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Immunomodulation and liver protection of Yinchenhao decoction against concanavalin A-induced chronic liver injury in mice

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Journal of Integrative Medicine 2015年第4期13卷 262-268页

作者： Shi-li Jiang xu-dong hu Ping Liu Department of Liver Cirrhosis Shuguang Hospital Shanghai University of Traditional Chinese Medicine Department of Biology Shanghai University of Traditional Chinese Medicine E-institute of Shanghai Municipal Education Committee Shanghai University of Traditional Chinese Medicine

OBJECTIVE：This study investigated the immunoregulatory and protective roles of Yinchenhao decoction,a compound of Chinese herbal medicine,in a mouse model of concanavalin A（Con A）-induced chronic liver ***：Female Bal B/c mice were randomly divided into 4 groups：normal control,Con A model,Con A model treated with Yinchenhao decoction（400 mg/kg,orally）,and Con A model treated with dexamethasone（0.5 mg/kg,orally）.All treatments were given once a day for 28 *** of the normal control,mice received tail vein injection of Con A（10 mg/kg）on days 7,14,21,and 28,at 1 h after treatment with Yinchenhao decoction or dexamethasone or saline to induce chronic liver ***：Repeated Con A injection induced chronic liver injury,which was evidenced by infl ammatory cell infi ltration and necrosis,increased serum alanine aminotranferease activities,decreased albumin levels,and an imbalanced expression of immunoregulatory genes in the liver tissues including signifi cantly enhanced interferon-γ,interleukin-4,monocyte chemotactic protein-1,and cluster of differentiation 163 m RNA levels,and reduced tumor necrosis factor-αand interleukin-6 m RNA *** with Yinchenhao decoction signifi cantly reversed the Con A-induced changes in immunoregulatory gene expression in the liver tissues,reduced serum alanine aminotranferease activity,enhanced serum albumin level,and attenuated the extent of liver infl ammation and ***,Yinchenhao decoction did not result in hepatocyte degeneration and spleen weight loss that were observed in mice received long-term treatment with ***：Yinchenhao decoction treatment protected liver against the Con A-induced chronic liver damage and improved liver function,which were associated with the modulation of gene expression related to immune/infl ammatory response.

关键词： concanavalin A liver injury chronic hepatitis chronic drug-induced cytokines immune liver protection Yinchenhao decoction mice

On the Responsible Use of Chatbots in Bioinformatics

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Genomics, Proteomics & Bioinformatics 2024年第1期22卷 1-3页

作者： Gangqing hu Li Liu dong xu Department of Microbiology Immunology&Cell BiologyWest Virginia UniversityMorgantownWV 26506USA College of Health Solutions Arizona State UniversityPhoenixAZ 85004USA Biodesign Institute Arizona State UniversityTempeAZ 85281USA Department of Electrical Engineer and Computer Science Christopher S.Bond Life Sciences CenterUniversity of MissouriColumbiaMO 65211USA

Large language model(LLM)-based chatbots like Chat Generative Pre-trained Transformer(ChatGPT),equipped with broad biological knowledge[1],have demonstrated an impressive capability for bioinformatics coding[2].When given well-crafted instructions,these chatbots hold the potential to significantly augment bioinformatics education and research[3,4].However,opportunities entail both rewards and *** commentary explores the challenges of using chatbots in bioinformatics and proposes strategies to manage the associated risks while maximizing the benefits.

关键词： equipped while education

Efficient concentration of trace analyte with ordered hotspot construction for a robust and sensitive SERS platform

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International Journal of Extreme Manufacturing 2024年第3期6卷 532-542页

作者： Youdi hu Yanlei hu Zhenyu Wang Jiale Yong Wei Xiong dong Wu Shixiang xu Shenzhen Key Laboratory of Micro-Nano Photonic Information Technology College of Physics and Optoelectronic EngineeringShenzhen UniversityShenzhenGuangdong 518060People’s Republic of China CAS Key Laboratory of Mechanical Behavior and Design of Materials Key Laboratory of Precision Scientific Instrumentation of Anhui Higher Education InstitutesDepartment of Precision Machinery and Precision InstrumentationUniversity of Science and Technology of ChinaHefeiAnhui 230027People’s Republic of China Wuhan National Laboratory for Optoelectronics Huazhong University of Science and TechnologyWuhanHubeiPeople’s Republic of China

Surface-enhanced Raman scattering(SERS)platform,which enables trace analyte detection,has important application *** structuring/modifying the surface of the SERSsubstrate,analyte in highly diluted solutions can be concentrated into localized active areas for highly sensitive ***,subject to the difficulty of the fabrication process,itremains challenging to balance hot-spot construction and the concentration capacity of analyte ***,preparing SERS substrates with densely ordered hot spots andefficient concentration capacity is of great significance for highly sensitive ***,we propose an Ag and fluoroalkyl-modified hierarchical armour substrate(Ag/F-HA),which has a double-layer stacking design to combine analyte concentration with hotspot *** microarmour structure is fabricated by femtosecond-laser processing to serve as asuperhydrophobic and low-adhesive surface to concentrate analyte,while the anodic aluminium oxide(AAO)template creates a nanopillar array serving as dense and ordered hot *** the synergistic action of hot spots and analyte concentration,Ag/F-HA achieves a detectionlimit down to 10^(-7)M doxorubicin(DOX)molecules with a RSD of 7.69%.Additionally,Ag/F-HA exhibits excellent robustness to resist external disturbances such as liquid splash or *** on our strategy,SERS substrates with directional analyte concentrations are further explored by patterning microcone arrays with *** work opens a way to the realistic implementation of SERS in diverse scenarios.

关键词： surface-enhanced Raman scattering anodic aluminium oxide femtosecond laser processing concentration of trace analytes mechanical robustness

Twisted Integration of Complex Oxide Magnetoelectric Heterostructures via Water‑Etching and Transfer Process

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Nano-Micro Letters 2024年第1期16卷 360-369页

作者： Guannan Yang Guohua dong Butong Zhang xu xu Yanan Zhao Zhongqiang hu Ming Liu State Key Laboratory for Manufacturing Systems Engineering Electronic Materials Research LaboratoryKey Laboratory of the Ministry of EducationEngineering Research Center of Spin Quantum Sensor ChipsUniversities of Shaanxi ProvinceSchool of Electronic Science and EngineeringXi’an Jiaotong UniversityXi’an 710049People’s Republic of China

Manipulating strain mode and degree that can be applied to epitaxial complex oxide thin films have been a cornerstone of strain *** recent years,lift-off and transfer technology of the epitaxial oxide thin films have been developed that enabled the integration of heterostructures without the limitation of material types and crystal ***,twisted integration would provide a more interesting strategy in artificial magnetoelectric heterostructures.A specific twist angle between the ferroelectric and ferromagnetic oxide layers corresponds to the distinct strain regulation modes in the magnetoelectric coupling process,which could provide some insight in to the physical *** this work,the La_(0.67)Sr_(0.33)MnO_(3)(001)/0.7Pb(Mg_(1/3)Nb_(2/3))O_(3)-0.3PbTiO_(3)(011)(LSMO/PMN-PT)heterostructures with *** *** angles were assembled via water-etching and transfer *** transferred LSMO films exhibit a fourfold magnetic anisotropy with easy axis along LSMO.A coexistence of uniaxial and fourfold magnetic anisotropy with LSMO[110]easy axis is observed for the 45°Sample by applying a 7.2 kV cm^(−1)electrical field,significantly different from a uniaxial anisotropy with LSMO[100]easy axis for the 0°*** fitting of the ferromagnetic resonance field reveals that the strain coupling generated by the 45°twist angle causes different lattice distortion of LSMO,thereby enhancing both the fourfold and uniaxial *** work confirms the twisting degrees of freedom for magnetoelectric coupling and opens opportunities for fabricating artificial magnetoelectric heterostructures.

关键词： Magnetoelectric heterostructures Twist angle Epitaxial lift-off Magnetic anisotropy Ferromagnetic resonance

High mobility group box-1 release from H2O2-injured hepatocytes due to sirt1 functional inhibition

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World Journal of Gastroenterology 2019年第36期25卷 5434-5450页

作者： Ting-Jie Ye Yan-Lin Lu Xiao-Feng Yan xu-dong hu Xiao-Ling Wang Department of Biology School of Basic Medical Sciences Shanghai University of Traditional Chinese Medicine Shanghai 201203 China Department of Oncology and Institute of Traditional Chinese Medicine in Oncology Longhua Hospital Shanghai University of Traditional Chinese Medicine Shanghai 200032 China

BACKGROUND High mobility group box-1 (HMGB1), recognized as a representative of damageassociated molecular patterns, is released during cell injury/death, triggering the inflammatory response and ultimately resulting in tissue damage. Dozens of studies have shown that HMGB1 is involved in certain diseases, but the details on how injured hepatocytes release HMGB1 need to be elicited. AIM To reveal HMGB1 release mechanism in hepatocytes undergoing oxidative stress. METHODS C57BL6/J male mice were fed a high-fat diet for 12 wk plus a single binge of ethanol to induce severe steatohepatitis. Hepatocytes treated with H2O2 were used to establish an in vitro model. Serum alanine aminotransferase, liver H2O2 content and catalase activity, lactate dehydrogenase and 8-hydroxy-2- deoxyguanosine content, nicotinamide adenine dinucleotide (NAD+) levels, and Sirtuin 1 (Sirt1) activity were detected by spectrophotometry. HMGB1 release was measured by enzyme linked immunosorbent assay. HMGB1 translocation was observed by immunohistochemistry/immunofluorescence or Western blot. Relative mRNA levels were assayed by qPCR and protein expression was detected by Western blot. Acetylated HMGB1 and poly(ADP-ribose)polymerase 1 (Parp1) were analyzed by Immunoprecipitation. RESULTS When hepatocytes were damaged, HMGB1 translocated from the nucleus to the cytoplasm because of its hyperacetylation and was passively released outside both in vivo and in vitro. After treatment with Sirt1-siRNA or Sirt1 inhibitor (EX527), the hyperacetylated HMGB1 in hepatocytes increased, and Sirt1 activity inhibited by H2O2 could be reversed by Parp1 inhibitor (DIQ). Parp1 and Sirt1 are two NAD+-dependent enzymes which play major roles in the decision of a cell to live or die in the context of stress . We showed that NAD+ depletion attributed to Parp1 activation after DNA damage was caused by oxidative stress in hepatocytes and resulted in Sirt1 activity inhibition. On the contrary, Sirt1 suppressed Parp1 by neg

关键词： Sirtuin1 Poly ADP-ribose polymerase 1 High mobility group box-1 Hepatocytes Hydrogen peroxide

Effect of wire mesh casing treatment on axial compressor performance and stability

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Chinese Journal of Aeronautics 2024年第3期37卷 60-76页

作者： Ming ZHANG Jiaming ZHANG Jiahao hu xu dong Dakun SUN Xiaofeng SUN School of Energy and Power Engineering Beihang UniversityBeijing 100191China Beihang Hangzhou Innovation Institute Yuhang Hangzhou 310023China National Key Laboratory of Science and Technology on Aero-Engine Aero-Thermodynamics Beihang UniversityBeijing 100191China

In this paper,a kind of Wire Mesh Casing Treatment(WMCT)is proposed to improve the stable operating range of the *** contrast to the traditional circumferential groove,as for WMCT,a layer of wire mesh is laid on the surface of the circumferential *** studies were conducted on the low-speed axial flow compressor,including the groove width,axial location,and mesh *** optimum axial location for WMCT is related to its groove width.A higher wire mesh count results in a smaller compressor stall margin *** simulations were carried out to study the effect of WMCT on the flow structure of the *** wire mesh in the WMCT has a certain flow resistance,which restricts the flow into and out of the *** to the WMCT,the flow parameter in the tip region of the rotor is less sensitive to changes in the operating conditions of the *** WMCT causes the rotor tip blade loading to shift backward,inhibiting the formation of spill forward of the leakage flow,and thus improving the stability of the *** flow resistance on the groove surface is a new degree-of-freedom for the casing treatment designer.

关键词： Axial compressor Wire mesh casing treatment Tip clearance flow Stall margin Blade loading

Gastric metastasis from small cell lung cancer:A case report

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World Journal of Gastroenterology 2015年第5期21卷 1684-1688页

作者： Song Gao xu-dong hu Su-Zhen Wang Ning Liu Wei Zhao Qing-Xi Yu Wen-Hong Hou Shuang-hu Yuan Department of Radiation Oncology Shandong Cancer Hospital and Institute School of Medicine and Life Sciences University of Jinan-Shandong Academy of Medical Sciences

Small cell lung cancer(SCLC) represents a group of highly malignant tumors that give rise to early and widespread metastases at the time of *** preferential metastatic sites are the brain,liver,adrenal glands,bone,and bone ***,metastases of the gastrointestinal system,especially the stomach,are rare; most cases of stomach metastasis are asymptomatic and,as a result,are usually only discovered at *** report a case of gastric metastasis originating from *** patient was a 66-year-old man admitted to our hospital due to abdominal *** underwent gastroscopy,with the pathological report of the tissue biopsy proving it to be a small cell *** was positive for CD56,synaptophysin,and *** results confirmed the diagnosis of gastric metastasis of a neuroendocrine small cell carcinoma from the lung.

关键词： Gastric metastasis Small cell lung cancer Immunohi

Ultrasound-guided fascia iliaca compartment block combined with general anesthesia for amputation in an acute myocardial infarction patient after percutaneous coronary intervention: A case report

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World Journal of Clinical Cases 2019年第17期7卷 2567-2572页

作者： Chen Ling Xing-Qing Liu Yi-Qun Li Xian-Jie Wen xu-dong hu Kai Yang Department of Anesthesiology Affiliated Foshan Hospital of Southern Medical University and Second People’s Hospital of Foshan

BACKGROUND Fascia iliaca compartment block is a technique that blocks three nerves,similar to a 3-in-1 nerve *** block provides analgesia for patients undergoing lower limb surgery,and is a simple technique that is easy to ***,we report a case of fascia iliaca compartment block in a patient with myocardial infarction who underwent emergency middle thigh *** SUMMARY A 78-year-old female patient weighing 38 kg with gangrene and occlusive peripheral atherosclerosis of the right leg underwent an emergency middle thigh *** patient had a history of hypertension,coronary heart disease,cerebral infarction,anterior wall myocardial infarction,and had recently undergone percutaneous coronary intervention consisting of coronary angiography and right coronary artery stent *** the patient's condition,an ultrasound-guided fascia iliaca compartment block combined with general anesthesia was implemented for *** fascia iliaca compartment block provided analgesia for the operation,and reduced the dosage of general *** also alleviated adverse cardiovascular effects caused by pain stress,and ensured the safety of the patient during the perioperative *** block also provided postoperative *** patient had a good prognosis,and was subsequently discharged from *** Fascia iliaca compartment block provides surgical *** also alleviates adverse cardiovascular effects,and ensures patient safety during the perioperative period.

关键词： Ultrasound-guided Fascia iliaca compartment block Acute myocardial infarction Case report Percutaneous coronary intervention

High-speed PGC demodulation model and method with subnanometer displacement resolution in a fiber-optic micro-probe laser interferometer

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Photonics Research 2024年第5期12卷 921-931页

作者： YISI dong WENWEN LI JiNRAN ZHANG WENRUI LUo HAIJIN FU xu XING PENGCHENG hu YONGKANG dong JIUBIN TAN Center of Ultra-precision Optoelectronic Instrument Harbin Institute of TechnologyHarbin 150080China Key Laboratory of Ultra-precision Intelligent Instrumentation(Harbin Institute of Technology) Ministry of Industry and Information TechnologyHarbin 150080China National Key Laboratory of Science and Technology on Tunable Laser Harbin Institute of TechnologyHarbin 150001China

As the key of embedded displacement measurement,a fiber-optic micro-probe laser interferometer(FMI)is of great interest in developing high-end equipment as well as precision ***,conventional phasegenerated carrier(PGC)approaches are for low-speed scenes and local error analysis,usually neglecting the global precision analysis and dynamic effect of system parameters under high-speed measurement,thus hindering their broad *** present a high-speed PGC demodulation model and method to achieve subnanometer displacement measurement precision in *** model includes a global equivalent resolution analysis and revelation of the demodulation error *** this model,the failure issues regarding the PGC demodulation method under high speed and large range are ***,an ultra-precision PGC demodulation algorithm based on the combination of static and dynamic delay adaptive regulation is proposed to enable high-speed and large-range displacement *** this paper,the proposed model and algorithm are validated through simulation and experimental *** results demonstrate a displacement resolution of 0.1 nm with a standard deviation of less than 0.5 nm when measuring at a high velocity of 1.5 m/s—nearly a tenfold increase of the latest study.

关键词： interferometer fiber displacement