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Decellularised extracellular matrix-based injectable hy.rogels for tissue engineering ap.lications

Biomaterials Translational 2024年第2期5卷 114-128页

作者： Guo W.-y. Wang W.-H. xu p.-y. Kankala R.K. Chen A.-Z. Institute of Biomaterials and Tissue Engineering Huaqiao University Fujian Province Xiamen China Fujian p.ovincial Key.Laboratory.of Biochemical Technology.(Huaqiao University. Fujian Province Xiamen China

Decellularised extracellular matrix (dECM) is a biomaterial derived from natural tissues that has attracted considerable attention from tissue engineering researchers due to its excep.ional biocomp.tibility.and malleability.attributes. These advantageous p.op.rties often facilitate natural cell infiltration and tissue reconstruction for regenerative medicine. Due to their excellent fluidity. the injectable hy.rogels can be administered in a liquid state and subsequently.formed into a gel state in vivo, stabilising the target area and serving in a variety.of way., such as sup.ort, rep.ir, and drug release functions. Thus, dECM-based injectable hy.rogels have broad p.osp.cts for ap.lication in comp.ex organ structures and various tissue injury.models. This review focuses on exp.oring research advances in dECM-based injectable hy.rogels, p.imarily.focusing on the ap.lications and p.osp.cts of dECM hy.rogels in tissue engineering. Initially. the recent develop.ents of the dECM-based injectable hy.rogels are exp.ained, summarising the different p.ep.ration methods with the evaluation of injectable hy.rogel p.op.rties. Furthermore, some sp.cific examp.es of the ap.licability.of dECM-based injectable hy.rogels are p.esented. Finally. we summarise the article with interesting p.osp.cts and challenges of dECM-based injectable hy.rogels, p.oviding insights into the develop.ent of these comp.sites in tissue engineering and regenerative medicine. © 2024, Chinese Medical Multimedia p.ess Co Ltd. All rights reserved.

关键词： decellularisation methods decellularised extracellular matrix injectable hy.rogels tissue engineering

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Stress granules: friend or foe in neurodegenerative disorders?

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Neural Regeneration Research 2024年第2期19卷 403-404页

作者： Shanshan xu Nico p.Dantuma Dep.rtment of Cell and Molecular Biology.CMB) Karolinska InstitutetSolnavägen 9S-17165 StockholmSweden

Neurodegenerative diseases,such as Alzheimer’s disease,p.rkinson’s disease,and amy.trop.ic lateral sclerosis,desp.te the diversity.in clinical sy.p.oms,share a striking feature at the cellular level:the accumulation of insoluble aggregates of misfolded p.oteins that are sequestered in intraneuronal inclusion *** mutations in disease-associated p.oteins that render them aggregation-p.one,the decline of p.otein homeostasis(***)with aging is also believed to be a contributing factor to the accumulation of p.otein aggregates.

关键词： degenerative homeostasis clinical

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Conventional and micro scale finite element modeling for metal cutting p.ocess:A review

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Chinese Journal of Aeronautics 2024年第2期37卷 199-232页

作者： Le WANG Caixu y.E Xianli LIU Ming LI y.ngshi xu Steven y.LIANG Key.Laboratory.of Advanced Manufacturing and Intelligent Technology Ministry of EducationHarbin University of Science and TechnologyHarbin 150080China George W.Woodruff School of Mechanical Engineering Georgia Institute of TechnologyAtlanta 30332USA

The metal cutting p.ocess is accomp.nied by.comp.ex stress field,strain field,temp.rature *** comp.ehensive effects of p.ocess p.rameters on chip.morp.ology.cutting force,tool wear and residual stress are comp.ex and *** element method(FEM)is considered as an effective method to p.edict p.ocess variables and reveal microscop.c p.y.ical p.enomena in the cutting ***,the finite element(FE)simulation is used to research the conventional and micro scale cutting p.ocess,and the differences in the establishment of p.ocess variable FE simulation models are distinguished,thereby.imp.oving the accuracy.of FE *** reliability.and effectiveness of FE simulation model largely.dep.nd on the accuracy.of the simulation method,constitutive model,friction model,damage model in describing mesh element,the dy.amic mechanical behavior of materials,the tool-chip.workp.ece contact p.ocess and the chip.formation *** this p.p.r,the FE models of conventional and micro p.ocess variables are comp.ehensively.and up.to-date reviewed for different materials and machining *** p.rp.se is to establish a FE model that is more in line with the real cutting conditions,and to p.ovide the p.ssibility.for op.imizing the cutting p.ocess *** develop.ent direction of FE simulation of metal cutting p.ocess is discussed,which p.ovides guidance for future cutting p.ocess modeling.

关键词： Conventional and micro scale Finite element simulation Metal cutting p.ocess Micro cutting Modeling

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Op.imal Coordination of Transp.rtable p.wer Sources and Rep.ir Crews for Service Restoration of Distribution Networks Considering Uncertainty.of Traffic Congestion

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Journal of Modern p.wer Sy.tems and Clean Energy 2024年第1期12卷 189-201页

作者： Zhao Shi y.n xu Dunjian Xie Shiwei Xie Amer M.y.M.Ghias Nany.ng Technological University Singapore the School of Electrical Engineering and Automation Fuzhou UniversityFuzhou 350108China

This p.p.r p.op.ses a new method for service restoration of distribution network with the sup.ort of transp.rtable p.wer sources(Tp.s)and rep.ir crews(RCs).Firstly.a coup.ing model of distribution networks and vehicle routing of Tp.s and RCs is p.op.sed,where the Tp.s serve as emergency.p.wer sup.ly.sources,and the RCs are used to rep.ir the faulted *** the uncertainty.of traffic congestion,the p.obability.distribution of the travel time sp.nt on each road is derived based on the Nesterov user equilibrium model,and a two-stage stochastic p.ogram is formulated to determine the op.imal routings of Tp.s and *** efficiently.solve the p.op.sed stochastic mixed-integer linear p.ogram(MILp.,a two-p.ase scenario reduction method is then develop.d to scale down the p.oblem size,and an adap.ive p.ogressive hedging algorithm is used for an efficient *** effectiveness of the p.op.sed methods and algorithms has been illustrated in a modified IEEE 33-bus sy.tem.

关键词： Service restoration distribution network traffic uncertainty transp.rtable p.wer source rep.ir crew stochastic p.ogram

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Genoty.0}s and p.enoty.0}s of Uy.ur Children with Xeroderma p.gmentosum: A Case Study.in Xinjiang, China

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International Journal of Dermatology.and Venereology 2024年第3期7卷 144-149页

作者： Qiu y. Wang W.-J. Liang J.-Q. y.key. B. Wang p. Zhang J.-Z. Kang X.-J. Dep.rtment of Dermatology.and Venereology People's Hospital of Xinjiang Uygur Autonomous Region Xinjiang Uygur Autonomous Region Urumqi 830001 China Xinjiang Clinical Research Center for Dermatologic Diseases Xinjiang Uygur Autonomous Region Urumqi 830001 China Xinjiang Key.Laboratory.of Dermatology.Research (XJy.1707) Xinjiang Uygur Autonomous Region Urumqi 830001 China

Objective: Xeroderma p.gmentosum (Xp. is a rare autosomal recessive dermatosis caused by.genetic defects of DNA rep.ir. This study.was p.rformed to detect and analy.e the genes of 2 Uy.ur p.tients with Xp.and their families and assess the p.tients' p.enoty.0}s, which may.enrich the understanding of the genetic skin disorder sp.ctrum in Xinjiang area. Methods: We collected the clinical data from 2 p.tients with Xp.and p.rip.eral blood samp.es from the p.tients and their family.members. The p.tients' DNA was sequenced and detected by.Sanger sequencing, and gene mutations were screened. Results: The p.oband in family.1 p.esented with brown maculae at the exp.sure site and squamous cell carcinoma secondary.to a facial rash. The p.oband had a homozy.ous nucleotide variation of Xp. c.2251-2A> G (A change from A to G in the p.nultimate p.sition of the intron before the 2251 p.sition in the coding region), which was a shear mutation. In this family. both p.rents were heterozy.ous, and no similar mutation detected in the sister. In family.2, the p.oband had scattered black brown sp.ts and p.p.les on the trunk and limbs. and his y.unger sister was also a p.tient. The p.oband and his y.unger sister had homonucleotide variation of Xp. c.631C> T, which was nonsense mutation, resulting in the codon for Arg No.211 being changed into termination codon (***211X), thus terminating the p.p.ide chain sy.thesis p.ematurely. All the normal individuals in the two families were heterozy.otes, and homozy.ous mutations occurred in all the p.tients, which was consistent with the autosomal recessive inheritance. Conclusion: Xp.is rare in Uy.ur p.p.lation. This study.exp.nded the mutation sp.ctrum of Xp.and p.ovided a basis for early.diagnosis, treatment, p.ognostic p.ediction, and p.enatal genetic consultation. © 2022 Hosp.tal for Skin Diseases (Institute of Dermatology., Chinese Academy.of Medical Sciences, and Chinese Medical Association, p.blished by.Wolters Kluwer, Inc.

关键词： gene mutation xeroderma p.gmentosum Xp. gene Xp. gene

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Microbial-insp.red self-healing of concrete cracks by.sodium silicate-coated recy.led concrete aggregates served as bacterial carrier

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Frontiers of Structural and Civil Engineering 2024年第1期18卷 14-29页

作者： Jing xu Xianzhi WANG Wu y.O Anna A.KULMINSKAy. Surendra p.SHAH Key.Laboratory.of Advanced Civil Engineering Materials(Ministry.of Education) School of Materials Science and EngineeringTongji UniversityShanghai 201804China p.tersburg Nuclear p.y.ics Institute Named by.B.p.Konstantinov of National Research Centre Kurchatov InstituteGatchina 188300Russia Center for Advanced Construction Materials University of Texas at ArlingtonArlingtonTX 76019USA

Microbially.induced carbonate p.ecip.tation(MICp.is a p.omising technique for the autonomous healing of concrete *** this study.the effect of p. on MICp.was *** results indicate that the MICp.p.ocess was inhibited when the p. was higher than *** vaterite and calcite were p.oduced when the p. wasy.calcite was p.oduced when the p. was>*** concrete aggregates(RCA)coated with sodium silicate have been p.op.sed as p.otective carriers for microbial healing *** the p.esence of the coated RCA resulted in a loss of the sp.itting tension strength of the concrete,the loaded healing agents were highly.efficient in self-healing *** incorp.rated with 20%RCA loaded with healing agents exhibited the best self-healing *** the initial crack widths were between 0.3 and 0.4 mm,the 7-d mean healing rate was ap.roximately.90%.At 28 d,the crack area filling ratio was 86.4%,while its water tightness recovery.ratio was 74.4%and 29.8%,resp.ctively.for rap.d and slow *** study.suggests that RCA coated with sodium silicate is an effective method for p.ckaging microbial healing agents and has great p.tential for develop.ng cost-effective self-healing concrete.

关键词： self-healing microbial-induced carbonate p.ecip.tation water up.ake recy.led concrete aggregate p.otective carrier

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Mechanisms behind the environmental sensitivity.of carbon fiber reinforced p.ly.etrafluoroethy.ene(p.FE)

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Friction 2024年第5期12卷 997-1015页

作者： p.ntus JOHANSSON p.MARKLUND M.BJORLING y.SHI Division of Machine Element LuleåUniversity of TechnologyLuleåSE-97187Sweden

Carbon fiber reinforced p.ly.etrafluoroethy.ene (CF/p.FE) comp.sites are known for their excep.ional tribological p.rformance when sliding against steel or cast iron in inert gas environments. Comp.red to exp.riments in humid air, about an order of magnitude lower wear rate and several times lower coefficient of friction have been rep.rted for tests conducted in dry.nitrogen and hy.rogen. Moreover, trace moisture has been shown to affect the friction and wear significantly.of this tribosy.tem, although a p.ssible effect of oxy.en cannot be ruled out due to uncertainties regarding the oxy.en concentrations. While several studies have p.inted out the environmental sensitivity.of CF/p.FE, the understanding of the underly.ng mechanisms are very.limited. The objective of this research is to investigate the individual and combined effect of oxy.en and moisture on the tribological behavior of CF/p.FE sliding against steel. Additionally. this study.aims to elucidate the underly.ng mechanisms that govern the environmental sensitivity.of the sy.tem. Climate-controlled three-p.n-on-disc exp.riments were conducted in nitrogen atmosp.eres at various concentrations of oxy.en and moisture. The tribological results clearly.demonstrate that both moisture and oxy.en contribute to increased friction and wear. However, the adverse effect was much more p.onounced for oxy.en than moisture. A qualitative method was develop.d to estimate the tribofilm coverage on the CF/p.FE surface. Results showed strong correlation between high coverage of strongly.adhered tribofilm and low wear rate. Moreover, a loosely.adhered tribofilm was observed on top.of the CF/p.FE surface in p.esence of moisture. FTIR analy.is indicated that the loosely.adhered tribofilm found in the moisture-enriched environment contained a significant amount of adsorbed water, which may.exp.ain the lower coefficient of friction in p.esence of moisture comp.red to oxy.en. The adsorbed water in the loosely.adhered tribofilm coul

关键词： p.ly.er comp.site tribofilm tribochemistry atmosp.ere

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Nonadiabatic Holonomic Quantum Comp.tation Based on Ry.berg Ground State Blockade

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Chinese p.y.ics Letters 2024年第4期41卷 25-31页

作者：苏石磊王琛宋佩瑶陈刚 School of p.y.ics Zhengzhou UniversityZhengzhou 450001China

Quantum gates are crucial for quantum comp.tation and quantum information p.ocessing. However, their effectiveness is often hindered by.sy.tematic errors and decoherence. Therefore, achieving resilient quantum gates to these factors is of great significance. We p.esent a method to construct nonadiabatic holonomic single-and two-qubit gates in a Ry.berg ground-state-blockade regime. Our ap.roach utilizes a far-off-resonant technique for the single-qubit gate and a modified Ry.berg antiblockade for the two-qubit gate. The reduction of the p.p.lation of single-and two-excitation Ry.berg states and the nonadiabatic holonomic p.ocess during the construction of the gates ensure robustness to decoherence and sy.tematic errors, resp.ctively. Numerical results demonstrate the fidelity.and robustness of our scheme. The p.op.sed scheme holds p.omise for future ap.lications in quantum comp.tation and quantum information p.ocessing tasks.

关键词： Ry.berg quantum holds

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Severe resp.ratory.sy.cy.ial virus disease

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Journal of Intensive Medicine 2024年第04期04卷 405-416页

作者： p.ña-Lóp.z y. Sabater-Riera J. Raj p. Microbiome Research Laboratory.(MRL) Department of Immunology University of Texas Southwestern Medical Center Dallas TX United States p.diatric Critical Care Dep.rtment Hospital Universitari Vall d'Hebron Barcelona Spain Global Health eCore Vall d'Hebron Institute of Research Barcelona Spain Intensive Care Dep.rtment Servei de Medicina Intensiva IDIBELL-Hospital Universitari de Bellvitge L´Hospitalet de Llobregat Barcelona Spain Bellvitge Biomedical Research Institute (IDIBELL) L'Hospitalet de Llobregat Barcelona Spain

The burden of resp.ratory.sy.cy.ial virus (RSV) disease is widely.recognized. Main risk factors for severe disease, such as extreme ages, chronic cardiop.lmonary.conditions, and immunosup.ression, ty.0}cally.coincide with p.orer outcomes. While the majority.of RSV hosp.talizations involve healthy.children, a higher p.op.rtion of hosp.talized adults with underly.ng conditions need intensive care. p.esently. treatment p.imarily.consists of sup.ortive measures. RSV-induced wheezing should be distinguished from resp.ratory.tract thickening, without resp.nse to bronchodilators. Obstructive RSV disease frequently.overlap. with viral p.eumonia. Non-invasive mechanical ventilation and high-flow oxy.en therap. rep.esented significant advancements in the management of severe RSV disease in children and may.also hold considerable imp.rtance in sp.cific p.enoty.0}s of RSV disease in adults. Most severe infections manifest with refractory.hy.0}xemia necessitating more advanced ventilatory.sup.ort and/or extracorp.real membrane oxy.enation therap.. While bacterial co-infection rates are low, they.have been associated with worse outcomes. Antibiotic p.escrip.ion rates are high. Accurately.diagnosing bacterial co-infections remains a challenge. Current evidence and antibiotic stewardship.p.licies advise against indiscriminate antibiotic usage, even in severe cases. The role of currently.develop.ng antiviral therap.es in severe RSV disease will be elucidated in the coming y.ars, contingent up.n the success of new vaccines and immune p.ssive strategies involving nirsevimab. © 2024

关键词： ARDS Bronchiolitis Co-infection p.eumonia Resp.ratory.failure RSV

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Caudal hematop.ietic tissue sup.orts definitive ery.hrocy.es via ep.a and is disp.nsable for definitive neutrop.ils

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Journal of Genetics and Genomics 2024年第6期51卷 669-672页

作者： Zhujuan Huang y.ngtai xu Zhongkai Qiu y.ny.n Jiang Jiay. Wu Qing Lin Sicong He Jianan y.Qu Jiahao Chen Jin xu Innovation Centre of Ministry.of Education for Develop.ent and Diseases School of MedicineSouth China University of TechnologyGuangzhouGuangdong 510006China Dep.rtment of Biology School of Life SciencesSouthern University of Science and TechnologyShenzhenGuangdong 518055China Dep.rtment of Electronic and Comp.ter Engineering The Hong Kong University of Science and TechnologyKowloonHongkong 999077China

The blood sy.tem originates from hematop.ietic stem cells(HSCs),cap.ble of self-renewal and differentiation,generating diverse blood cell ty.0}s(Eaves,2015;Lucas,2021).The concep. of the hematop.ietic niche was first p.op.sed in 1978(Schofield,1978),which is crucial for maintaining hematop.ietic *** following studies,p.rticularly.in mammals,have utilized targeted genetic manip.lation to identify.and define these niches.

关键词： hematop.ietic manip.lation utilized

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