检索结果-南通市图书馆

A new luciferase immunoprecipitation system assay provided serological evidence for missed diagnosis of severe fever with thrombocytopenia syndrome

引用

Virologica Sinica 2022年第1期37卷 107-114页

作者： Shengyao Chen Minjun xu Xiaoli Wu yuan Bai Junming Shi Min Zhou Qiaoli Wu Shuang Tang Fei Deng Bo Qin Shu Shen State Key Laboratory of Virology and National Virus Resource Center Wuhan Institute of VirologyChinese Academy of SciencesWuhan430071China Shaoxing Women and Children©s Hospital No.305 East Street RoadShaoxing312000China University of Chinese Academy of Sciences Beijing100049China Shaoxing People©s Hospital Zhejiang University School of MedicineShaoxing312000China

Severe fever with thrombocytopenia syndrome(SFTS),caused by SFTS virus(SFTSV)infection,was first reported in 2010 in China with an initial fatality of up to 30%.The laboratory confirmation of SFTSV infection in terms of detection of viral RNA or antibody levels is critical for SFTS diagnosis and *** this study,a new luciferase immunoprecipitation system(LIPS)assay based on p REN2 plasmid expressing SFTSV NP gene and tagged with Renilla luciferase(Rluc),was established and used to investigate the levels of antibody responses to *** 464 serum samples from febrile patients were collected in the hospital of Shaoxing City in Zhejiang Province in *** results showed that 82 of the 464 patients(17.7%)had antibody response to SFTSV,which were further supported by immunofluorescence assays(IFAs).Further,q RT-PCR and microneutralization tests showed that among the 82 positive cases,15 patients had viremia,10 patients had neutralizing antibody,and one had both(totally 26 patient).However,none of these patients were diagnosed as SFTS in the hospital probably because of their mild symptoms or subclinical *** the results indicated that at least the 26 patients having viremia or neutralizing antibody were the missed diagnosis of SFTS *** findings suggested the occurrence of SFTS and the SFTS incidence were higher than the reported level in Shaoxing in 2019,and that LIPS may provide an alternative strategy to confirm SFTSV infection in the laboratory.

关键词： Severe fever with thrombocytopenia syndrome(SFTS) Severe fever with thrombocytopenia syndrome virus(SFTSV) Luciferase immunoprecipitation systems(LIPS) Shaoxing Serological evidence Missed diagnosis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The Key Role of Subtle Substitution for a High-Performance Ester-Modified Oligothiophene-Based Polymer Used in Photovoltaic Cells

引用

Chinese Journal of Chemistry 2022年第24期40卷 2867-2874页

作者： Sunsun Li yuan Ding Lei xu Wenchao Zhao Jianqi Zhang Jinzhao Qin Yuyang Zhang Jingjing Zhao Chang He Qiming Peng Jianhui Hou Key Laboratory of Flexible Electronics(KLOFE)and Institute of Advanced Materials(IAM) Nanjing Tech University(NanjingTech)NanjingJiangsu211816 China Co-Innovation Center of Efficient Processing and Utilization of Forest Resources College of Materials Science and EngineeringNanjing Forestry UniversityNanjingJiangsu210037 China State Key Laboratory of Polymer Physics and Chemistry Beijing National Laboratory for Molecular SciencesInstitute of ChemistryChinese Academy of SciencesBeijing100190 China Key Laboratory of Nanosystem and Hierarchical Fabrication National Center for Nanoscience and TechnologyBeijing100190 China Jiangsu Seenbom Flexible Electronics Institute Co.Ltd NanjingJiangsu210043 China

In organic solar cells (OSCs), developing high-performing easily synthesized photoactive materials is essential for pursuing cost- effective balance. Herein, we have designed and synthesized a pair of wide-band-gap polymers (PBDE4T-0F and PBDE4T-2F), using the low synthesis cost dicarboxylic ester-substituted quaterthiophene as the building block. Despite the minor change of molecular structure for polymer PBDE4T-xF, the fluorine substituent in polymer PBDE4T-2F greatly enhances its interchain aggregation. The higher aggregation tendency of ester-modified polymer in solution is beneficial for reducing both the aggregate size and π-π stacking distance of blend film, which contribute to the highly efficient exciton dissociation and symmetric charge transport. An impressive power-conversion efficiency (PCE) of 16.1% is achieved for the PBDE4T-2F:BTP-eC9-based device, while its counterpart only delivers a PCE of 5.8% with distinctly lower short-circuit current density (J_(sc)) and fill factor. Notably, the aggregation effect of donor polymer has also been found to be associated with the energy level shifts, and thus the variation of charge transfer energy and voltage losses for blend system. The results suggest that simultaneously reduced voltage loss and increased J_(sc) can be expected by further finely tuning the aggregation behavior of the ester-modified oligothiophene-based donor polymer.

关键词： Organic solar cells Polymers Ester-modified oligothiophene Fluorine Aggregation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

铜复合金属材料抗菌特性试验研究

引用

工业微生物 2024年第4期54卷 75-81页

作者：于劲松黄煦任方圆仲歆怡曹慧袁敏叶泰吴秀秀郝丽玲徐斐上海理工大学健康科学与工程学院上海200093 上海食品快速检测工程技术研究中心上海200093

文章将大肠埃希氏菌作为试验菌种,采用平板计数法评价铜及铜复合金属材料的抗菌性能。试验中,将适宜稀释度的菌悬液分别滴加在空白样本(聚乙烯片)和实验样本(白铜片、磷铜片和铍青铜片)上接触培养一段时间,洗脱后将洗脱液涂布于平板上... 详细信息

文章将大肠埃希氏菌作为试验菌种,采用平板计数法评价铜及铜复合金属材料的抗菌性能。试验中,将适宜稀释度的菌悬液分别滴加在空白样本(聚乙烯片)和实验样本(白铜片、磷铜片和铍青铜片)上接触培养一段时间,洗脱后将洗脱液涂布于平板上进行培养,并进行菌落计数,以研究铜合金材料的抗菌特性,探索铜合金抗菌材料在诸多领域的深入应用。结果表明,接触白铜、磷铜、铍青铜3种材料24 h,稀释10~5倍的菌液培养24 h后基本无菌落生长。试验结果显示,铜合金材料的平均抗菌率R≥99%,且材料中起主要抗菌作用的成分是铜。铜合金材料的抗菌率与纯铜材料的抗菌率相近,且结果均符合Ⅰ级抗细菌率标准,所以判断这三类铜合金材料均具有强抗菌效果。

关键词：铜复合材料抗菌性大肠埃希氏菌

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Interfacial engineering of transition-metal sulfides heterostructures with built-in electric-field effects for enhanced oxygen evolution reaction

引用

Chinese Journal of Chemical Engineering 2022年第1期35卷 320-328页

作者： Shan Ni Hongnan Qu Huifang Xing Zihao xu Xiangyang Zhu Menglei yuan Meng Rong Li Wang Jiemiao Yu Yanqing Li Liangrong Yang Huizhou Liu CAS Key Laboratory of Green Process and Engineering State Key Laboratory of Biochemical EngineeringInstitute of Process EngineeringChinese Academy of SciencesBeijing 100190China School of Chemical Engineering University of Chinese Academy of SciencesBeijing 100049China Qingdao Institute of Bioenergy and Bioprocess Technology Chinese Academy of SciencesQingdao 266061China

Developing highly efficient,durable,and non-noble electrocatalysts for the sluggish anodic oxygen evolution reaction(OER)is the pivotal for meeting the practical demand in water ***,the current transition-metal electrocatalysts still suffer from low activity and durability on account of poor interfacial reaction *** this work,a facile solid-state synthesis strategy is developed to construct transition-metal sulfides heterostructures(denoted as MS_(2)/NiS_(2),M=Mo or W)for boosting OER *** a result,MoS2/NiS2 and WS2/NiS2 show lower overpotentials of 300 mV and 320 mV to achieve the current density of 10 mA·cm^(-2),and smaller Tafel slopes of 60 ***^(-1) and 83 ***^(-1)in 1 mol·L^(-1) KOH,respectively,in comparison with the single MoS2,WS2,NiS2,as well as even the benchmark *** experiments reveal that the designed heterostructures have strong electronic interactions and spontaneously develop a built-in electric field at the heterointerface with uneven charge distribution based on the difference of band structures,which promote interfacial charge transfer,improve absorptivity of OH-,and modulate the energy level more comparable to the ***,the designed transition-metal sulfides heterostructures exhibit a remarkably high electrocatalytic activity for *** study provides a simple strategy to manipulate the heterostructure interface via an energy level engineering method for OER and can be extended to fabricate other heterostructures for various energy-related applications.

关键词： Oxygen evolution reaction Transition-metal sulfides heterostructures Heterointerface Built-in electric field

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

METTL3-mediated m^(6)A RNA methylation regulates dorsal lingual epithelium homeostasis

引用

International Journal of Oral Science 2022年第3期14卷 287-296页

作者： Qiuchan Xiong Caojie Liu Xin Zheng Xinyi Zhou Kexin Lei Xiaohan Zhang Qian Wang Weimin Lin Ruizhan Tong Ruoshi xu Quan yuan State Key Laboratory of Oral Diseases&National Clinical Research Center for Oral Diseases&West China Hospital of Stomatology Sichuan UniversityChengduChina Department of Thoracic Oncology Cancer Centerand Laboratory of Clinical Cell TherapyWest China HospitalSichuan UniversityChengduChina

The dorsal lingual epithelium,which is composed of taste buds and keratinocytes differentiated from K14^(+)basal cells,discriminates taste compounds and maintains the epithelial barrier.N6-methyladenosine(m^(6)A)is the most abundant mRNA modification in eukaryotic *** METTL3-mediated m^(6)A modification regulates K14^(+)basal cell fate during dorsal lingual epithelium formation and regeneration remains *** we show knockout of Mettl3 in K14^(+)cells reduced the taste buds and enhanced *** of Mettl3 led to increased basal cell proliferation and decreased cell division in taste *** Mettl3 knock-in mice showed little impact on taste buds or keratinization,but displayed increased proliferation of cells around taste buds in a protective manner during post-irradiation ***,we revealed that the most frequent m^(6)A modifications were enriched in Hippo and Wnt signaling,and specific peaks were observed near the stop codons of Lats1 and *** study elucidates that METTL3 is essential for taste bud formation and could promote the quantity recovery of taste bud after radiation.

关键词： METTL3-mediated m^(6)A RNA methylation regulates dorsal lingual epithelium homeostasis RNA

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Feasibility of Transabdominal Real-time CDFI and HDFI Techniques for Fetal Pulmonary Vein Display in the First Trimester

引用

Current Medical Science 2022年第3期42卷 635-641页

作者： Dong-mei LIN Yun-xiao ZHU Ying TAN Yu-jun HUANG Kun yuan Wen-fen LIU Zuo-feng xu Department of Medical Ultrasonics the Seventh Affiliated Hospital of Sun Yat-sen UniversityShenzhen 518107China Department of Medical Ultrasonics South China Hospital of Shenzhen UniversityShenzhen 518000China

Objective This study aimed to assess the feasibility and usefulness of transabdominal color Doppler flow imaging(CDFI)technology and the high-definition flow imaging(HDFI)technique in detecting fetal pulmonary veins(PVs)in the first trimester(11–13^(+6)weeks).Methods From December 2018 to October 2019,328 pregnant women with 328 normal singleton fetuses(crown-rump length:45–84 mm)who had undergone CDFI and HDFI scans for fetal heart and vessel examination were enrolled in this *** cases were divided into three groups according to the gestational age:group A,11^(+0)−11^(+6)weeks;group B,12^(+0)−12^(+6)weeks;and group C,13^(+0)−13^(+6)*** sonograms and CDFI and HDFI images were analyzed by two senior radiologists independently and *** abilities of CDFI and HDFI to display PVs were *** Successful PV display rates via CDFI and HDFI were 2.3%and 68.2%(P<0.01),22.4%and 82.4%(P<0.01),41.5%and 91.2%(P<0.01)for group A,group B,and group C,*** total successful display rates for the two methods were 28.9%(CDFI)and 84.8%(HDFI)(P<0.01).Conclusions The HDFI technique is more valuable than CDFI for detecting PVs in early pregnancy(11–13^(+6)weeks).HDFI can detect at least one PV in all cases and may be used to detect pulmonary venous anomalies early.

关键词： pulmonary vein first trimester prenatal sonography high-definition flow imaging color Doppler flow imaging

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

3D-printed Mechanically Strong Calcium Phosphate Cement Scaffold with Metformin/Stem Cell-encapsulating Alginate Microbeads for Bone Tissue Engineering

引用

Journal of Bionic Engineering 2022年第6期19卷 1658-1670页

作者： Xiong Xiong yuanyuan Chen Rupan yuan Gengtao Qiu Michael D.Weir Hockin H.K.xu Jin Liu Jianping Ruan Xiaofeng Chang Shuxin Qu School of Life Science and Engineering Southwest Jiaotong UniversityChengdu610031China Sichuan Engineering Research Center for Biomimetic Synthesis of Natural Drugs School of Life Science and EngineeringSouthwest Jiaotong UniversityChengdu610031China Key Lab of Advanced Technologies of Materials Ministry of EducationSchool of Materials Science and EngineeringSouthwest Jiaotong UniversityChengdu610031China Department of Advanced Oral Sciences and Therapeutics University of Maryland School of DentistryBaltimoreMD21201USA Center for Stem Cell Biology and Regenerative Medicine University of Maryland School of MedicineBaltimoreMD21201USA University of Maryland Marlene and Stewart Greenebaum Cancer Center University of Maryland School of MedicineBaltimoreMD21201USA Key Laboratory of Shannxi Province for Craniofacial Precision Medicine Research Clinical Research Center of Shannxi Province for Dental and Maxillofacial DiseasesCollege of StomatologyXi’an Jiaotong UniversityXi’anShannxi710004China

The utilization of Calcium Phosphate Cement(CPC)is limited due to its low mechanical strength and difficulty to seed cells deep into the *** objectives of this study were to:(1)develop a 3D-printed CPC-dopamine-metformin scaffold encapsulating human periodontal ligament stem cells(hPDLSCs),(2)investigate the effect of dopamine on the performance of CPC,and(3)evaluate the effect of microbead degradation and metformin release on the osteogenic differentiation of the released *** mechanical property of the CPC scaffolds was elevated by adding dopamine,and the CPC scaffold with 7 wt.%dopamine had the highest compressive strength(7.35 MPa).Four types of microbeads with different content of alginate(oxidized alginate),hPDLSCs,and 2%metformin were *** and cell counting kit tests confirm that the hPDLSCs are protected by microbeads encapsulation during the CPC setting *** alkaline phosphatase test indicates that the osteogenic differentiation of hPDLSCs was enhanced by the fast release of cells and *** microbeads consisting of 2%oxidized alginate and 2%metformin were optimal for cell delivery due to favorable cell release and osteogenic *** CPC scaffold is promising used for bone regeneration in dental,craniofacial,and orthopedic applications.

关键词： Calcium phosphate cement 3D Printing Bionic Alginate microbeads Metformin

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A multichannel optical computing architecture for advanced machine vision

引用

Light(Science & Applications) 2022年第9期11卷 2235-2247页

作者： ZHIHAO xu XIAOYUN yuan TIANkuang ZHOU LU FANG Sigma Laboratory Department of Electronic EngineeringTsinghua UniversityBeijingChina Beijing National Research Center for Information Science and Technology(BNRist) BeijingChina Tsinghua Shenzhen International Graduate School ShenzhenChina Institute for Brain and Cognitive Science Tsinqhua University(THUIBCS)BeijingChina

Endowed with the superior computing speed and energy efficiency,optical neural networks(ONNs)have attracted ever-growing attention in recent *** optical computing architectures are mainly single-channel due to the lack of advanced optical connection and interaction operators,solving simple tasks such as hand-written digit classification,saliency detection,*** limited computing capacity and scalability of single-channel ONNs restrict the optical implementation of advanced machine ***,we develop Monet:a multichannel optical neural network architecture for a universal multiple-input multiple-channel optical computing based on a novel projection-interference-prediction framework where the inter-and intra-channel connections are mapped to optical interference and *** our Monet,optical interference patterns are generated by projecting and interfering the multichannel inputs in a shared *** patterns encoding the correspondences together with feature embeddings are iteratively produced through the projection-interference process to predict the final output *** the first time,Monet validates that multichannel processing properties can be optically implemented with high-efficiency,enabling real-world intelligent multichannel-processing tasks solved via optical computing,including 3D/motion *** experiments on different scenarios demonstrate the effectiveness of Monet in handling advanced machine vision tasks with comparative accuracy as the electronic counterparts yet achieving a ten-fold improvement in computing *** intelligent computing,the trends of dealing with real-world advanced tasks are *** the capacity and scalability limitations of single-channel ONN and further exploring the multichannel processing potential of wave optics,we anticipate that the proposed technique will accelerate the development of more powerful optical Al as critical support for modern advanced mach

关键词： computing multichannel projection

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

An investigation into the occupational protection status of clinical nursing staff exposed to anti-tumor drugs

引用

Journal of Medical Colleges of PLA(China) 2012年第2期27卷 113-119页

作者： yuan Yanqin xu Dezhong Department of Burn ＆ Plastic Surgery Tangdu Hospital Fourth Military Medical University Xi ＂an 710038 China Department of Epidemiology Fourth Military Medical University Xi ＇an 710032 China

Objective:To investigate the occupational protection status of clinical nursing staff vocationally exposed to anti-tumor ***:A self-designed questionnaire was used to survey 180 clinical nursing staff vocationally exposed to anti-tumor ***:Recognition of the need for protection and dependent occupational protection behaviors were very poor in clinical nursing staff vocationally exposed to anti-tumor *** management of the occupational protection of clinical nursing staff vocationally exposed to anti-tumor drugs was also seriously ***:There is deficiency in the understanding and related protection practices of clinical nursing staff vocationally exposed to anti-tumor drugs in our *** protection measures currently employed in medical practice are inadequate in virtually every aspect *** is recommended that all clinical nursing staff should receive full occupational protection training in these *** training must raise nursing staff's awareness of the need for occupational protection and standardize their occupational protection behaviors to conform to "best practice" *** "best practice" models should be quickly established and all staff made cognizant of them *** addition,where occupational protection systems are already in place,they should be improved to come into line with the new "best practice" models instigated.

关键词： Nursing staff Anti-tumor drug Occupational protection

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Thermal runaway propagation behavior of the Cell-to-Pack battery system

引用

Journal of Energy Chemistry 2023年第9期84卷 162-172页

作者： Huaibin Wang Qinzheng Wang Zhenyang Zhao Changyong Jin Chengshan xu Wensheng Huang Zhuchen yuan Shuyu Wang Yang Li Yanhong Zhao Junli Sun xuning Feng China People’s Police University LangFang 065000HebeiChina State Key Laboratory of Intelligent Green Vehicle and Mobility Tsinghua UniversityBeijing 100084China Laboratory of Explosion Science and Technology Beijing Institute of TechnologyBeijing 100084China Beijing Electric Vehicle Co.Ltd Beijing 100176China College of Mechanical Engineering University of Shanghai for Science and TechnologyShanghai 200093China

Structurally compact battery packs significantly improve the driving range of electric *** like Cell-to-Pack increase energy density by 15%-20%.However,the safety implications of multiple tightly-packed battery cells still require in-depth *** paper studies thermal runaway propagation behavior in a Cell-to-Pack system and assesses propagation speed relative to other *** investigation includes temperature response,extent of battery damage,pack structure deformation,chemical analysis of debris,and other *** suggest three typical patterns for the thermal runaway propagation process:ordered,disordered,and *** synchronous propagation pattern displayed the most severe damage,indicating energy release is the largest under the synchronous *** study identifies battery deformation patterns,chemical characteristics of debris,and other observed factors that can both be applied to identify the cause of thermal runaway during accident investigations and help promote safer designs of large battery packs used in large-scale electric energy storage systems.

关键词： Energy storage Cell-to-Pack Lithium-ion battery Thermal runaway Battery safety

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：