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Effects of the planarity and heterogeneity of networks on evolutionary two-player games

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Chinese Physics B 2018年第12期27卷 164-171页

作者： xu-sheng liu Zhi-Xi Wu Jian-Yue Guan Institute of Computational Physics and Complex Systems Lanzhou University

We study the effects of the planarity and heterogeneity of networks on evolutionary two-player symmetric games by considering four different kinds of networks, including two types of heterogeneous networks: the weighted planar stochastic lattice(a planar scale-free network) and the random uncorrelated scale-free network with the same degree distribution as the weighted planar stochastic lattice; and two types of homogeneous networks: the hexagonal lattice and the random regular network with the same degree k_0= 6 as the hexagonal lattice. Using extensive computer simulations, we found that both the planarity and heterogeneity of the network have a significant influence on the evolution of cooperation, either promotion or inhibition, depending not only on the specific kind of game(the Harmony, Snowdrift, Stag Hunt or Prisoner's Dilemma games), but also on the update rule(the Fermi, replicator or unconditional imitation rules).

关键词： evolutionary two-player games planarity heterogeneity

Steroid hormone 20-hydroxyecdysone promotes CTL1-mediated cellular immunity in Helicoverpa armigera

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Insect Science 2021年第5期28卷 1399-1413页

作者： Gui-Jie Wang Wen-Wen Wang Yu liu Lian-Qin Chai Guo-Xiu Wang xu-sheng liu Yu-Feng Wang Jia-Lin Wang Hubei Key Laboratory of Genetic Regulation and Integrative Biology School of Life SciencesCentral China Normal UniversityWuhan 430079China School of Life Sciences Henan UniversityKaifengHenan475004China

Mermithid nematodes,such as Ovomermis sinensis,are used as biological control agents against many insect pests,including cotton bollworm(Helicoverpa armigera).However,given the host's robust immune system,the infection rate of *** is low,thus restricting its widespread *** understand the host defense mechanisms against mermithid nematodes,we identified and characterized a protein involved in the recognition of ***,the potential ***-binding protein C-type lectin 1(HaCTLla and/or HaCTLIb),which was eluted from the surface of *** after incubation with *** *** is homologous to the previously reported HaCTLla *** was predominantly expressed in hemocytes and was induced by the steroid hormone 20-hydroxyecdysone through ecdysone receptor(HaEcR)or ultraspiracle(HaUSP),or *** assays confirmed the interactions of the HaCTLI proteins with *** but not with Romanomermis wuchangensis,a parasitic nematode of ***,the HaCTL1 proteins were secreted into the hemocoel and promoted hemocyte-mediated encapsulation and phagocytosis.A knockdown of HaEcR and/or HaUSP resulted in compromised encapsulation and ***,HaCTLI appears to modulate cellular immunity in the defense against parasitic nematodes,and the 20-hydroxyecdysone-HaEcR-HaUSP complex is involved in regulating the process.

关键词： C-type lectin encapsulation phagocytosis 20-hydroxyecdysone

Enhanced Field Emission from Large-Area Arrays of WlsO49 Pencil-Like Nanostructure

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Chinese Physics Letters 2010年第6期27卷 262-265页

作者： LI Zheng-Lin DENG Shao-Zhi xu Ning-sheng liu Fei CHEN Jun State Key Lab of Optoelectronic Materials and Technologies and Guangdong Province Key Laboratory of Display Material and Technology School of Physics and Engineering Sun Yat-Sen University Guangzhou 510275

Field enhancement and field screening are two major factors affecting field emission performance of arrays of quasi one-dimensional nanostruetures. We have observed enhanced field emission from large-area arrays of W18O49 pencil-like nanostructure due to both the effects of high aspect ratio and enlarged spacing between neighboring nanostructures. These arrays may be grown on silicon substrates by the multi-step thermal evaporation process. The spacing of nanotip-to-nanotip between neighboring nanostruetures may be increased by adjusting the growth temperature. The arrays are observed to have a typical turn-on field as low as about 1.26 MV/m and a threshold field as low as about 3.39 MV/m, resulting in increasing field enhancement and decreasing field screening effect.

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岸线形态与近岸底泥元素分布特征的相关性分析

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南京林业大学学报（自然科学版） 2017年第2期41卷 9-14页

作者：袁芳陈怀艳康昕盛晟徐驰刘茂松南京大学生命科学学院江苏南京210046 中国电建集团华东勘测设计研究院有限公司浙江杭州310014

【目的】岸线形态影响近岸水体的水动力状况、沉积过程、微生境及植被特征,对近岸沉积物的物理与化学特征有直接影响,研究其与近岸底泥元素空间分布的相互关系,用以指导滨岸带的生态修复。【方法】以太湖北部贡湖湾退圩还湖修复项目区... 详细信息

【目的】岸线形态影响近岸水体的水动力状况、沉积过程、微生境及植被特征,对近岸沉积物的物理与化学特征有直接影响,研究其与近岸底泥元素空间分布的相互关系,用以指导滨岸带的生态修复。【方法】以太湖北部贡湖湾退圩还湖修复项目区为研究对象,分别在项目区选取凹形、凸形和平直形3种岸线形态,按浅滩区、浅水区和深水区3个水深梯度采集样品,分析了不同微生境条件下底泥的粒级结构特征和总磷(TP)、总氮(TN)、有机碳(OC)的含量。【结果】(1)凹形、凸形岸线形态段不同水深梯度带间底泥粒级结构的差异均较大,而平直岸线段底泥粒级结构在水深梯度上的变化幅度相对较小,且不同岸线形态段间随水深的变化趋势不同,近岸底泥平均粒径在凸形岸线段随水深增加而增加,在凹形岸线段随水深增加而下降;(2)滨岸带近岸表层底泥中TN、TP、OC含量在凹形、凸形岸线形态段随水深的变化总体上大于平直岸线段,凹形和凸形岸线段近岸深水区TN、有机碳含量最高,TP在凸岸线段浅水区最低;(3)冗余分析发现,岸线形态与植被状况(植被类型、水深、植被盖度)是影响近岸底泥中TN、TP和有机碳含量的主要影响因子,而底泥的粒级结构特征与底泥中TN、TP和OC含量的相关性相对较小。【结论】与平直岸线相比,相对曲折的岸线形态更有利于增加不同水深梯度带底泥的异质性,对底泥元素的空间分布格局有显著影响。在湖滨带生态修复时,通过构建相对曲折的岸线形态,可有效促进不同水深底泥TN、TP、有机碳的再分配。

关键词：岸线形态生态修复冗余分析底泥粒级结构太湖地区

One-pot Synthesis of Spiroglycol

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One-pot Synthesis of Spiroglycol

The burden of upper motor neuron involvement is correlated with the bilateral limb involvement interval in patients with amyotrophic lateral sclerosis:a retrospective observational study

第三届全国化学工程与生物化工年会

作者： Jun Ming xu, Fu sheng liu, Shi Tao YU (College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao 266042,P.R.China)

＜正＞A novel synthesis of 5 through one-pot reaction was described. Under the optimum reacting conditions, the total yield and purity of 5 were 93.6% and 99.0% respectively. Compared with conventional method, total y... 详细信息

关键词： one-pot spiroglycol synthesis

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Neural Regeneration Research 2025年第5期20卷 1505-1512页

作者： Jieying Wu Shan Ye Xiangyi liu Yingsheng xu Dongsheng Fan Department of Neurology Peking University Third HospitalBeijingChina Beijing Municipal Key Laboratory of Biomarker and Translational Research in Neurodegenerative Diseases BeijingChina Key Laboratory for Neuroscience National Health Commission/Ministry of EducationPeking UniversityBeijingChina

Amyotrophic lateral sclerosis is a rare neurodegenerative disease characterized by the involvement of both upper and lower motor *** bilateral limb involvement significantly affects patients'daily lives and may lead them to be confined to ***,the effect of upper and lower motor neuron impairment and other risk factors on bilateral limb involvement is *** address this issue,we retrospectively collected data from 586 amyotrophic lateral sclerosis patients with limb onset diagnosed at Peking University Third Hospital between January 2020 and May 2022.A univariate analysis revealed no significant differences in the time intervals of spread in different directions between individuals with upper motor neuron-dominant amyotrophic lateral sclerosis and those with classic amyotrophic lateral *** used causal directed acyclic graphs for risk factor determination and Cox proportional hazards models to investigate the association between the duration of bilateral limb involvement and clinical baseline characteristics in amyotrophic lateral sclerosis *** factor analyses revealed that higher upper motor neuron scores(hazard ratio[HR]=1.05,95%confidence interval[CI]=1.01–1.09,P=0.018),onset in the left limb(HR=0.72,95%CI=0.58–0.89,P=0.002),and a horizontal pattern of progression(HR=0.46,95%CI=0.37–0.58,P<0.001)were risk factors for a shorter interval until bilateral limb *** results demonstrated that a greater degree of upper motor neuron involvement might cause contralateral limb involvement to progress more quickly in limb-onset amyotrophic lateral sclerosis *** findings may improve the management of amyotrophic lateral sclerosis patients with limb onset and the prediction of patient prognosis.

关键词： amyotrophic lateral sclerosis bilateral limb involvement Cox proportional hazards regression model horizontal spread restricted cubic spline analysis time interval upper motor neuron vertical spread

Development of a nomogram for overall survival in patients with esophageal carcinoma:A prospective cohort study in China

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 158-168页

作者： Shi-Shi Yu Xi Zheng Xiao-sheng Li Qian-Jie xu Wei Zhang Zhong-Li Liao Hai-Ke Lei Department of Gastroenterology Chongqing University Cancer HospitalChongqing 400030China Chongqing Cancer Multi-omics Big Data Application Engineering Research Center Chongqing University Cancer HospitalChongqing 400030China Department of Health Statistics School of Public HealthChongqing Medical UniversityChongqing 400016China

BACKGROUND Esophageal carcinoma(EC)presents a significant public health issue in China,with its prognosis impacted by myriad *** creation of a reliable prog-nostic model for the overall survival(OS)of EC patients promises to greatly advance the customization of treatment *** To create a more systematic and practical model that incorporates clinically significant indicators to support decision-making in clinical *** This study utilized data from a prospective longitudinal cohort of 3127 EC patients treated at Chongqing University Cancer Hospital between January 1,2018,and December 12,*** the least absolute shrinkage and selection operator regression alongside multivariate Cox regression analyses helped pinpoint pertinent variables for constructing the *** efficacy was assessed by concordance index(C-index),area under the receiver operating characteristic curve(AUC),calibration curves,and decision curve analysis(DCA).RESULTS Nine variables were determined to be significant predictors of OS in EC patients:Body mass index(BMI),Karnofsky performance status,TNM stage,surgery,radiotherapy,chemotherapy,immunotherapy,platelet-to-lymphocyte ratio,and albumin-to-globulin ratio(ALB/GLB).The model demonstrated a C-index of 0.715(95%CI:0.701-0.729)in the training cohort and 0.711(95%CI:0.689-0.732)in the validation *** the training cohort,AUCs for 1-year,3-year,and 5-year OS predictions were 0.773,0.787,and 0.750,respectively;in the validation cohort,they were 0.772,0.768,and 0.723,respectively,illustrating the model's *** curves and DCA verified the model's predictive accuracy and net *** A novel prognostic model for determining the OS of EC patients was successfully developed and validated to help clinicians in devising individualized treatment schemes for EC patients.

关键词： Esophageal carcinoma High-risk factors Prognosis Overall survival Prediction model

煤油超燃冲压发动机两相流场数值模拟(I)数值校验及总体流场特征

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推进技术 2004年第6期25卷 484-490页

作者：黄生洪徐胜利刘小勇中国科学技术大学力学和机械工程系安徽合肥230026 航天科工集团公司31所北京100074

针对一种带三维导流型凹槽的煤油超燃冲压发动机,考虑两相(颗粒随机轨道方法)、湍流(Menter的SSTk ω模型)和多步燃烧机理(代用燃料C12H23的17组分30步化学反应机理),对飞行马赫数M0为4和6的典型工况开展了初步数值研究。结果流道壁面... 详细信息

针对一种带三维导流型凹槽的煤油超燃冲压发动机,考虑两相(颗粒随机轨道方法)、湍流(Menter的SSTk ω模型)和多步燃烧机理(代用燃料C12H23的17组分30步化学反应机理),对飞行马赫数M0为4和6的典型工况开展了初步数值研究。结果流道壁面压强分布与试验值取得了较好的吻合,不过M0=6工况的第一凹槽组附近的存在约23%的数值误差。给出了误差原因。进一步分析表明(1)M0=6工况的分段燃料喷注对整体燃烧产生了有利影响,导致了较高的燃烧效率。(2)M0=4工况采用了不合理喷注参数,结果煤油穿透深度不足,获得了较低的燃烧效率。(3)三维导流型凹槽附近的湍流效应明显,对掺混产生了有利影响。不过超声速主流的湍流强度远大于亚声速主流情况。

关键词：冲压喷气发动机超音速燃烧二相流,湍流数值仿真

Small extracellular vesicles derived from human induced pluripotent stem cell-differentiated neural progenitor cells mitigate retinal ganglion cell degeneration in a mouse model of optic nerve injury

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Neural Regeneration Research 2025年第2期20卷 587-597页

作者： Tong Li Hui-Min Xing Hai-Dong Qian Qiao Gao sheng-Lan xu Hua Ma Zai-Long Chi State Key Laboratory of Ophthalmology Optometry and Visual ScienceEye HospitalWenzhou Medical UniversityWenzhouZhejiang ProvinceChina National Clinical Research Center for Ocular Diseases Eye HospitalWenzhou Medical UniversityWenzhouZhejiang ProvinceChina

Several studies have found that transplantation of neural progenitor cells(NPCs)promotes the survival of injured ***,a poor integration rate and high risk of tumorigenicity after cell transplantation limits their clinical *** extracellular vesicles(sEVs)contain bioactive molecules for neuronal protection and *** studies have shown that stem/progenitor cell-derived sEVs can promote neuronal survival and recovery of neurological function in neurodegenerative eye diseases and other eye *** this study,we intravitreally transplanted sEVs derived from human induced pluripotent stem cells(hiPSCs)and hiPSCs-differentiated NPCs(hiPSC-NPC)in a mouse model of optic nerve *** results show that these intravitreally injected sEVs were ingested by retinal cells,especially those localized in the ganglion cell *** with hiPSC-NPC-derived sEVs mitigated optic nerve crush-induced retinal ganglion cell degeneration,and regulated the retinal microenvironment by inhibiting excessive activation of *** analysis further revealed that hiPSC-NPC derived sEVs transported neuroprotective and anti-inflammatory miRNA cargos to target cells,which had protective effects on RGCs after optic nerve *** findings suggest that sEVs derived from hiPSC-NPC are a promising cell-free therapeutic strategy for optic neuropathy.

关键词： exosome miRNA neural progenitor cell neurodegeneration neuroinflammation neuroprotection optic nerve crush optic neuropathy retinal ganglion cell small extracellular vesicles