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Journal of Earth Science 2024年第4期35卷 1186-1195页

作者： Yangyang Zhang Yuelong Chen Dapeng Li Huan Kang Mingliang fang Yunliang xu School of Earth Science and Resources China University of GeosciencesBeijing100083China State Key Laboratory of Earthquake Dynamics Institute of GeologyChina Earthquake AdministrationBeijing100083China Jinchuan Group Company Limited Jinchang737104China China-Explo Tian Cheng(Beijing)Technology Company Limited Beijing100093China

Radon(Rn)and helium(He)gases from uranium decay form distinct anomalies related to buried uranium *** order to trace the geochemical anomalous sources from the volcanic-related uranium deposits in deeply buried areas,systematical Rn contents and He isotope ratios were analyzed from the Daguanchang uranium *** soil gas Rn concentrations above the deep uranium are ten times higher than those in barren areas,indicating that instantaneous Rn content measurements can be used to detect deeply buried *** helium isotope ratios(^(3)He/^(4)He)of the unmineralized samples from the mineralized drill hole(ZK1)are relatively lower and uniform compared to those of the samples from no-mineral drill hole(ZK2).However,the Th and U contents of the drill core samples from ZK1 are slightly lower than those of the samples from ZK2,indicating that the lower 3He/4He ratios in ZK1 are most likely due to the addition of 4He from underlying uranium *** differences in the instantaneous Rn contents are consistent with the variations in the He isotope ratios of the drill core *** results demonstrate that soil gas Rn and ^(3)He/^(4)He ratios are useful tracers and can indicate the existence of deeply buried volcanic-related hydrothermal uranium ores.

关键词： tracers radon helium ^(3)He/^(4)He ratio uranium deposits Daguanchang deposit

Life cycle assessment of homogeneous Fenton process as pretreatment for refractory pharmaceutical wastewater

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Frontiers of Chemical Science and Engineering 2024年第5期18卷 1-11页

作者： Maojun Zou Jie Wei Yuanyuan Qian Yanjing xu Zhihuang fang xuejing Yang Zhiyuan Wang School of Energy and Power Engineering University of Shanghai for Science and TechnologyShanghai 200093China Shanghai Engineering Laboratory of Lean Operational Technologies for Full Water System East China University of Science and TechnologyShanghai 200237China Mcwong Environmental Technology Company Limited Shanghai 200135China National Engineering Laboratory of High Concentration and Refractory Organic Wastewater Treatment Technology East China University of Science and TechnologyShanghai 200237China

The applicability of the life cycle assessment(LCA)to the Fenton process should be considered not only at the laboratory-scale but also at the *** this study,the LCA process was applied to evaluate the homo-geneous Fenton process for the treatment of high salinity pharmaceutical *** potential environmental impacts were calculated using Simapro software implemen-ting the CML 2001 methodology with normalization factors of 1995 *** data obtained directly from the full-scale wastewater treatment plant and labora-tory were used to conduct a life cycle inventory analysis,ensuring highly accurate *** normalized results,the Fenton process reveals sensitive indicators,primarily toxi-city indicators(human toxicity,freshwater aquatic toxicity,and marine aquatic toxicity),as well as acidification and eutrophication impacts,contributed by hydrogen peroxide and iron sludge incineration,***,hydrogen peroxide and iron sludge incineration contribute significantly,accounting for at least 78%of these *** sludge treatment phase,treatment of iron mud and infrastructure of hazardous waste incineration plants were the key contributors of environmental impacts,adding up to more than 95%.This study suggests the need to develop efficient oxidation processes and effective iron sludge treatment methods to reduce resource utilization and improve environmental benefits.

关键词： advanced oxidation processes full-scale life cycle assessment Fenton process pharmaceutical high-salinity wastewater

NiO@Ni nanoparticles embedded in N-doped carbon for efficient photothermal CO_(2) methanation coupled with H_(2)O splitting

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Nano Research 2024年第4期17卷 2283-2290页

作者： Yun Zhou Peng Zheng fang Wang fangna Gu Wenqing xu Qinyang Lu Tingyu Zhu Ziyi Zhong Guangwen xu Fabing Su Institute of Process Engineering Chinese Academy of SciencesBeijing 100190China Key Laboratory on Resources Chemicals and Materials of Ministry of Education Shenyang University of Chemical TechnologyShenyang 110142China Institute of Industrial Chemistry and Energy Technology Shenyang University of Chemical TechnologyShenyang 110142China School of Ecology and Environment Beijing Technology and Business UniversityBeijing 100048China Beijing Key Laboratory of Enze Biomass Fine Chemicals College of New Materials and Chemical EngineeringBeijing Institute of Petrochemical TechnologyBeijing 102617China International School of Beijing 10 An Hua Street Shunyi DistrictBeijing 100048China Department of Chemical Engineering Guangdong Technion Israel Institute of Technology(GTIIT)Shantou 515063China Technion Israel Institute of Technology(IIT) Haifa32000Israel

Photothermal carbon dioxide(CO_(2))methanation has attracted increasing interest in solar fuel synthesis,which employs the advantages of photocatalytic H_(2)O splitting as a hydrogen source and photothermal catalytic CO_(2) *** work prepared three-dimensional(3D)honeycomb N-doped carbon(NC)loaded with core–shell NiO@Ni nanoparticles generated in situ at 500℃(NiO@Ni/NC-500).Under the photothermal catalysis(200℃,1.5 W/cm^(2)),the CH_(4) evolution rate of NiO@Ni/NC-500 reached 5.5 mmol/(g·h),which is much higher than that of the photocatalysis(0.8 mmol/(g·h))and the thermal catalysis(3.7 mmol/(g·h)).It is found that the generated localized surface plasmon resonance enhances the injection of hot electrons from Ni to NiO,while thermal heating accelerates the thermal motion of radicals,thus generating a strong photo-thermal synergistic effect on the *** CO_(2) reduction to CH_(4) follows the*OCH *** work demonstrates the synergistic effect of NiO@Ni and NC can enhance the catalytic performance of photothermal CO_(2) reduction reaction coupled with water splitting reaction.

关键词： Ni localized surface plasmon resonance photothermal methanation

MiRNA-145-5p inhibits gastric cancer progression via the serpin family E member 1-extracellular signal-regulated kinase-1/2 axis

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 2123-2140页

作者： Hong-Xia bai xue-Mei Qiu Chun-Hong xu Jian-Qiang Guo Department of Gastroenterology The Second Hospital of Shandong UniversityJinan 250000Shandong ProvinceChina Department of Gastroenterology Liaocheng People’s HospitalLiaocheng 252000Shandong ProvinceChina Department of Reproductive Center Zaozhuang Maternal and Child Health Care HospitalZaozhuang 277000Shandong ProvinceChina

BACKGROUND MicroRNAs(miRNAs)regulate gene expression and play a critical role in cancer ***,there is still a limited understanding of the function and regulatory mechanism of miRNAs in gastric cancer(GC).AIM To investigate the role and molecular mechanism of miRNA-145-5p(miR145-5p)in the progression of *** Real-time polymerase chain reaction(RT-PCR)was used to detect miRNA expression in human GC tissues and *** ability of cancer cells to migrate and invade was assessed using wound-healing and transwell assays,*** proliferation was measured using cell counting kit-8 and colony formation assays,and apoptosis was evaluated using flow *** of the epithelial-mesenchymal transition(EMT)-associated protein was determined by Western *** of miR-145-5p were predicated using bioinformatics analysis and verified using a dual-luciferase reporter *** family E member 1(SERPINE1)expression in GC tissues and cells was evaluated using RT-PCR and immunohistochemical *** correlation between SERPINE1 expression and overall patient survival was determined using Kaplan-Meier plot *** association between SERPINE1 and GC progression was also tested.A rescue experiment of SERPINE1 overexpression was conducted to verify the relationship between this protein and *** mechanism by which miR-145-5p influences GC progression was further explored by assessing tumor formation in nude *** GC tissues and cells had reduced miR-145-5p expression and SERPINE1 was identified as a direct target of this *** of miR-145-5p was associated with decreased GC cell proliferation,invasion,migration,and EMT,and these effects were reversed by forcing SERPINE1 ***-Meier plot analysis revealed that patients with higher SERPINE1 expression had a shorter survival rate than those with lower SERPINE1 *** mouse tumorigenesis experiments confirmed that miR-145-5p target

关键词： Gastric cancer MicroRNA-145-5p Serpin family E member 1 Epithelial-mesenchymal transition Proliferation Extracellular signal-regulated kinase-1/2

Abnormal Innervation,Demyelination,and Degeneration of Spiral Ganglion Neurons as Well as Disruption of Heminodes are Involved in the Onset of Deafness in Cx26 Null Mice

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Neuroscience Bulletin 2024年第8期40卷 1093-1103页

作者： Yue Qiu Le Xie Xiaohui Wang Kai xu xue bai Sen Chen Yu Sun Department of Otorhinolaryngology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of Otolaryngology Nanchang UniversityNanchang 330006China

GJB2 gene mutations are the most common causes of autosomal recessive non-syndromic hereditary *** individuals suffering from severe to profound GJB2-related deafness,cochlear implants have emerged as the sole remedy for auditory *** previous studies have highlighted the crucial role of preserving cochlear neural components in achieving favorable outcomes after cochlear ***,we generated a conditional knockout mouse model(Cx26-CKO)in which Cx26 was completely deleted in the cochlear supporting cells driven by the Sox2 *** Cx26-CKO mice showed severe hearing loss and massive loss of hair cells and Deiter’s cells,which represented the extreme form of human deafness caused by GJB2 gene *** addition,multiple pathological changes in the peripheral auditory nervous system were found,including abnormal innervation,demyelination,and degeneration of spiral ganglion neurons as well as disruption of heminodes in Cx26-CKO *** findings provide invaluable insights into the deafness mechanism and the treatment for severe deafness in Cx26-null mice.

关键词： Spiral ganglion neurons Gjb2 Heminode Hearing loss

A Generic Strategy to Create Mechanically Interlocked Nanocomposite/Hydrogel Hybrid Electrodes for Epidermal Electronics

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Nano-Micro Letters 2024年第5期16卷 120-133页

作者： Qian Wang Yanyan Li Yong Lin Yuping Sun Chong bai Haorun Guo Ting fang Gaohua Hu Yanqing Lu Desheng Kong College of Engineering and Applied Sciences National Laboratory of Solid State Microstructureand Collaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjing 210023People’s Republic of China State Key Laboratory of Analytical Chemistry for Life Science and Jiangsu Key Laboratory of Artificial Functional MaterialsNanjing UniversityNanjing 210023People’s Republic of China College of Chemical Engineering and Technology Engineering Research Center of Seawater Utilization Technology of Ministry of EducationState Key Laboratory of Reliability and Intelligence of Electrical EquipmentHebei University of TechnologyTianjin 300130People’s Republic of China Key Laboratory of Intelligent Optical Sensing and Manipulation Nanjing UniversityNanjing 210093People’s Republic of China

Stretchable electronics are crucial enablers for next-generation wearables intimately integrated into the human *** the primary compliant conductors used in these devices,metallic nanostructure/elastomer composites often struggle to form conformal contact with the textured *** electrodes have been consequently developed based on conductive nanocomposite and soft hydrogels to establish seamless skin-device ***,chemical modifications are typically needed for reliable bonding,which can alter their original *** overcome this limitation,this study presents a facile fabrication approach for mechanically interlocked nanocomposite/hydrogel hybrid *** this physical process,soft microfoams are thermally laminated on silver nanowire nanocomposites as a porous interface,which forms an interpenetrating network with the *** microfoam-enabled bonding strategy is generally compatible with various *** resulting interlocked hybrids have a 28-fold improved interfacial toughness compared to directly stacked *** electrodes achieve firm attachment to the skin and low contact impedance using tissue-adhesive *** have been successfully integrated into an epidermal sleeve to distinguish hand gestures by sensing mus-cle *** nanocomposite/hydrogel hybrids reported here offer a promising platform to combine the benefits of both materials for epidermal devices and systems.

关键词： Stretchable electronics Epidermal electronics Silver nanowire Conductive nanocomposites Hydrogel

Enhancing Data Forwarding Efficiency in SIoT with Multidimensional Social Relations

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Computers, Materials & Continua 2024年第1期78卷 1095-1113页

作者： fang xu Songhao Jiang Yi Ma Manzoor Ahmed Zenggang Xiong Yuanlin Lyu School of Computer and Information Science Hubei Engineering UniversityXiaogan432000China School of Computer Science and Information Engineering Hubei UniversityWuhan430062China Artificial Intelligence Industrial Technology Research Institute Hubei Engineering UniversityXiaogan432000China

Effective data communication is a crucial aspect of the Social Internet of Things(SIoT)and continues to be a significant research *** paper proposes a data forwarding algorithm based on Multidimensional Social Relations(MSRR)in SIoT to solve this *** proposed algorithm separates message forwarding into intra-and cross-community forwarding by analyzing interest traits and social connections among *** new metrics are defined:the intensity of node social relationships,node activity,and community *** the community,messages are sent by determining which node is most similar to the sender by weighing the strength of social connections and node *** a node performs cross-community forwarding,the message is forwarded to the most reasonable relay community by measuring the node activity and the connection between *** proposed algorithm was compared to three existing routing algorithms in simulation *** indicate that the proposed algorithmsubstantially improves message delivery efficiency while lessening network overhead and enhancing connectivity and coordination in the SIoT context.

关键词： SIoT data forwarding social attributes social relations community

Matrix metalloproteinase 2 contributes to adult eclosion and immune response in the small hive beetle,Aethina tumida

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Insect Science 2024年第3期31卷 733-747页

作者： Lixian Wu Yajing xu Liangbin Li Dainan Cao fang Liu Hongxia Zhao Guangdong Key Laboratssory of Animal Conservation and Resource Utilization Guangdong Public Laboratory of Wild Animal Conservation and UtilizationInstitute of ZoologyGuangdong Academy of SciencesGuangzhouChina

During the pupal-adult eclosion process of holometabolous insects,the old cuticle is shed and replaced by a completely different new cuticle that requires tanning and expansion,along with extensive extracellular matrix(ECM)*** vertebrates,matrix metalloproteinases(MMPs),a class of zinc-dependent endopeptidases,play key roles in regulating the ECM that surrounds ***,little is known about these extracellular proteinases available in *** small hive beetle(SHB),Aethina tumida,is a widespread invasive parasite of honey *** this study,6 MMP homologs were identified in the SHB *** interference experiments showed that all 6 AtMmps are not required for the larval-pupal transition,only AtMmp2 was essential for pupal-adult eclosion in *** of AtMmp2 resulted in eclosion defects and wing expansion failure,as well as mortality within 3 d of adult *** analysis revealed that knockdown of AtMmp2 significantly increased expression of the Toll and Imd pathways,chitin metabolism,and cross-linking(such as the pro-phenoloxidase activating cascade pathway and the tyrosine-mediated cuticle sclerotization and pigmentation pathway).These data revealed evolutionarily conserved functions of Mmp2 in controlling adult eclosion and wing expansion,also provided a preliminary exploration of the novel function of regulating Toll and Imd pathways,as well as new insights into how MMPs regulate insect development and defense barriers.

关键词： Aethina tumida adult eclosion immune response matrix metalloproteinase RNAinterference

Deep reinforcement learning using least-squares truncated temporal-difference

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CAAI Transactions on Intelligence Technology 2024年第2期9卷 425-439页

作者： Junkai Ren Yixing Lan Xin xu Yichuan Zhang Qiang fang Yujun Zeng College of Intelligence Science and Technology National University of Defense TechnologyChangshaChina State Key Laboratory of Astronautic Dynamics Xi'an Satellite Control CenterXi'anChina

Policy evaluation(PE)is a critical sub-problem in reinforcement learning,which estimates the value function for a given policy and can be used for policy ***,there still exist some limitations in current PE methods,such as low sample efficiency and local convergence,especially on complex *** this study,a novel PE algorithm called Least-Squares Truncated Temporal-Difference learning(LST2D)is *** LST2D,an adaptive truncation mechanism is designed,which effectively takes advantage of the fast convergence property of Least-Squares Temporal Difference learning and the asymptotic convergence property of Temporal Difference learning(TD).Then,two feature pre-training methods are utilised to improve the approximation ability of ***,an Actor-Critic algorithm based on LST2D and pre-trained feature representations(ACLPF)is proposed,where LST2D is integrated into the critic network to improve learning-prediction *** simulation studies were conducted on four robotic tasks,and the corresponding results illustrate the effectiveness of *** proposed ACLPF algorithm outperformed DQN,ACER and PPO in terms of sample efficiency and stability,which demonstrated that LST2D can be applied to online learning control problems by incorporating it into the actor-critic architecture.

关键词： Deep reinforcement learning policy evaluation temporal difference value function approximation

DGConv: A Novel Convolutional Neural Network Approach for Weld Seam Depth Image Detection

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Computers, Materials & Continua 2024年第2期78卷 1755-1771页

作者： Pengchao Li fang xu Jintao Wang Haibing Guo Mingmin Liu Zhenjun Du State Key Laboratory of Robotics Shenyang Institute of AutomationChinese Academy of SciencesShenyang110016China Institutes for Robotics and Intelligent Manufacturing Chinese Academy of SciencesShenyang110169China University of Chinese Academy of Sciences Beijing100049China Shenyang SIASUN Robot&Automation Co. Ltd.Shenyang110168China

We propose a novel image segmentation algorithm to tackle the challenge of limited recognition and segmentation performance in identifying welding seam images during robotic intelligent ***,to enhance the capability of deep neural networks in extracting geometric attributes from depth images,we developed a novel deep geometric convolution operator(DGConv).DGConv is utilized to construct a deep local geometric feature extraction module,facilitating a more comprehensive exploration of the intrinsic geometric information within depth ***,we integrate the newly proposed deep geometric feature module with the Fully Convolutional Network(FCN8)to establish a high-performance deep neural network algorithm tailored for depth image ***,we enhance the FCN8 detection head by separating the segmentation and classification *** enhancement significantly boosts the network’s overall detection ***,for a comprehensive assessment of our proposed algorithm and its applicability in real-world industrial settings,we curated a line-scan image dataset featuring weld *** dataset,named the Standardized Linear Depth Profile(SLDP)dataset,was collected from actual industrial sites where autonomous robots are in ***,we conducted experiments utilizing the SLDP dataset,achieving an average accuracy of 92.7%.Our proposed approach exhibited a remarkable performance improvement over the prior method on the identical ***,we have successfully deployed the proposed algorithm in genuine industrial environments,fulfilling the prerequisites of unmanned robot operations.

关键词： Weld image detection deep learning semantic segmentation depth map geometric feature extraction