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Topsoil organic carbon mineralization and CO_2 evolution of three paddy soils from South China and the temperature dependence

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Journal of Environmental Sciences 2007年第3期19卷 319-326页

作者： ZHANG xu-hui li lian-qing PAN Gen-xing Institute of Resources Ecosystem and Environment of Agriculture Nanjing Agricultural University Nanjing 210095 China.

Carbon mineralization and its response to climatic warming have been receiving global attention for the last decade. Although the virtual influence of temperature effect is still in great debate, little is known on the mineralization of organic carbon （SOC） of paddy soils of China under warming. SOC mineralization of three major types of China＇s paddy soils is studied through laboratory incubation for 114 d under soil moisture regime of 70% water holding capacity at 20℃ and 25℃ respectively. The carbon that mineralized as CO2 evolved was measured every day in the first 32 d and every two days in the following days. Carbon mineralized during the 114 d incubation ranged from 3.51 to 9.22 mg CO2-C/gC at 20℃ and from 4.24 to 11.35 mg CO2-C/gC at 25℃ respectively; and a mineralizable C pool in the range of 0.24 to 0.59 gC/kg, varying with different soils. The whole course of C mineralization in the 114 d incubation could be divided into three stages of varying rates, representing the three subpools of the total mineralizable C： very actively mineralized C at 1-23 d, actively tnineralized C at 24--74 d and a slowly mineralized pool with low and more or less stabilized C mineralization rate at 75-114 d. The calculated Q10 values ranged from 1.0 to 2.4, varying with the soil types and N status. Neither the total SOC pool nor the labile C pool could account for the total mineralization potential of the soils studied, despite a well correlation of labile C with the shortly and actively mineralized C, which were shown in sensitive response to soil warming. However, the portion of microbial C pool and the soil C/N ratio controlled the C mineralization and the temperature dependence. Therefore, C sequestration may not result in an increase of C mineralization proportionally. The relative control of C bioavailability and microbial metabolic activity on C mineralization with respect to stabilization of sequestered C in the paddy soils of China is to be further studied.

关键词： C mineralization carbon pool laboratory incubation paddy soil soil warming

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Propofol induces ferroptosis and inhibits malignant phenotypes of gastric cancer cells by regulating miR-125b-5p/STAT3 axis

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World Journal of Gastrointestinal Oncology 2021年第12期13卷 2114-2128页

作者： Yi-Ping liu Zhong-Zhi Qiu xu-hui li En-You li Department ofAnesthesiology First Affiliated Hospital of Harbin Medical UniversityHarbin 150001Heilongjiang ProvinceChina Department of Gastroenterology Heilongjiang Forest Industry Federation(Red Cross)HospitalHarbin 150008Heilongjiang ProvinceChina

BACKGROUND Gastric cancer is a common malignancy with poor prognosis,in which ferroptosis plays a crucial function in its *** is a widely used anesthetic and has antitumor potential in gastric ***,the effect of propofol on ferroptosis during gastric cancer progression remains *** To explore the function of propofol in the regulation of ferroptosis and malignant phenotypes of gastric cancer *** MTT assays,colony formation assays,Transwell assays,wound healing assay,analysis of apoptosis,ferroptosis measurement,luciferase reporter gene assay,and quantitative reverse transcription polymerase chain reaction were used in this *** Our data showed that propofol was able to inhibit proliferation and induce apoptosis of gastric cancer ***,propofol markedly repressed the invasion and migration of gastric cancer ***,propofol enhanced the erastin-induced inhibition of growth of gastric cancer ***,propofol increased the levels of reactive oxygen species,iron,and Fe2+in gastric cancer ***,propofol suppressed signal transducer and activator of transcription(STAT)3 expression by upregulating miR-125b-5p and propofol induced ferroptosis by targeting STAT3 in gastric cancer *** miR-125b-5p inhibitor or STAT3 overexpression reversed propofol-attenuated malignant phenotypes of gastric cancer *** Propofol induced ferroptosis and inhibited malignant phenotypes of gastric cancer cells by regulating the miR-125b-5p/STAT3 *** may serve as a potential therapeutic candidate for gastric cancer.

关键词： Gastric cancer Progression Ferroptosis Propofol miR-125b-5p STAT3

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Analysis on characteristics of 1-D apodized and chirped photonic crystals containing negative refractive materials

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Optoelectronics Letters 2008年第6期4卷 440-442页

作者： TONG Kai CUI Wei-wei xu Xiao-hui li Zhi-quan College of Electric Engineering University of Yanshan Qinhuangdao 066004China

Using transfer matrix method,the optical transmission properties of 1-D photonic crystals composed partially of negative refraction media are analyzed. The transmission spectra of periodic photonic crystal,chirped photonic crystal and apodized photonic crystal are numerically simulated respectively. By contrast with optical transmission properties of ordinary photo-nic crystals made of positive refraction media,the transmission spectra of apodized photonic crystal become unregular,the Bragg flat-headed area recurs but the peak of transmission does not change significantly. Futhermore,the band gap range of chirped photonic crystal diminishes gradually.

关键词：连续变频信号光子晶体折射材料晶体特征

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Microstructural characteristics of Nd_2Fe_(14)B/α-Fe nanocomposite ribbons bearing Nb element

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Rare Metals 2008年第3期27卷 299-302页

作者： WANG Zhanyong liU Wenqing ZHOU Bangxin NI Jiansen xu hui li Qiang Department of Materials Engineering Shanghai Institute of Technology Shanghai 200235 China Institute of Materials Shanghai University Shanghai 200072 China

The effects of Nb on the microstructure and magnetic properties of （Nd0.9Dy0.1）9.5Fe79_xCo5NbxB6.5 （x = 0, 1） nanocomposite magnets were investigated. A fine and uniform microstructure was achieved for the ribbons annealed at 710℃ for 4 min, enhancing the interaction coupling between grains and improving the magnetic properties. The results of three-dimensional atom probe （3DAP） indicated that Fe-Nb-B inter- granular phase existed at the grain boundaries, suppressing the grain growth during the crystallization process. The coercivity was improved from 224 to 643 kA/m for the modification of the microstructure.

关键词： Nd2Fe14B/α-Fe nanocomposite magnet 3DAP magnetic properties

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Pear Blossom Blast Caused by Pseudomonas syringae pv. syringae in China

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Agricultural Sciences in China 2008年第9期7卷 1091-1096页

作者： QIU Wen HUAI Yan xu Fu-shou xu li-hui XIE Guan-lin li Bin YU Shan-hong liU Jun-ying Institute of Biotechnology Zhejiang University Hangzhou 310029 P.R.China Zhejiang Provincial Agricultural Bureau Hangzhou 310029 P.R.China Hangzhou Plant Protection Station Hangzhou 310020 P.R.China

This study was done to determine the causal organism of the pear blossom and bud blast in China. It was identified by a bacteriological test, electro-microscopic observation, Koch＇s postulate test, Biolog, fatty acid methyl esters （FAMEs）, and a polymerase chain reaction （PCR） test, and compared with the standard reference strains. Six representative strains out of 20 pathogenic bacterial isolates from 16 diseased samples showed characteristics similar to three standard strains of Pseudomonas syringae pv. syringae from Belgium. They were identified as P. syringae pv. syringae with a Biolog similarity of 0.57-0.86 and FAMEs similarity of 0.58-0.81. The bacterium was reisolated from the symptomatic plants and blossoms. Identification as P. syringae pv. syringae was confirmed by using PCR primers and sequence tests, and compared with the above-mentioned results. The data supported the fact that the pear blossom and bud blast in China could be caused by P. syringae pv. syringae.

关键词： pear blossom blast pear bud blast Pseudomonas syringae pv. syringae confirmation

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Suppression of bcl-2 Gene by RNA Interference Increases Chemosensitivity to Cisplatin in Nasopharyngeal Carcinoma Cell line CNE1

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Acta Biochimica et Biophysica Sinica 2004年第11期36卷 749-753页

作者： Zhi-Hua YIN, Cai-Ping REN, Feng li, xu-Yu YANG, hui li, Ming ZHAO, and Kai-Tai YAOCancer Research Institute, Central South University, Changsha 410078, China Cancer Research Institute Central South University

To explore the effect of suppressing BCL-2 expression using RNA interference (RNAi) technique in nasopharyngeal carcinoma cell line CNE1. CNE1 cell lines stably expressing shRNAs targeted bcl-2 and GL3 gene were established and gene expression inhibition was assessed by Western blotting analysis. The effect of suppressing bcl-2 by RNAi on cell growth was studied, the apoptosis induction and the sensitization of CNE1 cells to cisplatin were quantified by MTT assay and flow cytometry. The results showed that: stable transfection of CNE1

关键词： RNA interference nasopharyngeal carcinoma bcl-2 cisplatin

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In situ synthesis and phase analysis of low density O'-sialon-based multiphase ceramics

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Rare Metals 2010年第2期29卷 214-219页

作者： xu Xiongwen, liANG hui, li Xiaolei, JI huiming, LU huixiang, and WAN Yizao Key Laboratory for Advanced Ceramics and Machining Technology(Ministry of Education), Tianjin University, Tianjin 300072, China Key Laboratory for Advanced Ceramics and Machining Technology (Ministry of Education) Tianjin University

In situ formed low density O＇-sialon-based multiphase ceramics were prepared by liquid-phase sintering method at 1400°C with Si3N4, SiO2 and Al2O3 as raw *** phases were identified by X-ray diffraction（XRD）.The quantitative phase analysis was finished by matrix-flushing method and the substitution parameter x value of O＇-sialon was *** effects of sintering additives on the phase composition of the material were *** results show that, when using Y2O3 alone, Al6Si2O13 phase can be formed in the material, but when using Y2O3 and MgO, MgAl2O4 phase can be preferentially formed and the Al6Si2O13 is not *** mechanical properties of the material were measured and the relationships between microstructure and mechanical properties were *** sample with Y2O3 and MgO sintering additives, using fused quartz alone as SiO2 source, displays a combination of high bending strength（163 MPa） and good fracture toughness（3.11 MPa·m1/2）.Bending strength and fracture toughness of the samples increase with the increase of the content and aspect ratio of elongated grains and decrease with the increase of the porosity.

关键词： ceramics sialon phase analysis bending strength fracture toughness

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Dexamethasone increases susceptibility of Aspergillus fumigatus to hydrogen peroxide via down-regulation of Afyapl gene expression in vitro

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Chinese Medical Journal 2011年第22期124卷 3773-3777页

作者： xu hui li li-juan WAN Zhe li Ruo-yu liU Wei Department of Dermatology Peking University First Hospital and Research Center for Medical Mycology Peking University Beijing 100034 China

Background Glucocorticoid is speculated to be able to have Aspergillus fumigatus （A. tum/gatus） I^e~ng more susceptible to reactive oxygen species （ROS） by inhibiting Afyapl, the transcription factor activating protein-1 （AP-1） homologue in A. fumigatus, which may provide a clue to expand the clinical use of glucocorticoid in patients with fungal infections. In this study, we used dexamethasone to determine the direct effect on oxidative killing susceptibility of A. fumigatus in vitro, as well as the expression level of Afyapl gene and its target genes （catalase and superoxide dismutase （SOD） genes）. Methods A. fumigatus spores were treated with different concentrations （0, 0.02, 0.2 mg/ml） of glucocorticoids and assigned to four groups （A： 0.5 hour, B： 2 hours, C： 7 hours, D： 16 hours） according to the time of treatment. The H202 oxidative killing assay was done, using the standard method-spot test, in each group of A. fumigatus. We measured the oxidative killing susceptibility as well as the expression level of the gene Afyapl, CATA, SOD1 and SOD2 in A. fumigatus at each group. The antifungal susceptibility to itraconazole and amphotericin B in each group of A. fumigatus was also measured with M38-A2 method. Results The oxidative killing susceptibility of A. fumigatus was increased, consistent with the reduction of Afyapl, CATA, SOD1 and SOD2 gene expression level after being treated with dexamethasone for 0.5 hours. However, these observations were disappeared along with being treated for longer time. The antifungal susceptibility to itraconazole and amphotericin B in the A. fumigatus strains treated with dexamethasone indicated no change, compared with those without dexamethasone treatment. Conclusion Dexamethasone can have A. fumigatus being more susceptible to ROS when treated for shorter period （0.5 to 2 hours） via the reduction of Afyapl gene expression as well as the down-stream enzyme-coding gene expression.

关键词： Aspergillus fumigatus Afyapl dexamethasone oxidative killing

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Global,regional,and national burden of kidney,bladder,and prostate cancers and their attributable risk factors,1990–2019

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Military Medical Research 2022年第3期9卷 303-318页

作者： Hao Zi Shao-Hua He Xie-Yuan Leng Xiao-Feng xu Qiao Huang Hong Weng Cong Zhu Lu-Yao li Jia-Min Gu xu-hui li Dao-Jing Ming Xiao-Dong li Shuai Yuan Xing-Huan Wang Da-lin He Xian-Tao Zeng Department of Urology Zhongnan Hospital of Wuhan UniversityWuhan430071China Center for Evidence-Based and Translational Medicine Zhongnan Hospital of Wuhan UniversityWuhan430071China Precision Medicine Centre The Second People’s Hospital of HuaihuaHuaihua418000China The First School of Clinical Medicine Anhui Medical UniversityHefei230000China Department of Urology Xianyang Central HospitalXianyang712000China Department of Urology The First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an710061China Institutes of Evidence-Based Medicine and Knowledge Translation Henan UniversityKaifeng475000China Department of Urology Huaihe Hospital of Henan UniversityKaifeng475000China Institute of Urology Wuhan UniversityWuhan430071China

Background:The burden of kidney,bladder,and prostate cancers has changed in recent *** study aims to investigate the global and regional burden of,and attributable risk factors for genitourinary cancers during the past 30 ***:We extracted data of kidney,bladder,and prostate cancers from the Global Burden of Disease 2019 database,including incidence,mortality,disability-adjusted life-years(DALYs),and attributable risk factors from 1990 to *** annual percentage changes(EAPC)were calculated to assess the changes in age-standardized incidence rate,age-standardized mortality rate(ASMR),and age-standardized DALYs rate(ASDR).The associations between cancers burden and socio-demographic index(SDI)were also ***:Compared with 1990,the global incident cases in 2019 were higher by 154.78%,123.34%,and 169.11%for kidney,bladder,and prostate cancers,*** the 30-year study period,there was a downward trend in ASMR and ASDR for bladder cancer(EAPC=–0.68 and–0.83,respectively)and prostate cancer(EAPC=–0.75 and–0.71,respectively),but an upward trend for kidney cancer(EAPC=0.35 and 0.12,respectively).Regions and countries with higher SDI had higher incidence,mortality,and DALYs for all three types of *** burden of bladder and prostate cancers was mainly distributed among older men,whereas the burden of kidney cancer increased among middle-aged *** related mortality and DALYs decreased,but high body mass index(BMI)and high fasting plasma glucose(FPG)related mortality and DALYs increased among kidney,bladder,and prostate cancers during the study ***:Kidney,bladder,and prostate cancers remain major global public health challenges,but with distinct trend for different disease entity across different regions and socioeconomic *** proactive intervention strategies,at both the administrative and academic levels,based on the dynamic changes,are needed.

关键词： Genitourinary cancer Kidney cancer Bladder cancer Prostate cancer Incidence Mortality Disability-adjusted life-years Global Burden of Disease

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Antifungal activity of ibuprofen against aspergillus species and its interaction with common antifungal drugs

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Chinese Medical Journal 2010年第19期123卷 2701-2705页

作者： li li-juan CHEN Wei xu hui WAN Zhe li Ruo-yu liU Wei Department of Dermatovenerology Peking University First Hospital Research Center for Medical Mycology Peking University Beijing 100034 China

Background The incidence of invasive aspergillosis （IA） has increased in frequency in immunocompromised patients with a variety of diseases. The poor prognosis might be due to limited treatment option. This study aimed to evaluate antifungal activity of ibuprofen against clinical isolates of aspergillus species, as well as its interaction with azoles or with amphotericin B or with micafungin. Methods Antifungal activity of ibuprofen against 10 strains of Aspergillus fumigatus, Aspergillus flavus, and Aspergillus terreus were tested with both disk diffusion assay and standard broth microdilution method. To determine whether ibuprofen combined with itraconazole, voriconazole, amphotericin B, or micafungin had interactive effects on aspergillus spp., we used both disk diffusion assay and Chequerboard method. Results As for disk diffusion method, ibuprofen produced a zone of growth inhibition with diameters of （20.1±3.9） mm at 48 hours of incubation. As for broth microdilution method, the minimal inhibitory concentration （MIC） ranges of ibuprofen against aspergillus spp. were 1000-2000 μg/ml, and the minimal fungicidal concentration （MFC） ranges of that was 2000-8000 μg/ml. For 2 of 5 isolates, when ibuprofen combined with itraconazole or voriconazole, the zones of growth inhibition were larger than those of the individual drug. The results of Chequerboard method showed that fractional inhibitory concentration index （FICI） ranges were 1.125-2.500. Conclusions Ibuprofen is active against aspergillus spp.. And ibuprofen does not affect the in vitro activity of itraconazole, voriconazole, amphotericin B or micafungin against aspergillus spp.

关键词： aspergillus spp. ibuprofen antifungal susceptibility drug interaction

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