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Mannitol inhibits the proliferation of neural stem cell by a p38 mitogen-activated protein kinase-dependent signaling pathway

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Chinese Journal of Traumatology 2024年第1期27卷 42-52页

作者： Hai-Zhen Duan Xin Zhou Quan Hu Meng-Long Liu Shu-Hong Wang Ji Zhang xu-heng jiang Tian-Xi Zhang An-Yong Yu Department of Emergency Affiliated Hospital of Zunyi Medical UniversityZunyi563000Guizhou provinceChina Dazhou Vocational College of Chinese Medicine Dazhou635000Sichuan provinceChina Dachuan District Traditional Chinese Medicine Hospital Dazhou635000Sichuan provinceChina

Purpose:Mannitol is one of the first-line drugs for reducing cerebral edema through increasing the extracellular osmotic ***,long-term administration of mannitol in the treatment of cerebral edema triggers damage to neurons and *** that neural stem cell(NSC)is a subpopulation of main regenerative cells in the central nervous system after injury,the effect of mannitol on NSC is still *** present study aims to elucidate the role of mannitol in NSC ***:C57 mice were derived from the animal house of Zunyi Medical University.A total of 15 pregnant mice were employed for the purpose of isolating NSCs in this ***,mouse primary NSCs were isolated from the embryonic cortex of mice and subsequently identified through immunofluorescence *** order to investigate the impact of mannitol on NSC proliferation,both cell counting kit-8 assays and neurospheres formation assays were *** vitro effects of mannitol were examined at various doses and time *** order to elucidate the role of Aquaporin 4(AQP4)in the suppressive effect of mannitol on NSC proliferation,various assays including reverse transcription polymerase chain reaction,western blotting,and immunocytochemistry were conducted on control and mannitol-treated ***,the phosphorylated p38(p-p38)was examined to explore the potential mechanism underlying the inhibitory effect of mannitol on NSC ***,to further confirm the involvement of the p38 mitogen-activated protein kinase-dependent(MAPK)signaling pathway in the observed inhibition of NSC proliferation by mannitol,SB203580 was *** data were analyzed using SPSS 20.0 software(SPSS,Inc.,Chicago,IL).The statistical analysis among multiple comparisons was performed using one-way analysis of variance(ANOVA),followed by Turkey’’s post hoc test in case of the data following a normal distribution using a Shapiro-Wilk normality *** betwe

关键词： Mannitol Cerebral edema Neural stem cell Proliferation AQP4 p38 MAPK signaling pathway

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Impact of an ionic surfactant on the ion transfer behaviors at meso-liquid/liquid interface arrays

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Chinese Chemical Letters 2015年第3期26卷 285-288页

作者： Kui Gao xu-heng jiang Dao-Pan Hu Shu-Juan Bian Meng Wang Yong Chen School of Chemical and Environmental Engineering Shanghai Institute of Technology

The influence of ionic surfactants,cetyltrimethylammonium bromide（CTAB）,self-assembled within silica-nanochannels of a hybrid mesoporous silica membrane（HMSM） on simple ion transfer（IT）behaviors at the meso-water/1,2-dichloroethane（W/DCE） interface arrays supported by such a HMSM was investigated by voltammetry for the first ***,it is found that the CTAB in HMSM can dramatically enhance the peak-current responses corresponding to ITs of some anions and even lower their Gibbs transfer energies from W to DCE,which could be ascribed to an anion-exchange process between anions and the bromide of CTAB associated with partial ion-dehydration induced by the *** work will provide a new strategy to study anion transfer processes and improve the electroanalytical performance for anion detection at the liquid/liquid interface.

关键词： surfactant ionic silica voltammetry bromide assembled anion dramatically shaped hydrophobic

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Efficient recovery of tungsten from scheelite concentrates using a sulfur-phosphorus mixed acid leaching system

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Tungsten 2024年第4期6卷 821-832页

作者： jiang-Tao Li Li-Li Gao Zhong-Wei Zhao xu-heng Liu Xing-Yu Chen School of Metallurgy and Environment Central South University Key Laboratory of Hunan Province for Metallurgy and Material Processing of Rare Metals

In recent years,a new process for leaching scheelite concentrates with sulfur-phosphorus mixed acid has been successfully *** process suffers from the elimination of the retarding effect of calcium sulfate,the selective extraction of tungsten from the H3PW12O40-H2SO4-H3PO4mixture solution,and the removal of introduced ***,in this paper,we investigated the inhibition measures of a calcium sulfate-blocking membrane,the selective extraction of tungsten by ion exchange,and the removal of phosphorus by the magnesium ammonium salt *** results showed that the addition of calcium sulfate whisker seeds and a higher H3PO4concentration inhibited spontaneous diffuse nucleation,promoted crystal growth,and avoided the formation of a dense blocking *** 98 wt.% of the scheelite concentrate was digested by *** selective adsorption of PW12O403-was realized using D301 resin,and the extraction efficiency of tungsten exceeded 99.9%.After desorption with ammonia water,PW12O403-was depolymerized into WO42-and PO43-.99.9 wt.% of phosphorus was removed in the form of MgNH4PO4by the magnesium ammonium salt method,and the residual phosphorus concentration in the solution was lower than 10 mg·*** purification,the highest-grade ammonium paratungstate product was prepared by evaporative crystallization.

关键词： Calcium sulfate Ion exchange Scheelite concentrates Sulfur-phosphorus mixed acid Tungsten

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Three-dimensional forest foodscape in large herbivores’habitat based on UAV with LiDAR detection

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Integrative Zoology 2024年第2期19卷 343-346页

作者： heng BAO Guangshun jiang College of Wildlife and Protected Area Northeast Forestry UniversityHarbinChina Feline Research Center of National Forestry and Grassland Administration HarbinChina Research Center for Northeast Asia Biodiversity Conservation HarbinChina

Traditionally,wildlife habitat research mainly extracts two-dimensional habitat ***,they live in three-dimensional space,and the three-dimensional structure of the forest ecosystem is an important factor affecting the composition of the mammal community(Fig.1a,b),and the three-dimensional structure of the forest also determines the behavior pattern of wildlife multidimensional habitat selection or use(Flaspohler et al.2010;Palminteri et al.2012;Müller et al.2014).For instance,forest structure determines the vertical distribution of annual edible shoots,fruits,or seed nuts resources in space,providing additional ecological niches for frugivores,rodents,and other species,and then leading to niche differentiation of wild animals in vertical space utilization,thus increasing species coexistence(*** et al.2023).

关键词： habitat forest dimensional

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Design and high-power testing of offline conditioning cavity for CiADS RFQ high-power coupler

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Nuclear Science and Techniques 2024年第9期35卷 18-27页

作者： Ruo-xu Wang Yuan He Long-Bo Shi Chen-Xing Li Zong-heng xue Tian-Cai jiang Xian-Bo xu Lie-Peng Sun Zhou-Li Zhang Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China Lanzhou University Lanzhou 730000China

To validate the design rationality of the power coupler for the RFQ cavity and minimize cavity contamination,we designed a low-loss offline conditioning cavity and conducted high-power *** offline cavity features two coupling ports and two tuners,operating at a frequency of 162.5 MHz with a tuning range of 3.2 *** the installation angle of the coupling ring and the insertion depth of the tuner helps minimize cavity *** performed electromagnetic structural and multiphysics simulations,revealing a minimal theoretical power loss of 4.3%.However,when the cavity frequency varied by110 kHz,theoretical power losses increased to10%,necessitating constant tuner adjustments during *** simulations indicated that increased cavity temperature did not affect frequency *** completion of the offline high-power conditioning platform,we measured the transmission performance,revealing a power loss of 6.3%,exceeding the theoretical *** utilized efficient automatic range scanning and standing wave resonant *** fully condition the power coupler,a 15°phase difference between two standing wave points in the condition-ing system was ***,the maximum continuous wave power surpassed 20 kW,exceeding the expected target.

关键词： RFQ cavity Power coupler Offline conditioning Resonant cavity

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Adverse Effects of Opioid Analgesics in Osteoarthritis Treatment:A Global Meta-Analysis,2000-2022

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China CDC weekly 2024年第25期6卷 589-596,I0001-I0012页

作者： heng jiang Xing Xing He Zhu Tuo Dong School of Public Health Harbin Medical UniversityHarbin CityHeilongjiang ProvinceChina School of Public Health Peking UniversityBeijingChina

Osteoarthritis(OA)treatment commonly depends on nonsteroidal anti-inflammatory drugs and opioid ***,the clinical use of opioids is controversial due to their adverse effects and addiction *** study,drawing on 24 randomized controlled trials(RCTs)with a total of 9,586 patients,thoroughly explored the various side effects associated with opioid use in OA *** results provide additional insight into the non-addictive risks of opioids and may assist clinicians in their judicious use,potentially fostering the advancement of safer treatment *** reducing the risks of misuse and addiction,public health and safety can be enhanced.

关键词： potential thoroughly insight

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A proteomic landscape of pharmacologic perturbations for functional relevance

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Journal of Pharmaceutical Analysis 2024年第1期14卷 128-139页

作者： Zhiwei Liu Shangwen jiang Bingbing Hao Shuyu Xie Yingluo Liu Yuqi Huang heng xu Cheng Luo Min Huang Minjia Tan Jun-Yu xu State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai201203China School of Chinese Materia Medica Nanjing University of Chinese MedicineNanjing210023China Zhongshan Institute for Drug Discovery Shanghai Institute of Materia MedicaChinese Academy of SciencesZhongshanGuangdong528400China State Key Laboratory of Pharmaceutical Biotechnology Nanjing UniversityNanjing210023China

Pharmacological perturbation studies based on protein-level signatures are fundamental for drug discovery. In the present study, we used a mass spectrometry (MS)-based proteomic platform to profile the whole proteome of the breast cancer MCF7 cell line under stress induced by 78 bioactive compounds. The integrated analysis of perturbed signal abundance revealed the connectivity between phenotypic behaviors and molecular features in cancer cells. Our data showed functional relevance in exploring the novel pharmacological activity of phenolic xanthohumol, as well as the noncanonical targets of clinically approved tamoxifen, lovastatin, and their derivatives. Furthermore, the rational design of synergistic inhibition using a combination of histone methyltransferase and topoisomerase was identified based on their complementary drug fingerprints. This study provides rich resources for the proteomic landscape of drug responses for precision therapeutic medicine.

关键词： Proteomics Drug Perturbation Drug target Drug combination

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Dynamic analysis of tethered defunct satellites with solar panels

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Astrodynamics 2024年第2期8卷 297-309页

作者： Rui Qi Yang Zhang heng jiang Rui Zhong School of Aerospace Engineering Beijing Institute of TechnologyBeijing 100081China School of Aerospace Astronautics Beihang UniversityBeijing 100191China

A precise dynamic model for towing and removing a defunct satellite with solar panels in orbit using a tethered net often has low computational efficiency owing to the complex contact and collision between the net and panels,which is not conducive to *** solve this problem,a“single main tether–multiple subtether”bifurcation structure with beads was employed as the tethered net *** study investigated the dynamics of tethered defunct satellites with solar panels,particularly the behavior of the attitude of the tethered satellite,oscillation of the main tether,and vibration of solar panels under different *** results showed that different attachment configurations of the subtethers and the flexibility of the main tether have an evident impact on the dynamic characteristics of the system.

关键词： space debris flexible solar panels tethered towing Kane’s method dynamics modeling

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A Novel On-Site-Real-Time Method for Identifying Characteristic Parameters Using Ultrasonic Echo Groups and Neural Network

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Chinese Journal of Mechanical Engineering 2024年第1期37卷 215-228页

作者： Shuyong Duan Jialin Zhang heng Ouyang xu Han Guirong Liu State Key Laboratory of Reliability and Intelligence of Electrical Equipment Hebei University of TechnologyTianjin 300401China Department of Aerospace Engineering and Engineering Mechanics University of CincinnatiCincinnati 45221USA

On-site and real-time non-destructive measurement of elastic constants for materials of a component in a in-service structure is a challenge due to structural complexities,such as ambiguous boundary,variable thickness,nonuniform material *** work develops for the first time a method that uses ultrasound echo groups and artificial neural network(ANN)for reliable on-site real-time identification of material *** use of echo groups allows the use of lower frequencies,and hence more accommodative to structural *** train the ANNs,a numerical model is established that is capable of computing the waveform of ultrasonic echo groups for any given set of material properties of a given *** waveform of an ultrasonic echo groups at an interest location on the surface the structure with material parameters varying in a predefined range are then computed using the numerical *** results in a set of dataset for training the ANN *** the ANN is trained,the material parameters can be identified simultaneously using the actual measured echo waveform as input to the *** tests have been conducted both numerically and experimentally to evaluate the effectiveness and accuracy of the currently proposed *** results show that the maximum identification error of numerical example is less than 2%,and the maximum identification error of experimental test is less than 7%.Compared with currently prevailing methods and equipment,the proposefy the density and thickness,in addition to the elastic ***,the reliability and accuracy of inverse prediction is significantly ***,it has broad applications and enables real-time field measurements,which has not been fulfilled by any other available methods or equipment.

关键词： Parameter identification Ultrasonic echo group High-precision modeling Artificial neural network NDT

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Photoexcitation of Dihydroquinazolinone Anionic Compounds:Difluoroalkylarylation and Difluoroalkylamination of Alkenes

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CCS Chemistry 2024年第10期6卷 2549-2559页

作者： Jian-Xiong Yang Jia-Qing Hu Qi Wen Jie xu Yan Zhang heng jiang School of Chemistry and Chemical Engineering Chemistry and Biomedicine Innovation Center(Chem BIC)Nanjing UniversityNanjing 210023 Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs Shanghai Frontiers Science Center of Drug Target Identification and DeliverySchool of Pharmaceutical SciencesShanghai Jiao Tong UniversityShanghai 200240

The direct excitation of dihydroquinazolinone(DHQ)anions by visible light has been demonstrated by photophysical *** excited-state DHQ anion serves as both a potent reductant and a radical precursor in a redox neutral radical cascade,circumventing the use of an external photoredox *** gem-difluoroalkyl radicals(CF_(2)H and CF_(2)R)are produced from the excited-state DHQ anions,leading to the first example of intermolecular 1,2-difluoroalkylarylation(CF_(2)H-and CF_(2)R-arylation)of alkenes in overall redox-neutral ***,1,2-difluoroalkylamination of styrenes has also been realized,offering a practical pathway for the preparation of diverseβ-CF_(2)H *** general and efficient strategy for the generation of CF_(2)H and CF_(2)R radicals exhibits great potential for applications in drug discovery.

关键词： excited state anion difluoromethyl radical difluoromethylation photochemistry radical chemistry

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