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Association between matrix Gla protein and ulcerative colitis according to DNA microarray data

Gastroenterology Report 2020年第1期8卷 66-75,I0002,I0003页

作者： xu-yang dong Mei-xu Wu Hui-Min Zhang Hong Lyu Jia-Ming Qian Hong yang Department of Gastroenterology Peking Union Medical College HospitalPeking Union Medical CollegeChinese Academy of Medical SciencesBeijing 100730China

Background:Matrix Gla protein(MGP)is a secreted protein contributed to the immunomodulatory functions of mesenchymal stromal *** profiling found a significantly higher expression level of the extracellular matrix gene MGP in patients with ulcerative colitis(UC).However,little is known about the role of MGP in UC and its upstream signaling *** study aimed to identify the expression of MGP in UC and its upstream regulator ***:Colonicmucosa biopsies were obtained frompatients with UC and healthy *** profiling was used to explore underlying genes correlating with UC *** were fed with water containing different concentrations of dextran sodiumsulfate(DSS)to induce an experimental *** tissues were collected and evaluated using immunohistochemistry,immunoblot,real-time polymerase chain reaction,and chromatin immunoprecipitation *** analysis was performed to identify candidate MGP gene-promoter sequence and transcription-initiation ***-reporter gene assay was conducted to examine the potential transcription factor ofMGP gene ***:The expression of MGP was significantly increased in colonic tissues from UC patients and DSS-induced colitis models,and was positively correlated with disease *** analysis showed a conserved binding site for Egr-1 in the upstream region of human MGP *** significantly higher level of Egr-1 gene expression was found in UC patients than in healthy *** activity of luciferase was significantly enhanced in the Egr-1 expression plasmid cotransfected group than in the control group and was further inhibited when co-transfected with the Egr-1 binding-site mutated MGP ***:Up-regulated expression of MGP was found in UC patients and DSS-induced *** expression of MGP can be regulated by Egr-1.

关键词： ulcerative colitis matrix Gla protein Egr-1

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Genotypic and environmental variation in barley limit dextrinase activity and its relation to malt quality

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2006年第5期7卷 386-392页

作者： WANG xu-dong yang Juan ZHANG Guo-ping Department of Agronomy Zhefiang University Hangzhou 310029 China

Variation in the limit dextrinase activity of barley malt, and the relationships between limit dextrinase activity and malt quality parameters were investigated using eight cultivars grown at seven diverse locations in China for two successive years. Limit dextrinase activity varied with genotype and location, with the levels ranging from 0.245 U/g to 0.980 U/g. The results showed that the variation in limit dextrinase activity was more attributable to the environment (location and year) than to the genotype. The response of limit dextrinase activity to the environment differed markedly among cultivars, and was reflected by large difference in coefficient of variation of cultivars across diverse locations. Regression analysis showed that limit dextrinase activity was negatively correlated with malt viscosity (r=?0.52, P<0.01), positively correlated with Kolbach index (r=0.38, P<0.01) and malt extract (r=0.30, P<0.05), but had no significant correlation with malt protein content and diastatic power.

关键词： Barley (Hordeum vulgare L.) Limit dextrinase activity Genotype Environment Malt quality

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Efficient One-pot Synthesis of 12-Aryl-8, 9, 10, 12- tetrahydrobenzo [a]anthen-11-ones Under Solvent-free Conditions

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Chemical Research in Chinese Universities 2013年第1期29卷 82-86页

作者： JIA xu-dong HAN Song-yang DUAN Hai-feng LIN Ying-jie CAO Jun-gang LIANG Da-peng WUMao-cheng Department of Organic Chemistry College of Chemistry Jilin University Changchun 130012 P. R. China

Multi-component condensation of 2-naphthol, aromatic aldehydes, and cyclic 1,3-dicarbonyl compounds catalyzed by ionic liquid [NSPTEA][HSO4] was accomplished for the synthesis of a series of 12-aryl-8,9,10,12- tetrahydrobenzo[a]xanthen-11-ones under solvent-free conditions. High yields, ease recovery, short reaction time and reusability of catalyst are significant advantages. ZrOC12＂8H20 was also found to act as an effective catalyst towards this transformation.

关键词： Aldehyde Ionic liquid ZrOCI28HzO Multi-component reaction Solvent-free condition

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Distribution and conservation of near threatened plants in China

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Plant Diversity 2023年第3期45卷 272-283页

作者： Qin Liu Tian-Tian xue Xiao-Xia Zhang xu-dong yang Fei Qin Wen-Di Zhang Lei Wu Rainer W.Bussmann Sheng-Xiang Yu State Key Laboratory of Systematic and Evolutionary Botany Institute of BotanyChinese Academy of SciencesBeijing 100093China College of Forestry Central South University of Forestry and TechnologyChangsha 410004China College of Life Sciences University of Chinese Academy of SciencesBeijing 100049China Institute of Botany and Bakuriani Alpine Botanical Garden Ilia State UniversityBotanical Str.1Tbilisi 0105Georgia Department of Botany State Museum for Natural History KarlsruheErbprinzenstraße 13Karlsruhe 76133Germany

Plants classified as Near Threatened(NT) are at high risk of becoming threatened because of anthropogenic interference and climate *** in conservation efforts,such species have however long been ***,we obtained 98,419 precise occurrence points for 2442 NT plants in China,and used species richness,species complementarity,and weighted endemism that consider all,endemic and narrow-ranged species in order to identify the diversity hotspots of NT *** we evaluated the conservation effectiveness of current nature reserves for *** results indicate that the diversity hotspots of NT plants were mainly confined to southwestern and southern China,and only 35.87% of hotspots and 71.5% of species were protected by nature *** hotspots in southwestern China(e.g.,Sichuan,Yunnan,Guangxi,and Hainan) were identified as conservation *** that NT plants include large proportions of endemic and narrow-ranged species,they represent an important value in conservation ***,more conservation efforts in the future should be tilted towards NT ***,when comparing with the recently updated NT list,there are already 87 species raised to threatened categories,while 328 species were lowered to least concern,56 species were now categorized as data deficient,and 119 species considered as uncertain due to changes of scientific *** is essential to carry out a continuous assessment of species’ threatened categories to realize targeting conservation.

关键词： Conservation Distribution patterns Diversity hotspots Nature reserves Red list Near threatened species

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Alterations in lymphocyte subset patterns and co-stimulatory molecules in patients with Alzheimer disease

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Chinese Medical Journal 2009年第12期122卷 1469-1472页

作者： xuE Shou-ru xu dong-hua yang Xin-xin dong Wan-li Department of Neurology First Affiliated Hospital of SooChow University Suzhou Jiangsu 215006 China

Alzheimer disease （AD） is characterized by the .presence of β-amyloid （Aβ） plaques in the *** evidence of inflammatory parameters, such as, complement factors, proinflammatory cytokines and lymphocytes has been found to be co-localized with Aβ plaques. The research in the past decades has demonstrated abnormalities of both the humoral and cellular immune responses, suggesting an association of immunological aberration and AD. The total percentage of lymphocytes was not found to be altered,

关键词： lymphocytes costimulatory molecule Alzheimer disease

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Pregnancy outcomes in women with heart disease

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Chinese Medical Journal 2010年第17期123卷 2324-2330页

作者： LIU Hua xu Ji-wen ZHAO xu-dong YE Tai-yang LIN Jian-hua LIN Qi-de Department of Obstetrics and Gynecology Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai Obstetrical Cardiology Intensive Care Center Shanghai 200127 China

Background As the Shanghai Obstetrical Cardiology Intensive Care Center, our hospital has accumulated a large number of clinical data of pregnant women with heart disease. This paper is a retrospective analysis of 1142 pregnancies in women with heart disease so as to evaluate the maternal and fetal outcomes of these *** A retrospective analysis was carried out for pregnancies in 1142 women with heart disease who delivered in Shanghai Obstetrical Cardiology Intensive Care Center between 1993 and *** In this study, main heart diseases in pregnancy were arrhythmia （n=359, 31.4%）, congenital heart disease （CHD; n=291,25.5%）, and myocarditis and its sequelae （n=284, 24.9%）; based on the functional classification criteria of New York Heart Association （NYHA）, more than half （n=678, 59.4%） of patients were classified NYHA Class Ⅰ; pregnant women in NHYA Class Ⅰ-Ⅱ （n=951, 83.3%） commonly had arrhythmia, myocarditis and its sequelae, while those in NHYA Class Ⅲ-Ⅳ （n=191, 16.7%） mainly had CHD, rheumatic heart disease （RHD）, cardiopathy induced by hypertensive disorders complicating pregnancy, and peripartum cardiomyopathy （PPCM）. Cardiac failure occurred in 97 （8.5%）patients, and 8 （0.7%） maternal deaths and 12 （1.1%） perinatal deaths were reported in this study. Compared with those in NHYA Class Ⅰ-Ⅱ, women in NHYA Class Ⅲ-Ⅳ had a significantly lower gestational age at birth （P 〈0.05）, lower birth weight （P 〈0.01）, and higher incidence of preterm delivery, small for gestational age and perinatal death （P 〈0.01）. The incidence of cardiac failure in pregnant women with cardiopathy induced by hypertensive disorders complicating pregnancy and PPCM was relatively high, with a rate of 80% and 52.2%, respectively. After cardiac operation, 131（90.3%） women were in classified NHYA Class Ⅰ-Ⅱ and 14 （9.7%） in NHYA Class Ⅲ-Ⅳ.Conclusions Arrhythmia is the type of heart disease that has a highest incidence in patients with heart disease in pregnancy, while main types

关键词： heart disease cardiac function pregnancy outcome

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Induced neural stem cells regulate microglial activation through Akt-mediated upregulation of CXCR4 and Crry in a mouse model of closed head injury

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Neural Regeneration Research 2025年第5期20卷 1416-1430页

作者： Mou Gao Qin dong Dan Zou Zhijun yang Lili Guo Ruxiang xu Department of Neurosurgery Sichuan Academy of Medical Sciences and Sichuan Provincial People’s HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaChengduSichuan ProvinceChina Department of Neurosurgery Chinese PLA General HospitalBeijingChina Department of Neurology Fu Xing HospitalCapital Medical UniversityBeijingChina

Microglial activation that occurs rapidly after closed head injury may play important and complex roles in neuroinflammation-associated neuronal damage and *** previously reported that induced neural stem cells can modulate the behavior of activated microglia via CXCL12/CXCR4 signaling,influencing their activation such that they can promote neurological ***,the mechanism of CXCR4 upregulation in induced neural stem cells remains *** this study,we found that nuclear factor-κB activation induced by closed head injury mouse serum in microglia promoted CXCL12 and tumor necrosis factor-αexpression but suppressed insulin-like growth factor-1 ***,recombinant complement receptor 2-conjugated Crry(CR2-Crry)reduced the effects of closed head injury mouse serum-induced nuclear factor-κB activation in microglia and the levels of activated microglia,CXCL12,and tumor necrosis factor-α.Additionally,we observed that,in response to stimulation(including stimulation by CXCL12 secreted by activated microglia),CXCR4 and Crry levels can be upregulated in induced neural stem cells via the interplay among CXCL12/CXCR4,Crry,and Akt signaling to modulate microglial *** agreement with these in vitro experimental results,we found that Akt activation enhanced the immunoregulatory effects of induced neural stem cell grafts on microglial activation,leading to the promotion of neurological recovery via insulin-like growth factor-1 secretion and the neuroprotective effects of induced neural stem cell grafts through CXCR4 and Crry upregulation in the injured cortices of closed head injury ***,these beneficial effects of Akt activation in induced neural stem cells were positively correlated with the therapeutic effects of induced neural stem cells on neuronal injury,cerebral edema,and neurological disorders post–closed head *** conclusion,our findings reveal that Akt activation may enhance the immunoregulatory effects of induced neura

关键词： Akt signaling cerebral edema closed head injury Crry CXCR4 induced neural stem cell microglia neuroinflammation

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DIATOM COMMUNITY SUCCESSION AND NUTRIENT EVOLUTION RECORDED FROM A SEDIMENT CORE OF THE LONGGAN LAKE, A LARGE SHALLOW LAKE IN EAST CHINA

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水生生物学报 2006年第6期30卷 702-710页

作者： dong xu-Hui and yang Xiang-dong (Nanjing Institute of Geography & Limnology, the Chinese Academy of Sciences, Nanjing 210008, China) Nanjing Institute of Geography & Limnology the Chinese Academy of Sciences Nanjing 210008

The Longgan Lake is a shallow mesotrophic macrophyte-dominated lake. According to the high-resolution diatom research from its sediment core, the diatom community succession was built, and the total phosphorus (TP) and chlorophyll-a (Chl-a) concentration were quantitatively reconstructed for the past 2000 years, based on the diatom-TP and diatom-Chla transfer functions. The shifts of diatom assemblages also mirrored the developments of aquatic plant, reflecting the characters of aquatic ecosystem evolution. The inferred epilimnetic TP concentration fluctuated within a small range of 36 to 62μg/L, indicating the lake remained a relative stable mesotrophic status in the long historical period. The periodical variations of the diatom assemblage and trophic status suggest a mitigating function of shallow macrophyte-dominated lakes to nutrient input. The changes of lakes’ trophic status don’t linearly respond to the human disturbance in the catchment. The dynamics mechanism of phosphorus in macrophyte-dominated lakes, as inferred from diatoms, will provide a scientific foundation for the prediction of trophic status change in a shallow lake, as well as the lake ecological restoration and management decisions.

关键词： Diatom assemblage Nutrient Quantitative reconstruction Aquatic macrophyte Longgan Lake

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基于网络拓扑结构的多摄像头移动对象辅助协同跟踪

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武汉大学学报（信息科学版） 2017年第8期42卷 1117-1122页

作者：郑毅许涛徐栋杨婷婷李响华东师范大学地理信息科学教育部重点实验室上海200062

针对当前公共安全监控系统在应对突发事件时,因监视器数量多、信息量大、事件变化快等因素而导致的不能及时有效地对移动对象进行跟踪的问题,提出了一种基于拓扑结构的多摄像头移动对象辅助协同跟踪方法。首先将城市路网中的摄像头监控... 详细信息

针对当前公共安全监控系统在应对突发事件时,因监视器数量多、信息量大、事件变化快等因素而导致的不能及时有效地对移动对象进行跟踪的问题,提出了一种基于拓扑结构的多摄像头移动对象辅助协同跟踪方法。首先将城市路网中的摄像头监控区域抽象为虚拟节点定位至结点弧段模型中,构建摄像头网络拓扑结构;根据拓扑关系搜索出与发现移动对象的摄像头关联的摄像头集合;再分析摄像头间的空间邻近关系和时间差异,获取时序关系最优的摄像头组作为重点监控区域进行移动对象跟踪,并定期进行协同更新。最后建立了一个模拟监控系统验证了利用多摄像头协同方法实现对移动对象实时跟踪的有效性。

关键词：网络拓扑结构多摄像头搜索多摄像头协同移动对象跟踪

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A low redox potential and long life organic anode material for sodium-ion batteries

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Journal of Energy Chemistry 2025年第1期100卷 557-564页

作者： Zhi Li yang Wei Kang Zhou Xin Huang Xing Zhou Jie xu Taoyi Kong Junwei Lucas Bao Xiaoli dong Yonggang Wang Department of Chemistry and Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials Institute of New Energy Collaborative Innovation Center of Chemistry for Energy Materials (iChEM) Fudan University Department of Chemistry Boston College School of Materials Science and Engineering Anhui University of Technology

Sodium-ion batteries （SIBs） with organic electrodes are an emerging research direction due to the sustainability of organic materials based on elements like C,H,O,and sodium ***,organic electrode materials for SIBs are mainly used as cathodes because of their relatively high redox potentials（>1 V）.Organic electrodes with low redox potential that can be used as anode are ***,a novel organic anode material （tetrasodium 1,4,5,8-naphthalenetetracarboxylate,Na4TDC） has been developed with low redox potential （<0.7 V） and excellent cyclic *** three-sodium storage mechanism was demonstrated with various in-situ/ex-situ spectroscopy and theoretical calculations,showing a high capacity of 208 mAh/g and an average decay rate of merely 0.022%per ***,the Na4TDC-hard carbon composite can further acquire improved capacity and cycling stability for 1200 cycles even with a high mass loading of up to 20 mg *** pairing with a thick Na3V2（PO4）3cathode (20.6 mg cm-2),the as-fabricated full cell exhibited high operating voltage （2.8 V）,excellent rate performance and cycling stability with a high capacity retention of 88.7% after 200 cycles,well highlighting the Na4TDC anode material for SIBs.

关键词： Organic anode material Low redox potential Composite anode Sodium-ion batteries

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