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Neural Regeneration Research 2011年第10期6卷 762-766页

作者： Jingdong Zhang Kan xu Jinlu yu jun Wang Qi Luo Department of Neurosurgery First Hospital of Jilin University Changchun 130021 Jilin Province China

Calcium alginate gel（CAG） has been shown to successfully model aneurysm embolization within a short period of ***,gradually degrading CAG potentially results in aneurysm *** the present study,a regenerative embolic material was designed by seeding rat fibroblasts in a *** study investigated the feasibility of constructing a 3-dimensional culture *** fibroblasts grew well and firmly attached to the *** was conducive for fibroblast growth,and resulted in a 3-dimensional culture *** show that CAG can be used theoretically as a vascular,regenerative,embolic material.

关键词： intracranial aneurysm embolic material detachable coil fibroblast alginate neural regeneration

Cuproptosis mediates copper-induced testicular spermatogenic cell death

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Asian Journal of Andrology 2024年第3期26卷 295-301页

作者： Jing-Yi Zhang xu-jun yu jun-jun Li Yao Xiao Guang-Sen Li Fang Yang Liang Dong Chengdu University of Traditional Chinese Medicine Chengdu 611137China Chengdu Fifth People’s Hospital The Fifth People’s Hospital of Chengdu University of Traditional Chinese MedicineChengdu 611130China TCM Regulating Metabolic Diseases Key Laboratory of Sichuan Province Hospital of Chengdu University of Traditional Chinese MedicineChengdu 610072China Department of Surgery The Reproductive and Women-Children HospitalChengdu University of Traditional Chinese MedicineChengdu 610041China

Cuproptosis,a novel mechanism of programmed cell death,has not been fully explored in the context of spermatogenic *** investigated the potential involvement of cuproptosis in spermatogenic cell death using a mouse model of copper *** male Institute of Cancer Research(ICR)mice were randomly divided into four groups that received daily oral gavage withsodium chloride(control)or copper sulfate(CuSO_(4))at 50 mg kg^(−1),100 mg kg^(−1),or 200 mg kg^(−1),for 42 consecutive *** to copper overload exhibited a disruption in copper ***,significant upregulated expression of keycuproptosis factors was accompanied by a significant rise in the rates of testicular tissue cell *** revealed the presence of ferredoxin 1(Fdx1)in Sertoli cells,Leydig cells,and spermatogenic cells at various stages oftesticular development,and the Fdx1-positive staining area was significantly increased in copper-overloaded *** and decreased adenosine triphosphate levels were also observed,further implicating mitochondrial damage *** analyses revealed pathological lesions and blood−testis barrier destruction in the testicular tissue,accompaniedby decreased sperm concentration and motility,in copper-overloaded *** summary,our results indicate that copper-overloadedmice exhibit copper homeostasis disorder in the testicular tissue and that cuproptosis participates in spermatogenic cell *** findings provide novel insights into the pathogenic mechanisms underlying spermatogenic cell death and provide initialexperimental evidence for the occurrence of cuproptosis in the testis.

关键词： blood−testis barrier cuproptosis ferredoxin 1 spermatogenic cell death

Vapor Online Monitor Model of Vapor Power Station Based on UML

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Wuhan University Journal of Natural Sciences 2001年第4期6卷 775-778页

作者： Jin Ye, Tang xu\|zhang, yu jun\|qing, Zhou Dong\|ru School of Computer, Wuhan University, Wuhan 430072, China School of Computer Wuhan University Wuhan China

We presents a vapor online monitor system model of vapor power station developed by visual tool rational rose 2000. Use cases such as on line instrument (onlineinstr), control, query, report, real database (realdb) and alarm are generated according to the system requirements. Use case view and class view of the system are formed at the same time. As for all the UML models of the system, this paper focuses the discussion on the class view, the component diagram of the control class and the sequence diagram of the query class. Corresponding C++ codes are produced and finally transferred into the spot running software.

关键词： online monitor model UML

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典型平滑滤波的数字图像被动取证

电子与信息学报 2013年第10期35卷 2287-2293页

作者：徐俊瑜苏育挺天津大学电子信息工程学院天津300072

数字图像被动取证技术是国际上正在兴起的一个研究领域,它在不需要其它辅助信息的条件下,仅根据接收到的数字图像,即可实现对图像资源的真实性和完整性验证。针对数字图像处理和编辑篡改中常用的一种处理模式——平滑滤波,该文设计了一... 详细信息

数字图像被动取证技术是国际上正在兴起的一个研究领域,它在不需要其它辅助信息的条件下,仅根据接收到的数字图像,即可实现对图像资源的真实性和完整性验证。针对数字图像处理和编辑篡改中常用的一种处理模式——平滑滤波,该文设计了一种基于频域残差的图像滤波检测算法。首先,在检测端对待测图像进行低通滤波,获取并分析其频域残差特性;其次,将频域残差转换到归一化的Radon域;最后,对Radon变换曲线建模,将模型参数作为滤波检测的分类特征。实验结果表明,该算法对3种典型的空域滤波模板——高斯模板、均值模板、中值模板,均有较好的检测效果,并能对模板的尺寸做出判断,弥补了前人研究的不足。

关键词：数字图像取证平滑滤波 Radon变换

HIV-1 Subtype Diversity and Factors Affecting Drug Resistance among Patients with Virologic Failure in Antiretroviral Therapy in Hainan Province,China,2014–2020

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Biomedical and Environmental Sciences 2023年第9期36卷 800-813页

作者： yu De E xu yu jun LI Mu YANG yuan LIANG Hua yue ZHONG Shan Mei QIN Cai LAN Ya Nan LI Da Wei yu Ji Peng PANG yuan QIN xue Qiu LIANG Hao ZHU Kao Kao YE Li LIANG Bing yu Guangxi Key Laboratory of AIDS Prevention and Treatment School of Public HealthGuangxi Medical UniversityNanning 530021GuangxiChina International School of Public Health and One Health Hainan Medical UniversityHaikou 571199HainanChina Prevention and Treatment Department the Fifth People's Hospital of Hainan Province&Affiliated Dermatology Hospital of Hainan Medical UniversityHaikou 570102HainanChina Collaborative Innovation Centre of Regenerative Medicine and Medical BioResource Development and Application Co-constructed by the Province and Ministry Life Sciences InstituteGuangxi Medical UniversityNanning 530021GuangxiChina Oncology Medical College Guangxi Medical UniversityNanning 530021GuangxiChina The First Clinical Medical College Guangxi Medical UniversityNanning 530021GuangxiChinaGuangxi Key Laboratory of AIDS Prevention and TreatmentSchool of Public HealthGuangxi Medical UniversityNanning 530021GuangxiChina

Objective This study aimed to determine the HIV-1 subtype distribution and HIV drug resistance(HIVDR)in patients with ART failure from 2014 to 2020 in Hainan,*** A 7-year cross-sectional study was conducted among HIV/AIDS patients with ART failure in *** used online subtyping tools and the maximum likelihood phylogenetic tree to confirm the HIV subtypes with pol *** resistance mutations(DRMs)were analyzed using the Stanford University HIV Drug Resistance *** A total of 307 HIV-infected patients with ART failure were included,and 241 available pol sequences were *** 241 patients,CRF01_AE accounted for 68.88%,followed by CRF07_BC(17.00%)and eight other subtypes(14.12%).The overall prevalence of HIVDR was 61.41%,and the HIVDR against non-nucleoside reverse transcriptase inhibitors(NNRTIs),nucleotide reverse transcriptase inhibitors(NRTIs),and protease inhibitors(PIs)were 59.75%,45.64%,and 2.49%,*** patients,hypoimmunity or opportunistic infections in individuals,and samples from 2017 to 2020 increased the odd ratios of ***,HIVDR was less likely to affect female *** common DRMs to NNRTIs were K103N(21.99%)and Y181C(20.33%),and M184V(28.21%)and K65R(19.09%)were the main DRMs against *** The present study highlights the HIV-1 subtype diversity in Hainan and the importance of HIVDR surveillance over a long period.

关键词： HIV-1 subtypes Antiretroviral therapy Virological failure Drug resistance

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基于预印本的科学交流机制探析

科学技术哲学研究 2022年第4期39卷 111-116页

作者：许玉俊山西大学科技与社会研究所太原030006

随着科学技术的发展,学术交流形式呈现出多样化,预印本已成为学术交流的一种重要形式,它为科学家公开自己的研究成果及获取文献带来极大的自由性。然而,学界关于预印本的争论不绝于耳,且愈演愈烈。面对预印本在实践中的这种两难境地,有... 详细信息

随着科学技术的发展,学术交流形式呈现出多样化,预印本已成为学术交流的一种重要形式,它为科学家公开自己的研究成果及获取文献带来极大的自由性。然而,学界关于预印本的争论不绝于耳,且愈演愈烈。面对预印本在实践中的这种两难境地,有必要考察其出现的动力学基础,进而剖析预印本在科学交流系统中所蕴含的特征、发挥的功能及其被认可度,这对于反思科学研究成果的内在交流机制具有重要的现实意义。

关键词：预印本学术交流出版

Toosendanin increases free-Ca2+ concentration in NG108-15 cells υia L-type Ca2+ channels

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Acta Pharmacologica Sinica 2004年第5期 55-59页

作者： Tong-hui xu, jun DING, yu-liang SHI2Key Laboratory of Neurobiology, Shanghai Institutes for Biological Sciences,Chinese Academy of Sciences, Shanghai 200031, China

AIM: To examine if toosendanin (TSN) affects intracellular free-Ca2+ concentration ([Ca2+]i) in neuroblastomagliomahybrid cells (NG108-15 cells). METHODS: The [Ca2+]i was determined by laser-scanning confocal microscopicimaging technique in which Fluo-3 was used as Ca2+ indicator. RESULTS: TSN induced an increase in resting[Ca2+]i and in high K+-evoked Ca2+ transient in differentiated NG108-15 cells. The TSN-induced increase in [Ca2+]iwas dose-dependent and disappeared in CdCl2-, nifedipine-containing or Ca2+-free solution, and appeared afterwashing out the Ca2+ channel blockers or adding Ca2+. CONCLUSION: TSN increased [Ca2+]i in differentiatedNG108-15 cells. The [Ca2+]i enhancement was due to the influx of extracellular Ca2+ and related to L-type Ca2+channels.

关键词： toosendanin intracellular calcium concentration confocal microscopy calcium indicator neuroblastomaglioma hybrid cells L-type Ca2+ channels

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一种高效率低电压3倍负压电荷泵的设计

电子科技大学学报 2005年第1期34卷 73-76页

作者：徐骏宇高正平电子科技大学微电子与固体电子学院成都610054

根据正压电荷泵的理论推导出负压电荷泵的基本单元,得出了低电压供电的2倍负压泵和为提高其效率而采取的一些优化方法。最后在2倍负压泵的基础上给出一个1.5V工作电压高性能3倍负压泵的设计实例。该3倍负压泵的设计经流片证明是成功的,... 详细信息

根据正压电荷泵的理论推导出负压电荷泵的基本单元,得出了低电压供电的2倍负压泵和为提高其效率而采取的一些优化方法。最后在2倍负压泵的基础上给出一个1.5V工作电压高性能3倍负压泵的设计实例。该3倍负压泵的设计经流片证明是成功的,并且已经应用于量产产品中。

关键词：电荷泵 3倍负压泵效率

陆地观测卫星数据中心:大数据挑战及一种解决方案

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武汉大学学报（信息科学版） 2017年第1期42卷 7-13页

作者：徐文邵俊喻文勇冯鹏中国资源卫星应用中心北京100094 武汉大学测绘遥感信息工程国家重点实验室湖北武汉430079

为应对陆地观测卫星数据及应用的多样性、存储数据规模的急速增长、数据处理与应用的高时效性、系统高可扩展性、系统资源整合的紧迫性等挑战,结合大数据技术,提出了一种基于Hadoop平台支持大数据处理与分析的陆地观测卫星数据中心架构... 详细信息

为应对陆地观测卫星数据及应用的多样性、存储数据规模的急速增长、数据处理与应用的高时效性、系统高可扩展性、系统资源整合的紧迫性等挑战,结合大数据技术,提出了一种基于Hadoop平台支持大数据处理与分析的陆地观测卫星数据中心架构解决方案,以提高陆地观测卫星数据利用水平与决策支持能力,提升国家空间信息资源应用水平,培育我国陆地观测卫星数据应用新的经济增长点。

关键词：陆地观测卫星数据中心大数据系统架构 Hadoop

Reaction behavior of silicon-rich diasporic bauxite with ammonium sulfate during roasting

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Journal of Central South University 2022年第1期29卷 22-31页

作者： xu yu-jun XIN Hai-xia DUAN Hua-mei LI Yan-dong WU Yan LIN Jie ZHAI yu-chun School of Materials Science and Engineering Northeastern UniversityShenyang 110819China School of Resources and Materials Northeastern University at QinhuangdaoQinhuangdao 066004China School of Metallurgy Northeastern UniversityShenyang 110819China College of Materials Science and Engineering Chongqing UniversityChongqing 400044China Chongqing Key Laboratory of Extraordinary Bond Engineering and Advanced Materials Technology Yangtze Normal UniversityChongqing 408000China

The separation of Al from the silicon-rich diasporic bauxite is of great significance in alumina ***,we proposed a low-temperature ammonium sulfate roasting-water leaching process to extract aluminum from silicon-rich diasporic *** including roasting temperature,dosage of ammonium sulfate,roasting time,and particle size of ore were *** the condition of roasting temperature of 400℃,roasting time of 5 h,ammonium sulfate dosage of 2.5 times of the theoretical value and ore particle size of 80−96μm,more than 98%leaching rate of aluminum was *** phase transformation and mechanism during the roasting process were revealed by using X-ray diffraction,thermogravimetric analysis,differential thermal analysis,and scanning electron microscope *** diaspore and kaolinite phases in the silicon-rich diasporic bauxite could react with ammonium sulfate to form corresponding sulfates(NH_(4))_(3)Al(SO_(4))_(3) Al(SO_(4))_(2) and Al_(2)(SO_(4))_(3).The proposed technology could provide an effective method for the direct and separation of aluminum from silicon-rich diasporic bauxite.

关键词： silicon-rich diasporic bauxite ammonium sulfate roasting separation