therapy(PDT). Upon supramolecular complexation of TPA-H and SAC4A through electrostatic interaction,the fluorescence and reactive oxygen species(ROS) generation of TPA-H were largely inhibited. In hypoxic tumors, the azo group of SAC4A can be reduced to aniline derivative and release the included TPA-H to recover its pristine fluorescence and ROS. Interestingly, the free TPA-H undergoes cell membrane-to-mitochondria translocation during cell imaging, achieving a real-time self-reporting PDT system. In vivo tumor imaging and therapy reveal that this as-prepared supramolecular complexes have good biosafety and efficient antitumor activity under hypoxia. Such hypoxia-responsive supramolecular photosensitizer system will enrich image-guided photodynamic therapy.

关键词： Hypoxia is a significant feature in most of solid tumors. Hence, developing hypoxia-responsive phototheranostic system is still a challenge. In this contribution, a supramolecular assembly strategy based on sulfonate-functionalized azocalixarene(SAC4A)and cationic aggregation-induced emission photosensitizer(namely TPA-H) was proposed for hypoxia-responsive bioimaging and photodynamic therapy(PDT). Upon supramolecular complexation of TPA-H and SAC4A through electrostatic interaction,the fluorescence and reactive oxygen species(ROS) generation of TPA-H were largely inhibited. In hypoxic tumors, the azo group of SAC4A can be reduced to aniline derivative and release the included TPA-H to recover its pristine fluorescence and ROS. Interestingly, the free TPA-H undergoes cell membrane-to-mitochondria translocation during cell imaging, achieving a real-time self-reporting PDT system. In vivo tumor imaging and therapy reveal that this as-prepared supramolecular complexes have good biosafety and efficient antitumor activity under hypoxia. Such hypoxia-responsive supramolecular photosensitizer system will enrich image-guided photodynamic therapy.

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A Review on Vision-Language-Based Approaches: Challenges and Applications

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Computers, Materials & Continua 2025年第2期82卷 1733-1756页

作者： Huu-Tuong Ho Luong Vuong nguyen Minh-Tien Pham Quang-Huy Pham Quang-Duong Tran Duong nguyen Minh Huy Tri-hai nguyen Department of Artificial Intelligence FPT UniversityDanang550000Vietnam Department of Business FPT UniversityDanang550000Vietnam Faculty of Information Technology School of TechnologyVan Lang UniversityHo Chi Minh City70000Vietnam

In multimodal learning, Vision-Language Models (VLMs) have become a critical research focus, enabling the integration of textual and visual data. These models have shown significant promise across various natural language processing tasks, such as visual question answering and computer vision applications, including image captioning and image-text retrieval, highlighting their adaptability for complex, multimodal datasets. In this work, we review the landscape of Bootstrapping Language-Image Pre-training (BLIP) and other VLM techniques. A comparative analysis is conducted to assess VLMs’ strengths, limitations, and applicability across tasks while examining challenges such as scalability, data quality, and fine-tuning complexities. The work concludes by outlining potential future directions in VLM research, focusing on enhancing model interpretability, addressing ethical implications, and advancing multimodal integration in real-world applications.

关键词： Bootstrapping language-image pre-training(BLIP) multimodal learning vision-language model(VLM) vision-language pre-training(VLP)

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Anti-programmed death-1 immunotherapy-promising treatment for metastatic colorectal cancer:A case report

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World Journal of Gastrointestinal Oncology 2025年第2期17卷 291-298页

作者： Tian-Hao Guo Sheng-Wei Hong Wen-Jian Zhu Yi-Fan Hui Wen-Li Qiu Yan Wu xuan Li Fei Ke Liu Li hai-Bo Cheng Institute of Health and Regimen Jiangsu Open UniversityNanjing 210036Jiangsu ProvinceChina The First Clinical Medical College Nanjing University of Chinese MedicineNanjing 210023Jiangsu ProvinceChina Department of Radiology Affiliated Hospital of Nanjing University of Chinese MedicineNanjing 210029Jiangsu ProvinceChina Department of Oncology Affiliated Hospital of Nanjing University of Chinese MedicineNanjing 210029Jiangsu ProvinceChina Department of Pathology Jiangsu Provincial Hospital of Traditional Chinese Medicine(Affiliated Hospital of Nanjing University of Chinese Medicine)Nanjing 210029Jiangsu ProvinceChina

BACKGROUND Colorectal cancer(CRC)is the third most prevalent form of cancer *** patients with CRC,colorectal liver metastasis(CRLM)is the foremost direct contributor to *** recent years,immunotherapy has swiftly risen to prominence as a vital approach for treating a range of solid tumors,including *** present a unique case of a patient suffering from CRLM,with the goal of offering an insightful example and relevant references for the treatment of *** SUMMARY We report a patient who experienced liver metastasis after undergoing successful surgical removal of CRC,with the postoperative pathological stage identified as *** patient has been receiving a combination treatment of Western and Traditional Chinese *** assessments of the patient’s condition have been conducted,encompassing evaluations of serum carcinoembryonic antigen levels,carbohydrate antigen 199,and observations of the tongue complexion and its *** patient achieved clinical remission after anti-programmed death-1 immunotherapy when various systemic therapies *** the diagnosis of CRLM,the patient has survived for more than 6 years,surpassing the expected survival time for those with advanced *** This case illustrates the considerable promise of anti-programmed death-1 immunotherapy in managing CRLM,especially in scenarios of drug resistance and disease progression.

关键词： Colorectal cancer Colorectal liver metastasis Drug resistance Immunotherapy Anti-programmed death-1 Case report

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Landslide Susceptibility Mapping Using RBFN-Based Ensemble Machine Learning Models

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 467-500页

作者： Duc-Dam nguyen nguyen Viet Tiep Quynh-Anh Thi Bui Hiep Van Le Indra Prakash Romulus Costache Manish Pandey Binh Thai Pham Faculty of Civil Engineering University of Transport TechnologyThanh XuanHa Noi100000Vietnam Faculty of Hydraulic Engineering Hanoi University of Civil EngineeringHa Noi100000Vietnam DDG(R)Geological Survey of India Gandhinagar382010India Research Institute of the University of Bucharest Bucharest050663Romania National Institute of Hydrology and Water Management Bucharest013686Romania Department of Civil Engineering Transilvania University of BrasovBrasov500152Romania Danube Delta National Institute for Research and Development Tulcea820112Romania Marwadi University Research Center(MURC) Marwadi UniversityRajkotGujaratBharat360003India Department of Civil Engineering Faculty of Engineering&TechnologyMarwadi UniversityRajkotGujaratBharat360003India

This study was aimed to prepare landslide susceptibility maps for the Pithoragarh district in Uttarakhand,India,using advanced ensemble models that combined Radial Basis Function Networks(RBFN)with three ensemble learning techniques:DAGGING(DG),MULTIBOOST(MB),and ADABOOST(AB).This combination resulted in three distinct ensemble models:DG-RBFN,MB-RBFN,and ***,a traditional weighted method,Information Value(IV),and a benchmark machine learning(ML)model,Multilayer Perceptron Neural Network(MLP),were employed for comparison and *** models were developed using ten landslide conditioning factors,which included slope,aspect,elevation,curvature,land cover,geomorphology,overburden depth,lithology,distance to rivers and distance to *** factors were instrumental in predicting the output variable,which was the probability of landslide *** analysis of the models’performance indicated that the DG-RBFN model,with an Area Under ROC Curve(AUC)of 0.931,outperformed the other *** AB-RBFN model achieved an AUC of 0.929,the MB-RBFN model had an AUC of 0.913,and the MLP model recorded an AUC of *** results suggest that the advanced ensemble ML model DG-RBFN was more accurate than traditional statistical model,single MLP model,and other ensemble models in preparing trustworthy landslide susceptibility maps,thereby enhancing land use planning and decision-making.

关键词： Landslide susceptibility map spatial analysis ensemble modelling information values(IV)

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Optimization of the in Vitro Fertilization System in Cỏ Goat Oocytes

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Open Journal of Animal Sciences 2025年第1期15卷 39-50页

作者： Van Khanh nguyen Huong Thi Thu Vu Au Thi Hoang Yen Thi Kim Pham Dat Van Le Quan xuan Huu Lan Anh Thi nguyen Huong Le Thi nguyen Lan Doan Pham Key Laboratory of Animal Cell Biotechnology National Institute of Animal Sciences Hanoi Vietnam

This study aimed to optimization of the in vitro fertilization system in Cỏ goat oocytes to achieve the maximum possible blastocyst development rate. In Experiment 1, we assessed the effects of IVF media on the in vitro fertilization of Cỏ goat oocytes. There was no significant difference in the cleavage, blastocyst, or hatching rates between TALP-Fert and BO-IVF media. Experiment 2 was performed to assess the concentration of sperm in the in vitro fertilization of Cỏ goat oocytes. The matured Cỏ goat oocytes were fertilized in BO-IVF for four sperm concentrations: 5 × 105, 1 × 106, 2 × 106 and 3 × 106 sperm/ml. The blastocyst rate of 2 × 106 sperm/ml and 3 × 106 sperm/ml groups was higher than that of 5 × 105 sperm/ml and 1 × 106 sperm/ml groups (P Experiment 3 was performed to assess the IVF duration on the in vitro fertilization of Cỏ goat oocytes. The matured Cỏ goat oocytes were fertilized in BO-IVF with sperm concentration of 3 × 106 sperm/ml for 18, 20, 22 and 24 h. The cleavage, blastocyst, and hatching blastocyst rates of 18 h group were lower than those of 20, 22 and 24 h groups (P 0.05). In conclusion, the matured Cỏ goat oocytes were fertilized in BO-IVF with sperm concentration of 3 × 106 sperm/ml for 20 hours, which is suitable for the in vitro Cỏ goat embryo production.

关键词： Cỏ Goat Oocytes In Vitro Fertilizaition Media In Vitro Fertilizaition Duration Sperm Concentration In Vitro Embryos

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Synthesis of lutetium hydrides at high pressures

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Matter and Radiation at Extremes 2025年第1期10卷 98-104页

作者： Yuan-Ao Peng Han-Yu Wang Fu-hai Su Pu Wang hai-An Xu Lin Liu Lun-xuan Yu Ross T.Howie Wan Xu Eugene Gregoryanz Xiao-Di Liu University of Science and Technology of China Hefei 230026China Key Laboratory of Materials Physics Institute of Solid State PhysicsHFIPSChinese Academy of SciencesHefei 230031China Centre for Science at Extreme Conditions and School of Physics and Astronomy University of EdinburghEdinburgh EH93FDUnited Kingdom Center for High Pressure Science and Technology Advanced Research Shanghai 201203China

High-pressure synthesis of lutetium hydrides from molecular hydrogen(H_(2))and lutetium(Lu)is systematically investigated using synchrotron X-ray diffraction,Raman spectroscopy,and visual *** demonstrate that the reaction pathway between H_(2)and Lu invariably follows the sequence Lu→LuH_(2)→LuH_(3)and exhibits a notable time dependence.A comprehensive diagram representing the formation and synthesis of lutetium hydrides as a function of pressure and time is *** findings indicate that the synthesis can be accelerated by elevated temperature and decelerated by increased ***,two critical pressure thresholds at ambient temperature are identified:the synthesis of LuH_(2)from Lu commences at a minimum pressure of~3 GPa,while~28 GPa is the minimum pressure at which LuH_(2)fails to transform into LuH_(3)within a time scale of *** underscores the significant impact of temporal factors on synthesis,with the reaction completion time increasing sub-linearly with rising ***,the cubic phase of LuH_(3)can be obtained exclusively through compressing the trigonal LuH_(3)phase at~11.5 *** also demonstrate that the bandgap of LuH_(3)slowly closes under pressure and is noticeably lower than that of LuH_(2).

关键词： synthesis ambient representing

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Predictive value of tacrolimus concentration/dose ratio in first posttransplant week for CYP3A5-polymorphism in kidney-transplant recipients

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World Journal of Transplantation 2025年第2期15卷 197-204页

作者： Pham-Thai Dung Hoang-xuan Su nguyen-Chi Tue nguyen-Huu Ben nguyen-Minh Phuong Tuan-Ngoc Tran Phan-Ba Nghia Diem-Thi Van nguyen Thi-Thuy Dung Hoang-Trung Vinh Lionel Rostaing Pham-Quoc Toan Center of Critical Care Medicine Emergency and Clinical ToxicologyMilitary HospitalHanoï100000Viet Nam Institute of Biomedicine and Pharmacy Vietnam Military Medical UniversityHanoï100000Viet Nam Department of Post-Transplant Intensive Care and Treatment Center of Organ Transplantation-Military HospitalHanoï100000Viet Nam Department of Occupational Medicine Vietnam Military Medical UniversityHanoï100000Viet Nam Department of Military Medical Command and Organization Vietnam Military Medical UniversityHanoï100000Viet Nam Department of Nephrology and Dialysis Military HospitalHanoï100000Viet Nam Department of Nephrology HemodialysisApheresisand Kidney TransplantationGrenoble University HospitalGrenoble 38043Auvergne-Rhone-AlpesFrance

BACKGROUND Tacrolimus(TAC)is metabolized primarily by the CYP3A-encoded enzyme family(CYP3A4,CYP3A5,and CYP3A7).Individuals expressing the CYP3A51 allele are considered fast metabolizers and generally require higher TAC doses to reach therapeutic *** To evaluate the predictive value of the TAC concentration-to-dose(C0/D)ratio for identifying CYP3A5 poly-morphisms in renal transplant *** Eighty-six de novo kidney transplant recipients with TAC-based immunosuppression from the Department of Nephrology and Dialysis at Military Hospital 103(Hanoi,Vietnam)were included in this retrospective *** samples were collected within the first week post-transplantation to monitor TAC levels and to perform genotyping for CYP3A5 genetic *** The CYP3A53/3 genotype was identified in 37 patients(43%),CYP3A51/3 in 40 patients(46.5%),and CYP3A51/1 in 9 patients(10.5%).Patients carrying the CYP3A51/3 or CYP3A51/1 genotype,classified as fast metabolizers(CYP3A5 expressers),had significantly lower TAC C0 concentrations and C0/D ratios compared to slow meta-bolizers(CYP3A53/3 genotype)at multiple time points during follow-up(all P<0.001).Notably,the TAC C0/D ratio obtained on day 1(0.91)was shown to predict CYP3A5 polymorphism with a sensitivity of 84.6%and a specificity of 84.6%.CONCLUSION This study demonstrates that the TAC C0/D ratio provides a reliable predictive value for CYP3A5 polymorphisms,which can be used to individualize TAC dosing in renal transplant recipients in Vietnam and other low-income countries.

关键词： Tacrolimus CYP3A5 Renal transplant recipient Concentration-to-dose Kidney transplant

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