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Genotype distribution and evolutionary analysis of rotavirus associated with acute diarrhea outpatients in Hubei,China,2013–2016

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Virologica Sinica 2022年第4期37卷 503-512页

作者： Ting Zhang Jing Li Yong-Zhong Jiang Jun-Qiang xu xu-hua guan Li-Qiang Wang Jie Chen Yi Liang Hubei Key Laboratory of Cell Homeostasis College of Life SciencesWuhan UniversityWuhan430072China Hubei Provincial Center for Disease Control and Prevention Wuhan430079China

Group A human rotaviruses(RVAs)annually cause the deaths of 215,000 infants and young *** understand the epidemiological characteristics and genetic evolution of RVAs,we performed sentinel surveillance on RVA prevalence in a rotavirus-surveillance network in Hubei,*** 2013 to 2016,a total of 2007 fecal samples from hospital outpatients with acute gastroenteritis were collected from four cities of Hubei *** the 2007 samples,153(7.62%)were identified positive for RVA by real-time *** infection in Hubei mainly occurred in autumn and *** highest detection rate of RVA infection was in 1–2 years old of outpatients(16.97%).No significant difference of RVA positive rate was observed between females and *** performed a phylogenetic analysis of the G/P genotypes based on the partial VP7/VP4 gene sequences of RVAs.G9P[8]was the most predominant strain in all four years but the prevalence of G2P[4]genotype increased rapidly since *** reconstructed the evolutionary time scale of RVAs in Hubei,and found that the evolutionary rates of the G9,G2,P[8],and P[4]genotypes of RVA were 1.069×10^(-3),1.029×10^(-3),1.283×10^(-3)and 1.172×10^(-3)nucleotide substitutions/site/year,***,using a molecular clock model,we showed that most G9,G2,P[8],and P[4]genotype strains dated from the recent ancestor in 2005,2005,1993,and 2013,*** finding of the distribution of RVAs in infants and young children in Hubei Province will contribute to the understanding of the epidemiological characteristics and genetic evolution of RVAs in China.

关键词： Group A human rotavirus(RVA) Prevalence Phylogenetic analysis Evolution Hubei Province

Elevated Arsenic Exposure Is Associated with an Increased Risk of Chronic Hepatitis B Virus Infection： NHANES （2003-2014） in U.S. Adults

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Current Medical Science 2018年第4期38卷 610-617页

作者： Wei-hua ZHANG Jiao huaNG Mei FENG Ye-qing TONG xu-hua guan Hong-wei JIANG Sheng WEI Department of Epidemiology and Biostatistics Key Laboratory of Environment and Health of Ministry of Education School of Public Health Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 China Department of Preventive Medicine School of Medicine Ningbo University Ningbo 315211 China Institute of Infectious Disease Control and Prevention Hubei Provincial Center for Disease Control and Prevention Wuhan 430079 China

Studies concerning the association between arsenic exposure and hepatitis B virus （HBV） infection have been lacking. The present study aimed to examine the association between total urinary arsenic （TUA） and infection ofHBV. A total of 5186 participants from National Health and Nutrition Examination Survey （NHANES） 2003-2014 were included in the analysis. We used logistic regression to evaluate the association. We defined two measures of TUA. TUA1 was the sum of arsenous acid, arsenicacid, monomethylarsonic acid and dimethylarsenic acid. TUA2 was defined as TUA minus arsenobetaine and arsenocholine. The results showed that the weighted overall prevalence of HBV infection was 6.08%. For NHANES 2003-2014, the medians （interquartile range） of TUA1 and TUA2 were 5.60 μg/L （3.97-8.09 μg/L） and 4.91 μg/L （2.36-9.11 μg/L）, respectively. Comparing the highest quartile to the lowest quartile after multivariable adjustment showed that the odds ratios （ORs） and 95% confidence intervals （CIs） for TUA1 and TUA2 were 2.44 （1.40-4.27） and 2.84 （1.60-5.05）, respectively. In conclusion, elevated urinary arsenic was associated with the risk of HBV infection. Further studies, especially prospective studies, are needed to confirm the causal relationship between arsenic exposure and HBV infection.

关键词： arsenic exposure hepatitis B infection National Health and Nutrition Examination Survey

Automatic Requirement Dependency Extraction Based on Integrated Active Learning Strategies

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Machine Intelligence Research 2024年第5期21卷 993-1010页

作者： Hui guan Guorong Cai Hang xu Department of Computer Science and Technology Shenyang University of Chemical TechnologyShenyang110142China Key Laboratory of Industrial Intelligence Technology on Chemical Process Shenyang110142China

Since requirement dependency extraction is a cognitively challenging and error-prone task,this paper proposes an automatic requirement dependency extraction method based on integrated active learning *** this paper,the coefficient of variation method was used to determine the corresponding weight of the impact factors from three different angles:uncertainty probability,text similarity difference degree and active learning variant prediction divergence *** combining the three factors with the proposed calculation formula to measure the information value of dependency pairs,the top K dependency pairs with the highest comprehensive evaluation value are selected as the optimal *** the optimal samples are continuously added into the initial training set,the performance of the active learning model using different dependency features for requirement dependency extraction is rapidly ***,compared with other active learning strategies,a higher evaluation measure of requirement dependency extraction can be achieved by using the same number of ***,the proposed method using the PV-DM dependency feature improves the weight-F1 by 2.71%,the weight-recall by 2.45%,and the weight-precision by 2.64%in comparison with other strategies,saving approximately 46%of the labelled data compared with the machine learning approach.

关键词： Requirement dependency dependency extraction dependency features integrated active learning strategies coefficient of variation

W-band millimeter wave vialess microstrip-to-microstrip vertical transition in multilayer LCP substrate

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The Journal of China Universities of Posts and Telecommunications 2024年第3期31卷 87-94页

作者： Liu Weihong Zhang xu guan Dongyang School of Electronic Engineering Xian University of Posts and TelecommunicationsXi'an 710121China

In this paper,a W-band broadband vialess microstrip(MS)-to-MS vertical transition in multilayer liquid crystal polymer(LCP)substrate is presented,which consists of two MS lines in the top layer,a common ground plane and slotline resonators in the second layer,and a close-loop transmission-line in the third *** increase the passband of the vialess vertical transition,an H-shaped slotline resonator is introduced,which greatly improves the impedance performance of the slotline resonator,and the full-wave simulated results indicate that insertion loss(IL)is less than 2 dB and return loss(RL)is better than 10 dB at *** verify this design,the broadband vertical transition is fabricated and *** measured results indicate that a broadband vertical transition with RL better than 10 dB and IL less than 5.67 dB can be obtained in the frequency range from 70.00 GHz to 104.09 *** to the fabrication error in the preparation process,the measured results are deteriorated compared to the simulated results,and the investigation indicates that the deviation is caused by the thickness error of the LCP substrate.

关键词： W-band broadband microstrip(MS)-to-MS vialess vertical transition liquid crystal polymer(LCP)

Nanoforming of transferred metal contacts for enhanced twodimensional field effect transistors

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Nano Research 2024年第4期17卷 3210-3216页

作者： Shuoheng xu Zheng huang Jie guan Yaowu Hu The Institute of Technological Sciences Wuhan UniversityWuhan 430072China School of Power and Mechanical Engineering Wuhan UniversityWuhan 430072China School of Physics Southeast UniversityNanjing 211189China

Two-dimensional transition metal chalcogenides(2D-TMDs)have attracted much attention because of their unique layered structure and physical properties for transistor *** transferred metal contacts on these low-dimensional materials or their homogeneous and heterogeneous multilayers have generated huge interest to avoid deposition *** this paper,we show that there are large physical gaps at both the edge contact and surface contact between the transferred electrodes and the 2D materials.A method called laser shock induced superplastic deformation(LSISD)is proposed to tackle this issue and enhance the performance of the *** enhancement mechanism was investigated by molecular dynamics(MD)simulations of the nanoforming process,atomic force microscopy(AFM),scanning electron microscopy(SEM),transmission electron microscopy(TEM)characterizations of the interfaces,and density functional theory(DFT)*** force effect of laser shock can reduce the contact gap between metals and *** electrical performances of the transistors before and after LSISD,along with MD simulations,are used to find the optimal process *** addition,this paper applies the LSISD method to the short-channel MoS_(2)/graphene vertical transistors to show potential improvement in interface contact and electrical *** paper demonstrates the first report on using mechanical force induced by laser shock to enhance metal–semiconductor interfaces and transistor performances.

关键词： laser shock nanoforming metal-semiconductor contact electronics two-dimensional transistors

Quantitative Analysis of Frosting Characteristics on the Drip Tray of A Cryogenic Valve for LNG Ships

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China Ocean Engineering 2024年第4期38卷 572-585页

作者： BAI xu CHEN guan-yu DU Yue xu Cao CHEN Jia-jing School of Naval Architecture&Ocean Engineering Jiangsu University of Science and TechnologyZhenjiang 212003China

Cryogenic valves play a crucial role in the production and transportation of liquefied natural gas(LNG),and are primarily responsible for efficiently controlling the inflow and outflow of LNG and regulating ***,due to their operation in low-temperature and high-humidity environments,crucial components such as drip trays are susceptible to frosting,which may lead to LNG leakage,thereby causing severe safety *** this study,the user-defined function(UDF)is employed to redevelop Fluent,which integrates the frost growth model with the Eulerian multiphase flow model,to conduct a quantitative analysis of frosting on drip trays of cryogenic *** effects of environmental parameters,such as wind speed,ambient temperature,air humidity,and cold surface temperature on the growth of the frost layer were *** study reveals a limiting wind speed between 1 m/s and 2 m/*** reaching this limit speed,the growth of the frost layer reaches its maximum,and further increases in the wind speed have no significant effect on the growth of the frost ***,the influence of the change in the flow field on droplet impingement and freezing during the growth of the frost layer is considered through the coupling method of the kinematic characteristics of water droplets and the collection coefficient of water *** study identifies the influence of different parameters on the droplet impact efficiency,leading to the modification of the frost layer on the drip tray.

关键词： LNG carrier drip tray frost effective impact coefficient

Aldehyde oxidase mediated enantioselective metabolic health risk of dinotefuran

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Science China Chemistry 2024年第6期67卷 2079-2091页

作者： Liwei xu Xinxin xu hua Kuang Chuanlai xu Xiaoling Wu State Key Laboratory of Food Science and Resources Jiangnan UniversityWuxi214122China International Joint Research Laboratory for Biointerface and Biodetection and School of Food Science and Technology Jiangnan UniversityWuxi214122China Collaborative Innovation center of Food Safety and Quality Control in Jiangsu Province Jiangnan UniversityWuxi214122China

Chiral pollutants often pose significant differential environmental health *** this study,the biotransformation of chiral dinotefuran(DIN)and its enantioselective metabolic toxicity mechanisms have been systemically ***,reversedphase chromatography-high resolution mass spectrometry was developed to quantify the content of DIN R/S chiral enantiomer with pg level sensitivity,revealing a lower elimination rate constant(K_(e))of S-DIN(0.730 h^(-1))than R-DIN(0.746 h^(-1)).Secondly,the interaction mechanism between DIN metabolism and important endogenous bioactive molecules,such as aldehyde oxidase(AOX)and neurotransmitters,was *** DIN nitro-group was converted into a guanidine group by the reducing site of nearby flavin adenine dinucleotide(FAD)in AOX with the preferred higher affinity of ***,the endogenous tryptophan(Trp)aldehyde metabolic intermediate,5-hydroxyindoleacetaldehyde(5-HIAL),provides a persistent electron donor for DIN reduction via the oxidation-catalyzed site in AOX,resulting in remarkable up-regulation of monoamine neurotransmitters such as serotonin and ***,the higher level of neurotransmitters further mediated dysregulation of oxylipin homeostasis via the serotonergic pathway,where S-DIN exhibited more pronounced liver lipid damage and environmental health risk with the accumulated lipid biomarkers,oxidized triglyceride(OxTG)and oxidized sphingomyelin(OxSM).This study elucidates the AOX-mediated enantioselectivity metabolic pathway of DIN,providing a new analytical method for chiral pollutants and paves the way for their health risk assessments.

关键词： neonicotinoid dinotefuran enantiomer aldehyde oxidase metabolomics health risk

Protein lysine crotonylation in cellular processions and disease associations

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Genes & Diseases 2024年第5期11卷 219-235页

作者： Hongling Zhao Yang Han Pingkun Zhou hua guan Shanshan Gao Beijing Key Laboratory for Radiobiology Beijing Institute of Radiation MedicineBeijing 100850China

Protein lysine crotonylation(Kcr)is one conserved form of posttranslational modifications of proteins,which plays an important role in a series of cellular physiological and pathological *** e-amino groups are the primary sites of such modification,resulting in four-carbon planar lysine crotonylation that is structurally and functionally distinct from the acetylation of these *** levels of Kcr modifications have been identified on both histone and non-histone *** present review offers an update on the research progression regarding protein Kcr modifications in biomedical contexts and provides a discussion of the mechanisms whereby Kcr modification governs a range of biological *** addition,given the importance of protein Kcr modification in disease onset and progression,the potential viability of Kcr regulators as therapeutic targets is elucidated.

关键词： Cell biology Disease Lysine crotonylation Posttranslational modification Therapeutic target

Microstructure and property of laser additive manufactured alloy Ti-6Al-2V-1.5Mo-0.5Zr-0.3Si after aged at different temperatures

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Rare Metals 2024年第5期43卷 2275-2281页

作者： Guo-Chao Li xu Cheng hua-Ming Wang National Engineering Laboratory of Additive Manufacturing for Large Metallic Components and Engineering Research Center of Ministry of Education on Laser Direct Manufacturing for Large Metallic Components School of Materials Science and EngineeringBeihang UniversityBeijing 100191China

The solid solution and aging treatment for conventional manufacturing processes might not be suitable for laser additive manufactured titanium alloys due to the different lamellar *** this study,the influence of aging temperatures(600,700 and 800°C)on microstructure and mechanical properties of titanium alloy Ti-6Al-2V-1.5Mo-0.5Zr-0.3Si was *** results indicate that after solid solution treatment at 970°C followed by water quenching,the alloy mainly consists of coarsening lamellar a phase in martensite α' *** at 600°C will not change the size of primary lamellar α phase but lead to huge amount of secondary a phases(α_(s))generating with very fine *** increasing the aging temperature,the number of α_(s) decreases but with coarsened *** aged at 800°C,the width of the asphase reaches 350 nm,almost 7 times wider than that aged at 600°*** changing size of α_(s) obviously influences the property of the *** fine α_(s) leads to high strength and microhardness but low plasticity,and specimen aged at 700°C with suitable assize has the best comprehensive properties.

关键词： α+βtitanium alloy Laser additive manufacturing Solid solution and aging treatment Microstructure Room temperature tensile property