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Single-Nucleus RNA Sequencing Reveals Cardiac Macrophage Landscape in Hypoplastic Left Heart Syndrome

Congenital Heart Disease 2024年第2期19卷 233-246页

作者： Xiaozhuo xu Yilin Huang xu Han First Clinical Medical College Affiliated Hospital of Nanjing University of Chinese MedicineNanjing210008China Department of Geriatrics Affiliated Hospital of Nanjing University of Chinese MedicineNanjing210029China

Background:Hypoplastic left heart syndrome(HLHS)is one of the most challenging congenital heart diseases in clinical *** cardiac tissues,resident macrophages fulfill critical functions in maintaining a stable cardiac state and have strong regenerative capacity and organ ***,the molecular mechanisms of macro-phages in HLHS remained ***:Single-nucleus RNA sequencing(snRNA-seq)data of HLHS and healthy control(donors)samples obtained from the Gene Expression Omnibus(GEO)database were normalized and clustered using the Seurat ***“FindMarkers”function was used to screen differentially expressed genes(DEGs)between the HLHS and donor groups and to analyze the functional enrichment of the set of genes of ***,cell-cell communication,pseudotime,and single-cell regulatory network inference and cluster-ing(SCENIC)analyses were used to study the mechanisms of macrophages in ***:Based on the snRNA-seq data of HLHS and donors,we identified a total of 9 cell clusters,among which the proportion of macrophages was significantly less in the HLHS group than in the control *** of macrophage subpopulations(Macrophages 1,2,and 3)showed that Macrophages 1 was mainly involved in nervous system development,angiogenesis,and apoptotic *** addition,analysis of communication between Macro-phages 1 and cardiomyocytes revealed that ligand-acceptor pairs such as GAS6/AXL,IL6,IGF1,THY1,and L1CAM were present only in the donor ***,pesudotime and SCENIC analyses demonstrated that FOXO3 and ELF2 played a critical role for Macrophages 1 to maintain cardiac function in patients with ***:Our study improved the current understanding of the molecular mechanisms of macrophage devel-opment in HLHS,showing that manipulating the regulatory role of macrophages in the heart can be a novel treat-ment for HLHS.

关键词： Hypoplastic left heart syndrome single-nucleus RNA sequencing macrophage cellular subpopulation transcription factor

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The Essential 2-rank for Classical Groups

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Acta Mathematica Sinica,English Series 2024年第9期40卷 2169-2186页

作者： Jian Bei AN Yong xu Department of Mathematics University of AucklandAucklandNew Zealand School of Mathematics and Statistics He’nan University of Science and TechnologyLuoyang 471023P.R.China

Let G be a symplectic or orthogonal group defined over a finite field with odd characteristic and let D≤G be a Sylow *** this paper,we classify the essential 2-subgroups and determine the essential 2-rank of the Frobenius category FD(G).Together with the results of An–Dietrich and Cao–An–Zeng,this completes the work of essential subgroups and essential ranks of classical groups.

关键词： Frobenius category conjugation families essential 2-rank symplectic groups orthogonal groups

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Design Research of a Novel Aftercool-Humidifier Concept for Humid Air Turbine Cycle

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Journal of Thermal Science 2024年第3期33卷 951-969页

作者： ZHANG Junzheng xu Zhen School of Energy and Power Engineering Shandong UniversityJi’nan250061China Shandong Engineering Laboratory for High-efficiency Energy Conservation and Energy Storage Technology&Equipment Shandong UniversityJi’nan250061China

Humid air turbine cycle(HAT)has potential of electrical efficiencies comparable to combined cycle,with lower investment cost and NO_(x) *** typical heat exchanger network of HAT consists of intercooler(if there is),aftercooler,recuperator,economizer and humidifier,which brings higher efficiency but makes the system more *** simplify HAT layout,a novel humidifier concept is proposed by integrating the aftercooler into traditional counter-current *** on this concept,a one-dimensional model including pressure drop and exergy calculation is established to distinguish the thermodynamic and hydrodynamic characteristics,and then the structural parameters,such as the number of rows and columns,tube diameter,pitch and type for a micro HAT are *** results show that the aftercool-humidifier plays the same role as original aftercooler and humidifier,and can match the in-tube air,out-tube air and water stream well with lower *** the case of micro HAT cycle,the volume of heat and mass transfer area can be reduced by 47%compared with traditional *** major thermal resistance occurred in the convection heat transfer process inside the tube;however,using enhanced tube cannot effectively improve the compactness of device.

关键词： humid air turbine cycle humidifier thermodynamic analysis one-dimensional model

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龙舟锻炼对大学生心理健康的影响研究——以常州工程职业技术学院为例

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当代体育科技 2022年第8期12卷 196-198页

作者：徐文杰常州工程职业技术学院体育与健康管理学院江苏常州213000

当代大学生的身心健康是人们一直关注的重点,我国高职院校除了培养大学生成为有知识的人才外,还要关心大学生在校期间的身心健康状况。对此,很多高校采取鼓励大学生开展各种运动的方法,以提高大学生身体素质和心理健康水平。其中,我国... 详细信息

当代大学生的身心健康是人们一直关注的重点,我国高职院校除了培养大学生成为有知识的人才外,还要关心大学生在校期间的身心健康状况。对此,很多高校采取鼓励大学生开展各种运动的方法,以提高大学生身体素质和心理健康水平。其中,我国优秀的民族传统体育项目——龙舟,开始从民间走进大学校园,并迅速成为大学校园中深受学生喜欢的体育项目。大学生在划龙舟的过程中得到了身体与心理上的锻炼,对促进自身的心理健康有着很大的帮助。该文以常州工程职业技术学院为例,重点研究了龙舟锻炼对大学生心理健康产生的有利影响,以更好地推广高校龙舟运动。

关键词：龙舟锻炼大学生心理健康影响研究

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ICU重症脑损伤机械通气患者应用舒适化浅镇静护理的效果

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中国医药指南 2022年第32期20卷 30-33页

作者：徐文洁福建省顺昌县医院重症医学科福建顺昌353200

目的分析ICU重症脑损伤机械通气患者应用舒适化浅镇静护理的效果。方法选取2020年1月至2021年12月我院收治的74例ICU重症脑损伤机械通气患者纳入研究对象,按随机分组方式将患者分为观察组(36例)和对照组(38例),对照组ICU重症脑损伤患者... 详细信息

目的分析ICU重症脑损伤机械通气患者应用舒适化浅镇静护理的效果。方法选取2020年1月至2021年12月我院收治的74例ICU重症脑损伤机械通气患者纳入研究对象,按随机分组方式将患者分为观察组(36例)和对照组(38例),对照组ICU重症脑损伤患者实施常规护理,观察组ICU重症脑损伤患者应用舒适化浅镇静护理,评测两组患者平均症状消退时间、麻醉药物使用剂量、并发症发生率、舒适度评分、护理前后生活质量评分改善、预后情况。结果试验结果显示,采用舒适化浅镇静护理模式的观察组ICU机械通气患者咳嗽、咳血、咳痰、气喘等症状消退时间明显短于对照组(P<0.05);右美托咪定、丙泊酚使用剂量明显低于对照组(P<0.05);观察组谵妄、肺部感染、呼吸机相关性肺炎、意外拔管、气管堵塞等并发症发生率显著低于对照组(P<0.05);舒适度评分显著高于对照组(P<0.05);各项生活质量评分改善情况显著优于对照组(P<0.05);ICU入住时间、机械通气时间明显短于对照组(P<0.05)。结论ICU重症脑损伤机械通气患者应用舒适化浅镇静护理具有良好的效果,能显著减少机械通气期间的并发症和麻醉药物使用量,促进患者的各项症状更快速的恢复,提高患者的舒适度和生活质量。

关键词：重症脑损伤机械通气舒适化浅镇静护理舒适度并发症生活质量

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基于多维度的高校环境设计课程评价与优化策略研究

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鞋类工艺与设计 2022年第21期2卷 77-79页

作者：徐文杰淮阴师范学院江苏淮安223001

课程评价是课程建设与发展的重要环节,以往设计类教学论文侧重观点阐述,鲜有通过定量研究给出发展策略及建议。以环境设计基础课程《空间形式与组合设计》教学为例,采用归纳法、层次分析法。揭示教学策略方向、课程学习方法及专业发展... 详细信息

课程评价是课程建设与发展的重要环节,以往设计类教学论文侧重观点阐述,鲜有通过定量研究给出发展策略及建议。以环境设计基础课程《空间形式与组合设计》教学为例,采用归纳法、层次分析法。揭示教学策略方向、课程学习方法及专业发展趋势。

关键词：基础课程空间形态新文科策略及建议

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From charge storage mechanism to performance:A strategy toward boosted lithium/sodium storage through heterostructure optimization

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Journal of Energy Chemistry 2024年第1期88卷 112-124,I0003页

作者： Xiaoke Zhang Guangfa Deng Mianying Huang Zhaohui xu Jianlin Huang xuan xu Zhiguang xu Maochan Li Lei Hu Xiaoming Lin Key Laboratory of Theoretical Chemistry of Environment Ministry of EducationSchool of ChemistrySouth China Normal UniversityGuangzhou 510006GuangdongChina Anhui Laboratory of Functional Coordinated Complexes for Materials Chemistry and Application School of Chemical and Environmental EngineeringAnhui Polytechnic UniversityWuhu 241000AnhuiChina National Engineering Research Center for Carbohydrate Synthesis Key Lab of Fluorine and Silicon for Energy Materials and Chemistry of Ministry of EducationJiangxi Normal UniversityNanchang 330022JiangxiChina

Solving the problems of low electrical conductivity and poor cycling durability in transition metal oxidesbased anode materials for lithium-ion batteries(LIBs)and sodium-ion batteries(SIBs)has already turned into an urgent *** this paper,we successfully synthesized Co_(2)VO_(4)/Co compounds with Co-VMOF(metal-organic framework)as a sacrificial template and investigated their electrochemical mechanism in order to improve the electrochemical properties of LIBs and *** optimized heaping configuration and the existence of metallic Co catalyzed the formation of radical ions,thereby facilitating higher conductivity,shortening Li+and Na+transport paths,and providing more active ***_(2)VO_(4)/Co constructed with 2-methylimidazole as a ligand showed a discharge capacity of 1605.1 mA h g^(-1)after 300 cycles at 0.1 A g^(-1)in LIB and 677.2 mA h g^(-1)in *** functional theory(DFT)calculation emphasizes the crucial role of Co_(2)VO_(4)/Co in enhancing electrode conductivity,decreasing the migratory energy barrier,and thereby strengthening electrochemical *** heterostructure building technique may pave the way for the development of high-performance LIBs and ***,the problem of the low first-loop coulombic efficiency faced by transition metal oxides is improved.

关键词： Metal-organic framework Heterostructure Lithium-ion batteries Sodium-ion batteries DFT calculation

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A gold-based multiplex immunochromatographic sensor for detecting paclitaxel

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Nano Research 2024年第7期17卷 6420-6429页

作者： Xiaoqian Jiang Aihua Qu Xinxin xu Hua Kuang Liqiang Liu Chuanlai xu State Key Laboratory of Food Science and Technology Jiangnan UniversityWuxi 214122China International Joint Research Laboratory for Biointerface and Biodetection and School of Food Science and TechnologyJiangnan UniversityWuxi 214122China

Paclitaxel(PTX),methotrexate(MTX),and 5-fluorouracil(5-FU)are commonly-used small molecule anti-tumor drugs for breast ***,drug resistance occurs with long-term treatment or excessive use,and the high concentrations of PTX,MTX,and 5-FU in patients may lead to side effects with dose-limiting toxicities,such as myelosuppression,hepatotoxicity,and peripheral ***,concentration monitoring of PTX,MTX,and 5-FU in clinical treatment is very *** prepared highly sensitive and specific monoclonal antibodies using several haptens,and established a multiple paper-based sensor utilizing optical signals of gold nanoparticles,which simultaneously detected PTX,MTX,and 5-FU in human plasma or urine with 10 min.A portable scanner for quantitative detection in plasma and urine samples was used,and the calculated limit of detection(cLOD)values were 0.002 and 0.142μg/mL for PTX,0.187 and 0.976 ng/mL for MTX,and 0.057 and 0.128μg/mL for 5-FU,*** the recovery test,the recovery rates and the coefficient of variation were 85.84%–108.81%and 1.23%–8.80%,respectively,indicating the reliability and accuracy of the multiple gold immunochromatographic strip(GIS).In addition,for the determination of collected clinical plasma samples,the correlation between the test data of the multiple GIS and liquid chromatography–tandem mass spectrometry(LC–MS/MS)was ***,the developed multiple GIS could be applied to the rapid detection of PTX,MTX,and 5-FU in different clinical samples.

关键词： paclitaxel methotrexate 5-fluorouracil immunochromatographic assay plasma urine

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校园龙舟文化研究——以常州工程职业技术学院为例

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当代体育科技 2022年第1期12卷 141-144页

作者：徐文杰常州工程职业技术学院江苏常州213000

该文以常州工程职业技术学院龙舟文化活动为研究对象,挖掘龙舟文化在校园传承的价值,梳理龙舟文化校园传承的内容与分类,以及龙舟文化与校园文化融合所产生的教化效应。归纳龙舟文化与校园文化的融合路径,即申报龙舟文化传承基地,加强... 详细信息

该文以常州工程职业技术学院龙舟文化活动为研究对象,挖掘龙舟文化在校园传承的价值,梳理龙舟文化校园传承的内容与分类,以及龙舟文化与校园文化融合所产生的教化效应。归纳龙舟文化与校园文化的融合路径,即申报龙舟文化传承基地,加强龙舟文化国际交流,扩展龙舟校园文化的产学研规模。以期从龙舟校园文化实践角度,发现龙舟文化在高校校园中形成的教化、凝聚作用,并服务于常州高校校园文化的发展。

关键词：高校龙舟文化常州传承

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Evaluation on Configuration Stiffness of Overconstrained 2R1T Parallel Mechanisms

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Chinese Journal of Mechanical Engineering 2024年第3期37卷 62-82页

作者： xuejian Ma Zhenghe xu Yundou xu Yu Wang Jiantao Yao Yongsheng Zhao Parallel Robot and Mechatronic System Laboratory of Hebei Province Yanshan UniversityQinhuangdao 066004China Key Laboratory of Advanced Forging and Stamping Technology and Science of Ministry of National Education Yanshan UniversityQinhuangdao 066004China

Currently,two rotations and one translation(2R1T)three-degree-of-freedom(DOF)parallel mechanisms(PMs)are widely applied in five-DOF hybrid machining ***,there is a lack of an effective method to evaluate the configuration stiffness of mechanisms during the mechanism design *** is a challenge to select appropriate 2R1T PMs with excellent stiffness performance during the design *** the operational status of 2R1T PMs,the bending and torsional stiffness are considered as indices to evaluate PMs'configuration ***,a specific method is proposed to calculate these stiffness ***,the various types of structural and driving stiffness for each branch are assessed and their specific values ***,a rigid-flexible coupled force model for the over-constrained 2R1T PM is established,and the proposed evaluation method is used to analyze the configuration stiffness of the five 2R1T PMs in the entire ***,the driving force and constraint force of each branch in the whole working space are calculated to further elucidate the stiffness evaluating results by using the proposed method *** obtained results demonstrate that the bending and torsional stiffness of the 2RPU/UPR/RPR mechanism along the x and y-directions are larger than the other four mechanisms.

关键词： Parallel mechanism Stiffness Over-constrained Three degrees of freedom

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