METTL3-mediated m^(6)A RNA methylation regulates dorsal lingual epithelium homeostasis

作     者：Qiuchan Xiong Caojie Liu Xin Zheng Xinyi Zhou Kexin Lei Xiaohan Zhang Qian Wang Weimin Lin Ruizhan Tong Ruoshi Xu Quan Yuan Qiuchan Xiong;Caojie Liu;Xin Zheng;Xinyi Zhou;Kexin Lei;Xiaohan Zhang;Qian Wang;Weimin Lin;Ruizhan Tong;Ruoshi Xu;Quan Yuan

作者机构：State Key Laboratory of Oral Diseases&National Clinical Research Center for Oral Diseases&West China Hospital of StomatologySichuan UniversityChengduChina Department of Thoracic OncologyCancer Centerand Laboratory of Clinical Cell TherapyWest China HospitalSichuan UniversityChengduChina 

出 版 物：《International Journal of Oral Science》 (国际口腔科学杂志（英文版）)

年 卷 期：2022年第14卷第3期

页      面：287-296页

核心收录：

学科分类：1003[医学-口腔医学] 1001[医学-基础医学(可授医学、理学学位)] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China(81970913 and 82125006) 

主　　题：METTL3-mediated m^(6)A RNA methylation regulates dorsal lingual epithelium homeostasis RNA 

摘      要：The dorsal lingual epithelium,which is composed of taste buds and keratinocytes differentiated from K14^(+)basal cells,discriminates taste compounds and maintains the epithelial barrier.N6-methyladenosine(m^(6)A)is the most abundant mRNA modification in eukaryotic *** METTL3-mediated m^(6)A modification regulates K14^(+)basal cell fate during dorsal lingual epithelium formation and regeneration remains *** we show knockout of Mettl3 in K14^(+)cells reduced the taste buds and enhanced *** of Mettl3 led to increased basal cell proliferation and decreased cell division in taste *** Mettl3 knock-in mice showed little impact on taste buds or keratinization,but displayed increased proliferation of cells around taste buds in a protective manner during post-irradiation ***,we revealed that the most frequent m^(6)A modifications were enriched in Hippo and Wnt signaling,and specific peaks were observed near the stop codons of Lats1 and *** study elucidates that METTL3 is essential for taste bud formation and could promote the quantity recovery of taste bud after radiation.